| Key Question |
Eligibility Criteria |
Number of Articles Meeting Eligibility Criteria and Not in Prior Systematic Reviewa |
| Efficacy of screening |
RCT
Mass screening
|
0 |
| Epidemiology of obesity |
| a. Prevalence |
Large U.S. population-based surveys |
1 |
| b. Health risks |
Prospective cohort studies with absolute rates of health risk reported over ≥10 yrs |
14 |
Efficacy of treatment for weight reduction or intermediate outcomes |
| a. Counseling and behavioral treatment |
- RCT (of fair or good quality)
- Outcome: weight loss or BMI reduction; glucose tolerance, blood pressure, lipid disorders
- Duration: ≥1 yr
- BMI ≥25 kg/m2
- 12 month followup |
21 |
| b. Medications |
- RCT (of fair or good quality)
- Outcome: weight loss or BMI reduction; glucose tolerance, blood pressure, lipid disorders
- Duration: ≥6 mos
- Population: generalizable to typical U.S. primary care population
|
10 |
| c. Surgery |
- RCT (of fair or good quality)
- Outcome: weight loss or BMI reduction; glucose tolerance, blood pressure, lipid disorders
- Duration: ≥1 year
- Cohort
- Initial BMI ≥25 kg/m2
- Surgical procedure
|
2 |
| Harms of screening and treatment |
Same studies as efficacy of counseling/behavioral and medication interventions
For surgery, same studies as efficacy plus multiple cohorts and 1 non-RCT
|
21 counseling
15 medication
2 surgery
|
|
Notes: RCT = randomized controlled trial; BMI = body mass index
a References 11,28,29,31
|