Screening for Hereditary Hemochromatosis: Systematic Review, Table 1

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Term/Test	Men	Women
Screening-positive for elevated iron measures
Transferrin saturation, %^42-44	>50	>45
Serum ferritin level, µg/L^44,45	>300	>200
Possible iron overload
Repeat transferrin saturation, % or	>50	>45
Repeat serum ferritin, µg/L or	>300	>200
Initial increased transferrin saturation and serum ferritin level plus clinical examination
Provisional primary iron overload⁴⁴
Repeated transferrin saturation shows increased serum ferritin levels not due to liver disease, inflammation, or secondary causes of iron overload
Iron overload: documented⁴⁴
Meets all the provisional primary iron overload criteria and shown to have increased body iron stores by >1 of the following: Hepatic iron concentration (biopsy): >90 µm/g, >5000 µg/g dry weight Iron removed to reach iron depletion (phlebotomy): >4 g iron removed Histology: suggestive of hemochromatosis and: Hepatic iron index: >1.9 or Hepatic iron staining: 3+, 4+