Figure 3: Detail of Reproductive History Model (Text Description)

Ovarian Cancer Prevention

Figure 3: Detail of Reproductive History Model (Text Description)

Figure 3 shows a detailed schematic of the reproductive history model that will be incorporated in the existing model. The reproductive history includes menarche, ovulatory or anovulatory cycles, contraception use, pregnancy, lactation, and menopause. While on OCs, women are at risk for both short- and long-term harms, some of which may be fatal. Possible OC-associated outcomes include ovarian cancer, deep vein thrombosis, pulmonary embolism, stroke, myocardial infarction, breast cancer, colorectal cancer, cervical cancer, endometrial cancer, endometrial hyperplasia, meningioma, melanoma, dysfunctional uterine bleeding (DUB), endometriosis, dysmenorrhea, other benign gynecological disorders, acne, and premenstrual dysphoric disorder (PMDD) as well as death from other causes. The final choice of specific outcomes included in the model will be determined by the initial estimate of lifetime risk of those outcomes in OC users and nonusers relative to the difference in ovarian cancer risk in OC users and nonusers.

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