Table 2. Outcomes Table Assumptions

Benefits and Harms	Condition (reference)	This Review RR or OR (95% CI)	Results of WHI* HR (95% CI)	Incidence or Mortality Rates by Age Group
				55-64		65-74		75-84
				55-59	60-64	65-69	70-74	75-79	80-84
Benefits	Hip fracture23	0.76 (0.56-1.01)	0.66 (0.33-1.33)	0.00089	0.001528	0.002372	0.005305	0.010184	0.017315
	Wrist fracture24	0.44 (0.23-0.84)	NA	0.006053		0.00671		0.008113
	Vertebral fracture25	0.60 (0.36-0.99)	0.66 (0.32-1.34)	0.0068	0.0093	0.0123	0.0161	0.0205	0.0252
	Colorectal cancer27	0.80 (0.74-0.86)	0.63 (0.32-1.24)	0.000712	0.001121	0.001568	0.002274	0.002951	0.003838
Uncertain Benefits	Dementia incidence26	0.66 (0.53-0.82)	NA	0.005**		0.01		0.02**
Harms	Coronary heart disease incidence22	0.91 (0.67-1.33)	1.29 (1.02-1.63)	0.00174	0.00264	0.00308		0.00398**
	Overall stroke incidence22	1.12 (1.01-1.23)	1.41 (0.66-2.31)	0.00064*	0.00121	0.00229		0.00469**
	Thromboembo- lism incidence (1 <year)29	3.49 (2.33-5.59)	NA	NA	NA	NA	NA	NA	NA
	Thromboembo- lism incidence (overall)29	2.14 (1.64-2.81)	2.11 (1.26-3.55)	0.00013		0.00013		0.00013
	Breast cancer incidence (<5 years)27	1.0 - 1.14	NA	0.002963	0.003473	0.004044	0.004555	0.004833	0.004681
	Breast cancer incidence (>5 years)27	1.23 - 1.35	1.26 (1.00-1.59)	0.002963	0.003473	0.004044	0.004555	0.004833	0.004681
	Cholecystitis (<5 years)28	1.8 (1.6-2.0)	NA	0.00357		0.00357		0.00357
	Cholecystitis (>5 years)28	2.5 (2.0-2.9)	NA	0.00357		0.00357		0.00357

*Nominal CIs are indicated for main outcomes of the trial (breast cancer, CHD), adjusted CIs for secondary outcomes.
**Data based on extrapolated values.
Note: NA indicates not available; WHI, Women's Health Initiative.

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