National Healthcare Quality and Disparities Report
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AHRQ Research Studies Date
Topics
- Adverse Events (3)
- Cancer (1)
- Cardiovascular Conditions (6)
- Children/Adolescents (1)
- Chronic Conditions (1)
- Comparative Effectiveness (2)
- COVID-19 (1)
- Diabetes (2)
- Elderly (1)
- Evidence-Based Practice (2)
- Healthcare Cost and Utilization Project (HCUP) (1)
- Heart Disease and Health (2)
- Hospital Discharge (1)
- Hospitalization (1)
- Hospital Readmissions (1)
- Imaging (1)
- Kidney Disease and Health (1)
- Maternal Care (1)
- Medication (1)
- Mortality (4)
- Neurological Disorders (1)
- Newborns/Infants (2)
- (-) Outcomes (21)
- Palliative Care (1)
- Patient-Centered Outcomes Research (1)
- Pregnancy (1)
- Quality Improvement (1)
- Quality of Care (1)
- Racial and Ethnic Minorities (1)
- Respiratory Conditions (2)
- (-) Risk (21)
- Rural Health (1)
- Sex Factors (1)
- Stroke (1)
- Surgery (8)
- Transplantation (2)
- Women (2)
AHRQ Research Studies
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Research Studies is a compilation of published research articles funded by AHRQ or authored by AHRQ researchers.
Results
1 to 21 of 21 Research Studies DisplayedWeekes AJ, Raper JD, Lupez K
Development and validation of a prognostic tool: pulmonary embolism short-term clinical outcomes risk estimation (PE-SCORE).
The objective of this study was to develop and validate a prognostic model for clinical deterioration or death within days of pulmonary embolism (PE) diagnosis using point-of-care criteria. In this study, the investigators used prospective registry data from six emergency departments. The primary composite outcome was death or deterioration (respiratory failure, cardiac arrest, new dysrhythmia, sustained hypotension, and rescue reperfusion intervention) within 5 days.
AHRQ-funded; HS025979.
Citation: Weekes AJ, Raper JD, Lupez K .
Development and validation of a prognostic tool: pulmonary embolism short-term clinical outcomes risk estimation (PE-SCORE).
PLoS One 2021 Nov 18;16(11):e0260036. doi: 10.1371/journal.pone.0260036..
Keywords: Respiratory Conditions, Risk, Outcomes
Delaney LD, Howard R, Palazzolo K
Outcomes of a presurgical optimization program for elective hernia repairs among high-risk patients.
The authors evaluated the feasibility of evidence-based patient optimization before surgery by implementing a low-cost preoperative optimization clinic. They found that a hernia optimization clinic safely improved management of high-risk patients and increased operative yield for the institution. They concluded that their results represented an opportunity to create sustainable and scalable models that provide longitudinal care and optimize patients to improve outcomes of hernia repair.
AHRQ-funded; HS025778.
Citation: Delaney LD, Howard R, Palazzolo K .
Outcomes of a presurgical optimization program for elective hernia repairs among high-risk patients.
JAMA Netw Open 2021 Nov;4(11):e2130016. doi: 10.1001/jamanetworkopen.2021.30016..
Keywords: Surgery, Risk, Evidence-Based Practice, Quality Improvement, Quality of Care, Outcomes
Czosek RJ, Anderson JB, Baskar S
Predictors and outcomes of heart block during surgical stage I palliation of patients with a single ventricle: a report from the NPC-QIC.
This study investigated patient and surgical risks of heart block and its effect on 12-month transplant-free survival in children with a single ventricle. In total, 1423 patients were identified from the National Pediatric Cardiology Improvement Collaborative with and without heart block. One-year outcomes were analyzed. A very small percentage (2%) developed heart block during their surgical admission. Associated risk factors for block included heterotaxy syndrome and atrial flutter/fibrillation. Patients with complete heart block had lower 12-month survival, which wasn’t true for patients with second degree block. At 12 months of age, 43% of patients with heart block died and were more likely to experience mortality than patients without heart block.
AHRQ-funded; HS021114.
Citation: Czosek RJ, Anderson JB, Baskar S .
Predictors and outcomes of heart block during surgical stage I palliation of patients with a single ventricle: a report from the NPC-QIC.
Heart Rhythm 2021 Nov;18(11):1876-83. doi: 10.1016/j.hrthm.2021.05.019..
Keywords: Children/Adolescents, Heart Disease and Health, Cardiovascular Conditions, Surgery, Palliative Care, Risk, Outcomes
Klein IA, Rosenberg SM, Reynolds KL
Impact of cancer history on outcomes among hospitalized patients with COVID-19.
Researchers investigated whether a current cancer diagnosis or cancer history is an independent risk factor for death in hospitalized patients with COVID-19. They found that patients with a history of cancer hospitalized for COVID-19 had similar mortality to matched hospitalized patients with COVID-19 without cancer, and a lower risk of complications, while patients with active cancer or recent cancer treatment had a similar risk for adverse outcomes compared with survivors of cancer. They concluded that active cancer, systemic cancer therapy, and a cancer history are not independent risk factors for death from COVID-19 among hospitalized patients, and hospitalized patients without cancer are more likely to have severe COVID-19.
AHRQ-funded; HS023680.
Citation: Klein IA, Rosenberg SM, Reynolds KL .
Impact of cancer history on outcomes among hospitalized patients with COVID-19.
Oncologist 2021 Aug;26(8):685-93. doi: 10.1002/onco.13794..
Keywords: COVID-19, Cancer, Risk, Mortality, Hospitalization, Outcomes
Li K, Ferguson T, Embil J
Risk of kidney failure, death, and cardiovascular events after lower limb complications in patients with CKD.
Investigators sought to determine how interim lower limb complications modify the subsequent risk of progression to kidney failure, all-cause mortality before kidney failure, and cardiovascular events in a cohort of patients with chronic kidney disease (CKD) stages G3 to G5. Patient-level data obtained from several administrative databases from Manitoba, Canada, were analyzed. They found that interim lower limb complications were associated with an increased risk of kidney failure, all-cause mortality before kidney failure, and cardiovascular-related hospitalization. They stated that clinical trials of screening and treatment strategies for patients with CKD at risk for lower limb complications may help determine optimal strategies to manage this risk.
AHRQ-funded; HS018574.
Citation: Li K, Ferguson T, Embil J .
Risk of kidney failure, death, and cardiovascular events after lower limb complications in patients with CKD.
Kidney Int Rep 2021 Feb;6(2):381-88. doi: 10.1016/j.ekir.2020.11.010..
Keywords: Kidney Disease and Health, Cardiovascular Conditions, Chronic Conditions, Risk, Adverse Events, Mortality, Outcomes
Berger BO, Wolfson C, Reid LD
AHRQ Author: Reid LD
Adverse birth outcomes among women of advanced maternal age with and without health conditions in Maryland.
This study examined the association between advanced maternal age (AMA) and adverse birth outcomes among women with and without preexisting and pregnancy-related health conditions. Data for singleton births from the population-based Maryland Pregnancy Risk Assessment Monitoring System 2004-2015 were used to compare women aged 20-34 years and 35 years and older. Findings indicated that AMA is associated with adverse birth outcomes among women with and without health conditions compared with younger women with similar health status. Recommendations included improved screening and management of health conditions during pregnancy for older women, regardless of parity.
AHRQ-authored.
Citation: Berger BO, Wolfson C, Reid LD .
Adverse birth outcomes among women of advanced maternal age with and without health conditions in Maryland.
Womens Health Issues 2021 Jan-Feb;31(1):40-48. doi: 10.1016/j.whi.2020.08.008..
Keywords: Pregnancy, Newborns/Infants, Outcomes, Women, Risk
Bath J, Smith JB, Woodard J
Complex relationship between low albumin level and poor outcome after lower extremity procedures for peripheral artery disease.
Researchers sought to examine the association of low albumin level with outcomes in patients undergoing open and endovascular lower extremity procedures for peripheral artery disease. Subjects were patients with peripheral artery disease undergoing lower extremity procedures, selected from Cerner Health Facts database using ICD-9 diagnosis and procedure codes. They found that low preoperative albumin levels were associated with in-hospital death, prolonged length of stay, and severe morbidity after open and endovascular lower extremity procedures. They recommended that elective procedures be deferred until albumin levels have been optimized.
Citation: Bath J, Smith JB, Woodard J .
Complex relationship between low albumin level and poor outcome after lower extremity procedures for peripheral artery disease.
J Vasc Surg 2021 Jan;73(1):200-09. doi: 10.1016/j.jvs.2020.04.524..
Keywords: Cardiovascular Conditions, Surgery, Outcomes, Mortality, Risk
Chang AL, Hurwitz E, Miyamura J
Maternal risk factors and perinatal outcomes among pacific islander groups in Hawaii: a retrospective cohort study using statewide hospital data.
This study compared perinatal outcomes between Pacific Islander and White women who delivered a singleton liveborn in any Hawaii hospital from January 2010 to December 2011. Significant differences in perinatal outcomes between Pacific Islander and White women and newborns were noted. All Pacific Islander groups had an increased risk of hypertension. Native Hawaiians had the highest risk of low birthweight infants.
AHRQ-funded; HS021903.
Citation: Chang AL, Hurwitz E, Miyamura J .
Maternal risk factors and perinatal outcomes among pacific islander groups in Hawaii: a retrospective cohort study using statewide hospital data.
BMC Pregnancy Childbirth 2015 Oct 05;15:239. doi: 10.1186/s12884-015-0671-4.
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Keywords: Maternal Care, Risk, Racial and Ethnic Minorities, Outcomes, Newborns/Infants
Tsilimingras D, Schnipper J, Duke A
Post-discharge adverse events among urban and rural patients of an urban community hospital: a prospective cohort study.
The researchers aimed to determine the rate of postdischarge adverse events (AEs), classify the types of post-discharge AEs, and identify risk factors for post-discharge AEs in urban and rural patients. They found that post-discharge AEs were common in both urban and rural patients and many were preventable or ameliorable.
AHRQ-funded; HS018694.
Citation: Tsilimingras D, Schnipper J, Duke A .
Post-discharge adverse events among urban and rural patients of an urban community hospital: a prospective cohort study.
J Gen Intern Med 2015 Aug;30(8):1164-71. doi: 10.1007/s11606-015-3260-3..
Keywords: Adverse Events, Hospital Discharge, Outcomes, Risk, Rural Health
Shah UH, Mandl LA, Mertelsmann-Voss C
Systemic lupus erythematosus is not a risk factor for poor outcomes after total hip and total knee arthroplasty.
The researchers sought to determine if systemic lupus erythematosus (SLE) remains an independent risk factor for poor arthroplasty outcomes or if other factors, such as avascular necrosis , continue to play a role. They found that SLE was not an independent risk factor for poor short-term pain or function after either hip or knee arthroplasty.
AHRQ-funded; HS016075.
Citation: Shah UH, Mandl LA, Mertelsmann-Voss C .
Systemic lupus erythematosus is not a risk factor for poor outcomes after total hip and total knee arthroplasty.
Lupus 2015 Aug;24(9):900-8. doi: 10.1177/0961203314566635.
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Keywords: Surgery, Risk, Outcomes, Adverse Events
Fink HA, Hemmy LS, MacDonald R
Intermediate- and long-term cognitive outcomes after cardiovascular procedures in older adults: a systematic review.
This study summarized evidence about cognitive outcomes in adults aged 65 years or older at least 3 months after coronary or carotid revascularization, cardiac valve procedures, or ablation for atrial fibrillation. It concluded that intermediate- and long-term cognitive impairment in older adults attributable to the studied cardiovascular procedures may be uncommon.
AHRQ-funded; 2902007100641.
Citation: Fink HA, Hemmy LS, MacDonald R .
Intermediate- and long-term cognitive outcomes after cardiovascular procedures in older adults: a systematic review.
Ann Intern Med 2015 Jul 21;163(2):107-17. doi: 10.7326/m14-2793..
Keywords: Cardiovascular Conditions, Elderly, Neurological Disorders, Outcomes, Patient-Centered Outcomes Research, Risk, Surgery
Santos CA, Brennan DC, Chapman WC
Delayed-onset cytomegalovirus disease coded during hospital readmission in a multicenter, retrospective cohort of liver transplant recipients.
The researchers sought to determine the risk factors and outcomes of delayed-onset CMV disease among a representative cohort of liver transplant recipients from multiple centers. They found that delayed-onset CMV disease coded during hospital readmission occurred more commonly than early-onset CMV disease and that prior transplant failure or rejection was a risk factor for delayed-onset CMV disease.
AHRQ-funded; HS019455.
Citation: Santos CA, Brennan DC, Chapman WC .
Delayed-onset cytomegalovirus disease coded during hospital readmission in a multicenter, retrospective cohort of liver transplant recipients.
Liver Transpl 2015 May;21(5):581-90. doi: 10.1002/lt.24089..
Keywords: Healthcare Cost and Utilization Project (HCUP), Risk, Transplantation, Outcomes
Ault MJ, Rosen BT, Scher J
Thoracentesis outcomes: a 12-year experience.
The researchers evaluated specific demographic and clinical factors that have been commonly associated with complications such as iatrogenic pneumothorax, re-expansion pulmonary edema and bleeding. They found that thoracenteses had a very low complication rate and concluded that current clinical guidelines and practice patterns may not reflect evidence-based best practices.
AHRQ-funded; HS021202.
Citation: Ault MJ, Rosen BT, Scher J .
Thoracentesis outcomes: a 12-year experience.
Thorax 2015 Feb;70(2):127-32. doi: 10.1136/thoraxjnl-2014-206114..
Keywords: Risk, Evidence-Based Practice, Respiratory Conditions, Respiratory Conditions, Outcomes
Chang SH, Luo S, O'Brian KK
Association between metformin use and progression of monoclonal gammopathy of undetermined significance to multiple myeloma in US veterans with diabetes mellitus: a population-based retrospective cohort study.
The authors assessed the association between metformin use and progression of monoclonal gammopathy of undetermined significance to multiple myeloma. They found that metformin use was associated with a reduced risk of progression to multiple myeloma.
AHRQ-funded; HS022330.
Citation: Chang SH, Luo S, O'Brian KK .
Association between metformin use and progression of monoclonal gammopathy of undetermined significance to multiple myeloma in US veterans with diabetes mellitus: a population-based retrospective cohort study.
Lancet Haematol 2015 Jan;2(1):e30-6. doi: 10.1016/s2352-3026(14)00037-4.
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Keywords: Diabetes, Medication, Outcomes, Risk
Spangler EL, Goodney PP, Schanzer A
Outcomes of carotid endarterectomy versus stenting in comparable medical risk patients.
The purpose of this study was to compare risk-stratified outcomes of carotid artery stenting (CAS) and carotid endarterectomy (CEA). Included in the study group were 11,336 patients who underwent isolated primary CEA and 544 who underwent primary CAS. The researchers found that asymptomatic normal- and high-risk patients do equally well after CEA or CAS. However, normal- and high-risk symptomatic patients have substantially worse outcomes with CAS compared with CEA.
AHRQ-funded; HS021581.
Citation: Spangler EL, Goodney PP, Schanzer A .
Outcomes of carotid endarterectomy versus stenting in comparable medical risk patients.
J Vasc Surg 2014 Nov;60(5):1227-31, 31.e1. doi: 10.1016/j.jvs.2014.05.044..
Keywords: Outcomes, Comparative Effectiveness, Risk, Cardiovascular Conditions, Heart Disease and Health
Huesch MD
The impact of short breaks from cardiac surgery on mortality and stay length in California.
In this small, exploratory study, the researchers sought to investigate potential surgical “forgetting” among cardiac surgeons taking a break from performing isolated coronary artery bypass graft (CABG) surgery in a large state-wide study in California. Patients operated on by surgeons who had not performed isolated CABG in the prior calendar month stayed in hospital 0.5 day longer.
AHRQ-funded; HS021868.
Citation: Huesch MD .
The impact of short breaks from cardiac surgery on mortality and stay length in California.
J Healthc Qual 2014 Sep-Oct;36(5):42-9. doi: 10.1111/jhq.12018..
Keywords: Surgery, Outcomes, Mortality, Risk
Santos CA, Brennan DC, Fraser VJ
Delayed-onset cytomegalovirus disease coded during hospital readmission after kidney transplantation.
The researchers sought to expand understanding of the scope, risk factors and outcomes associated with delayed-onset cytomegalovirus (CMV) disease among kidney transplant reci
AHRQ-funded; HS019455
Citation: Santos CA, Brennan DC, Fraser VJ .
Delayed-onset cytomegalovirus disease coded during hospital readmission after kidney transplantation.
Transplantation. 2014 Jul 27;98(2):187-94. doi: 10.1097/TP.0000000000000030..
Keywords: Transplantation, Hospital Readmissions, Risk, Outcomes
Strom Williams JL, Lynch CP, Winchester R
Gender differences in composite control of cardiovascular risk factors among patients with type 2 diabetes.
This study examined the gender differences in multiple cardiovascular disease (CVD) risk factor control in adults with type 2 diabetes seen in diverse clinical settings. It found that women had significantly poorer composite control of CVD risk outcomes compared with men, adjusting for relevant confounding factors. In unadjusted analyses, women had higher mean systolic blood pressure and LDL cholesterol levels compared with men.
AHRQ-funded; HS011418.
Citation: Strom Williams JL, Lynch CP, Winchester R .
Gender differences in composite control of cardiovascular risk factors among patients with type 2 diabetes.
Diabetes Technol Ther 2014 Jul;16(7):421-7. doi: 10.1089/dia.2013.0329..
Keywords: Cardiovascular Conditions, Risk, Diabetes, Outcomes, Sex Factors
Lyerly MJ, Houston JT, Boehme AK
Safety of intravenous tissue plasminogen activator administration with computed tomography evidence of prior infarction.
The researchers sought to determine if the presence of a previous stroke on pretreatment computed tomography (CT) is a predictor of hemorrhagic complications and functional outcomes after the administration of intravenous (IV) tissue plasminogen activator (tPA). Their data suggest that a prior stroke on CT should not be viewed as a reason to withhold this treatment unless it occurred within the last 3 months.
AHRQ-funded; HS013852.
Citation: Lyerly MJ, Houston JT, Boehme AK .
Safety of intravenous tissue plasminogen activator administration with computed tomography evidence of prior infarction.
J Stroke Cerebrovasc Dis 2014 Jul;23(6):1657-61. doi: 10.1016/j.jstrokecerebrovasdis.2014.01.011..
Keywords: Stroke, Risk, Outcomes, Imaging
Cox CL, Huston LJ, Dunn WR
Are articular cartilage lesions and meniscus tears predictive of IKDC, KOOS, and Marx activity level outcomes after anterior cruciate ligament reconstruction? A 6-year multicenter cohort study.
This study of 1,512 ACLR patients who were followed for 6 years found that both articular cartilage injury and meniscus tears/treatment at the time of ACLR were significant predictors of International Knee Documentation Center (IKDC) and Knee injury Osteoarthritis Outcome Score (KOOS) scores after ACLR. Having a grade 4 medial femoral condyle lesion significantly reduced a patient’s Marx activity level score at 6 years.
AHRQ-funded; HS016075
Citation: Cox CL, Huston LJ, Dunn WR .
Are articular cartilage lesions and meniscus tears predictive of IKDC, KOOS, and Marx activity level outcomes after anterior cruciate ligament reconstruction? A 6-year multicenter cohort study.
Am J Sports Med. 2014 May;42(5):1058-67. doi: 10.1177/0363546514525910..
Keywords: Outcomes, Surgery, Risk
Jonsson Funk M, Visco AG, Weidner AC
Long-term outcomes of vaginal mesh versus native tissue repair for anterior vaginal wall prolapse.
This study estimated the rate of repeat surgery after vaginal mesh versus native tissue repair for anterior vaginal wall prolapse. The researchers found that the overall risk of any future surgery was higher in the women receiving mesh; however, native tissue and vaginal mesh surgery had similar 5-year risks for recurrent prolapse.
AHRQ-funded; HS017950
Citation: Jonsson Funk M, Visco AG, Weidner AC .
Long-term outcomes of vaginal mesh versus native tissue repair for anterior vaginal wall prolapse.
Int Urogynecol J. 2013 Aug;24(8):1279-85. doi: 10.1007/s00192-013-2043-9..
Keywords: Comparative Effectiveness, Surgery, Women, Outcomes, Risk