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Table 1. Risk Factors for Fractures in Women 50-65 Years of Age

Risk Factor Relative Risk (95% confidence interval) References
Age: per 2 years 1.11 (1.01-1.21) 26
Age: per 5 years 1.94 (1.55-2.42) 27
Body Mass Index per increase of: 0.01 kg/m2 0.4 (0.3-0.6) 28
Body Mass Index: 10 kg/m2 0.58 (0.36-0.92) 27
Body Mass Index: ≥25.6 kg/m2 0.7 (0.5-0.9) wrist;
1.6 (1.0-2.4) ankle
26
Body Mass Index: ≥28.6 kg/m2 0.5 (0.4-0.7) wrist;
2.0 (1.3-3.1) ankle
26
Body Mass Index: Low 1.1 (1.0-1.2) 29
Height: per 0.1 m 1.58 (1.18-2.12) 27
Mother with fracture 1.27 (1.16-1.40) 30
Grandmother with hip fracture 3.70 (1.55-8.85) 31
Hormone replacement therapy: Current use 0.82 (0.74-0.91) 30
Hormone replacement therapy: per 5 years use 0.5 (0.2-0.9) 28
Hormone replacement therapy: >2 years use 0.44 (0.22-0.89) 32
Hormone replacement therapy: Long history of use 0.70 (0.50-0.96) 33
African American 0.54 (0.41-0.72) 30
Diabetes mellitus 9.17 (3.38-24.92) 27
Chronic conditions 1.3 (1.1-1.5) 26
Disability pension 3.79 (2.15-6.68) 27
Long-term work disability 1.3 (1.1-1.6) 26
Self-rated health (fair/poor) 1.79 (1.52-2.11) 30
Moderate daily physical activity 0.61 (0.37-0.99) 32
Alcohol: ≥100 g/wk 1.70 (1.08-2.67) 33
Alcohol: Regular use 1.4 (1.3-4.4) 29
Alcohol: 1 to 6 drinks/wk 0.85 (0.75-0.96) 30
Smoking: Current 1.5 (1.3-1.5);
1.14 (1.00-1.30)
26,30
Smoking: Former 1.09 (1.00-1.19) 30
Smoking: ≥11 cigarettes/day 3.0 (1.9-4.6) 26
Unmarried 2.16 (1.28-3.64) 27
College education or higher 1.26 (1.16-1.38) 30
Age at menopause 0.94 (0.88-0.99) 32
Years since menopause: 10 to 19 1.18 (1.01-1.38) 30
Years since menopause: 20 to 29 1.31 (1.12-1.54) 30
Years since menopause: 30 1.51 (1.26-1.81) 30
Oophorectomy <45 years 3.64 (1.01-13.04) 33
5 or more children 2.5 (1.1-6.7) 29

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