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AHRQ Research Studies
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Research Studies is a compilation of published research articles funded by AHRQ or authored by AHRQ researchers.
Results
1 to 25 of 74 Research Studies DisplayedAmick HR, Gartlehner G, Gaynes BN
Comparative benefits and harms of second generation antidepressants and cognitive behavioral therapies in initial treatment of major depressive disorder: systematic review and meta-analysis.
This systematic review sought to identify the benefits and harms of second generation antidepressants and cognitive behavioral therapies (CBTs) in the initial treatment of a current episode of major depressive disorder in adults. It concluded that the available evidence suggests no difference in treatment effects of second generation antidepressants and CBT, either alone or in combination, although small numbers may preclude detection of small but clinically meaningful differences.
AHRQ-funded; 290-2012-00008I
Citation: Amick HR, Gartlehner G, Gaynes BN .
Comparative benefits and harms of second generation antidepressants and cognitive behavioral therapies in initial treatment of major depressive disorder: systematic review and meta-analysis.
BMJ 2015 Dec 8;351:h6019. doi: 10.1136/bmj.h6019..
Keywords: Medication, Behavioral Health, Comparative Effectiveness, Depression
Yu SH, Silverberg JI
Association between atopic dermatitis and depression in US adults.
The researchers sought to determine the prevalence of depression in US adults with atopic dermatitis (AD). They concluded that approximately one in three US adults with AD reported any symptoms of depression and one in three adults with AD met diagnostic criteria for major depressive disorder.
AHRQ-funded; HS023011.
Citation: Yu SH, Silverberg JI .
Association between atopic dermatitis and depression in US adults.
J Invest Dermatol 2015 Dec;135(12):3183-6. doi: 10.1038/jid.2015.337..
Keywords: Depression, Behavioral Health, Risk, Skin Conditions
Hamblin RJ, Lewin AB, Salloum A
Clinical characteristics and predictors of hoarding in children with anxiety disorders.
This investigation was conducted to describe the clinical characteristics of anxious children with significant hoarding behavior and to examine the contributions of anxiety, obsessive compulsive, and inattentive and hyperactive/impulsive symptoms in the prediction of hoarding. Its findings suggest a pattern of behavioral and emotional dysregulation for children who hoard and provide further insight into the relationships between anxiety, attention problems, and hoarding.
AHRQ-funded; HS018665.
Citation: Hamblin RJ, Lewin AB, Salloum A .
Clinical characteristics and predictors of hoarding in children with anxiety disorders.
J Anxiety Disord 2015 Dec;36:9-14. doi: 10.1016/j.janxdis.2015.07.006.
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Keywords: Children/Adolescents, Anxiety, Behavioral Health
Olfson M, Gerhard T, Huang C
Premature mortality among adults with schizophrenia in the United States.
The objective of the study was to describe overall and cause-specific mortality rates and standardized mortality ratios for adults with schizophrenia compared with the US general population. In a US national cohort of adults with schizophrenia, excess deaths from cardiovascular and respiratory diseases implicate modifiable cardiovascular risk factors, including especially tobacco use.
AHRQ-funded; HS021112.
Citation: Olfson M, Gerhard T, Huang C .
Premature mortality among adults with schizophrenia in the United States.
JAMA Psychiatry 2015 Dec;72(12):1172-81. doi: 10.1001/jamapsychiatry.2015.1737..
Keywords: Mortality, Behavioral Health, Patient-Centered Outcomes Research, Risk
Jones AL, Cochran SD, Leibowitz A
Usual primary care provider characteristics of a patient-centered medical home and mental health service use.
This study sought to examine qualities of a usual provider that align with the patient-centered medical home (PCMH) goals of access, comprehensiveness, and patient-centered care, It concluded that access to a usual provider is associated with increased receipt of needed mental health services. Patients who have a usual provider with PCMH qualities are more likely to receive mental health counseling.
AHRQ-funded; HS021721.
Citation: Jones AL, Cochran SD, Leibowitz A .
Usual primary care provider characteristics of a patient-centered medical home and mental health service use.
J Gen Intern Med 2015 Dec;30(12):1828-36. doi: 10.1007/s11606-015-3417-0.
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Keywords: Patient-Centered Healthcare, Behavioral Health, Primary Care
Mitchell SE, Martin JM, Krizman K
Design and rationale for a randomized controlled trial to reduce readmissions among patients with depressive symptoms.
This study aims to examine the effectiveness of RED-D, a modified brief Cognitive behavioral therapy (CBT) protocol delivered as a post-discharge extension of the Re-Engineered Discharge (RED), in reducing 30-day readmissions rates and emergency department use as well as depressive symptoms for medical patients with comorbid depressive symptoms.
AHRQ-funded; HS019700.
Citation: Mitchell SE, Martin JM, Krizman K .
Design and rationale for a randomized controlled trial to reduce readmissions among patients with depressive symptoms.
Contemp Clin Trials 2015 Nov;45(Pt B):151-6. doi: 10.1016/j.cct.2015.08.016.
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Keywords: Depression, Emergency Department, Hospital Discharge, Hospital Readmissions, Behavioral Health
Brent DA, Brunwasser SM, Hollon SD
Effect of a cognitive-behavioral prevention program on depression 6 years after implementation among at-risk adolescents: a randomized clinical trial.
The objective of this paper is to determine whether a cognitive-behavioral prevention (CBP) program reduced the incidence of depressive episodes, increased depression-free days, and improved developmental competence 6 years after implementation. Over the 75-month follow-up, youths assigned to CBP had a lower incidence of depression; the CBP program's overall significant effect was driven by a lower incidence of depressive episodes during the first 9 months after enrollment.
AHRQ-funded; HS022990.
Citation: Brent DA, Brunwasser SM, Hollon SD .
Effect of a cognitive-behavioral prevention program on depression 6 years after implementation among at-risk adolescents: a randomized clinical trial.
JAMA Psychiatry 2015 Nov;72(11):1110-8. doi: 10.1001/jamapsychiatry.2015.1559.
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Keywords: Behavioral Health, Children/Adolescents, Depression, Patient-Centered Outcomes Research
Olfson M, Wang S, Blanco C
National trends in hospital-treated self-harm events among middle-aged adults.
This study assessed national trends in hospital-treated self-harm events focusing on adults aged 45-64years. Between 2001 and 2011, there was a disproportionate national increase in hospital-treated self-harm events among middle-aged adults that mirrored national trends in suicide. The increase was largely accounted for by an overall increase in mental health hospitalizations of middle-aged adults.
AHRQ-funded; HS021112.
Citation: Olfson M, Wang S, Blanco C .
National trends in hospital-treated self-harm events among middle-aged adults.
Gen Hosp Psychiatry 2015 Nov-Dec;37(6):613-9. doi: 10.1016/j.genhosppsych.2015.08.004.
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Keywords: Healthcare Cost and Utilization Project (HCUP), Behavioral Health, Hospitalization
Epstein RA, Fonnesbeck C, Potter S
Psychosocial interventions for child disruptive behaviors: a meta-analysis.
The researchers conducted a systematic review and meta-analysis to synthesize existing literature on the comparative effectiveness of psychosocial interventions for children and adolescents, 18 years of age with disruptive behavior disorders. It concluded that the 3 intervention categories were more effective than the control conditions. Interventions with a parent component, either alone or in combination with other components, were likely to have the largest effect.
AHRQ-funded; 290201200009I.
Citation: Epstein RA, Fonnesbeck C, Potter S .
Psychosocial interventions for child disruptive behaviors: a meta-analysis.
Pediatrics 2015 Nov;136(5):947-60. doi: 10.1542/peds.2015-2577..
Keywords: Behavioral Health, Children/Adolescents, Comparative Effectiveness, Patient-Centered Outcomes Research
Patnode CD, Henderson JT, Thompson JH
Behavioral counseling and pharmacotherapy interventions for tobacco cessation in adults, including pregnant women: a review of reviews for the U.S. Preventive Services Task Force.
The researchers reviewed the effectiveness and safety of pharmacotherapy and behavioral interventions for tobacco cessation. They concluded that behavioral and pharmacotherapy interventions improve rates of smoking cessation among the general adult population, alone or in combination. Data on the effectiveness and safety of electronic nicotine delivery systems are limited.
AHRQ-funded; 290201200015I.
Citation: Patnode CD, Henderson JT, Thompson JH .
Behavioral counseling and pharmacotherapy interventions for tobacco cessation in adults, including pregnant women: a review of reviews for the U.S. Preventive Services Task Force.
Ann Intern Med 2015 Oct 20;163(8):608-21. doi: 10.7326/m15-0171..
Keywords: Behavioral Health, Evidence-Based Practice, Medication, Pregnancy, Prevention, Tobacco Use, U.S. Preventive Services Task Force (USPSTF), Women
Sulzer SH
Does "difficult patient" status contribute to de facto demedicalization? The case of borderline personality disorder.
This study relies on 22 in-depth interviews with mental health clinicians in the United States to evaluate how they describe patients with borderline personality disorder (BPD), how the diagnosis of BPD affects the treatment clinicians are willing to provide, and the implications for patients. Its findings suggest patients with BPD are routinely labeled “difficult,” and subsequently routed out of care through a variety of direct and indirect means.
AHRQ-funded; HS000032.
Citation: Sulzer SH .
Does "difficult patient" status contribute to de facto demedicalization? The case of borderline personality disorder.
Soc Sci Med 2015 Oct;142:82-9. doi: 10.1016/j.socscimed.2015.08.008..
Keywords: Behavioral Health, Clinician-Patient Communication, Access to Care
Radovic A, Reynolds K, McCauley HL
Parents' role in adolescent depression care: primary care provider perspectives.
This study aimed to understand how primary care providers (PCPs) perceive barriers to adolescent depression care in order to inform strategies to increase treatment engagement. PCPs perceived that parental unwillingness to accept the depression diagnosis, family dysfunction, and trauma were common barriers. PCPs contrasted this with examples of good family support they believed would enable adolescents to attend follow-up appointments and have a “life coach” at home.
AHRQ-funded; HS022989; HS019486.
Citation: Radovic A, Reynolds K, McCauley HL .
Parents' role in adolescent depression care: primary care provider perspectives.
J Pediatr 2015 Oct;167(4):911-8. doi: 10.1016/j.jpeds.2015.05.049..
Keywords: Caregiving, Children/Adolescents, Depression, Behavioral Health, Primary Care
Zhang Y, Talisa V, Baik SH
Part D plan switching among Medicare beneficiaries with schizophrenia.
The authors examined Medicare plan switching and factors affecting switching among beneficiaries with schizophrenia. They found several factors that affected the likelihood of switching, including age, geographic region, and proportion of prescriptions filled by beneficiaries who were covered or whose prescriptions required utilization review in the original plan. They concluded that plan switching among Medicare beneficiaries with schizophrenia was relatively infrequent but may be driven by the need for better drug coverage and less restrictive utilization policies.
AHRQ-funded; HS018657.
Citation: Zhang Y, Talisa V, Baik SH .
Part D plan switching among Medicare beneficiaries with schizophrenia.
Psychiatr Serv 2015 Oct;66(10):1105-8. doi: 10.1176/appi.ps.201400476.
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Keywords: Healthcare Costs, Medicare, Behavioral Health
Storch EA, Salloum A, Johnco C
Phenomenology and clinical correlates of family accommodation in pediatric anxiety disorders.
This study assessed the nature and clinical correlates of family accommodation in pediatric anxiety, as well as validating a mechanistic model. It concluded that family accommodation was associated with increased anxiety severity and externalizing behaviors, having a diagnosis of separation anxiety, and increased functional impairment. Family accommodation partially mediated the relationship between anxiety severity and functional impairment.
AHRQ-funded; HS018665.
Citation: Storch EA, Salloum A, Johnco C .
Phenomenology and clinical correlates of family accommodation in pediatric anxiety disorders.
J Anxiety Disord 2015 Oct;35:75-81. doi: 10.1016/j.janxdis.2015.09.001.
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Keywords: Children/Adolescents, Anxiety, Behavioral Health, Children/Adolescents, Family Health and History
Johnco CJ, Salloum A, De Nadai AS
Incidence, clinical correlates and treatment effect of rage in anxious children.
This study examined the incidence and clinical correlates of rage in children with anxiety disorders. Change in rage during treatment for anxiety was also examined. It found that rage was associated with a more severe clinical profile, including increased anxiety severity, functional impairment, family accommodation and caregiver strain, as well as poorer relationships with parents, siblings, extended family and peers.
AHRQ-funded; HS018665.
Citation: Johnco CJ, Salloum A, De Nadai AS .
Incidence, clinical correlates and treatment effect of rage in anxious children.
Psychiatry Res 2015 Sep 30;229(1-2):63-9. doi: 10.1016/j.psychres.2015.07.071..
Keywords: Anxiety, Behavioral Health, Children/Adolescents, Family Health and History
Johnco CJ, Salloum A, Lewin AB
The impact of comorbidity profiles on clinical and psychosocial functioning in childhood anxiety disorders.
This study compared the profile of children with a primary anxiety disorder without comorbidity to those with different comorbidity profiles in a treatment-seeking sample of 111 children recruited from community mental health settings. It found that anxiety severity and depressive symptomatology did not vary by comorbidity profile. Anxious children without comorbidity had lower levels of aggressive and externalizing behaviors compared to the comorbid ADHD group.
AHRQ-funded; HS018665.
Citation: Johnco CJ, Salloum A, Lewin AB .
The impact of comorbidity profiles on clinical and psychosocial functioning in childhood anxiety disorders.
Psychiatry Res 2015 Sep 30;229(1-2):237-44. doi: 10.1016/j.psychres.2015.07.027..
Keywords: Children/Adolescents, Anxiety, Behavioral Health
McNellis R, Lewis P
AHRQ Author: McNellis R
Behavioral counseling to promote a healthful diet and physical activity for cardiovascular disease prevention in adults with cardiovascular risk factors.
This case study quiz is based on the recommendations of the USPSTF. The case concerns a 34-year-old man who smokes. When he presents for his annual checkup for hypertension, his blood pressure is elevated (142/95 mm Hg), and he has gained 10 lb (4.5 kg) since his last visit.
AHRQ-authored.
Citation: McNellis R, Lewis P .
Behavioral counseling to promote a healthful diet and physical activity for cardiovascular disease prevention in adults with cardiovascular risk factors.
Am Fam Physician 2015 Sep 15;92(6):509-10.
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Keywords: Behavioral Health, Cardiovascular Conditions, Case Study, Lifestyle Changes, Nutrition, Prevention, Risk, U.S. Preventive Services Task Force (USPSTF)
Grossman DC, Elder RW
Aligning the work of two U.S. Task Forces on behavioral counseling recommendations.
This paper highlights the collaboration and alignment between topics and recommendations related to behavioral counseling interventions from the U.S. Preventive Services Task Force (USPSTF) and Community Preventive Services Task Force (CPSTF). It also explores opportunities for greater alignment between the two Task Forces and compares and contrasts the groups and their current approaches to making recommendations that involve behavioral counseling interventions.
AHRQ-funded; 290201000004I.
Citation: Grossman DC, Elder RW .
Aligning the work of two U.S. Task Forces on behavioral counseling recommendations.
Am J Prev Med 2015 Sep;49(3 Suppl 2):S174-83. doi: 10.1016/j.amepre.2015.06.003.
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Keywords: Behavioral Health, Evidence-Based Practice, Guidelines, Health Promotion, U.S. Preventive Services Task Force (USPSTF)
Curry SJ, McNellis RJ
AHRQ Author: McNellis RJ
Behavioral counseling in primary care: perspectives in enhancing the evidence base.
This article introduces a special issue containing eight articles that were written for a behavioral counseling interventions (BCI) Expert Forum convened in November 2013 by the US Preventive Services Task Force. The authors briefly discuss each of the papers. The forum brought together experienced behavioral counseling researchers, senior leaders in NIH and CDC, members of the USPSTF, and senior members of the AHRQ team supporting the USPSTF.
AHRQ-authored.
Citation: Curry SJ, McNellis RJ .
Behavioral counseling in primary care: perspectives in enhancing the evidence base.
Am J Prev Med 2015 Sep;49(3 Suppl 2):S125-8. doi: 10.1016/j.amepre.2015.06.004..
Keywords: Behavioral Health, Evidence-Based Practice, Guidelines, U.S. Preventive Services Task Force (USPSTF)
Curry SJ, Whitlock EP
Behavioral counseling interventions expert forum: overview and primer on U.S. Preventive Services Task Force methods.
In November 2013, the U.S. Preventive Services Task Force convened an expert forum on behavioral counseling interventions. The forum brought together NIH, CDC, and AHRQ leaders, leading behavioral counseling researchers, and members of the U.S. preventive Services Task Force to discuss issues related to optimizing evidence-based behavioral counseling recommendations. This paper provides an overview of the methods used by the Task Force to develop counseling recommendations.
AHRQ-funded; 290201000004I.
Citation: Curry SJ, Whitlock EP .
Behavioral counseling interventions expert forum: overview and primer on U.S. Preventive Services Task Force methods.
Am J Prev Med 2015 Sep;49(3 Suppl 2):S129-37. doi: 10.1016/j.amepre.2015.04.017.
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Keywords: Behavioral Health, Evidence-Based Practice, Guidelines, Prevention, U.S. Preventive Services Task Force (USPSTF)
Davis MM, Balasubramanian BA, Cifuentes M
Clinician staffing, scheduling, and engagement strategies among primary care practices delivering integrated care.
This study examined the interrelationship among behavioral health clinician staffing, scheduling, and a primary care practice's approach to delivering integrated care. It concluded that practices' approaches to staffing by primary care clinicians and behavioral health clinicians, scheduling, and delivery of integrated care mutually influenced each other and were shaped by the local context.
AHRQ-funded; HS022981.
Citation: Davis MM, Balasubramanian BA, Cifuentes M .
Clinician staffing, scheduling, and engagement strategies among primary care practices delivering integrated care.
J Am Board Fam Med 2015 Sep-Oct;28 Suppl 1:S32-40. doi: 10.3122/jabfm.2015.S1.150087.
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Keywords: Behavioral Health, Patient-Centered Healthcare, Healthcare Delivery, Primary Care: Models of Care, Primary Care, Community-Based Practice
Gunn R, Davis MM, Hall J
Designing clinical space for the delivery of integrated behavioral health and primary care.
This study sought to describe features of the physical space in which practices integrating primary care and behavioral health care work and to identify the arrangements that enable integration of care. Two dominant spatial layouts emerged across practices: type-1 layouts were characterized by having primary care clinicians (PCCs) and behavioral health clinicians (BHCs) located in separate work areas, and type-2 layouts had BHCs and PCCs sharing work space.
AHRQ-funded; HS022981.
Citation: Gunn R, Davis MM, Hall J .
Designing clinical space for the delivery of integrated behavioral health and primary care.
J Am Board Fam Med 2015 Sep-Oct;28 Suppl 1:S52-62. doi: 10.3122/jabfm.2015.S1.150053.
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Keywords: Behavioral Health, Healthcare Delivery, Patient-Centered Healthcare, Primary Care
Cifuentes M, Davis M, Fernald D
Electronic health record challenges, workarounds, and solutions observed in practices integrating behavioral health and primary care.
This article describes the electronic health record (EHR)-related experiences of practices striving to integrate behavioral health and primary care using tailored, evidenced-based strategies from 2012 to 2014; and the challenges, workarounds and initial health information technology (HIT) solutions that emerged during implementation. The researchers found that as practices gained experience with integration, they began to move beyond workarounds to more permanent HIT solutions.
AHRQ-funded; HS022981.
Citation: Cifuentes M, Davis M, Fernald D .
Electronic health record challenges, workarounds, and solutions observed in practices integrating behavioral health and primary care.
J Am Board Fam Med 2015 Sep-Oct;28(Suppl 1):S63-72. doi: 10.3122/jabfm.2015.S1.150133..
Keywords: Behavioral Health, Primary Care, Electronic Health Records (EHRs), Evidence-Based Practice
Murray DM, Kaplan RM, Ngo-Metzger Q
AHRQ Author: Kaplan RM, Ngo-Metzger Q
Enhancing coordination among the U.S. Preventive Services Task Force, Agency for Healthcare Research and Quality, and National Institutes of Health.
This paper focuses on the relationships among the U.S. Preventive Services Task Force (USPSTF); Agency for Healthcare Research and Quality (AHRQ); and NIH. The authors describe the steps that have been taken recently by NIH to enhance their coordination. They also discuss several challenges that remain and consider potential remedies that NIH, AHRQ, and investigators can take to provide the USPSTF with the data it needs to make recommendations.
AHRQ-authored.
Citation: Murray DM, Kaplan RM, Ngo-Metzger Q .
Enhancing coordination among the U.S. Preventive Services Task Force, Agency for Healthcare Research and Quality, and National Institutes of Health.
Am J Prev Med 2015 Sep;49(3 Suppl 2):S166-73. doi: 10.1016/j.amepre.2015.04.024..
Keywords: Behavioral Health, U.S. Preventive Services Task Force (USPSTF)
Alcantara C, Klesges LM, Resnicow K
Enhancing the evidence for behavioral counseling: a perspective from the society of behavioral medicine.
The members of the Society of Behavioral Medicine (SBM)-a multidisciplinary scientific organization committed to improving population health through behavior change- review the USPSTF mandate and current recommendations for behavioral counseling interventions and provide a perspective for the future that calls for concerted and coordinated efforts among SBM, USPSTF, and other organizations invested in the rapid and wider uptake of beneficial, feasible, and referable primary care-focused behavioral counseling interventions.
AHRQ-funded; 290201000004I.
Citation: Alcantara C, Klesges LM, Resnicow K .
Enhancing the evidence for behavioral counseling: a perspective from the society of behavioral medicine.
Am J Prev Med 2015 Sep;49(3 Suppl 2):S184-93. doi: 10.1016/j.amepre.2015.05.015.
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Keywords: Behavioral Health, Evidence-Based Practice, Guidelines, Health Promotion, Primary Care, U.S. Preventive Services Task Force (USPSTF)