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Research Studies is a monthly compilation of research articles funded by AHRQ or authored by AHRQ researchers and recently published in journals or newsletters.
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1 to 12 of 12 Research Studies DisplayedFiscella K
Tackling disparities in influenza vaccination in primary care: it takes a team.
This article discusses a study in the same issue by Maurer. Fiscella describes reasons involving influenza vaccination disparities and points out that the emergence of accountable care organizations creates opportunities for better integration of primary care and public health.
AHRQ-funded; HS022440.
Citation: Fiscella K .
Tackling disparities in influenza vaccination in primary care: it takes a team.
J Gen Intern Med 2014 Dec;29(12):1579-81. doi: 10.1007/s11606-014-2999-2.
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Keywords: Disparities, Influenza, Primary Care, Teams, Vaccination
Geynisman DM, Chien CR, Smieliauskas F
Economic evaluation of therapeutic cancer vaccines and immunotherapy: a systematic review.
The researchers performed a comprehensive literature review of cost and cost-effectiveness research on therapeutic cancer vaccines and monoclonal antibodies, to better understand the economic impacts of these treatments. They discussed the implications surrounding the economic factors involved in cancer immunotherapies and suggested that further research on cost and cost-effectiveness of newer cancer vaccines and immunotherapies were warranted as this is a rapidly growing field with many new drugs on the horizon.
AHRQ-funded; HS018535.
Citation: Geynisman DM, Chien CR, Smieliauskas F .
Economic evaluation of therapeutic cancer vaccines and immunotherapy: a systematic review.
Hum Vaccin Immunother 2014;10(11):3415-24. doi: 10.4161/hv.29407.
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Keywords: Cancer, Healthcare Costs, Vaccination, Value
Ahrens KA, Louik C, Kerr S
Seasonal influenza vaccination during pregnancy and the risks of preterm delivery and small for gestational age birth.
The researchers examined the associations between seasonal influenza vaccination during pregnancy and the risks of PTD and SGA among a multiyear retrospective cohort of pregnancies. With the exception of pre-term delivery (PTD) associated with the 2009–10 seasonal vaccine, they found no meaningful increases in PTD or small for gestational age risks associated with seasonal trivalent influenza vaccination during pregnancy.
AHRQ-funded; HS018463.
Citation: Ahrens KA, Louik C, Kerr S .
Seasonal influenza vaccination during pregnancy and the risks of preterm delivery and small for gestational age birth.
Paediatr Perinat Epidemiol 2014 Nov;28(6):498-509. doi: 10.1111/ppe.12152..
Keywords: Influenza, Vaccination, Pregnancy, Labor and Delivery
Campbell LJ, Li Q, Li Y
Healthcare worker influenza vaccination in Oregon nursing homes: correlates of facility characteristics.
The authors identified nursing home (NH) characteristics that may be associated with employee influenza vaccination rates (EVRs). They concluded that, as NHs generally have low EVRs, it may be necessary to target low-performing facilities to achieve substantial improvements.
AHRQ-funded; HS000044.
Citation: Campbell LJ, Li Q, Li Y .
Healthcare worker influenza vaccination in Oregon nursing homes: correlates of facility characteristics.
J Am Med Dir Assoc 2014 Oct;15(10):768-72. doi: 10.1016/j.jamda.2014.06.005.
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Keywords: Provider: Health Personnel, Influenza, Nursing Homes, Prevention, Vaccination
Perry LM, Winthrop KL, Curtis JR
Vaccinations for rheumatoid arthritis.
The goal of this paper is to highlight the most recent literature on the key vaccines and the specific considerations for the rheumatologist and their rheumatoid arthritis (RA) patients, with a particular focus on influenza, pneumococcal, and herpes zoster vaccines. It is important for rheumatologists to understand which vaccines are live and what potential contraindications exist for giving vaccines to RA patients.
AHRQ-funded; HS018517
Citation: Perry LM, Winthrop KL, Curtis JR .
Vaccinations for rheumatoid arthritis.
Curr Rheumatol Rep. 2014 Aug;16(8):431. doi: 10.1007/s11926-014-0431-x..
Keywords: Arthritis, Vaccination, Prevention
Khazeni N, Hutton DW, Collins CI
Health and economic benefits of early vaccination and nonpharmaceutical interventions for a human influenza A (H7N9) pandemic: a modeling study.
In order to determine how quickly vaccination should be completed to reduce infections, deaths, and health care costs in a severe influenza pandemic in a large metropolitan area, researchers used a dynamic transmission model. They found that vaccination in an influenza-A (H7N9) pandemic would need to be completed much faster than in the 2009 pandemic to substantially reduce morbidity, mortality, and health care costs.
AHRQ-funded; HS019816
Citation: Khazeni N, Hutton DW, Collins CI .
Health and economic benefits of early vaccination and nonpharmaceutical interventions for a human influenza A (H7N9) pandemic: a modeling study.
Ann Intern Med. 2014 May 20;160(10):684-94. doi: 10.7326/M13-2071..
Keywords: Vaccination, Influenza, Mortality, Healthcare Costs, Public Health
Humiston SG, Poehling KA, Szilagyi PG
School-located influenza vaccination: can collaborative efforts go the distance?
This commentary discusses school-located influenza vaccination during the school day and includes the survey results from Kempe et al., in the same issue. The authors conclude that increasing influenza vaccination rates will require vaccinating “outside the box,” utilizing a site in which school-aged youth already tend to congregate.
AHRQ-funded; HS021163.
Citation: Humiston SG, Poehling KA, Szilagyi PG .
School-located influenza vaccination: can collaborative efforts go the distance?
Acad Pediatr 2014 May-Jun;14(3):219-20. doi: 10.1016/j.acap.2014.03.004.
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Keywords: Children/Adolescents, Influenza, Vaccination
Panozzo CA, Becker-Dreps S, Pate V
Direct, indirect, total, and overall effectiveness of the rotavirus vaccines for the prevention of gastroenteritis hospitalizations in privately insured US children, 2007-2010.
This study demonstrated how direct, indirect, total, and overall effectiveness estimates and absolute benefits of rotavirus vaccines vary through the years following vaccine introduction. It found that direct effectiveness of 1 or more doses of rotavirus vaccine in preventing rotavirus gastroenteritis hospitalizations ranged from 87 to 92 percent each year.
AHRQ-funded; HS017950
Citation: Panozzo CA, Becker-Dreps S, Pate V .
Direct, indirect, total, and overall effectiveness of the rotavirus vaccines for the prevention of gastroenteritis hospitalizations in privately insured US children, 2007-2010.
Am J Epidemiol. 2014 Apr 1;179(7):895-909. doi: 10.1093/aje/kwu001..
Keywords: Comparative Effectiveness, Vaccination, Children/Adolescents, Hospitalization
Glanz JM, Wagner NM, Narwaney KJ
A mixed methods study of parental vaccine decision making and parent-provider trust.
Given the growing public health problem of parental vaccine hesitancy, researchers investigated parental vaccine decisionmaking through the use of focus groups and a mailed survey. They found that parents had overall trust in their pediatricians but not in the information they provided about vaccines. Parents refusing or delaying vaccines were twice as likely to begin thinking about vaccines before their child was born.
AHRQ-funded; HS019760
Citation: Glanz JM, Wagner NM, Narwaney KJ .
A mixed methods study of parental vaccine decision making and parent-provider trust.
Acad Pediatr. 2013 Sep-Oct;13(5):481-8. doi: 10.1016/j.acap.2013.05.030..
Keywords: Children/Adolescents, Vaccination, Education: Patient and Caregiver, Healthcare Utilization, Decision Making
Williams SE, Rothman RL, Offit PA
A randomized trial to increase acceptance of childhood vaccines by vaccine-hesitant parents: a pilot study.
This pilot study evaluated an educational intervention (a video and written information) to improve parental attitudes and vaccine-uptake in vaccine-hesitant parents. It found a modest increase in parental attitudes toward vaccines but no difference in receipt of vaccines between the intervention and control groups at 12 weeks.
AHRQ-funded; HS019675
Citation: Williams SE, Rothman RL, Offit PA .
A randomized trial to increase acceptance of childhood vaccines by vaccine-hesitant parents: a pilot study.
Acad Pediatr. 2013 Sep-Oct;13(5):475-80. doi: 10.1016/j.acap.2013.03.011..
Keywords: Children/Adolescents, Vaccination, Education: Patient and Caregiver, Healthcare Utilization
Tsui J, Gee GC, Rodriguez HP
Exploring the role of neighborhood socio-demographic factors on HPV vaccine initiation among low-income, ethnic minority girls.
This study of neighborhood factors associated with human papillomavirus (HPV) vaccine uptake, especially among disadvantaged groups, found that initiation rates were highest among girls from the most disadvantaged neighborhoods. However, mother’s awareness of HPV, age, and insurance status were also strong predictors for initiation.
AHRQ-funded; HS020172
Citation: Tsui J, Gee GC, Rodriguez HP .
Exploring the role of neighborhood socio-demographic factors on HPV vaccine initiation among low-income, ethnic minority girls.
J Immigr Minor Health. 2013 Aug;15(4):732-40. doi: 10.1007/s10903-012-9736-x..
Keywords: Vaccination, Children/Adolescents, Women, Health Insurance, Disparities
Vawdrey DK, Natarajan K, Kanter AS
Informatics lessons from using a novel immunization information system.
This paper describes the informatics challenges and lessons learned during nearly 15 years of collecting, using, and exchanging electronic immunization information. The authors report on their experience with developing and using the EzVac system for 1) clinical care, both in local and global settings, 2) public health reporting, 3) consumer engagement, and 4) clinical and informatics research.
AHRQ-funded; HS018158.
Citation: Vawdrey DK, Natarajan K, Kanter AS .
Informatics lessons from using a novel immunization information system.
Stud Health Technol Inform 2013;192:589-93..
Keywords: Health Information Technology (HIT), Registries, Public Reporting, Vaccination
