Institution: Denver Health and Hospital Authority
Grant Title: Strategies to Identify Undiagnosed HIV Infection in the Emergency Department
Grant Number: K02 HS17526
Duration: 5 years (2008-2013)
Total Award: $556,200
Project Description: This research has three main aims:
- Use large prospectively-collected database to derive a clinical prediction instrument to accurately identify HIV seropositivity.
- Conduct a nested prospective cohort study to externally validate the clinical prediction instrument in the emergency department (ED).
- Conduct a quasi-experimental equivalent time-samples clinical trial to assess the clinical effectiveness of using an empirically-derived clinical instrument, a conventional HIV behavioral risk screening instrument, or no screening as a means to stratify ED patients into groups at risk for HIV infection in the ED.
Career Goals: Dr. Haukoos is an Assistant Professor and Director of Research in the Department of Emergency Medicine at the Denver Health Medical Center. He received his MD from the University of California, Los Angeles (UCLA), and did his residency in Emergency Medicine at Harbor-UCLA Medical Center. Following his residency, he completed a fellowship in Clinical Research at the same location and simultaneously
earned his MSc in Epidemiology from UCLA School of Public Health. The grantee's long-term careers goals include conducting high quality collaborative health services research and develop an extramurally-funded Emergency Medicine Research Center in Denver in order to provide infrastructure for conducting clinical and health services research and for developing a successful and sustained research fellowship training program.
Progress to Date: The derivation of a clinical prediction instrument to identify HIV seropositivity has recently been completed. The results of this work were accepted for presentation at the 2009 Conference on Retroviruses and Opportunistic Infections and a manuscript is also being developed. The grantee has four publications and four more in press.
Future Plans: Work on Aim #2 is underway. Additional related analyses will include modifying the current clinical prediction instrument in an effort to make it easier to use in an ED environment. The grantee will also use Classification and Regression Tree Analysis to derive a second instrument to predict HIV seropositivity.
Highlights and Specific Accomplishments:
- Fellow, American College of Emergency Physicians.
- Member, Grants Committee, Society for Academic Emergency Medicine.
- Associate Editor, Academic Emergency Medicine.
K-Generated Publications: (selected)
Backlund B, Bonnett C, Faragher J, Haukoos JS, Kendall J. Pilot study to determine the feasibility of training army national guard medics to perform focused cardiac ultrasonography. Prehospital Emergency Care. 2010. 14:118-23.
Haukoos JS, Mehta S, Harvey L, et al. Research priorities for human immunodeficiency virus and sexually transmitted infections surveillance, screening, and intervention in emergency departments: Consensus-based recommendations. Academic Emergency Medicine. 2009. 16:1138-142.
Haukoos JS, Lyons MS. Idealized models or incremental program evaluation: Translating emergency department HIV testing into practice. Academic Emergency Medicine. 2009. 16:1044-048.
Haukoos JS, Hopkins E, Byyny RL, et al. Design and implementation of a controlled clinical trial to evaluate the effectiveness and efficiency of opt-out rapid HIV screening in the emergency department. Academic Emergency Medicine. 2009. 16:800-08.
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