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Appendix Figure 2. Histograms of Cost-effectiveness Ratios Resulting from Probabilistic Sensitivity Analyses Based on Universal and Targeted Screening (Text Description)

Appendix Figure 2 depicts 2 histograms showing the cost-effectiveness ratios resulting from probabilistic sensitivity analyses for targeted screening and for universal screening. For the analyses, 129 critical parameters were simultaneously varied over probability distributions on the basis of published 95% CIs or other reasonable ranges. A cost-effectiveness ratio was computed for each of 1000 iterations for targeted and universal screening of people 55 years of age.

The histograms depict the data in the table below. In the histograms, dollars per quality-adjusted life-year are represented on the horizontal axes. Frequencies are represented on the vertical axes.

Data for Appendix Figure 2

Targeted Screening

Upper limit of bin
(CE ratios)
Frequency
$16,750 1
$19,746 5
$22,742 35
$25,738 103
$28,733 128
$31,729 121
$34,725 131
$37,721 98
$40,717 71
$43,713 73
$46,709 45
$49,705 36
$52,701 34
$55,697 25
$58,693 23
$61,689 9
$64,685 8
$67,681 10
$70,677 7
$73,673 4
$76,669 11
$79,665 6
$82,660 6
$85,656 2
$88,652 1
$91,648 1
$94,644 1
$97,640 0
$100,636 0
$103,632 2
$106,628 2
More 1

Universal Screening

Upper limit of bin
(CE ratios)
Frequency
$32,164 1
$38,400 17
$44,636 67
$50,872 114
$57,108 194
$63,344 125
$69,580 116
$75,816 93
$82,052 66
$88,288 51
$94,524 33
$100,760 34
$106,997 24
$113,233 8
$119,469 12
$125,705 10
$131,941 7
$138,177 6
$144,413 3
$150,649 6
$156,885 3
$163,121 2
$169,357 2
$175,593 0
$181,829 1
$188,065 2
$194,301 0
$200,537 1
$206,773 0
$213,009 1
$219,245 0
More 1

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