RFA HS-96-003 Projects: Research
on the Outcomes of Pharmaceutical Therapy
Community-Based Pharmaceutical Care: A Controlled
Principal Investigator: Morris Weinberger, Ph.D., Indiana University, Indianapolis, IN 46202-5167
Grant Number: HS09083
Project Period: 06/96-05/00
NTIS Number: PB2001-108114
Summary: The purpose of this study was to develop
algorithms to facilitate pharmaceutical care for the treatment of
asthma. A randomized controlled
trial, with 460 patients in a pharmacy intervention group and 2 control
groups (peak flow monitoring, usual care), was undertaken. The pharmacy intervention group was
given patient-specific clinical information displayed on their computer
workstations when filling prescriptions.
Asthma patients receiving the pharmaceutical care program had more
emergency department visits and hospitalizations for acute exacerbation
than the usual care group. Authors
concluded that while the pharmaceutical care program demonstrated
substantial improvement in both medication compliance and health related
quality of life at 6 months and sustained at one year, similar levels of
improvement were observed in both control groups.
Publications to Date
Amsler, M.F., Murray, M.D., Tierney, W.M., Brewer, N., Harris, L.E., Marrero, D.G., & Weinberger, M. (2001). Pharmaceutical care in chain
pharmacies: beliefs and attitudes of pharmacists and patients. Journal of the American Pharmacological
Association (Wash) 41(6):850-5.
Hanlon, J.T., Schmader, K.E., Ruby, C.M., & Weinberger, M. (2001). Suboptimal prescribing in older
inpatients and outpatients. Journal of American
Stroupe, K.T., Gaskins, D., & Murray, M.D. (1999). Health-care costs of inner-city patients with
asthma. The Journal of Asthma 36(8):645-55.
Tierney, R.M., Horton, S.M., Hannan, T.J., & Tierney, W.M. (1998). Relationships between symptom relief, quality of life, and satisfaction with hospice care. Palliative Medicine 12(5):333-344.
Weinberger, M., Murray, M.D., Marrero, D.G., Brewer, N., Lykens, M., Harris, L.E., & Tierney
W.M. (2001). A pharmaceutical care program for patients with reactive airways
disease. American Journal of Health-system
Weinberger, M., Murray, M.D., Marrero, D.G., Brewer, N., Lykens, M., Harris, L.E., Newell, A.J., Collins, J., & Tierney, W.M. (2002). Issues in conducting randomized
trials of health services research interventions in practice settings: the case
of retail pharmacies. Health Services
Weinberger, M., Murray, M.D., Marrero, D.G., Brewer, N., Lykens, M., Harris, L.E., Seshadri, R., Caffrey, H., Roesner, J.F., Smith, F., Newell, A.J., Collins, J.C., McDonald, C.J., & Tierney, W.M. (2002). The effectiveness of pharmacist care for patients
with reactive airways disease: a randomized controlled trial. Journal of the American Medical Association 288(13):1594-602.
Zhou, X.H., Li, C., Gao, S., & Tierney, W.M. (2001). Methods for testing equality of means of health
care costs in a paired design study. Statistics
in Medicine 20(11):1703-20.
Prospective Drug Use Review on Health Outcomes
Principal Investigator: Frank M. Ahern, Ph.D., Pennsylvania State University, University Park, PA 16802
Grant Number: HS09075
Project Period: 08/96-07/98
NTIS Number: PB2003-102310
Summary:, The purpose of this study was to compare
two different models of outpatient prospective drug utilization review
(ProDUR) programs in the State of Pennsylvania. One model allowed active participation by a pharmacist
in the process while the other did not.
The study aimed to 1) conduct a descriptive epidemiological
analysis of psychotropic drug use, prescribing patterns, and yield of
ProDUR interventions; 2) compute estimates of drug-related outcome measures;
and 3) evaluate the independent effects of two different ProDUR procedures
on health outcomes. The
investigators used data from the Pharmaceutical Assistance Contract for
the Elderly (PACE) and Medicaid.
While findings suggest that both ProDUR systems had an impact on
prescription drug utilization and on exposure to inappropriate drug use, the program that allowed active participation by a pharmacist had a more
positive impact on utilization measures than the program that did not
allow such participation.
Ahern, F.M. (2002). Impact of prospective drug use review on health. Final report for August 1996-July 2000. Pennsylvania State University;
National Center for Health Statistics, Hyattsville, MD; Div. of Health
Examination Statistics; Agency for Healthcare Research and Quality, Rockville, MD.
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