123. Treatment Recommendations: Medications (Continued)

Treating Tobacco Use and Dependence: 2008 Update
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Meta-analysis (2008): Effectiveness and abstinence rates for various medications and medication combinations compared to placebo at 6-months post-quit (n = 86 studies) (Continued)

Medication Number of arms Estimated odds ratio
(95% C.I.)
Estimated abstinence rate
(95% C.I.)
Placebo 80 1.0 13.8
Combination therapies      
Patch (long-term; > 14 weeks) + ad lib NRT (gum or spray) 3 3.6 (2.5, 5.2) 36.5 (28.6, 45.3)
Patch + Bupropion SR 3 2.5 (1.9, 3.4) 28.9 (23.5, 35.1)
Patch + Nortriptyline 2 2.3 (1.3, 4.2) 27.3 (17.2, 40.4)
Patch + Inhaler 2 2.2 (1.3, 3.6) 25.8 (17.4, 36.5)
Patch + Second generation antidepressants (paroxetine, venlafaxine) 3 2.0 (1.2, 3.4) 24.3 (16.1, 35.0)
Medications not shown to be effective      
Selective Serotonin Reuptake Inhibitors (SSRIs) 3 1.0 (0.7, 1.4) 13.7 (10.2, 18.0)
Naltrexone 2 0.5 (0.2, 1.2) 7.3 (3.1, 16.2)

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Page last reviewed October 2014
Internet Citation: 123. Treatment Recommendations: Medications (Continued). October 2014. Agency for Healthcare Research and Quality, Rockville, MD. http://www.ahrq.gov/professionals/clinicians-providers/guidelines-recommendations/tobacco/clinicians/presentations/2008update-full/slide123.html