Figure. Search Results and Article Flow by Key Question (Text Description)

The figure depicts the process by which articles were selected for review.

The first box contains the text: "Abstracts reviewed. Searches: key question 1, key question 2, key question 3, background (n = 1886)."

An arrow points from the first box to a second beneath it, that reads: "Total articles reviewed from searches and outside sources (n = 256)"

Three arrows point down from the second box to 3 boxes below it. These read: "Articles reviewed for key question 1 (n = 134)," "Articles reviewed for key question 2 (n = 69)," and "Articles reviewed for key question 3 (n = 55)."

Two arrows point down from the box labeled "Articles reviewed for key question 1 (n = 134)" to two boxes beneath it. The first of these boxes reads:

"Articles excluded for key question 1 (n = 120):
   Study quality: 4
   No primary data: 1
   Population <18 y: 7
   Study disease definition: 6
   Did not report relevant outcomes: 25
   Study design: 7
   Not a screening population: 46
   Did not report C282Y genotype: 19
   In full review, not compatible with final synthesis: 5."

The second of these boxes reads: "Articles included for key question 1 (n = 14 [11 studies])."

Beneath the box labeled "Articles reviewed for key question 2 (n = 69)" are two more boxes. The first of these reads:

"Articles excluded for key question 2 (n = 61):
   Study quality: 15
   Study design: 29
   Did not report relevant outcomes: 14
   Study disease definition: 1
   No phlebotomy treatment: 2."

The second of these boxes reads: "Articles included for key question 2 (n = 8 [5 studies])."

Beneath the box labeled "Articles reviewed for key question 3 (n = 55)" are also two boxes. The first of these reads:

"Articles excluded for key question 3 (n = 47):
   Study quality: 8
   Population <18 y: 1
   Not correct population: 10
   Study disease definition: 5
   Study design: 9
   Did not report relevant prevalence or risk measures: 7
   Did not report relevant outcomes: 1
   Did not include original data: 3
   No HFE testing: 3."

The second of these boxes reads: "Articles included for key question 3 (n = 8 [7 studies])."

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