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Exhibit 2-1. Key Questions and Words for the Colorectal Cancer Screening Systematic Review

1. What are the recent trends in the use and quality of colorectal cancer screening?

  • Demographic: Age, gender, ethnicity, race, language, literacy, socioeconomic status (SES), education, culture.
  • Type of tests: colonoscopy, sigmoidoscope, computed tomography (CT) colonography, stool tests (DNA stool, fecal immunochemical testing [FIT], fecal occult blood test using guaiac [gFOBT]).
  • Geographic areas, State.
  • Health insurance.
  • Health systems.
  • Provider characteristics by specialty training, age, experience.
  • Exclusions: familial adenomatous polyposis (FAP), hereditary nonpolyposis colorectal cancer (HNPCC), ulcerative colitis (UC), Crohns, other hereditary polyposis syndromes.
  • Quality: Office or home FOBT.
  • Too frequent screening or surveillance/overutilization.

2. What factors influence the use of colorectal cancer screening?

  • By:
    • Providers.
    • Individuals.
  • Perceived effectiveness.
  • Guideline recommendations.
  • Insurance coverage.
  • Cost to patient (out of pocket).
  • Marital status-someone to go with you.
  • Provider reimbursement.
  • Invasiveness, complexity, amount of patient time/effort.
  • Physical and psychological comfort.
  • Social networks.
  • Changes over time.
  • Profitability.
  • Other health behaviors.
  • Provider characteristics, age, or years since med school graduation.
  • Access and capacity.
  • Number of specialists per population.
  • Media coverage.
  • Provider recommendation.
  • Perceived risk.
  • Knowledge.
  • Comorbidities.

3. Which strategies are effective in increasing the appropriate use of colorectal cancer screening and followup?

  • Appropriate means.
  • Includes repeat screening.
  • Any recommended test (screened/not screened) excluding in-office digital rectal examination (DRE) and FOBT.
  • Strategies.
  • Informed decision making.
  • Popular media.
  • Reminder systems: provider and patient.
  • Financial incentives (Reimbursement policies, patient copayment, pay for performance).
  • Patient navigators (staffing and rearrangements).
  • Increase in capacity.
  • Governmental.
  • Use of technology in monitoring.
  • Appropriate use.
  • Differential levels of benefit.
  • At what levels.
  • Patient.
  • Provider.
  • Health system.
  • Community.

4. What are the current and projected capacities to deliver colorectal cancer screening and surveillance at the population level?

  • Endoscopy.
  • Sigmoidoscopy.
  • Colonoscopy.
  • CT colonography or virtual colonoscopy.
  • Scalability, speaker to cover.
  • Future demand, speaker to cover.
  • Tracking Systems (Surveillance).
  • Coordination (tracking systems).
  • Communication (tracking systems).
  • Referral backlog.
  • Trained workforce.
  • Geographic distribution, urban/rural, urban/inner city.

5. What are the effective approaches for monitoring the use and quality of colorectal cancer screening?

  • Levels.
  • Practice.
  • Program.
  • Population.
  • What kinds of monitoring.
  • Healthcare Effectiveness Data and Information Set (HEDIS) measures.
  • Primary care practices.
  • Quality control by objective methods.
  • Detection rates.

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