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AHRQ Research Studies
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Research Studies is a compilation of published research articles funded by AHRQ or authored by AHRQ researchers.
Results
1 to 25 of 64 Research Studies DisplayedScally CP, Yin H, Birkmeyer JD
Comparing perioperative processes of care in high and low mortality centers performing pancreatic surgery.
The researchers compared high and low mortality hospitals in order to identify differences in patient care impacting safety. They concluded that high and low mortality hospitals both have high compliance with common quality measures; however, high mortality hospitals performed worse in other areas of perioperative care, indicating possible targets for quality improvement efforts.
AHRQ-funded; HS020937.
Citation: Scally CP, Yin H, Birkmeyer JD .
Comparing perioperative processes of care in high and low mortality centers performing pancreatic surgery.
J Surg Oncol 2015 Dec;112(8):866-71. doi: 10.1002/jso.24085.
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Keywords: Surgery, Mortality, Quality Improvement, Outcomes, Patient Safety
Lee GE, Fisher BT, Xiao R
Burden of influenza-related hospitalizations and attributable mortality in pediatric acute lymphoblastic leukemia.
The researchers investigated the rate of influenza hospitalizations and attributable mortality in children with cancer. They concluded that the burden of influenza-related hospitalizations in children with acute lymphoblastic leukemia is high and associated with significantly increased resource utilization and attributable mortality.
AHRQ-funded; HS020939.
Citation: Lee GE, Fisher BT, Xiao R .
Burden of influenza-related hospitalizations and attributable mortality in pediatric acute lymphoblastic leukemia.
J Pediatric Infect Dis Soc 2015 Dec;4(4):290-6. doi: 10.1093/jpids/piu066..
Keywords: Children/Adolescents, Hospitalization, Influenza, Mortality, Children/Adolescents
Ericson JE, Popoola VO, Smith PB
Burden of invasive staphylococcus aureus infections in hospitalized infants.
This study compared demographics and mortality of inf ants with invasive methicillin-resistant S aureus (MRSA) and methicillin-susceptible S aureus (MSSA), to determine the annual proportion of S aureus infections that were MRSA. It found that infant mortality after invasive MRSA and MSSA infections was similar, but MSSA caused more infections and more deaths in infants than MRSA.
AHRQ-funded; HS022872.
Citation: Ericson JE, Popoola VO, Smith PB .
Burden of invasive staphylococcus aureus infections in hospitalized infants.
JAMA Pediatr 2015 Dec;169(12):1105-11. doi: 10.1001/jamapediatrics.2015.2380..
Keywords: Newborns/Infants, Methicillin-Resistant Staphylococcus aureus (MRSA), Mortality, Hospitalization, Risk
Warnock DG, Powell TC, Donnelly JP
Categories of hospital-associated acute kidney injury: time course of changes in serum creatinine values.
The objective of this study was to categorize hospital-associated acute kidney injury (HA-AKI) based on the timing of minimum and peak inpatient serum creatinine (sCr) and describe the association with inpatient mortality. It concluded that risk of short-term inpatient mortality is associated with AKI, and this risk is attenuated with recovery of kidney function in the hospital.
AHRQ-funded; HS013852.
Citation: Warnock DG, Powell TC, Donnelly JP .
Categories of hospital-associated acute kidney injury: time course of changes in serum creatinine values.
Nephron 2015;131(4):227-36. doi: 10.1159/000441956.
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Keywords: Kidney Disease and Health, Adverse Events, Hospitalization, Mortality
Keim-Malpass J, Adelstein K, Kavalieratos D
Legacy making through illness blogs: online spaces for young adults approaching the end-of-life.
The study analyzed the illness blogs of five young women (aged 25-39 years) at the end-of-life using a narrative approach. Key elements of legacy making and grief processing were explored. The women had varying experiences before their death, but uniform posthumous occurrences with the use of the blog for a space of grief for loved ones.
AHRQ-funded; HS022989.
Citation: Keim-Malpass J, Adelstein K, Kavalieratos D .
Legacy making through illness blogs: online spaces for young adults approaching the end-of-life.
J Adolesc Young Adult Oncol 2015 Dec;4(4):209-12. doi: 10.1089/jayao.2015.0003.
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Keywords: Cancer, Mortality, Web-Based, Young Adults
Olfson M, Gerhard T, Huang C
Premature mortality among adults with schizophrenia in the United States.
The objective of the study was to describe overall and cause-specific mortality rates and standardized mortality ratios for adults with schizophrenia compared with the US general population. In a US national cohort of adults with schizophrenia, excess deaths from cardiovascular and respiratory diseases implicate modifiable cardiovascular risk factors, including especially tobacco use.
AHRQ-funded; HS021112.
Citation: Olfson M, Gerhard T, Huang C .
Premature mortality among adults with schizophrenia in the United States.
JAMA Psychiatry 2015 Dec;72(12):1172-81. doi: 10.1001/jamapsychiatry.2015.1737..
Keywords: Mortality, Behavioral Health, Patient-Centered Outcomes Research, Risk
Scialla JJ, Parekh RS, Eustace JA
Race, mineral homeostasis and mortality in patients with end-stage renal disease on dialysis.
In this study, the researchers determined the race-specific relationship between mineral parameters and mortality in patients initiating hemodialysis. They concluded that aberrant phosphorus homeostasis, reflected by higher phosphorus and FGF23, may be a risk factor for mortality in patients initiating hemodialysis, particularly among African Americans.
AHRQ-funded; HS08365.
Citation: Scialla JJ, Parekh RS, Eustace JA .
Race, mineral homeostasis and mortality in patients with end-stage renal disease on dialysis.
Am J Nephrol 2015;42(1):25-34. doi: 10.1159/000438999.
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Keywords: Kidney Disease and Health, Racial and Ethnic Minorities, Mortality, Kidney Disease and Health
Donnelly JP, Wang HE, Locke JE
Hospital-onset Clostridium difficile infection among solid organ transplant recipients.
The researchers examined hospital-onset Clostridium difficile infection (CDI) from 2012 to 2014 among transplant recipients in the University HealthSystem Consortium, which includes academic medical center-affiliated hospitals in the United States. They found that factors associated with CDI among transplant recipients included transplant type, risk of mortality, comorbidities, and inpatient complications.
AHRQ-funded; HS013852.
Citation: Donnelly JP, Wang HE, Locke JE .
Hospital-onset Clostridium difficile infection among solid organ transplant recipients.
Am J Transplant 2015 Nov;15(11):2970-7. doi: 10.1111/ajt.13491.
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Keywords: Clostridium difficile Infections, Healthcare-Associated Infections (HAIs), Transplantation, Adverse Events, Mortality
Grenda TR, Revels SL, Yin H
Lung cancer resection at hospitals with high vs low mortality rates.
The objective of this study was to evaluate perioperative outcomes in patients who underwent lung cancer resection at high-mortality hospitals [HMHs] and low-mortality hospitals [LMHs]) in order to better understand the factors related to differences in mortality rates after lung cancer resection. It concluded that failure-to-rescue rates are higher at HMHs, which may explain the large differences between hospitals in mortality rates following lung cancer resection.
AHRQ-funded; HS000053; HS020937.
Citation: Grenda TR, Revels SL, Yin H .
Lung cancer resection at hospitals with high vs low mortality rates.
JAMA Surg 2015 Nov;150(11):1034-40. doi: 10.1001/jamasurg.2015.2199..
Keywords: Cancer: Lung Cancer, Surgery, Mortality, Outcomes, Patient Safety
Hu Y, McMurry TL, Stukenborg GJ
Readmission predicts 90-day mortality after esophagectomy: analysis of surveillance, epidemiology, and end results registry linked to Medicare outcomes.
The purpose of this study was to characterize postesophagectomy readmissions and determine their relationship with subsequent 90-day mortality. It found that one in 5 esophagectomy patients are readmitted early after discharge. Readmitted patients have a 5-fold increase in early mortality.
AHRQ-funded; HS018049.
Citation: Hu Y, McMurry TL, Stukenborg GJ .
Readmission predicts 90-day mortality after esophagectomy: analysis of surveillance, epidemiology, and end results registry linked to Medicare outcomes.
J Thorac Cardiovasc Surg 2015 Nov;150(5):1254-60. doi: 10.1016/j.jtcvs.2015.08.071..
Keywords: Hospital Readmissions, Mortality, Outcomes, Registries, Surgery
Kramer RD, Cooke CR, Liu V
Variation in the contents of sepsis bundles and quality measures. a systematic review.
The researchers sought to determine the degree of agreement on component elements of sepsis bundles and the associated timing goals for completion of each element. They also evaluated the amount of variation between metrics associated with bundles. They found that no bundle included metrics evaluating timeliness or completeness of sepsis recognition. Also, there was a lack of consensus on component elements and timing goals across highly recognized sepsis bundles.
AHRQ-funded; HS020672.
Citation: Kramer RD, Cooke CR, Liu V .
Variation in the contents of sepsis bundles and quality measures. a systematic review.
Ann Am Thorac Soc 2015 Nov;12(11):1676-84. doi: 10.1513/AnnalsATS.201503-163BC.
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Keywords: Sepsis, Mortality, Guidelines, Antimicrobial Stewardship, Outcomes
Vogel JA, Seleno N, Hopkins E
Denver ED Trauma Organ Failure Score outperforms traditional methods of risk stratification in trauma.
The objective of this study was to compare prognostic accuracies of the Denver Emergency Department (ED) Trauma Organ Failure (TOF) Score, ED Sequential Organ Failure Assessment (SOFA) score, and ED base deficit and ED lactate for inhospital mortality in adult trauma patients. It concluded that The Denver ED TOF Score more accurately predicts inhospital mortality in adult trauma patients compared to the other three.
AHRQ-funded; HS017526.
Citation: Vogel JA, Seleno N, Hopkins E .
Denver ED Trauma Organ Failure Score outperforms traditional methods of risk stratification in trauma.
Am J Emerg Med 2015 Oct;33(10):1440-4. doi: 10.1016/j.ajem.2015.07.006..
Keywords: Emergency Medical Services (EMS), Risk, Mortality, Comparative Effectiveness, Emergency Department
Ning J, Peng S, Ueno N
Has racial difference in cause-specific death improved in older patients with late-stage breast cancer?
The researchers evaluated factors associated with overall, breast cancer-specific and other-cause mortalities using contemporary population data. They concluded that breast cancer-specific mortality among older women modestly improved from 2002 to 2009 across all races, but not other-cause mortality. Racial disparity in mortality persisted, but did not widen in this period.
AHRQ-funded; HS002026.
Citation: Ning J, Peng S, Ueno N .
Has racial difference in cause-specific death improved in older patients with late-stage breast cancer?
Ann Oncol 2015 Oct;26(10):2161-8. doi: 10.1093/annonc/mdv330.
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Keywords: Cancer, Cancer: Breast Cancer, Elderly, Mortality, Racial and Ethnic Minorities
Hemmila MR, Osborne NH, Henke PK
Prophylactic inferior vena cava filter placement does not result in a survival benefit for trauma patients.
The researchers examined the relationship between prophylactic inferior vena cava (IVC) filter use, mortality, and venous thromboembolic events (VTE). They found that high rates of prophylactic IVC filter placement have no effect on reducing trauma patient mortality and are associated with an increase in deep venous thromboembolism (DVT) events.
AHRQ-funded; HS018728.
Citation: Hemmila MR, Osborne NH, Henke PK .
Prophylactic inferior vena cava filter placement does not result in a survival benefit for trauma patients.
Ann Surg 2015 Oct;262(4):577-85. doi: 10.1097/sla.0000000000001434..
Keywords: Blood Clots, Outcomes, Mortality, Injuries and Wounds, Prevention
Valley TS, Sjoding MW, Ryan AM
Association of intensive care unit admission with mortality among older patients with pneumonia.
The purpose of this study was to estimate the relationship between ICU admission and outcomes for elderly patients with pneumonia. It concluded that among Medicare beneficiaries hospitalized with pneumonia, ICU admission of patients for whom the decision appeared to be discretionary was associated with improved survival and no significant difference in costs.
AHRQ-funded; HS020672.
Citation: Valley TS, Sjoding MW, Ryan AM .
Association of intensive care unit admission with mortality among older patients with pneumonia.
JAMA 2015 Sep 22-29;314(12):1272-9. doi: 10.1001/jama.2015.11068..
Keywords: Patient Safety, Intensive Care Unit (ICU), Elderly, Mortality, Hospitalization
Weiss JW, Peters D, Yang X
Systolic BP and mortality in older adults with CKD.
This study sought to determine whether a nonlinear relationship between BP and mortality - as described for the broader chronic kidney disease (CKD) population and for older adults in the general population - is present for older adults with CKD. It found that in a cohort of older adults, a relationship between higher SBP and mortality was present only for younger members of this cohort and not for those older than 70.
AHRQ-funded; HS019456.
Citation: Weiss JW, Peters D, Yang X .
Systolic BP and mortality in older adults with CKD.
Clin J Am Soc Nephrol 2015 Sep 4;10(9):1553-9. doi: 10.2215/cjn.11391114.
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Keywords: Blood Pressure, Mortality, Elderly, Kidney Disease and Health
Fendler TJ, Spertus JA, Kennedy KF
Alignment of do-not-resuscitate status with patients' likelihood of favorable neurological survival after in-hospital cardiac arrest.
This study assessed whether patients’ decisions for do-not-resuscitate (DNR) orders after a successful resuscitation from in-hospital cardiac arrest are aligned with their expected prognosis. It concluded that although DNR orders after in-hospital cardiac arrest were generally aligned with patients’ likelihood of favorable neurological survival, only one-third of patients with the worst prognosis had DNR orders.
AHRQ-funded; HS020671.
Citation: Fendler TJ, Spertus JA, Kennedy KF .
Alignment of do-not-resuscitate status with patients' likelihood of favorable neurological survival after in-hospital cardiac arrest.
JAMA 2015 Sep 22-29;314(12):1264-71. doi: 10.1001/jama.2015.11069.
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Keywords: Shared Decision Making, Mortality
Vickers BP, Shi J, Lu B
Comparative study of ED mortality risk of US trauma patients treated at level I and level II vs nontrauma centers.
The researchers used National Emergency Department Sample (NEDS) data to explore the hypothesis that severely injured trauma victims properly triaged to a level I or level II trauma center have significantly lower odds of death than those undertriaged to a non-trauma center. They found that trauma patients with Injury Severity Score of greater than 25 received most benefit from proper triage. Efforts to reduce undertriage should focus on this population.
AHRQ-funded; HS022277.
Citation: Vickers BP, Shi J, Lu B .
Comparative study of ED mortality risk of US trauma patients treated at level I and level II vs nontrauma centers.
Am J Emerg Med 2015 Sep;33(9):1158-65. doi: 10.1016/j.ajem.2015.05.010..
Keywords: Healthcare Cost and Utilization Project (HCUP), Emergency Department, Trauma, Comparative Effectiveness, Mortality
Jenkins PC, Richardson CR, Norton EC
Trauma surge index: advancing the measurement of trauma surges and their influence on mortality.
The authors developed a new measure of hospital capacity strain corresponding to trauma admissions and examined the relationship between trauma surges and inpatient mortality. Their Trauma Surge Index (TSI) method can be implemented by hospitals and trauma systems to examine periods of high-capacity strain retrospectively, identify specific resources that might have been needed, and better direct future investments in an evidence-based manner.
AHRQ-funded; HS020672.
Citation: Jenkins PC, Richardson CR, Norton EC .
Trauma surge index: advancing the measurement of trauma surges and their influence on mortality.
J Am Coll Surg 2015 Sep;221(3):729-38.e1. doi: 10.1016/j.jamcollsurg.2015.05.016.
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Keywords: Emergency Preparedness, Hospitals, Injuries and Wounds, Mortality, Trauma
Desai JR, Vazquez-Benitez G, Xu Z
Who must we target now to minimize future cardiovascular events and total mortality? Lessons from the Surveillance, Prevention and Management of Diabetes Mellitus (SUPREME-DM) cohort study.
This report examined trends in cardiovascular events and mortality in US health systems to help guide the design of targeted clinical and public health strategies to reduce cardiovascular events and mortality rates. It concluded that in order to sustain improvements health systems that have successfully focused on care improvement in high-risk adults with diabetes or heart disease must broaden their improvement strategies to target lower risk adults who have not yet developed diabetes or hearat disease.
AHRQ-funded; HS019859.
Citation: Desai JR, Vazquez-Benitez G, Xu Z .
Who must we target now to minimize future cardiovascular events and total mortality? Lessons from the Surveillance, Prevention and Management of Diabetes Mellitus (SUPREME-DM) cohort study.
Circ Cardiovasc Qual Outcomes 2015 Sep;8(5):508-16. doi: 10.1161/circoutcomes.115.001717.
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Keywords: Cardiovascular Conditions, Diabetes, Mortality, Risk
Brooke BS, Goodney PP, Kraiss LW
Readmission destination and risk of mortality after major surgery: an observational cohort study.
This study examined the association between readmission destination and mortality risk in the USA in Medicare beneficiaries after a range of common operations. It found that patients who are readmitted to hospital after various major operations consistently achieve improved survival if they return to the hospital where their surgery took place.
AHRQ-funded; HS021581.
Citation: Brooke BS, Goodney PP, Kraiss LW .
Readmission destination and risk of mortality after major surgery: an observational cohort study.
Lancet 2015 Aug 29;386(9996):884-95. doi: 10.1016/s0140-6736(15)60087-3..
Keywords: Hospital Readmissions, Mortality, Surgery, Elderly, Outcomes, Hospitals
Bewtra M, Newcomb CW, Wu Q
Mortality associated with medical therapy versus elective colectomy in ulcerative colitis: a cohort study.
This study sought to determine whether patients with advanced ulcerative colitis (UC) treated with elective colectomy have improved survival compared with those treated with medical therapy. It found that elective colectomy was associated with improved survival compared with long-term medical therapy, although this result did not remain statistically significant in all sensitivity analyses.
AHRQ-funded; HS018517.
Citation: Bewtra M, Newcomb CW, Wu Q .
Mortality associated with medical therapy versus elective colectomy in ulcerative colitis: a cohort study.
Ann Intern Med 2015 Aug 18;163(4):262-70. doi: 10.7326/m14-0960..
Keywords: Comparative Effectiveness, Mortality, Outcomes, Surgery, Digestive Disease and Health
Rust G, Zhang S, Malhotra K
Paths to health equity: local area variation in progress toward eliminating breast cancer mortality disparities, 1990-2009.
The researchers examined county-level, age-adjusted breast cancer mortality rates for women who were 35 to 74 years old during the period of 1989-2010. They found that more than half of the counties (54%) showed persistent, unchanging disparities. Roughly 1 in 4 (24%) had a divergent pattern of worsening black/white disparities.
AHRQ-funded; HS022444.
Citation: Rust G, Zhang S, Malhotra K .
Paths to health equity: local area variation in progress toward eliminating breast cancer mortality disparities, 1990-2009.
Cancer 2015 Aug 15;121(16):2765-74. doi: 10.1002/cncr.29405..
Keywords: Cancer: Breast Cancer, Disparities, Racial and Ethnic Minorities, Mortality, Racial and Ethnic Minorities
Guo MW, Ahn HJ, Juarez DT
Length of stay and deaths in diabetes-related preventable hospitalizations among Asian American, Pacific Islander, and white older adults on Medicare, Hawai'i, December 2006-December 2010.
The objective of this study was to compare in-hospital deaths and length of stays for diabetes-related preventable hospitalizations (D-RPHs) in Hawai‘i for Asian American, Pacific Islander, and white Medicare recipients aged 65 years or older. It found that Native Hawaiians were more likely to die during a D-RPH and were hospitalized at a younger age for a D-RPH than other studied racial/ethnic groups.
AHRQ-funded; HS019990.
Citation: Guo MW, Ahn HJ, Juarez DT .
Length of stay and deaths in diabetes-related preventable hospitalizations among Asian American, Pacific Islander, and white older adults on Medicare, Hawai'i, December 2006-December 2010.
Prev Chronic Dis 2015 Aug 6;12:E124. doi: 10.5888/pcd12.150092..
Keywords: Mortality, Hospitalization, Diabetes, Racial and Ethnic Minorities, Elderly
Xu X, Buta E, Anhang Price R
Methodological considerations when studying the association between patient-reported care experiences and mortality.
This study illustrated methodological considerations when assessing the relationship between patient care experiences and mortality. It found that the association between overall care experiences and mortality was significant for deaths not amenable to medical care and all-cause mortality, but not for amenable deaths.
AHRQ-funded; HS016980; HS016978.
Citation: Xu X, Buta E, Anhang Price R .
Methodological considerations when studying the association between patient-reported care experiences and mortality.
Health Serv Res 2015 Aug;50(4):1146-61. doi: 10.1111/1475-6773.12264..
Keywords: Medical Expenditure Panel Survey (MEPS), Patient Experience, Mortality, Quality of Care, Research Methodologies