Community-Acquired Skin Infections in the Age of Methicillin-Resistant Organisms

Table 15 and Figures 1-4

Table 15. Time to resolution according to various characteristics, retrospective, prospective, and all cases

 

 

Retrospective (N = 263)

Prospective (N = 114)

Total (N = 377)

 

N

Time to Resolution
(Days)

ANOVA
P-Value

N

Time to Resolution
(Days)

Anova P-Value

N

Time to Resolution
(Days)

ANOVA P-Value

Demographics
Gender
   Female
   Male

131
132

10.8 ± 6.3
10.8 ± 6.3

0.028

66
48

14.7 ± 8.6
15.9 ± 11.5

0.529

197
180

12.1 ± 7.4
13.7 ± 9.5

0.079

Age group (years)
   < 20
   20 to < 40
   40 to < 65
   65 to 96

60
66
88
48

10.8 ± 4.5
11.4 ± 6.2
12.6 ± 10.1
12.4 ± 7.1

0.467

27
34
38
14

18.1 ± 14.9
13.4 ± 8.5
14.4 ± 7.2
16.3 ± 6.7

0.280

87
100
126
62

13.1 ± 9.7
12.1 ± 7.1
13.2 ± 9.3
13.3 ± 7.1

0.768

Age group (years)
   < 40
   ≥40

126
136

11.2 ± 5.5
12.6 ± 9.1

0.129

61
52

15.5 ± 12.0
14.9 ± 7.0

0.733

187
188

12.6 ± 8.4
13.2 ± 8.6

0.465

Rurality
   Non-rural
   Rural

183
80

10.7 ± 6.3
14.6 ± 9.0

< 0.001

82
31

14.9 ± 9.3
16.3 ± 11.4

0.520

265
111

12.0 ± 7.6
15.1 ± 10.0

0.004

Insurance
   Private
   Medicaid
   Medicare
   Uninsured

152
44
44
18

11.7 ± 7.8
11.3 ± 8.0
12.8 ± 7.7
11.6 ± 5.6

0.824

76
20
10
2

14.5 ± 10.7
14.9 ± 8.2
20.1 ± 8.2
15.0 ± 1.4

0.433

228
64
54
20

12.7 ± 8.9
12.4 ± 8.2
14.1 ± 8.2
12.8 ± 8.5

0.641

Race
   Caucasian
   Non-Caucasian

191
8

12.5 ± 8.0
8.5 ± 1.6

0.163

107
7

15.4 ± 10.1
12.9 ± 6.8

0.515

298
15

13.5 ± 8.9
10.5 ± 5.1

0.198

Ethnicity
   Hispanic
   Non-Hispanic

10
178

13.4 ± 10.8
12.6 ± 8.2

0.773

2
112

8.5 ± 7.8
15.3 ± 9.9

0.334

12
290

12.6 ± 10.2
13.7 ± 9.0

0.682

Patient Presenting Characteristics
Site of Infection
   Face/neck
   Groin/pubic/ lower extremities
   Thorax/upper  extremities

34
122
104

13.5 ± 10.7
13.4 ± 8.5
9.6 ± 4.1

<0.001

15
47
45

18.3 ± 10.7
15.8 ± 11.5
13.2 ± 7.3

0.184

49
169
149

15.0 ± 10.8
14.0 ± 9.4
10.7 ± 5.5

< 0.001

Temperature (°F)
   < 99°
   ≥99°

206
24

11.5 ± 7.3
15.1 ± 10.0

0.031

101
10

14.6 ± 9.2
20.8 ± 16.0

0.256

307
34

12.5 ± 8.1
16.8 ± 12.1

0.053

Duration of infection prior to being seen
   < 5 days
   ≥5 days

132
89

11.4 ± 6.7
13.1 ± 8.9

0.099

65
41

15.0 ± 11.3
15.4 ± 8.3

0.851

197
130

12.6 ± 8.6
13.9 ± 8.8

0.199

Patient hospitalized
   Yes
   No

11
252

21.6 ± 14.9
11.4 ± 6.8

<0.001

3
109

31.0 ± 26.3
14.6 ± 8.8

0.392

14
361

23.6 ± 17.1
12.4 ± 7.6

0.029

Patient had at least 1 risk factor
   Yes
   No

69
194

13.8 ± 8.9
11.2± 6.9

0.016

39
75

15.6 ± 9.2
15.0 ± 10.3

0765

108
269

14.4 ± 9.0
12.3 ± 8.2

0.025

Patient had diabetes
   Yes
   No

35
228

15.4 ± 10.4
11.3 ± 6.9

0.032

19
95

15.1 ± 4.4
15.3 ± 10.7

0.888

54
323

15.3 ± 8.7
12.5 ± 8.4

0.026

Wound type
   Abscess only
   Cellulitis only
   Abscess and cellulitis

93
143
27

10.5 ± 6.1
12.3 ± 8.1
14.0 ± 8.6

0.059

18
66
24

18.4 ± 13.8
15.1 ± 9.7
14.0 ± 7.2

0.347

111
209
51

11.8 ± 8.3
13.2 ± 8.7
14.0 ± 7.9

0.224

Treatment at Office
Incision and drainage done
   Yes
   No

85
178

10.2 ± 5.6
12.7 ± 8.3

0.014

32
82

14.4 ± 8.4
15.5 ± 10.4

0.582

117
260

11.4 ± 6.7
13.6 ± 9.1

0.019

Culture done
   Yes
   No

92
171

13.4 ± 8.7
11.1 ± 6.8

0.029

50
64

13.4 ± 7.3
16.7 ± 11.4

0.088

142
235

13.4 ± 8.2
12.6 ± 8.7

0.368

Wound packed
   Wound packed
   Wound not packed
   Incision and drainage not done

30
55
178

9.8 ± 6.9
10.5 ± 4.8
12.7 ± 8.3

0.046

8
22
82

19.6 ± 11.2
12.5 ± 7.0
15.5 ± 10.4

0.200

38
77
260

11.8 ± 8.8
11.1 ± 5.5
13.6 ± 9.1

0.054

For those who had incision and
   Wound packed
   Wound not packed

30
55

9.8 ± 6.9
10.5 ± 4.8

0.592

8
22

19.6 ± 11.2
12.5 ± 7.0

0.046

38
77

11.8 ± 8.8
11.1 ± 5.5

0.615

Antibiotics Prescribed
Antibiotic prescribed at first visit
   Yes
   No

246
17

12.1 ± 7.7
9.1 ± 6.0

0.123

111
3

15.3 ± 10.0
13.7 ± 5.5

0.783

357
20

13.1 ± 8.6
9.8 ± 6.0

0.095

Initial antibiotics covered MRSA
   Yes
   No

70
176

11.4 ± 6.6
12.3 ± 8.0

0.421

58
56

15.1 ± 8.7
15.4 ± 11.1

0.862

128
232

13.1 ± 7.8
13.0 ± 8.9

0.974

Antibiotics covered MRSA at some time during infection
   Yes
   No

91
157

13.3 ± 8.3
11.4 ± 7.1

0.064

68
46

16.0 ± 10.0
14.0 ± 9.7

0.286

159
203

14.4 ± 9.2
12.0 ± 7.8

0.006

Total number of antibiotics used over the course of the infection
   ≤ 2
   > 2

241
22

10.9 ± 6.4
22.6 ±10.9

< 0.001

103
11

14.1 ± 7.8
26.1 ± 18.4

0.056

344
33

11.8 ± 7.0
23.8 ± 13.6

< 0.001

Total number of antibiotics used over course of infection
   0
   1
   2
   3
   4
   5
   6

15
176
50
16
3
3
0

8.3 ± 5.9
9.6 ± 3.7
16.0 ± 10.3
21.1 ± 10.0
22.7 ± 12.6
22.7 ± 12.6

< 0.001

1
77
25
8
2
0
1

8.0
13.9 ± 8.1
14.9 ± 7.2
25.3 ± 17.6
31.0 ± 34.0
---
23.0

0.005

16
253
75
24
5
3
1

8.3 ± 5.7
11.0 ± 5.8
15.7 ± 9.3
22.5 ± 12.8
26.0 ± 19.7
30.7 ± 14.6
23.0

< 0.001

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Figure 1. Map of offices participating in CA-MRSA study

This map of Iowa shows counties that participated in the IRENE CA_MRSA study. Participating cities include: Bloomfield, Guttenberg, Davenport, Blue Grass, Manchester, Le Mars, Riverside, Sigourney, Iowa City, and Urbandale

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Figure 2. Antibiotics prescribed at initial visit

This graph titled Antiobiotics Prescribed at Initial Visit shows the types and number of antibiotics that were prescribed at the initial visit for a skin or soft tissue infection. The most commonly prescribed antibiotics were cephalosporins, with 127 prescriptions written. The second most common were TMP-sulfas, with 48 prescriptions written.

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Figure 3. Antibiotics prescribed at first follow-up visit

This graph, titled Antibiotics Prescribed at First Follow-Up Visit, shows that 210 patients out of 261 patients received no prescription for antibiotics during a first follow-up visit.

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Figure 4. Antibiotics prescribed at initial prospective visit
N=114 individuals

This graph titled Antibiotics Prescribed at Initial Prospective Visit shows the types and number of antibiotics that were prescribed at the initial visit for a skin or soft tissue infection. The most commonly prescribed antibiotics were TMP-sulfas, with 33 prescriptions written, and cephalosporins, with 32 prescriptions written.

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Page last reviewed October 2014
Internet Citation: Table 15 and Figures 1-4. October 2014. Agency for Healthcare Research and Quality, Rockville, MD. http://www.ahrq.gov/research/findings/final-reports/mrsa/iowa_mrsatabfigs.html