Appendix Figure 2. Histograms of Cost-effectiveness Ratios Resulting from
Probabilistic Sensitivity Analyses Based on Universal and Targeted Screening
(Text Description)
Appendix Figure
2 depicts 2 histograms showing the cost-effectiveness ratios resulting from
probabilistic sensitivity analyses for targeted screening and for universal
screening. For the analyses, 129 critical parameters were simultaneously varied
over probability distributions on the basis of published 95% CIs or other reasonable
ranges. A cost-effectiveness ratio was computed for each of 1000 iterations
for targeted and universal screening of people 55 years of age.
The histograms depict the data in the table below. In the histograms,
dollars per quality-adjusted life-year are represented on the horizontal axes.
Frequencies are represented on the vertical axes.
Data for Appendix Figure 2
Targeted Screening
Upper limit of bin
(CE ratios) |
Frequency |
| $16,750 |
1 |
| $19,746 |
5 |
| $22,742 |
35 |
| $25,738 |
103 |
| $28,733 |
128 |
| $31,729 |
121 |
| $34,725 |
131 |
| $37,721 |
98 |
| $40,717 |
71 |
| $43,713 |
73 |
| $46,709 |
45 |
| $49,705 |
36 |
| $52,701 |
34 |
| $55,697 |
25 |
| $58,693 |
23 |
| $61,689 |
9 |
| $64,685 |
8 |
| $67,681 |
10 |
| $70,677 |
7 |
| $73,673 |
4 |
| $76,669 |
11 |
| $79,665 |
6 |
| $82,660 |
6 |
| $85,656 |
2 |
| $88,652 |
1 |
| $91,648 |
1 |
| $94,644 |
1 |
| $97,640 |
0 |
| $100,636 |
0 |
| $103,632 |
2 |
| $106,628 |
2 |
| More |
1 |
Universal Screening
Upper limit of bin (CE ratios) |
Frequency |
| $32,164 |
1 |
| $38,400 |
17 |
| $44,636 |
67 |
| $50,872 |
114 |
| $57,108 |
194 |
| $63,344 |
125 |
| $69,580 |
116 |
| $75,816 |
93 |
| $82,052 |
66 |
| $88,288 |
51 |
| $94,524 |
33 |
| $100,760 |
34 |
| $106,997 |
24 |
| $113,233 |
8 |
| $119,469 |
12 |
| $125,705 |
10 |
| $131,941 |
7 |
| $138,177 |
6 |
| $144,413 |
3 |
| $150,649 |
6 |
| $156,885 |
3 |
| $163,121 |
2 |
| $169,357 |
2 |
| $175,593 |
0 |
| $181,829 |
1 |
| $188,065 |
2 |
| $194,301 |
0 |
| $200,537 |
1 |
| $206,773 |
0 |
| $213,009 |
1 |
| $219,245 |
0 |
| More |
1 |
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