Research Activities, October 2013
No direct link between fatigue and disease activity in juvenile idiopathic arthritis
Fatigue is commonly reported by children with juvenile idiopathic arthritis (JIA). Some data suggest associations between fatigue and disease activity, while other data report associations with functional ability and aspects of mood, including anxiety and depression.
A new study found no significant relationship, after adjusting for pain, between fatigue and summary measures of disease activity in JIA, including the Juvenile Arthritis Disease Activity Score. In both the child- and parent/proxy-reported multivariable models of fatigue, functional ability (measured by the Childhood Health Assessment Questionnaire) was the only variable that remained significantly associated with fatigue, after adjustment for reported pain.
The researchers believe that routinely incorporating pain and fatigue into interventional and observational trials of JIA will enable better delineation of the relationships between these variables. Their findings were based on study of 309 children, who were treated at the rheumatology clinic of Children's Hospital in Seattle, WA. The study was funded by AHRQ (HS19482).
See "Disease activity and fatigue in juvenile idiopathic arthritis," by Sarah Ringold, M.D., Teresa M. Ward, Ph.D., and Carol A. Wallace, M.D., in the March 2013 issue of Arthritis Care & Research 65(3), pp. 391-397.