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Table 1

Evaluation of AHRQ's Pharmaceutical Outcomes Portfolio

Table 1: Level 1 Findings: Data and Methods

CERTPopulationFinding
HMOGout PatientsThere are limitations of administrative data for research on gout; this study showed that there were marked differences between men and women with gout with respect to epidemiology and treatment; administrative data may lead to misclassification.
UNCPediatricsUse of statewide Emergency Dept. discharge database without medical record validation would be an inadequate approach for surveillance of drug-related anaphylaxis in children
HMOAmbulatory patientsError-detection phase of study led to creation of 10 HMO 2,000,000 person data set to support investigations into errors in drug prescribing in ambulatory setting
UNCPediatricMEDMARX dataset is sufficiently powerful to identify trends in the pediatric population that warrant systems and process changes
HMOGeneral populationAutomated claims and pharmacy databases are not sufficient on their own for assessing appropriate renal dosing to determine prescribing errors of QT interval prolonging medications
PennResearchersGuidelines for the conduct of prospective meta-analyses
UABResearchers/PractitionersIdentification of tool (Achievable Benchmark of Care) for providing practitioners feedback (with benchmarks) on their performance to improve outcomes/compliance
HMOChrug-Strauss Syndrome patientsDevelopment of algorithms using claims data that suggests patients with Chrug-Strauss Syndrome can be successfully identified using algorithms based on administrative data
UNCGeneral populationFound that many hospitals report adverse drug events differently in the emergency discharge database (ICD-9 and E codes) and the database has limitations to be used for identifying anaphylaxis related to drugs.
UNCPediatricsLargest analysis of pediatric medication errors from the perioperative continuum of care. Used MEDMARX database in collaboration with USUHS to study drug-related anaphylaxis. Early findings suggest that pediatric patients are disproportionately vulnerable to an error medication.
HMOPediatricsIn study of prevalence of outpatient dosing errors, identified barriers to understanding the epidemiology of medication errors in children. Examples include prescribing medication that is not labeled for use in children, discrepancies in published dosing recommendations for many medications, unclear guidelines, and lack of readily available documented weights
GranteeGeneral population/researchersLarge multi-community randomized trial of an intervention to reduce antimicrobial resistance which innovatively linked health services measures with bacteria resistance patterns (nasopharyngeal carriage of resistant and susceptible S. pneumoniae)
DukeCHF inpatientsA registry of inpatients with heart failure containing data on clinical history, demographics, medications, and treatment patterns to better understand outcomes associated with heart failure management.
ArizonaGeneral populationThe Web-based drug-induced arrhythmias registry (www.qtdrugs.org) has been accessed by individuals nationally and internationally. Attributed with providing the information that contributed to identifying the cardiotoxic effects of methadone.

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Page last reviewed December 2007
Internet Citation: Table 1: Evaluation of AHRQ's Pharmaceutical Outcomes Portfolio. December 2007. Agency for Healthcare Research and Quality, Rockville, MD. http://www.ahrq.gov/research/findings/final-reports/pharmportfolio/table1.html