| Trial Characteristics | Minnesota (2) | UK (13) | Denmark (14) | |
|---|---|---|---|---|
| Frequency of testing | Annual | Biennial | Biennial | Biennial |
| Participants | More than 45,000 men and women ages 50-80 |
More than 150,000 men and women ages 45-74 |
More than 60,000 men and women ages 45-74 |
|
| Duration of followup, years | 18 | 18 | 8 | 10 |
| Hydration of slides | Yes (83%) | No | No | |
| Participation rate | 90% | 90% | 60% | 67% |
| Requiring colonoscopy | 38% | 28% | 5% | 5% |
| Positive predictive value | 1.9%† | 2.7%† | 10-12% | 8-18% |
| CRC mortality RRR (95% CI) |
33% (17%, 49%) |
21% (3%, 38%) |
15% (1%, 26%) |
18% (1%, 32%) |
| CRC mortality ARR | 4.6 | 2.9 | 0.8 | 1.4 |
*Participation defined as completing at least one test.
†Mostly rehydrated slides (83%).
RRR=relative risk reduction.
ARR=absolute risk reduction per 1,000 participants.