121. Treatment Recommendations: Medications (Continued)
Treating Tobacco Use and Dependence: 2008 Update
Text version of slide presentation.
Meta-analysis (2008): Effectiveness and abstinence rates for various medications and medication combinations compared to placebo at 6-months post-quit (n = 86 studies)
Medication | Number of arms | Estimated odds ratio (95% C.I.) | Estimated abstinence rate (95% C.I.) |
---|---|---|---|
Placebo | 80 | 1.0 | 13.8 |
Monotherapies | |||
Varenicline (2 mg/day) | 5 | 3.1 (2.5, 3.8) | 33.2 (28.9, 37.8) |
Nicotine Nasal Spray | 4 | 2.3 (1.7, 3.0) | 26.7 (21.5, 32.7) |
High Dose Nicotine Patch (> 25 mg) (These included both standard or long-term duration) | 4 | 2.3 (1.7, 3.0) | 26.5 (21.3, 32.5) |
Long-Term Nicotine Gum (> 14 weeks) | 6 | 2.2 (1.5, 3.2) | 26.1 (19.7, 33.6) |
Varenicline (1 mg/day) | 3 | 2.1 (1.5, 3.0) | 25.4 (19.6, 32.2) |
Nicotine Inhaler | 6 | 2.1 (1.5, 2.9) | 24.8 (19.1, 31.6) |
Clonidine | 3 | 2.1 (1.2, 3.7) | 25.0 (15.7, 37.3) |