Evidence on the Benefits and Harms of Screening and Treating Pregnant Women Who Are Asymptomatic for Bacterial Vaginosis: An Update Review. Table 1

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Table 1. Characteristics of Studies of Women at High Risk for Delivery Before 37 Weeks^a

Study, Year (Reference)	Country: Setting	Race^b	High-Risk Criteria	History of >1 PTD	Treatment Regimen	Rounds, n	Methods of Bacterial Vaginosis Diagnosis	Gestational Age at Treatment, wk	Delivery <37 Weeks in Untreated Bacterial Vaginosis- Positive Women, %	Delivery <37 Weeks in Treated Bacterial Vaginosis- Positive Women, %
Carey et al., 2000^57,c	United States; university, multicenter	White, 14.8%; black, 69.5%; Hispanic, 15.7%	PTD history	NR	Oral metronidazole, 2g repeated at 48 h	2	Gram stain	16- 24	22.5	30.0
Hauth et al., 1995⁶⁰	United States; university, Alabama	Black, 73.6%	PTD history or prepregnancy weight <50 kg	NR	Oral metronidazole, 250 mg 3 times/d for 7 d + Oral erythromycin, 333 mg 3 times/d for 14 d	2	Amsel criteria	>20	57.1	38.8
McDonald et al., 1997^58,c	Australia, 4 metropolitan area perinatal centers	White, 87.4%; Asian, 8.6%; aboriginal/ Torres Strait islander, 1%	PTD history	NR	Oral metronidazole 400 mg 2 times/d for 2d	2	Gram stain	>20	35.3	5.9
Morales et al., 1994⁵⁹	United States; university, Baltimore	Black, 47.5%	Penultimate pregnancy, PTD from idiopathic PTL, or PPROM	50% treatment, 39% control	Oral metronidazole, 250 mg 3 times/d for 7 d	1	Amsel criteria	<20	44.4	18.1
Odendaal et al., 2002^50,d	South Africa; tertiary academic hospital	NR	PTD history or midtrimester abortion	NR	Oral metronidazole, 400 mg 2 times/d for 2 d	2	Gram stain + Amsel criteria	15 to 26	23.5	42.9
Vermeulenand Bruinse., 1999⁶¹	Netherlands; 12 city hospitals	NR	PTD history, penultimate pregnancy, PPROM	8% treatment, 8% control^e	Vaginal clindamycin for 7 d	Gram stain	>20	NR	NR	NR

^a. NR = not reported; PPROM = preterm, premature rupture of membranes; PTD = preterm delivery; PTL = preterm labor.
^b. Data for race reflect the total population in each study, which may include women without bacterial vaginosis or history of PTD.
^c. Carey et al.⁵⁷ and McDonald et al.⁵⁸ performed subgroup analyses of high-risk women positive for bacterial vaginosis. These women are included in the total population of average-risk women in these respective studies.
^d. Odendaal et al.⁵⁰ included 2 distinct populations: low-risk women (e.g., primigravidae) and high-risk women (e.g., those with a history of PTD or midtrimester abortion).
^e. Includes women both positive and negative for bacterial vaginosis.

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Table 1. Characteristics of Studies of Women at High Risk for Delivery Before 37 Weeksa

Table 1. Characteristics of Studies of Women at High Risk for Delivery Before 37 Weeks^a