| Study Citation |
Reason for Exclusion |
|---|
| Adams PC, Kertesz AE, Valberg LS. Rate of iron reaccumulation following iron depletion in hereditary hemochromatosis.
Implications for venesection therapy. J Clin Gastroenterol 1993;16:207-10. [PMID: 8505491] |
Does not present relevant
outcomes |
| Adams PC. Factors affecting the rate of iron mobilization during venesection therapy for genetic hemochromatosis. Am J
Hematol 1998;58:16-9. [PMID: 9590143] |
Does not present relevant
outcomes |
| Askari AD, Muir WA, Rosner IA, Moskowitz RW, McLaren GD, Braun WE. Arthritis of hemochromatosis. Clinical spectrum,
relation to histocompatibility antigens, and effectiveness of early phlebotomy. Am J Med 1983;75:957-65. [PMID:
6650551] |
Quality |
| Barton JC, Bottomley SS. Iron deficiency due to excessive therapeutic phlebotomy in hemochromatosis. Am J Hematol
2000;65:223-6. [PMID: 11074539] |
< 20 patients |
| Batey RG, Hussein S, Sherlock S, Hoffbrand AV. The role of serum ferritin in the management of idiopathic
haemochromatosis. Scand J Gastroenterol 1978;13:953-7. [PMID: 725519] |
Does not present relevant
outcomes |
| Bodemann HH, Tanzi-Fetta RF, Schroter-Urban H, Volk BA, Keul J, Lohr GW. Ferritin in erythrocytes and plasma of patients
with iron overload. Blut 1985;51:25-31. [PMID: 3848335] |
Quality |
| Candell-Riera J, Lu L, Seres L, Gonzalez JB, Batlle J, Permanyer-Miralda G, et al. Cardiac hemochromatosis: beneficial effects
of iron removal therapy. An echocardiographic study. Am J Cardiol 1983;52:824-9. [PMID: 6624673] |
Quality |
| Cesana M, Mandelli C, Tiribelli C, Bianchi PA, Conte D. Concomitant primary hemochromatosis and beta-thalassemia trait:
iron depletion by erythrocytapheresis and desferrioxamine. Am J Gastroenterol 1989;84:150-2. [PMID: 2916524] |
< 20 patients |
| Chow LH, Frei JV, Hodsman AB, Valberg LS. Low serum 25-hydroxyvitamin D in hereditary hemochromatosis: relation to iron
status. Gastroenterology 1985;88:865-9. [PMID: 3838288] |
Quality |
| Cleton MI, de Bruijn WC, van Blokland WT, Marx JJ, Roelofs JM, Rademakers LH. Iron content and acid phosphatase activity
in hepatic parenchymal lysosomes of patients with hemochromatosis before and after phlebotomy treatment. Ultrastruct
Pathol 1988;12:161-74. [PMID: 3363682] |
< 20 patients |
| Cleton MI, Roelofs JM, Blok-Van Hoek CJ, De Bruijn WC. Integrated image and X-ray microanalysis of hepatic lysosomes in a
patient with idiopathic hemosiderosis before and after treatment by phlebotomy. Scan Electron Microsc 1986:999-1006.
[PMID: 3798023] |
< 20 patients |
| Conte D, Mandelli C, Cesana M, Ferrini R, Marconi M, Bianchi A. Effectiveness of erythrocytapheresis in idiopathic
hemochromatosis. Report of 14 cases. Int J Artif Organs 1989;12:59-62. [PMID: 2925263] |
Does not report relevant
outcomes |
| Conte D, Piperno A, Mandelli C, Fargion S, Cesana M, Brunelli L, et al. Clinical, biochemical and histological features of
primary haemochromatosis: a report of 67 cases. Liver 1986;6:310-5. [PMID: 3023781] |
Quality |
| Cundy T, Butler J, Bomford A, Williams R. Reversibility of hypogonadotrophic hypogonadism associated with genetic
haemochromatosis. Clin Endocrinol (Oxf). 1993;38:617-20. [PMID: 8334747] |
< 20 patients |
| Dabestani A, Child JS, Henze E, Perloff JK, Schon H, Figueroa WG, et al. Primary hemochromatosis: anatomic and physiologic
characteristics of the cardiac ventricles and their response to phlebotomy. Am J Cardiol 1984;54:153-9. [PMID: 6741807] |
< 20 patients |
| Dymock IW, Cassar J, Pyke DA, Oakley WG, Williams R. Observations on the pathogenesis, complications and treatment of
diabetes in 115 cases of haemochromatosis. Am J Med 1972;52:203-10. [PMID: 5058506] |
Quality |
| Easley RM Jr, Schreiner BF Jr, Yu PN. Reversible cardiomyopathy associated with hemochromatosis. N Engl J Med
1972;287:866-7. [PMID: 5071966] |
< 20 patients |
| Failla M, Giannattasio C, Piperno A, Vergani A, Grappiolo A, Gentile G, et al. Radial artery wall alterations in genetic
hemochromatosis before and after iron depletion therapy. Hepatology 2000;32:569-73. [PMID: 10960451] |
< 20 patients |
| Fargion S, Mandelli C, Piperno A, Cesana B, Fracanzani AL, Fraquelli M, et al. Survival and prognostic factors in 212 Italian
patients with genetic hemochromatosis. Hepatology 1992;15:655-9. [PMID: 1312985] |
Quality |
| Feely J, Counihan TB. Haemochromatosis presenting as angina and responding to venesection. Br Med J 1977;2:681-2.
[PMID: 902053] |
< 20 patients |
| Fellows IW, Stewart M, Jeffcoate WJ, Smith PG, Toghill PJ. Hepatocellular carcinoma in primary haemochromatosis in the
absence of cirrhosis. Gut 1988;29:1603-6. [PMID: 2850272] |
< 20 patients |
| Fracanzani AL, Fargion S, Romano R, Conte D, Piperno A, D'Alba R, et al. Portal hypertension and iron depletion in patients
with genetic hemochromatosis. Hepatology 1995;22:1127-31. [PMID: 7557861] |
Quality |
| Gama R, Smith MJ, Wright J, Marks V. Hypopituitarism in primary haemochromatosis; recovery after iron depletion. Postgrad
Med J 1995;71:297-8. [PMID: 7596937] |
< 20 patients |
| Goh J, Callagy G, McEntee G, O'Keane JC, Bomford A, Crowe J. Hepatocellular carcinoma arising in the absence of cirrhosis
in genetic haemochromatosis: three case reports and review of literature. Eur J Gastroenterol Hepatol 1999;11:915-9.
[PMID: 10514128] |
< 20 patients |
| Grima KM. Therapeutic apheresis in hematological and oncological diseases. J Clin Apher 2000;15:28-52. [PMID: 10767050] | Review article |
| Guillygomarc'h A, Mendler MH, Moirand R, Laine F, Quentin V, David V, et al. Venesection therapy of insulin
resistance-associated hepatic iron overload. J Hepatol 2001;35:344-9. [PMID: 11592595] |
Wrong population |
| Hash RB. Hereditary hemochromatosis. J Am Board Fam Pract 2001;14:266-73. [PMID: 11458969] Review article
Hines C Jr, Davis WD Jr, Ferrante WA. Hepatoma developing in hemochromatosis in spite of adequate treatment by multiple
phlebotomies. Am J Dig Dis 1971;16:349-55. [PMID: 4324431] |
Case report |
| Hramiak IM, Finegood DT, Adams PC. Factors affecting glucose tolerance in hereditary hemochromatosis. Clin Invest Med
1997;20:110-8. [PMID: 9088667] |
Quality |
| Hultcrantz R, Angelin B, Bjorn-Rasmussen E, Ewerth S, Einarsson K. Biliary excretion of iron and ferritin in idiopathic
hemochromatosis. Gastroenterology 1989;96:1539-45. [PMID: 2714579] |
Quality |
| Jakeman A, Thompson T, McHattie J, Lehotay DC. Sensitive method for nontransferrin-bound iron quantification by graphite
furnace atomic absorption spectrometry. Clin Biochem 2001;34:43-7. [PMID: 11239514] |
< 20 patients |
| Kaltwasser JP, Werner E, Schalk K, Hansen C, Gottschalk R, Seidl C. Clinical trial on the effect of regular tea drinking on iron
accumulation in genetic haemochromatosis. Gut 1998;43:699-704. [PMID: 9824354] |
Quality |
| Kelly TM, Edwards CQ, Meikle AW, Kushner JP. Hypogonadism in hemochromatosis: reversal with iron depletion. Ann Intern
Med 1984;101:629-32. [PMID: 6435491] |
Does not present relevant
outcomes |
| Kohan A, Niborski R, Daruich J, Rey J, Bastos F, Amerise G, et al. Erythrocytapheresis with recombinant human erythropoietin
in hereditary hemochromatosis therapy: a new alternative. Vox Sang 2000;79:40-5. [PMID: 10971213] |
< 20 patients |
| Leitman SF, Browning JN, Yau YY, Mason G, Klein HG, Conry-Cantilena C, et al. Hemochromatosis subjects as allogeneic
blood donors: a prospective study. Transfusion 2003;43:1538-44. [PMID: 14617312] |
Does not report relevant
outcomes |
| Limdi JK, Crampton JR. Hereditary haemochromatosis. QJM 2004;97:315-24. [PMID: 15152104] | Review article |
| Lombard M, Bomford A, Hynes M, Naoumov NV, Roberts S, Crowe J, et al. Regulation of the hepatic transferrin receptor in
hereditary hemochromatosis. Hepatology 1989;9:1-5. [PMID: 2642288] |
Does not present relevant
outcomes |
| Lufkin EG, Baldus WP, Bergstralh EJ, Kao PC. Influence of phlebotomy treatment on abnormal hypothalamic-pituitary
function in genetic hemochromatosis. Mayo Clin Proc 1987;62:473-9. [PMID: 3106726] |
Quality |
| Mainous AG 3rd, Wells B, Carek PJ, Gill JM, Geesey ME. The mortality risk of elevated serum transferrin saturation and
consumption of dietary iron. Ann Fam Med 2004;2:139-44. [PMID: 15083854] |
No phlebotomy treatment |
| Mandelli C, Cesarini L, Piperno A, Fargion S, Fracanzani AL, Barisani D, et al. Saturability of hepatic iron deposits in genetic
hemochromatosis. Hepatology 1992;16:956-9. [PMID: 1398502] |
Does not present relevant
outcomes |
| McDonnell SM, Witte DL, Cogswell ME, McIntyre R. Strategies to increase detection of hemochromatosis. Ann Intern Med
1998;129:987-92. [PMID: 9867752] |
Review article |
| Milman N, Pedersen P, a Steig T, Byg KE, Graudal N, Fenger K. Clinically overt hereditary hemochromatosis in Denmark
1948-1985: epidemiology, factors of significance for long-term survival, and causes of death in 179 patients. Ann Hematol
2001;80:737-44. [PMID: 11797115] |
Quality |
| Milman N. Hereditary haemochromatosis in Denmark 1950-1985. Clinical, biochemical and histological features in 179
patients and 13 preclinical cases. Dan Med Bull 1991;38:385-93. [PMID: 1914539] |
Does not report relevant
outcomes |
| Moirand R, Adams PC, Bicheler V, Brissot P, Deugnier Y. Clinical features of genetic hemochromatosis in women compared
with men. Ann Intern Med 1997;127:105-10. [PMID: 9229998] |
Does not report relevant
outcomes |
| Morcos M, Dubois S, Bralet MP, Belghiti J, Degott C, Terris B. Primary liver carcinoma in genetic hemochromatosis reveals a
broad histologic spectrum. Am J Clin Pathol 2001;116:738-43. [PMID: 11710692] |
Does not report relevant
outcomes |
| Muncunill J, Vaquer P, Galmes A, Obrador A, Parera M, Bargay J, et al. In hereditary hemochromatosis, red cell apheresis
removes excess iron twice as fast as manual whole blood phlebotomy. J Clin Apher 2002;17:88-92. [PMID: 12210712] |
< 20 patients |
| Muting D, Kalk JF, Fischer R, Wiewel D. Spontaneous regression of oesophageal varices after long-term conservative
treatment. Retrospective study in 20 patients with alcoholic liver cirrhosis, posthepatitic cirrhosis and haemochromatosis
with cirrhosis. J Hepatol 1990;10:158-62. [PMID: 2332585] |
Not phlebotomy treatment |
| Niederau C, Stremmel W, Strohmeyer GW. Clinical spectrum and management of haemochromatosis. Baillieres Clin
Haematol 1994;7:881-901. [PMID: 7881158] |
Review article |
| Niederau C, Strohmeyer G, Stremmel W. Epidemiology, clinical spectrum and prognosis of hemochromatosis. Adv Exp Med
Biol 1994;356:293-302. [PMID: 7887234] |
Review article |
| Olsson KS, Ritter B, Lundin PM. Liver affection in iron overload studied with serum ferritin and serum aminotransferases. Acta
Med Scand 1985;217:79-84. [PMID: 3976436] |
Quality |
| Piperno A, Vergani A, Salvioni A, Trombini P, Vigano M, Riva A, et al. Effects of venesections and restricted diet in patients
with the insulin-resistance hepatic iron overload syndrome. Liver Int 2004;24:471-6. [PMID: 15482345] |
Does not report relevant
outcomes |
| Propper R, Nathan D. Clinical removal of iron. Annu Rev Med 1982;33:509-19. [PMID: 6282184] Clinical review article
Prunescu CC, Prunescu P, Vilcu AL. Ultrastructure of the liver in idiopathic haemosiderosis and results of a treatment by
repeated bleedings. Morphol Embryol (Bucur) 1987;33:133-6. [PMID: 2956507] |
Case report |
| Riquelme A, Soza A, Nazal L, Martinez G, Kolbach M, Patillo A, et al. Histological resolution of steatohepatitis after iron
depletion. Dig Dis Sci 2004;49:1012-5. [PMID: 15309893] |
Case report |
| Sargent T, Saito H, Winchell HS. Iron absorption in hemochromatosis before and after phlebotomy therapy. J Nucl Med
1971;12:660-7. [PMID: 5000107] |
Does not report relevant
outcomes |
| Seamark CJ, Hutchinson M. Controversy in primary care: Should asymptomatic haemochromatosis be treated? BMJ
2000;320:1314-7. [PMID: 10807626] |
Case report |
| Sigal SH, Fleischner GM, Weiner FR. Hypogonadal-induced anemia in genetic hemochromatosis: implications for phlebotomy
therapy. Am J Gastroenterol 1995;90:152-3. [PMID: 7801923] |
Case report |
| Spellberg MA. Treatment of hemochromatosis. Am J Gastroenterol 1969;51:516-22. [PMID: 4894612] | Review article |
| Tiniakos G, Williams R. Cirrhotic process, liver cell carcinoma and extrahepatic malignant tumors in idiopathic
haemochromatosis. Study of 71 patients treated with venesection therapy. Appl Pathol 1988;6:128-38. [PMID: 2839215] |
Quality |
| Weintraub LR, Conrad ME, Crosby WH. The treatment of hemochromatosis by phlebotomy. Med Clin North Am
1966;50:1579-90. [PMID: 5339192] |
< 20 patients |
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