123. Treatment Recommendations: Medications (Continued)

Treating Tobacco Use and Dependence: 2008 Update

Text version of slide presentation.

Treatment Recommendations: Medications (Continued)

Meta-analysis (2008): Effectiveness and abstinence rates for various medications and medication combinations compared to placebo at 6-months post-quit (n = 86 studies) (Continued)

MedicationNumber of armsEstimated odds ratio
(95% C.I.)
Estimated abstinence rate
(95% C.I.)
Placebo801.013.8
Combination therapies   
Patch (long-term; > 14 weeks) + ad lib NRT (gum or spray)33.6 (2.5, 5.2)36.5 (28.6, 45.3)
Patch + Bupropion SR32.5 (1.9, 3.4)28.9 (23.5, 35.1)
Patch + Nortriptyline22.3 (1.3, 4.2)27.3 (17.2, 40.4)
Patch + Inhaler22.2 (1.3, 3.6)25.8 (17.4, 36.5)
Patch + Second generation antidepressants (paroxetine, venlafaxine)32.0 (1.2, 3.4)24.3 (16.1, 35.0)
Medications not shown to be effective   
Selective Serotonin Reuptake Inhibitors (SSRIs)31.0 (0.7, 1.4)13.7 (10.2, 18.0)
Naltrexone20.5 (0.2, 1.2)7.3 (3.1, 16.2)

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Current as of June 2009
Internet Citation: 123. Treatment Recommendations: Medications (Continued): Treating Tobacco Use and Dependence: 2008 Update. June 2009. Agency for Healthcare Research and Quality, Rockville, MD. http://www.ahrq.gov/professionals/clinicians-providers/guidelines-recommendations/tobacco/clinicians/presentations/2008update-full/slide123.html