Appendix 1. Search Strategies

Database: MEDLINE®
Dates: 1996 to September 2003

Syphilis Trials

1   syphilis.mp. or exp SYPHILIS/ (2504)
2   treponema pallidum.mp. (536)
3   1 or 2 (2682)
4   limit 3 to (human and English language and yr=2002-2003) (370)
5   limit 4 to (clinical trial or controlled clinical trial or guideline or meta analysis or multicenter study or practice guideline or randomized controlled trial or review) (54)
6   4 not 5 (316)
7   from 5 keep 1-54 (54)

Syphilis Not Trials

1   syphilis.mp. or exp SYPHILIS/ (2504)
2   treponema pallidum.mp. (536)
3   1 or 2   (2682)
4   limit 3 to (human and English language and yr=2002-2003) (370)
5   limit 4 to (clinical trial or controlled clinical trial or guideline or meta analysis or multicenter study or practice guideline or randomized controlled trial or review) (54)
6   4 not 5 (316)
7   from 5 keep 1-54 (54)
8   from 6 keep 1-316 (316)

Syphilis in Newborns

1   syphilis.mp. or exp SYPHILIS/ (2523)
2   treponema pallidum.mp. (539)
3   1 or 2   (2703)
4   limit 3 to (human and English language and all infant <birth to 23 months> and yr=1996-2002   and (clinical trial or guideline or meta analysis or multicenter study or practice guideline or review)) (33)
5   from 4 keep 1-33 (33)

Syphilis in Pregnancy

1   syphilis.mp. or exp SYPHILIS/ (2523)
2   treponema pallidum.mp. (539)
3   1 or 2   (2703)
4   exp Mass Screening/ or screen$.mp. (96999)
5   exp pregnancy/ or exp pregnancy complications/ or exp infant/ or fetus.mp. or fetal.mp. or disease transmission, vertical/ (252912)
6   3 and 4 and 5 (148)
7   limit 6 to (human and English language and yr=1996-2002) (124)
8   from 7 keep 1-124 (124)

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