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AHRQ Research Studies Date
Topics
- Access to Care (3)
- Adverse Events (2)
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- Chronic Conditions (1)
- Clinical Decision Support (CDS) (2)
- Clostridium difficile Infections (1)
- Comparative Effectiveness (1)
- Disparities (2)
- Education: Patient and Caregiver (1)
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- Healthcare-Associated Infections (HAIs) (2)
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- Health Services Research (HSR) (3)
- Hospital Readmissions (1)
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- Injuries and Wounds (1)
- Kidney Disease and Health (1)
- Mortality (2)
- Outcomes (3)
- Policy (1)
- Quality of Care (1)
- Risk (3)
- Shared Decision Making (1)
- Social Determinants of Health (1)
- Surgery (1)
- (-) Transplantation (14)
AHRQ Research Studies
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Research Studies is a compilation of published research articles funded by AHRQ or authored by AHRQ researchers.
Results
1 to 14 of 14 Research Studies DisplayedRodrigue JR, Fleishman A, Fitzpatrick S
Organ donation video messaging in motor vehicle offices: results of a randomized trial.
Since nearly all registered organ donors in the United States signed up via a driver's license transaction, motor vehicle (MV) offices represent an important venue for organ donation education. The researchers evaluated the impact of organ donation video messaging in MV offices. There was a relatively low uptake of the video intervention by customers that most likely contributed to the negative trial finding.
HS022061; HS024204
Citation: Rodrigue JR, Fleishman A, Fitzpatrick S .
Organ donation video messaging in motor vehicle offices: results of a randomized trial.
Prog Transplant 2015 Dec;25(4):332-8. doi: 10.7182/pit2015166..
Keywords: Transplantation, Health Promotion, Education: Patient and Caregiver
Donnelly JP, Wang HE, Locke JE
Hospital-onset Clostridium difficile infection among solid organ transplant recipients.
The researchers examined hospital-onset Clostridium difficile infection (CDI) from 2012 to 2014 among transplant recipients in the University HealthSystem Consortium, which includes academic medical center-affiliated hospitals in the United States. They found that factors associated with CDI among transplant recipients included transplant type, risk of mortality, comorbidities, and inpatient complications.
AHRQ-funded; HS013852.
Citation: Donnelly JP, Wang HE, Locke JE .
Hospital-onset Clostridium difficile infection among solid organ transplant recipients.
Am J Transplant 2015 Nov;15(11):2970-7. doi: 10.1111/ajt.13491.
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Keywords: Clostridium difficile Infections, Healthcare-Associated Infections (HAIs), Transplantation, Adverse Events, Mortality
Fumo DE, Kapoor V, Reece LJ
Historical matching strategies in kidney paired donation: the 7-year evolution of a web-based virtual matching system.
Failure to convert computer-identified possible kidney paired donation (KPD) exchanges into transplants has prohibited KPD from reaching its full potential. This study analyzes the progress of exchanges in moving from "offers" to completed transplants. The "offer" and 1-way success rates were 21.9 and 15.5 percent, respectively. Three reasons for failure were found that could be prospectively prevented by changes in protocol or software.
AHRQ-funded; HS020610.
Citation: Fumo DE, Kapoor V, Reece LJ .
Historical matching strategies in kidney paired donation: the 7-year evolution of a web-based virtual matching system.
Am J Transplant 2015 Oct;15(10):2646-54. doi: 10.1111/ajt.13337.
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Keywords: Health Information Technology (HIT), Transplantation, Shared Decision Making, Clinical Decision Support (CDS)
Bray M, Wang W, Song PX
Planning for uncertainty and fallbacks can increase the number of transplants in a kidney-paired donation program.
The researchers outlined and examined, through example and by simulation, four schemes for selecting potential matches in a realistic model of a kidney-paired donation system. Their proposed schemes take account of probabilities that chosen transplants may not be completed as well as allowing for contingency plans when the optimal solution fails.
AHRQ-funded; HS020610.
Citation: Bray M, Wang W, Song PX .
Planning for uncertainty and fallbacks can increase the number of transplants in a kidney-paired donation program.
Am J Transplant 2015 Oct;15(10):2636-45. doi: 10.1111/ajt.13413.
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Keywords: Transplantation, Clinical Decision Support (CDS), Health Information Technology (HIT)
Traino HM, Nonterah CW, Cyrus JW
Disparities in the completion of steps to kidney transplantation: protocol for a systematic review.
This review will catalogue disparities in the steps to transplantation as well as the barriers and facilitators to completion of each step identified in the extant literature. The results of the review will be used to generate recommendations for future research to improve equity in access to kidney transplantation.
AHRQ-funded; HS018113.
Citation: Traino HM, Nonterah CW, Cyrus JW .
Disparities in the completion of steps to kidney transplantation: protocol for a systematic review.
BMJ Open 2015 Sep 08;5(9):e008677. doi: 10.1136/bmjopen-2015-008677.
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Keywords: Disparities, Transplantation, Kidney Disease and Health, Access to Care, Guidelines
Parikh ND, Waljee AK, Singal AG
Downstaging hepatocellular carcinoma: a systematic review and pooled analysis.
The researchers aimed to characterize rates of successful downstaging to within Milan criteria and post-liver transplantation recurrence and survival among patients who underwent downstaging. They concluded that the success rate of downstaging hepatocellular carcinoma to within Milan criteria exceeds 40 percent; however, posttransplant HCC recurrence rates are high at 16 percent.
AHRQ-funded; HS022418.
Citation: Parikh ND, Waljee AK, Singal AG .
Downstaging hepatocellular carcinoma: a systematic review and pooled analysis.
Liver Transpl 2015 Sep;21(9):1142-52. doi: 10.1002/lt.24169..
Keywords: Cancer, Risk, Transplantation
Orman ES, Mayorga ME, Wheeler SB
Declining liver graft quality threatens the future of liver transplantation in the United States.
This study used the United Network for Organ Sharing (UNOS) database to inform a 20-year discrete event simulation estimating liver transplantation (LT) volume from 2010 to 2030. It found that if donor liver utilization practices remain constant, utilization will fall from 78 percent to 44 percent by 2030, resulting in 2,230 fewer LTs.
AHRQ-funded; HS019468.
Citation: Orman ES, Mayorga ME, Wheeler SB .
Declining liver graft quality threatens the future of liver transplantation in the United States.
Liver Transpl 2015 Aug;21(8):1040-50. doi: 10.1002/lt.24160..
Keywords: Healthcare Utilization, Health Services Research (HSR), Transplantation
McElroy LM, Schmidt KA, Richards CT
Early postoperative emergency department care of abdominal transplant recipients.
The goal of this study was to describe early postoperative ED care of transplant recipients. It found that transplant recipients have a high frequency of ED visits in the first post transplantation year and high rates of subsequent hospital admission.
AHRQ-funded; HS000078.
Citation: McElroy LM, Schmidt KA, Richards CT .
Early postoperative emergency department care of abdominal transplant recipients.
Transplantation 2015 Aug;99(8):1652-7. doi: 10.1097/tp.0000000000000781..
Keywords: Emergency Department, Transplantation, Hospital Readmissions, Hospitals
Davis AE, Mehrotra S, Friedewald JJ
Improving geographic equity in kidney transplantation using alternative kidney sharing and optimization modeling.
The authors analyzed current kidney allocation and developed an alternative kidney sharing strategy using a multiperiod linear optimization model, KSHARE, which aims to improve geographic equity in kidney transplantation while also respecting transplant system constraints and priorities. They used Organ Procurement and Transplant Network data to determine that enhancing the practice of sharing kidneys by the KSHARE model may increase geographic equity in kidney transplantation.
AHRQ-funded; HS021078.
Citation: Davis AE, Mehrotra S, Friedewald JJ .
Improving geographic equity in kidney transplantation using alternative kidney sharing and optimization modeling.
Med Decis Making 2015 Aug;35(6):797-807. doi: 10.1177/0272989x14557696.
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Keywords: Access to Care, Disparities, Health Services Research (HSR), Social Determinants of Health, Transplantation
Toro-Diaz H, Mayorga ME, Barritt AS
Predicting liver transplant capacity using discrete event simulation.
The researchers constructed a discrete event simulation model informed by current donor characteristics to predict future liver transplant trends through the year 2030. They found that by altering assumptions about the future donor pool, their model can be used to develop policy interventions to prevent a further decline in this lifesaving therapy.
AHRQ-funded; HS019468.
Citation: Toro-Diaz H, Mayorga ME, Barritt AS .
Predicting liver transplant capacity using discrete event simulation.
Med Decis Making 2015 Aug;35(6):784-96. doi: 10.1177/0272989x14559055.
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Keywords: Access to Care, Health Services Research (HSR), Policy, Transplantation
Santos CA, Brennan DC, Chapman WC
Delayed-onset cytomegalovirus disease coded during hospital readmission in a multicenter, retrospective cohort of liver transplant recipients.
The researchers sought to determine the risk factors and outcomes associated with delayed-onset cytomegalovirus (CMV) disease among liver transplant recipients. Data from a group of 7,229 adult liver transplant recipients showed that delayed onset CMV disease was twice as likely as early onset CMV disease, with transplant failure or rejection being a risk factor.
AHRQ-funded; HS019455
Citation: Santos CA, Brennan DC, Chapman WC .
Delayed-onset cytomegalovirus disease coded during hospital readmission in a multicenter, retrospective cohort of liver transplant recipients.
Liver Transpl. 2015 May;21(5):581-90. doi: 10.1002/lt.24089..
Keywords: Outcomes, Transplantation, Quality of Care, Chronic Conditions
Santos CA, Brennan DC, Chapman WC
Delayed-onset cytomegalovirus disease coded during hospital readmission in a multicenter, retrospective cohort of liver transplant recipients.
The researchers sought to determine the risk factors and outcomes of delayed-onset CMV disease among a representative cohort of liver transplant recipients from multiple centers. They found that delayed-onset CMV disease coded during hospital readmission occurred more commonly than early-onset CMV disease and that prior transplant failure or rejection was a risk factor for delayed-onset CMV disease.
AHRQ-funded; HS019455.
Citation: Santos CA, Brennan DC, Chapman WC .
Delayed-onset cytomegalovirus disease coded during hospital readmission in a multicenter, retrospective cohort of liver transplant recipients.
Liver Transpl 2015 May;21(5):581-90. doi: 10.1002/lt.24089..
Keywords: Healthcare Cost and Utilization Project (HCUP), Risk, Transplantation, Outcomes
Harris AD, Fleming B, Bromberg JS
Surgical site infection after renal transplantation.
The researchers sought to identify factors associated with the development of surgical site infection (SSI) among adult patients undergoing renal transplantation. They found that BMI was a risk factor for the development of SSI following renal transplantation. Somewhat surprisingly, they did not find other biologically plausible or transplant-specific risk factors such as presence of comorbid conditions or receipt of appropriate (type and dose) antibiotic prophylaxis.
AHRQ-funded; HS022291.
Citation: Harris AD, Fleming B, Bromberg JS .
Surgical site infection after renal transplantation.
Infect Control Hosp Epidemiol 2015 Apr;36(4):417-23. doi: 10.1017/ice.2014.77..
Keywords: Transplantation, Surgery, Healthcare-Associated Infections (HAIs), Injuries and Wounds, Risk, Adverse Events
Cauley RP, Potanos K, Fullington N
The effect of graft type on mortality in liver transplantation for hepatocellular carcinoma.
The researchers aimed to: (1) examine the risk of mortality in liver transplantation for hepatocellular carcinoma (HCC), (2) to establish if this risk is affected by partial graft use, and (3) to determine if this effect is mitigated by improved tumor-associated risk stratification. They found that the risk of mortality following LT does not differ by the type of graft used in recipients with favorable-risk HCC or those without HCC.
AHRQ-funded; HS019485.
Citation: Cauley RP, Potanos K, Fullington N .
The effect of graft type on mortality in liver transplantation for hepatocellular carcinoma.
Ann Transplant 2015 Mar 30;20:175-85. doi: 10.12659/aot.892613..
Keywords: Mortality, Cancer, Transplantation, Comparative Effectiveness, Outcomes