121. Treatment Recommendations: Medications (Continued)

Treating Tobacco Use and Dependence: 2008 Update

Text version of slide presentation.

Treatment Recommendations: Medications (Continued)

Meta-analysis (2008): Effectiveness and abstinence rates for various medications and medication combinations compared to placebo at 6-months post-quit (n = 86 studies)

MedicationNumber of armsEstimated odds ratio (95% C.I.)Estimated abstinence rate (95% C.I.)
Placebo801.013.8
Monotherapies   
Varenicline (2 mg/day)53.1 (2.5, 3.8)33.2 (28.9, 37.8)
Nicotine Nasal Spray42.3 (1.7, 3.0)26.7 (21.5, 32.7)
High Dose Nicotine Patch (> 25 mg) (These included both standard or long-term duration)42.3 (1.7, 3.0)26.5 (21.3, 32.5)
Long-Term Nicotine Gum (> 14 weeks)62.2 (1.5, 3.2)26.1 (19.7, 33.6)
Varenicline (1 mg/day)32.1 (1.5, 3.0)25.4 (19.6, 32.2)
Nicotine Inhaler62.1 (1.5, 2.9)24.8 (19.1, 31.6)
Clonidine32.1 (1.2, 3.7)25.0 (15.7, 37.3)

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Page last reviewed June 2009
Internet Citation: 121. Treatment Recommendations: Medications (Continued): Treating Tobacco Use and Dependence: 2008 Update. June 2009. Agency for Healthcare Research and Quality, Rockville, MD. http://www.ahrq.gov/professionals/clinicians-providers/guidelines-recommendations/tobacco/clinicians/presentations/2008update-full/slide121.html