Postmenopausal Hormone Replacement Therapy for Primary Prevention of Chronic Conditions: Summary of Evidence. Table 3. Outcomes Table: Hormone Replacement Therapy Use in 10,000 Women--Benefits and Harms per Year

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Benefits and Harms		Number of events prevented or caused per year
		Age 55-64		Age 65-74		Age 75-84
		This Review	WHI	This Review	WHI	This Review	WHI
Benefits (prevention)	Hip fractures	3	4	9	13	33	47
	Wrist fractures	34	—	37.5	—	45	—
	Vertebral fractures	32	27	57	49	91	78
	Cases of colon cancer	2	3	4	7	7	12.5
Uncertain Benefits	Cases of dementia	17*	—	34	—	68*	—
Harms (caused)	Coronary heart disease events	0	6	0	9	0	11.5
	Strokes	1*	4*	3	9	6*	19*
	Thromboembolic events during first year	3	—	3	—	3	—
	Thromboembolic events overall	1.5	1.4	1.5	1.4	1.5	1.4
	Breast cancer cases (<5 years' use)	0 to 2.5	—	0 to 6	—	0 to 7	—
	Breast cancer cases (>5 years' use)	7 to 11	8	10 to 15	11	11 to 17	12
	Cholecystitis cases (<5 years' use)	25	—	25	—	25	—
	Cholecystitis cases (>5 years' use)	53.5	—	53.5	—	53.5	—

*Estimates based on extrapolations.

Note: WHI indicates Women's Health Initiative.