Table 6. Two methods for assessing the strength of evidence Assessing the Evidence for Context-Sensitive Effectiveness and Safety GRADEAHRQ EPC ProgramHigh = Further research is very unlikely to change our confidence on the estimate of effect.High + High confidence that the evidence reflects the true effect. Further research is very unlikely to change our confidence in the estimate of effect.Moderate = Further research is likely to have an important impact on our confidence in the estimate of effect and may change the estimate.Moderate = Moderate confidence that the evidence reflects the true effect. Further research may change our confidence in the estimate of effect and may change the estimate.Low = Further research is very likely to have an important impact on our confidence in the estimate of effect and is likely to change the estimate.Low� = Low confidence that the evidence reflects the true effect. Further research is likely to change our confidence in the estimate of effect and is likely to change the estimate.Very Low = Any estimate of effect is very uncertain.Insufficient = Evidence either is unavailable or does not permit a conclusion.Return to Document Current as of December 2010 Internet Citation: Table 6. Two methods for assessing the strength of evidence: Assessing the Evidence for Context-Sensitive Effectiveness and Safety . December 2010. Agency for Healthcare Research and Quality, Rockville, MD. http://www.ahrq.gov/research/findings/final-reports/contextsensitive/contexttab6.html