159. Treatment Recommendations: Medications-Relative Effectiveness (Continued)

Treating Tobacco Use and Dependence: 2008 Update
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Meta-analysis (2008): Effectiveness and abstinence rates of medications relative to the nicotine patch (n = 86 studies).

Medication Number of arms Estimated odds ratio (95% C. I.)
Nicotine Patch (reference group) 32 1.0
Combination therapies    
Patch (long-term; > 14 weeks) + NRT (gum or spray) 3 1.9 (1.3, 2.7)
Patch + Bupropion SR 3 1.3 (1.0, 1.8)
Patch + Nortriptyline 2 0.9 (0.6, 1.4)
Patch + Inhaler 2 1.1 (0.7, 1.9)
Second-generation antidepressants & Patch 3 1.0 (0.6, 1.7)
Medications not shown to be effective    
Selective Serotonin Reuptake Inhibitors (SSRIs) 3 0.5 (0.4, 0.7)
Naltrexone 2 0.3 (0.1, 0.6)

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Page last reviewed October 2014
Internet Citation: 159. Treatment Recommendations: Medications-Relative Effectiveness (Continued). October 2014. Agency for Healthcare Research and Quality, Rockville, MD. http://www.ahrq.gov/professionals/clinicians-providers/guidelines-recommendations/tobacco/clinicians/presentations/2008update-full/slide159.html