Screening for Hereditary Hemochromatosis: Systematic Review . Appendix Table 1

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Appendix Table 1. Search Strategies^a

Key Question 1

Search #	Search Term(s)/Strategy
1	HEMOCHROMATOSIS/
2	hemochromatosis.ti,ab.
3	haemochromatosis.ti,ab.
4	Iron Overload/
5	iron overload.ti,ab.
6	c282y.ti,ab.
7	1 or 2 or 3 or 4 or 5 or 6
8	cohort studies/ or longitudinal studies/ or followup studies/ or prospective studies/
9	followup stud$.ti,ab.
10	cohort stud$.ti,ab.
11	longitudinal$.ti,ab.
12	prospective$.ti,ab.
13	INCIDENCE/
14	incidence.ti,ab.
15	predict$.ti,ab,hw.
16	natural history.ti,ab.
17	penetrance/
18	penetran$.ti,ab.
19	clinical expression$.ti,ab.
20	clinical presentation$.ti,ab.
21	clinical consequence$.ti,ab.
22	clinical feature$.ti,ab.
23	clinical manifestation$.ti,ab.
24	8 or 9 or 10 or 11 or 12 or 13 or 14 or 15 or 16 or 17 or 18 or 19 or 20 or 21 or 22 or 23
25	7 and 24
26	limit 25 to (humans and english language)
27	limit 26 to "all child (0 to 18 years)"
28	limit 27 to "all adult (19 plus years)"
29	27 not 28
30	26 not 29
31	(editorial or letter or news).pt.
32	30 not 31

Key Question 2

Search #	Search Term(s)/Strategy
1	HEMOCHROMATOSIS/
2	hemochromatosis.ti,ab.)
3	haemochromatosis.ti,ab.
4	Iron Overload/
5	iron overload.ti,ab.
6	1 or 2 or 3 or 4 or 5
7	BLOODLETTING/
8	blood lett$.ti,ab.)
9	PHLEBOTOMY/
10	phlebotom$.ti,ab.
11	venesect$.ti,ab.
12	7 or 8 or 9 or 10 or 11
13	6 and 12
14	Hemochromatosis/th [Therapy]
15	Iron Overload/th [Therapy]
16	13 or 14 or 15
17	limit 16 to (humans and english language)
18	limit 17 to "all child (0 to 18 years)"
19	limit 18 to "all adult (19 plus years)"
20	18 not 19
21	17 not 20
22	(editorial or letter or news).pt.
23	21 not 22

Key Question 3

Search #	Search Term(s)/Strategy
1	HEMOCHROMATOSIS/
1	HEMOCHROMATOSIS/
2	hemochromatosis.ti,ab.
3	haemochromatosis.ti,ab.
4	1 or 2 or 3
5	family/ or nuclear family/ or parents/ or fathers/ or mothers/ or siblings/
6	(family or families).ti,ab.
7	(relative or relatives).ti,ab.
8	sibling$.ti,ab.
9	(mother$ or father$).ti,ab.
10	parent$.ti,ab.
11	5 or 6 or 7 or 8 or 9 or 10
12	screen$.ti,ab,hw.
13	diagnos$.ti,ab,hw.
14	di.fs.
15	12 or 13 or 14
16	4 and 11 and 15
17	target$.ti,ab.
18	4 and 15 and 17
19	Risk Factors/
20	risk factor$.ti,ab.
21	increased risk$.ti,ab.
22	high risk.ti,ab.
23	prognostic factor$.ti,ab.
24	19 or 20 or 21 or 22 or 23
25	4 and 24
26	cascad$.ti,ab.
27	4 and 26
28	Liver Function Tests/
29	liver function.ti,ab.
30	(abnormal$ adj3 liver).ti,ab.
31	(increased adj3 liver).ti,ab.
32	(elevate$ adj3 liver).ti,ab.
33	28 or 29 or 30 or 31 or 32
34	4 and 33
35	16 or 18 or 25 or 27 or 34
36	limit 35 to english language
37	limit 36 to humans
38	limit 37 to "all child (0 to 18 years)"
39	limit 38 to "all adult (19 plus years)"
40	38 not 39
41	37 not 40
42	(editorial or letter or news).pt.
43	41 not 42

Background

Search #	Search Term(s)/Strategy
1	hemochromatosis)
2	hemochromatosis.ti,ab.
3	haemochromatosis.ti,ab.
4	1 or 2 or 3
5	PREVALENCE/
6	prevalen$.ti,ab.
7	5 or 6
8	4 and 7
9	HEMOCHROMATOSIS/ep [Epidemiology]
10	mo.fs.
11	"Cause of Death"/
12	Survival Rate/
13	Life Expectancy/
14	mortality.ti,ab.
15	10 or 11 or 12 or 13 or 14
16	4 and 15
17	8 or 9 or 16
18	limit 17 to english language
19	limit 18 to humans
20	limit 19 to "all child (0 to 18 years)"
21	limit 20 to "all adult (19 plus years)"
22	20 not 21
23	19 not 22
24	(letter or news or editorial).pt.
25	23 not 24

^aDatabases: MEDLINE®, DARE (Database of Abstracts of Reviews of Effects), Cochrane Database of Systematic Reviews, Cochrane Central Register of Controlled Trials. Dates searched: 1966 to February 2005.

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Appendix Table 1. Search Strategiesa

Key Question 1

Key Question 2

Key Question 3

Background

Appendix Table 1. Search Strategies^a