Potentially Harmful Drug-drug Interactions in the Elderly: a Review

Articles of Interest, March 23, 2012

A weekly compilation of articles appearing in recently released journals and newsletters, including articles funded by AHRQ or authored by AHRQ researchers, mentioning or discussing AHRQ staff, activities, and publications/products, or other research using AHRQ data or products.

This weekly compilation of articles appearing in recently released journals and newsletters includes:

  • Articles funded by the Agency for Healthcare Research and Quality (AHRQ) or authored by AHRQ researchers.
  • Articles mentioning or discussing AHRQ staff, activities, and publications/products.
  • Articles related to AHRQ-funded Evidence-based Practice Centers.
  • Articles related to the U.S. Preventive Services Task Force or Put Prevention into Practice program.
  • Articles mentioning the National Healthcare Disparities Report and National Healthcare Quality Report.
  • Other research using AHRQ data or products.

AHRQ-Funded/Authored Articles

American Journal of Geriatric Pharmacotherapy
Hines LE, Murphy JE. Potentially harmful drug-drug interactions in the elderly: a review. Am J Geriatr Pharmacother 2011 Dec; 9(6):364-77. [Supported by grants 1 R18 HS19220-01 and U18 HS17001-01 (both to first author).] Select to access the abstract.

Peron EP, Gray SL, Hanlon JT. Medication use and functional status decline in older adults: a narrative review. Am J Geriatr Pharmacother 2011 Dec; 9(6):378-91. [Supported in part by grants R01 HS17695, R01 HS18721, and K12 HS19461; cites AHRQ publication, Improving the Health Care of Older Americans: A Report of the AHRQ Task Force on Aging, 2001.] Select to access the abstract.

Linnebur SA, Fish DN, Ruscin JM, et al. Impact of a multidisciplinary intervention on antibiotic use for nursing home-acquired pneumonia. Am J Geriatr Pharmacother 2011 Dec; 9(6):442-50.e1. [Supported by investigator-initiated research grant R01 HS13618-01A1.] Select to access the abstract.

American Journal of Managed Care
Singh R, Anderson D, McLean-Plunkett E, et al. IT-enabled systems engineering approach to monitoring and reducing ADEs. Am J Manag Care 2012 Mar; 18(3):169-75. [Supported by grant R18 HS01702; cites AHRQ publication, Advances in Patient Safety: New Directions and Alternative Approaches, Volume 2: Culture and Redesign, and Volume 3: Performance and Tools, 2008.] Select to access the abstract.

American Journal of Medical Quality
Clancy CM. Commentary: Progress on a national patient safety imperative to eliminate CLABSI. Am J Med Qual 2012 Mar; 27(2):170-1. [Author is the AHRQ director; discusses AHRQ's expanded funding on preventing health care-associated infections with emphasis on central line-associated bloodstream infections (CLABSIs) and implementation of the Comprehensive Unit-based Safety Project (CUSP) and the Michigan Health and Hospital Association's Keystone Center for Patient Safety and Quality ("Keystone Project"); cites AHRQ Patient Safety Primer Health Care-Associated Infections, as published on AHRQ's Patient Safety Network (PSNet); cites AHRQ press release AHRQ Awards $34 Million To Expand Fight Against Healthcare-Associated Infections, 2011, and AHRQ publication, Eliminating CLABSI: A National Patient Safety Imperative. Second Progress Report on the National On the CUSP: Stop BSI Project, 2011, both as accessed on the AHRQ Web site; cites HHS news release on AHRQ publication, AHRQ's Efforts to Prevent and Reduce Healthcare-Associated Infections. Fact Sheet, 2009, as published on the AHRQ Web site.]

Applied Health Economics and Health Policy
Richards MR. Using the economics of certification to improve the safety and quality of male circumcision in developing countries: three models of implementation. Appl Health Econ Health Policy 2012 Mar 1; 10(2):77-85. [Supported by grant T32 HS17589-03.] Select to access the abstract.

BMC Medical Research Methodology
Bobo WV, Cooper VO, Epstein RA Jr, et al. Positive predictive value of automated database records for diabetic ketoacidosis (DKA) in children and youth exposed to antipsychotic drugs or control medications: a Tennessee Medicaid study. BMC Med Res Methodol 2011 Nov 23; 11:157. [Supported by Centers for Research and Education on Therapeutics (CERTs) grants HS10384 and 5 U18 HS17918-02.] Select to access the abstract.

Clinical Cardiology
Chin CT, Wang TY, Li S, et al. Comparison of the prognostic value of peak creatine kinase-MB and troponin levels among patients with acute myocardial infarction: a report from the Acute Coronary Treatment and Intervention Outcomes Network Registry-Get With The Guidelines. Clin Cardiol 2012 Mar 20. [Epub ahead of print. Supported by grant U18 HS16964.] Select to access the abstract.

Electronic Data Methods (EDM) Forum
Building the electronic clinical data infrastructure to improve patient outcomes: CER project profiles. EDM Forum 2012 Feb; Online. [Supported by American Recovery and Reinvestment Act (ARRA) grant U13 HS19564-01; describes three AHRQ-funded programs (under ARRA) and the eleven research projects being funded under these programs, the conduct and results of which are addressed and disseminated through the AHRQ-funded AcademyHealth EDM Forum; acknowledges Gurvaneet Randhawa, researcher in AHRQ's Center for Outcomes and Evidence, as the project officer for these grants; cites How Are Research Topics Chosen?, (published on AHRQ's Effective Health Care Program Web site) and Recovery Act Awards: Evidence Generation Awards. Fact Sheet, 2010, and Recovery Act Awards: Data Infrastructure Awards. Fact Sheet, 2010 (published on the AHRQ Web site); cites AHRQ-sponsored notices, Request for Applications (RFA) ARRA OS Recovery Act 2009 Limited Competition: Enhanced Registries for Quality Improvement and Comparative Effectiveness Research (R01), 2010, ARRA OS: Recovery Act 2009 Limited Competition: Scalable Distributed Research Networks for Comparative Effectiveness Research (R01), 2010, and ARRA-AHRQ Recovery Act 2009 Limited Competition: PROSPECT Studies: Building New Clinical Infrastructure for Comparative Effectiveness Research (R01), 2009, all published on the National Institutes of Health Office of Extramural Research Grants Web site.]

Inquiry
Encinosa WE, Bae J. Health information technology and its effects on hospital costs, outcomes, and patient safety. Inquiry 2011-2012 Winter; 48(4):288-303. [First author is a researcher in AHRQ's Center for Delivery, Organization, and Markets; uses AHRQ's 2007 Patient Safety Indicators (citing Patient Safety Indicators Overview on AHRQ's Quality Indicators Web site), 1997-2007 Healthcare Cost and Utilization Project (HCUP) Nationwide Inpatient Sample (NIS) data (citing AHRQ publication, Adult Hospital Stays with Infections Due to Medical Care, 2007, HCUP Statistical Brief 94, 2010, as published on AHRQ's HCUP Web site), and AHRQ's Elixhauser comorbidity measures (Elixhauser et al., Med Care, 1998); cites AHRQ technical review, Measures of Patient Safety Based on Hospital Administrative Data-The Patient Safety Indicators, 2002, and AHRQ-funded systematic review by Chaudhry et al. (Ann Intern Med, 2006) on the impact of health information technology on quality, efficiency, and costs of medical care, performed by the Southern California-University of California at San Francisco Evidence-based Practice Center (EPC); cites AHRQ publication, Advances in Patient Safety: From Research to Implementation, Volume 1: Research Findings, 2005.] Select to access the abstract.

International Journal of Medical Informatics
Lomotan EA, Hoeksema LJ, Edmonds DE, et al. Evaluating the use of a computerized clinical decision support system for asthma by pediatric pulmonologists. Int J Med Inform 2012 Mar; 81(3):157-65. [Supported in part by contract HHSA290-2008-10011; cites AHRQ publication, Clinical Practice Improvement and Redesign: How Change in Workflow Can Be Supported by Clinical Decision Support, 2009.] Select to access the abstract.

Journal of the American Board of Family Medicine
Meyers D. Introduction from the Agency for Healthcare Research and Quality. J Am Board Fam Med 2012 Mar; 25 Suppl 1:S1. [Author is director of AHRQ's Center for Primary Care, Prevention, and Clinical Partnerships; introduces the AHRQ-funded supplement which presents reports from delegates at an AHRQ-sponsored conference on lessons learned from reforms within primary care systems around the world.]

Phillips RL Jr. International Learning on Increasing the Value and Effectiveness of Primary Care (I LIVE PC). J Am Board Fam Med 2012 Mar; 25 Suppl 1:S2-S5. [Supported by contract HHSA290-2007-10008, task order 1 (to the Robert Graham Center); mentions the 2011 conference discussed above; notes that New Zealand's Best Practices Advocacy Center uses information from the USPSTF and AHRQ; author AHRQ's support of this special issue and its partnership with the Commonwealth Fund in supporting the conference on which it is based.]

Goodyear-Smith F, Gauld R, Cumming J, et al. International Learning on Increasing the Value and Effectiveness of Primary Care (I LIVE PC) New Zealand. J Am Board Fam Med 2012 Mar; 25 Suppl 1:S39-S44. [Supported in part by AHRQ, possibly under contract cited in article by Phillips cited above in this section.] Select to access the abstract.

Mayo Clinic Proceedings
Sprung J, Flick RP, Katusic SK, Colligan RC, Barbaresi WJ, et al. Attention-deficit/hyperactivity disorder after early exposure to procedures requiring general anesthesia. Mayo Clin Proc 2012 Feb; 87(2):120-9. [Supported in part by grant R01 HS29745 (attributed to the National Institutes of Health and for which fifth author is principal investigator).] Select to access the abstract.

Pharmacoeconomics
Shih YC, Chien CR, Xu Y, et al. Economic burden of renal cell carcinoma: Part I—an updated review. Pharmacoeconomics 2011 Apr 1; 29(4):315-29. [Supported in part by grant HS18535.] Select to access the abstract.

Shih YC, Chien CR, Xu Y, et al. Economic burden of renal cell carcinoma in the US: Part II—an updated analysis. Pharmacoeconomics 2011 Apr 1; 29(4):331-41. [Supported in part by grant R01 HS18535 (to first author).] Select to access the abstract.

Proceedings. Biological Sciences, Royal Society
Pitzer VE, Burgner D, Viboud C, Simonsen L, Andreasen V, Steiner CA, et al. Modelling seasonal variations in the age and incidence of Kawasaki disease to explore possible infectious aetiologies. Proc Biol Sci 2012 Mar 7. [Epub ahead of print. Sixth author is a researcher in AHRQ's Center for Delivery, Organization, and Markets; uses 1997-2005 (rotavirus) and 1989-2003 (Kawasaki disease) HCUP State Inpatient Databases (SID) data as accessed from AHRQ's HCUP Web site, citing AHRQ-authored article by Steiner, Elixhauser, and Schnaier (researchers in AHRQ's Center for Delivery, Organization, and Markets) (Eff Clin Pract, 2002).] Select to access the abstract.

Research in Social and Administrative Pharmacy
Hines LE, Saverno KR, Warholak TL, et al. Pharmacists' awareness of clinical decision support in pharmacy information systems: an exploratory evaluation. Res Social Adm Pharm 2011 Dec; 7(4):359-68. [Supported by grant U18 HS1700-01.] Select to access the abstract.

Social Work in Public Health
Lynch S. Health system factors affecting communication with pediatricians: gendered work culture in primary care. Soc Work Public Health 2011 Nov 8; 26(7):672-94. [Supported by grant R36 HS17749-01. Also refer to AHRQ-funded article by Gartlehner et al. (Int J Technol Assess Health Care, 2010) cited in Evidence-based Practice Centers-Related Articles.] Select to access the abstract.

AHRQ-Related Articles

American Journal of Health-System Pharmacy
Thompson-Moore N, Liebl MG. Health care system vulnerabilities: understanding the root causes of patient harm. Am J Health Syst Pharm 2012 Mar 1; 69(5):431-6. [Cites AHRQ publication, 20 Tips to Help Prevent Medical Errors. Patient Fact Sheet, 2011, as published on the AHRQ Web site; cites AHRQ-funded articles by Kitch et al. (Jt Comm J Qual Patient Saf, 2008), Scott et al. (Am J Crit Care, 2006), and Koppel et al. (JAMA, 2005).]

American Journal of Managed Care
Maeng DD, Graham J, Graf TR, et al. Reducing long-term cost by transforming primary care: evidence from Geisinger's medical home model. Am J Manag Care 2012 Mar; 18(3):149-55. [Cites AHRQ publication, Improving Evaluations of the Medical Home, 2011.] Select to access the abstract.

Annals of Family Medicine
Bayliss EA. Simplifying care for complex patients. Ann Fam Med 2012 Jan-Feb; 10(1):3-5. [Cites AHRQ-funded articles by Bayliss et al. (Fam Pract, 2008) and Jerant et al. (Med Care, 2008).]

Wexler RK, Wallace LS. Shaping health-related policy in the United States: 1 family physician at a time. Ann Fam Med 2012 Jan-Feb; 10(1):79-80. [Cites AHRQ-funded article by Rust and Cooper (J Am Board Fam Med, 2007).]

Archives of Surgery
Deveney K. The best method to repair diaphragmatic hernias: only the first chapter of the story. Arch Surg 2012 Mar 19. [Epub ahead of print. Comments on article by Paul et al. (Arch Surg, 2012) cited in Research by Others Using AHRQ Data or Products.]

Chamberlain CJ, Koniaris LG, Wu AW, et al. Disclosure of "nonharmful" medical errors and other events: duty to disclose. Arch Surg 2012 Mar; 147(3):282-6. [Cites AHRQ-authored article by Battles (researcher in AHRQ's Center for Quality Improvement and Patient Safety) et al. (Arch Pathol Lab Med, 1998); cites AHRQ-funded articles by Gallagher et al. (Chest, 2009, and JAMA, 2003), Fein et al. (J Gen Intern Med, 2007), Kuzel et al. (Ann Fam Med, 2004), and others.] Select to access the abstract.

Healthcare Financial Management
Wagner RD, O'Connor A, Moore MA. A patient-focused model for cost reduction. Healthc Financ Manage 2012 Jan; 66(1):88-93. [Notes that about "20 percent of patients contribute to 80 percent of an organization's costs, and most of which are related to chronic conditions, according to [AHRQ]."]

Inquiry
van Kleef RC, van de Ven WP, van Vliet RC. Risk-adjusting the doughnut hole to improve efficiency and equity. Inquiry 2011-2012 Winter; 48(4):313-21. [Cites AHRQ-funded articles by Bayliss et al. (Med Care, 2010), Fung et al. (Health Serv Res, 2010), Hsu et al. (JAMA, 2008), and others.] Select to access the abstract.

International Journal of Technology Assessment in Health Care
Forsetlund L, Kirkehei I, Harboe I, et al. A comparison of two search methods for determining the scope of systematic reviews and health technology assessments. Int J Technol Assess Health Care 2012 Jan; 28(1):59-64. [Mentions the coverage of AHRQ's and other organizations' Web sites on the new British National Health Service search engine NHS Evidence.]

Silva MT, de Almeida RT, Gava CM, et al. Brazilian Health Technology Assessment Bulletin: editorial process, dissemination strategies, critical appraisal, and initial impact. Int J Technol Assess Health Care 2012 Jan; 28(1):65-9. [Cites AHRQ-authored/funded article by Eisenberg (former AHRQ director) (JAMA, 1999).]

Journal of Allergy and Clinical Immunology
Busse WW, Morgan WJ, Taggart V, et al. Asthma outcomes workshop: Overview. J Allergy Clin Immunol 2012 Mar; 129(3 Suppl):S1-S8. [Summarizes objectives and outcomes of AHRQ-cosponsored workshop on asthma outcomes; lists Denise Dougherty (researcher in AHRQ's Office of Extramural Research, Education, and Priority Populations) as a member of the Planning Committee.] Select to access the abstract.

Szefler SJ, Wenzel S, Brown R, et al. Asthma outcomes: Biomarkers. J Allergy Clin Immunol 2012 Mar; 129(3 Suppl):S9-S23. [Notes that AHRQ and several NIH institutes "have agreed to an effort for [asthma] outcomes standardization"; acknowledges AHRQ support of the Asthma Outcomes workshop.] Select to access the abstract.

Cloutier MM, Schatz M, Castro M, et al. Asthma outcomes: Composite scores of asthma control. J Allergy Clin Immunol 2012 Mar; 129(3 Suppl):S24-S33. [Notes that AHRQ and several NIH institutes "have agreed to an effort for [asthma] outcomes standardization"; acknowledges AHRQ support of the Asthma Outcomes workshop.] Select to access the abstract.

Fuhlbrigge A, Peden D, Apter AJ, et al. Asthma outcomes: Exacerbations. J Allergy Clin Immunol 2012 Mar; 129(3 Suppl):S34-S48. [Notes that AHRQ and several NIH institutes "have agreed to an effort for [asthma] outcomes standardization"; acknowledges AHRQ support of the Asthma Outcomes workshop.] Select to access the abstract.

Akinbami LJ, Sullivan SD, Campbell JD, et al. Asthma outcomes: Healthcare utilization and costs. J Allergy Clin Immunol 2012 Mar; 129(3 Suppl):S49-S64. [Notes that AHRQ and several NIH institutes "have agreed to an effort for [asthma] outcomes standardization"; acknowledges AHRQ support of the Asthma Outcomes workshop.] Select to access the abstract.

Tepper RS, Wise RS, Covar R, et al. Asthma outcomes: Pulmonary physiology. J Allergy Clin Immunol 2012 Mar; 129(3 Suppl):S65-S87. [Notes that AHRQ and several NIH institutes "have agreed to an effort for [asthma] outcomes standardization"; acknowledges AHRQ support of the Asthma Outcomes workshop.] Select to access the abstract.

Wilson SR, Rand CS, Cabana MD, et al. Asthma outcomes: Quality of life. J Allergy Clin Immunol 2012 Mar; 129(3 Suppl):S88-S123. [Notes that AHRQ and several NIH institutes "have agreed to an effort for [asthma] outcomes standardization"; acknowledges AHRQ support of the Asthma Outcomes workshop.] Select to access the abstract

Krishnan JA, Lemanske RF Jr, Canino GJ, et al. Asthma outcomes: Symptoms. J Allergy Clin Immunol 2012 Mar; 129(3 Suppl):S124-S135. [Notes that AHRQ and several NIH institutes "have agreed to an effort for [asthma] outcomes standardization"; acknowledges AHRQ support of the Asthma Outcomes workshop.] Select to access the abstract.

Rand CS, Wright RJ, Cabana MD, et al. Mediators of asthma outcomes. J Allergy Clin Immunol 2012 Mar; 129(3 Suppl):S136-S141. [Notes that AHRQ and several NIH institutes "have agreed to an effort for [asthma] outcomes standardization"; acknowledges AHRQ support of the Asthma Outcomes workshop.] Select to access the abstract.

Journal of the American Board of Family Medicine
Roland M, Guthrie B, Thomé DC. Primary medical care in the United Kingdom. J Am Board Fam Med 2012 Mar; 25 Suppl 1:S6-S11. [Written as a contribution to the international meeting on the future of primary care discussed in article by Meyers (J Am Bd Fam Med, 2012) cited in AHRQ-Funded/Authors.] Select to access the abstract.

U.S. Preventive Services Task Force (USPSTF)/Put Prevention Into Practice (PPIP)-Related Articles

American Journal of Preventive Medicine
Tan A, Kuo YF, Goodwin JS. Integrating age and comorbidity to assess screening mammography utilization. Am J Prev Med 2012 Mar; 42(3):229-34. [Cites USPSTF recommendations on screening for breast cancer and related evidence update by Nelson et al. (both in Ann Intern Med, 2009); cites 3M HIS APR™-DRG Classification Software— Overview, 2009, as published on the Mortality Measurement page on the AHRQ Web site.] Select to access the abstract.

Riley WJ, Lownik EM, Scutchfield FD, et al. Public health department accreditation: setting the research agenda. Am J Prev Med 2012 Mar; 42(3):263-71. [Cites USPSTF-sponsored research agenda on broadening the evidence base for evidence-based guidelines (Am J Prev Med, 1998); cites AHRQ-authored article by Clancy (AHRQ director) (J Patient Saf, 2008).] Select to access the abstract.

Clinics in Geriatric Medicine
Hoffe S, Balducci L. Cancer and age: general considerations. Clin Geriatr Med 2012 Feb; 28(1):1-18. [Discusses and cites USPSTF recommendations on prostate cancer screening (Ann Intern Med, 2008).] Select to access the abstract.

JAMA
Lin FR. Hearing loss in older adults: who's listening? JAMA 2012 Mar 21; 307(11):1147-8. [Cites USPSTF-sponsored evidence review on screening adults aged 50 years and older for hearing loss (Ann Intern Med, 2011); comments on article by Pacal and Yueh cited below in this section.]

Pacala JT, Yueh B. Hearing deficits in the older patient: "I didn't notice anything". JAMA 2012 Mar 21; 307(11):1185-94. [Discusses and cites USPSTF 1996 recommendations on screening older adults for hearing loss and 2011 updated evidence review and subsequent recommendations, citing USPSTF recommendation statement, Screening for Hearing Loss in Older Adults, 2011, as published on the USPSTF Web site, and related evidence review by Chou et al. (Ann Intern Med, 2011).] Select to access the abstract.

Journal of Family Practice
Stephens LA, Stevermer JJ. PURLs: Counseling is a must with this smoking cessation aid. J Fam Pract 2012 Mar; 61(3):156-76. [Cites USPSTF recommendations on counseling and interventions to prevent tobacco use and tobacco-caused disease in adults and pregnant women (Ann Intern Med, 2009).]

Medical Clinics of North America
Wilkins JT, Lloyd-Jones DM. Are novel serum biomarkers informative? Med Clin North Am 2012 Jan; 96(1):1-11. [Cites USPSTF-sponsored systematic review and meta-analysis on C-reactive protein as a risk factor for coronary heart disease by Buckley et al. (Ann Intern Med, 2009).] Select to access the abstract.

de Ferranti SD. Childhood cholesterol disorders: the iceberg base or nondisease? Med Clin North Am 2012 Jan; 96(1):141-54. [Cites USPSTF-sponsored systematic evidence review on screening and treatment for lipid disorders in children and adolescents (Pediatrics, 2007); cites article by Grossman et al. (Arch Pediatr Adolesc Med, 2011), which uses the USPSTF recommendations on screening for lipid disorders in children (Pediatrics, 2007) as an example to detail the approach used by the USPSTF to issue recommendation statements.] Select to access the abstract.

Medscape Radiology
Brice J. Studies bolster arguments for mammography after age 40. Medscape Radiology 2012 Mar 22; Online. [Discusses updated 2009 USPSTF recommendations on breast cancer screening, citing article by Hendrick and Helvie (AJR Am J Roentgenol, 2012) on these recommendations.]

Townsend Letter
Hoekstra PP. The status and future of diagnostic infrared imaging for breast cancer. Townsend Letter 2012 Feb; Online:105-6. [Cites USPSTF recommendations on screening for breast cancer (Ann Intern Med, 2009). Also refer to articles by Klabunde et al. (Ann Fam Med, 2012) and Phillips (J Am Board Fam Med, 2012) cited in AHRQ-Funded/Authored Articles, article by Qaseem et al. (Ann Intern Med, 2012) cited in Evidence-based Practice Centers-Related Articles , and article by Liu et al. (JAMA, 2012) cited in Research by Others Using AHRQ Data or Products.]

Evidence-based Practice Centers-Related Articles

American Journal of Managed Care
Spetz J, Burgess JF, Phibbs CS. What determines successful implementation of inpatient information technology systems? Am J Manag Care 2012 Mar; 18(3):157-62. [Cites AHRQ Evidence Report/Technology Assessment, Costs and Benefits of Health Information Technology, 2006; cites AHRQ-funded systematic review by Chaudhry et al. (Ann Intern Med, 2006) on the impact of health information technology on quality, efficiency, and costs of medical care, performed by the Southern California-University of California at San Francisco EPC; cites AHRQ publication, Advances in Patient Safety: From Research to Implementation, Volume 3: Implementation Issues, 2005.] Select to access the abstract.

Leslie DL, Rosenheck R. Off-label use of antipsychotic medications in Medicaid. Am J Manag Care 2012 Mar 1; 18(3):e109-e117. [Cites AHRQ comparative effectiveness reviews, Off-Label Use of Atypical Antipsychotics: An Update, 2011 (prepared by the Southern California/RAND EPC under contract HHSA290-2007-10062-1) and Efficacy and Comparative Effectiveness of Off-Label Use of Atypical Antipsychotics, 2007 (prepared by the same EPC under contract 290-02-003), both published on AHRQ's Effective Health Care Program Web site; cites AHRQ-authored article by Donohue, Huskamp, and Zuvekas (researcher in AHRQ's Center for Financing, Access, and Cost Trends) (Health Aff, 2009).] Select to access the abstract.

Annals of Family Medicine
Delaney BC, Peterson KA, Speedie S, et al. Envisioning a learning health care system: the electronic primary care research network, a case study. Ann Fam Med 2012 Jan-Feb; 10(1):54-9. [Cites AHRQ-funded systematic review by Kaushal, Shojania, and Bates (Arch Intern Med, 2003) on the effects of computerized physician order entry and clinical decision support systems on medication safety, performed by the University of California San Francisco-Stanford EPC under contract 290-97-0013.] Select to access the abstract.

Annals of Internal Medicine
Mills G. Venous thromboembolism prophylaxis in hospitalized medical patients. Ann Intern Med 2012 Mar 20; 156(6):473. [Cites article by Lederle et al. (Ann Intern Med, 2011), which uses AHRQ evidence grading methods.]

Agutter PS, Malone PC. Venous thromboembolism prophylaxis in hospitalized medical patients. Ann Intern Med 2012 Mar 20; 156(6):473. [Cites article by Lederle et al. (Ann Intern Med, 2011), which uses AHRQ evidence grading methods.]

Cundiff DK. Venous thromboembolism prophylaxis in hospitalized medical patients. Ann Intern Med 2012 Mar 20; 156(6):473-474. [Cites article by Lederle et al. (Ann Intern Med, 2011), which uses AHRQ evidence grading methods.]

Qaseem A, Chou R, Humphrey LL, Shekelle P. Venous thromboembolism prophylaxis in hospitalized medical patients. Ann Intern Med 2012 Mar 20; 156(6):474-5. [Responds to comments by Mills, Agutter and Malone, and Cundiff cited above in this section; third author is a consultant for the USPSTF; last author reports pending grant monies from AHRQ.]

Inquiry
Korda H, Eldridge GN. Payment incentives and integrated care delivery: levers for health system reform and cost containment. Inquiry 2011-2012 Winter; 48(4):277-87. [Quotes text from AHRQ Evidence Report/Technology Assessment, Integration of Mental Health/Substance Abuse and Primary Care, 2008, in Table 1, "What we know about integrated care delivery models."] Select to access the abstract.

Ford EW, Huerta TR, Thompson MA, et al. The impact of accelerating electronic prescribing on hospitals' productivity levels: can health information technology bend the curve? Inquiry 2011-2012 Winter; 48(4):304-12. [Cites AHRQ-funded systematic review by Hussey et al. (Health Serv Res, 2009) on health care efficiency measures, which is based on research conducted by the Southern California EPC-RAND Corporation under contract 282-00-0005-21; cites AHRQ publication, Identifying, Categorizing, and Evaluating Health Care Efficiency Measures. Final Report, 2008, prepared by the Southern California EPC-RAND Corporation; cites AHRQ-authored article by Encinosa and Bernard (researchers in AHRQ's Center for Delivery, Organization, and Markets and Center for Financing, Access, and Cost Trends, respectively) (Inquiry, 2005).] Select to access the abstract.

International Journal of Technology Assessment in Health Care
Lyratzopoulos G, Barnes S, Stegenga H, et al. Updating clinical practice recommendations: is it worthwhile and when? Int J Technol Assess Health Care 2012 Jan; 28(1):29-35. [Cites AHRQ-funded Effective Health Care Program research report Assessment of the Need to Update Comparative Effectiveness Reviews: Report of an Initial Rapid Program Assessment (2005-2009), 2009; cites AHRQ-funded articles by Sampson et al. (J Clin Epidemiol, 2008), Shojania et al. (Ann Intern Med, 2007), and Shekelle et al. (JAMA, 2001) on AHRQ-sponsored clinical practice guidelines.] Select to access the abstract.

Gartlehner G, West SL, Mansfield AJ, Poole C, Tant E, Lux LJ, et al. Clinical heterogeneity in systematic reviews and health technology assessments: synthesis of guidance documents and the literature. Int J Technol Assess Health Care 2012 Jan; 28(1):36-43. [Supported by contract 290-02-0016 (to the RTI International to support the RTI International-University of North Carolina EPC); summarizes AHRQ-funded project reported in AHRQ methods research report Comparative Effectiveness Review Methods: Clinical Heterogeneity, 2010, prepared by the same EPC under contract 290-2007-10056I; notes that the methods manuals from AHRQ were one of the five out of nine reviewed that "provided explicit definitions of clinical heterogeneity," citing AHRQ publication, Methods Reference Guide for Effectiveness and Comparative Effectiveness Reviews, 2007, as published on AHRQ's Effective Health Care Program Web site; cites AHRQ comparative effectiveness review, Comparative Effectiveness of Second-Generation Antidepressants in the Pharmacologic Treatment of Adult Depression, 2007, as published on the AHRQ's Effective Health Care Program Web site, and AHRQ technical review, Meta-regression Approaches: What, Why, When, and How?, 2004; acknowledges support from Stephanie Chang, MD (researcher in AHRQ's Center for Outcomes and Evidence); first, second, third, and sixth authors report receiving other AHRQ funding.] Select to access the abstract.

Kidholm K, Ekeland AG, Jensen LK, et al. A Model for ASsessment of Telemedicine applications: MAST. Int J Technol Assess Health Care 2012 Jan; 28(1):44-51. [Cites AHRQ Evidence Report/Technology Assessment, Telemedicine for the Medicare Population: Update, 2006, prepared by the Oregon EPC under contract 290-02-0024.]

Staub LP, Dyer S, Lord SJ, et al. Linking the evidence: intermediate outcomes in medical test assessments. Int J Technol Assess Health Care 2012 Jan; 28(1):52-8. [Cites draft Methods Guide for Medical Test Review, 2010. Also refer to AHRQ-authored article by Encinosa and Bae (Inquiry, 2011-2012) cited in AHRQ-Funded/Authored Articles.] Select to access the abstract.

Research by Others Using AHRQ Data or Products

American Journal of Managed Care
Mohan D, Barnato AE, Rosengart MR, et al. Optimal approach to improving trauma triage decisions: a cost-effectiveness analysis. Am J Manag Care. 2012 Mar 1; 18(3):e91-e100. [Uses HCUP NIS data, citing Overview of the Nationwide Inpatient Sample (NIS), as published on AHRQ's HCUP Web site; uses data from AHRQ technical review, Closing the Quality Gap: A Critical Analysis of Quality Improvement Strategies, Volume 2, 2004, and Volume 3, 2005.] Select to access the abstract.

Annals of Family Medicine
Young RA, Devoe JE. Who will have health insurance in the future? An updated projection. Ann Fam Med 2012 Mar; 10(2):156-62. [Uses Medical Expenditure Panel Survey (MEPS) data as accessed from AHRQ's MEPS Web site.] Select to access the abstract.

Archives of Surgery
Paul S, Nasar A, Port JL, et al. Comparative analysis of diaphragmatic hernia repair outcomes using the Nationwide Inpatient Sample database. Arch Surg 2012 Mar 19. [Epub ahead of print. Uses 1999-2008 HCUP NIS data as accessed from AHRQ's HCUP Web site, and AHRQ's Elixhauser comorbidity measures (Elixhauser et al., Med Care, 1998); cites AHRQ-authored article by Sedrakyan (former AHRQ researcher) et al. (BMJ, 2004).] Select to access the abstract.

Turrentine FE, Hanks JB, Schirmer BD, et al. The relationship between body mass index and 30-day mortality risk, by principal surgical procedure. Arch Surg 2012 Mar; 147(3):236-42. [Uses HCUP Clinical Classifications Software for Services and Procedures, citing Clinical Classifications Software (CCS) for ICD-9-CM, as published on AHRQ's HCUP Web site.] Select to access the abstract.

Cochrane Database of Systematic Reviews
Lee SH, Cox KM, Grant R, et al. Patient positioning (mobilisation) and bracing for pain relief and spinal stability in metastatic spinal cord compression in adults. Cochrane Database Syst Rev 2012 Mar 14;3:CD007609. [Uses AHRQ's National Guideline Clearinghouse™ as a source for the literature review.] Select to access the abstract.

Inquiry
Herring B, Lentz LK. What can we expect from the "Cadillac tax" in 2018 and beyond? Inquiry 2011-2012 Winter; 48(4):322-37. [Uses 2008 and 2010 MEPS Insurance Component (MEPS IC) data, citing AHRQ publication, Employer-Sponsored Single, Employee-Plus-One, and Family Health Insurance Coverage: Selection and Cost, 2010, MEPS Statistical Brief 328, 2011; authors acknowledge support from Jim Branscome (researcher in AHRQ's Center for Financing, Access, and Cost Trends) in providing MEPS-IC data.] Select to access the abstract.

JAMA
Liu H, Waxman DA, Main R, et al. Utilization of anesthesia services during outpatient endoscopies and colonoscopies and associated spending in 2003-2009. JAMA 2012 Mar 21; 307(11):1178-84. [Uses AHRQ's HCUP Clinical Classifications Software, citing Clinical Classifications Software (CCS) for ICD-9-CM, as published on AHRQ's HCUP Web site; notes that national weights for the study's data source, Market Scan, were based on AHRQ's MEPS; further notes that screening colonoscopies are included in the list of USPSTF-recommended preventive services for which coverage is required under the Affordable Care Act.]

Oregon Center for Public Policy Issue Brief
[No authors listed]. How the Affordable Care Act lowers costs for small businesses. OCPP Issue Brief 2012 Mar 22; Online. [Uses 1999-2000 and 2009-2010 MEPS data. Also refer to articles by Bayliss et al. (Ann Fam Med, 2012) and Pitzer et al.  (Proc Biol Sci, 2012) cited in AHRQ-Funded/Authored Articles.] Select to access the abstract.

Current as of March 2012
Internet Citation: Potentially Harmful Drug-drug Interactions in the Elderly: a Review: Articles of Interest, March 23, 2012. March 2012. Agency for Healthcare Research and Quality, Rockville, MD. http://www.ahrq.gov/news/newsroom/articles-of-interest/032312.html