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Table 6.1. Biological Dosimetry Assays and Operational Parameters

Class of Biomarker Assay Time Window Operating Dose Window (Gy, acute photon-equivalent)
Prodromal signs and symptoms Onset of vomiting <12 hr 2–20
Hematological Depletion of peripheral blood lymphocytes <1.5 wk 2–8
Cytological Lymphocyte-metaphase spread dicentric < several monthsa 0.2–5
Lymphocyte-premature chromosome condensation <several monthsa 0.2–20

a Generally, blood is sampled 24 hours after radiation exposure for cytological chromosome aberration analysis of dose.

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