159. Treatment Recommendations: Medications-Relative Effectiveness (Co

Treating Tobacco Use and Dependence: 2008 Update

Text version of slide presentation.

Treatment Recommendations: Medications—Relative Effectiveness

Meta-analysis (2008): Effectiveness and abstinence rates of medications relative to the nicotine patch (n = 86 studies).

MedicationNumber of armsEstimated odds ratio (95% C. I.)
Nicotine Patch (reference group)321.0
Combination therapies  
Patch (long-term; > 14 weeks) + NRT (gum or spray)31.9 (1.3, 2.7)
Patch + Bupropion SR31.3 (1.0, 1.8)
Patch + Nortriptyline20.9 (0.6, 1.4)
Patch + Inhaler21.1 (0.7, 1.9)
Second-generation antidepressants & Patch31.0 (0.6, 1.7)
Medications not shown to be effective 0.8 (0.6, 1.0)
Selective Serotonin Reuptake Inhibitors (SSRIs)30.5 (0.4, 0.7)
Naltrexone20.3 (0.1, 0.6)

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Current as of June 2009
Internet Citation: 159. Treatment Recommendations: Medications-Relative Effectiveness (Co: Treating Tobacco Use and Dependence: 2008 Update. June 2009. Agency for Healthcare Research and Quality, Rockville, MD. http://www.ahrq.gov/professionals/clinicians-providers/guidelines-recommendations/tobacco/clinicians/presentations/2008update-full/slide159.html