Director's Update

Comparative Effectiveness of Oral Antidiabetic Drugs on Kidney Function

• Evaluated oral antidiabetic drugs & renal outcomes by using a national Veterans Health Administration (VHA) database of 93,577 diabetic patients.
• Compared with patients using the metformin, patients using sulfonylureas had an increased risk of a decline in kidney function, end-stage renal disease, or death.
• Because of these new findings, the current recommendation to limit the use of metformin alone in patients with mild to moderate kidney disease should be re-examined.
• New study from Effective Health Care Program's Developing Evidence to Inform Decisions about Effectiveness (DEcIDE) Network published in Nature's Kidney International.

Hung AM, Roumie CL, Greevy RA, Liu X, Grijalva CG, Murff HJ, Ikizler TA, Griffin MR. Comparative effectiveness of incident oral antidiabetic drugs on kidney function. Kidney Int 2012 Apr;81(7):698-706.

Image: The first page of the cited Kidney International article is shown.

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