National Healthcare Quality and Disparities Report
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AHRQ Research Studies
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Research Studies is a compilation of published research articles funded by AHRQ or authored by AHRQ researchers.
Results
51 to 75 of 167 Research Studies DisplayedShah UH, Mandl LA, Mertelsmann-Voss C
Systemic lupus erythematosus is not a risk factor for poor outcomes after total hip and total knee arthroplasty.
The researchers sought to determine if systemic lupus erythematosus (SLE) remains an independent risk factor for poor arthroplasty outcomes or if other factors, such as avascular necrosis , continue to play a role. They found that SLE was not an independent risk factor for poor short-term pain or function after either hip or knee arthroplasty.
AHRQ-funded; HS016075.
Citation: Shah UH, Mandl LA, Mertelsmann-Voss C .
Systemic lupus erythematosus is not a risk factor for poor outcomes after total hip and total knee arthroplasty.
Lupus 2015 Aug;24(9):900-8. doi: 10.1177/0961203314566635.
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Keywords: Surgery, Risk, Outcomes, Adverse Events
Fink HA, Hemmy LS, MacDonald R
Intermediate- and long-term cognitive outcomes after cardiovascular procedures in older adults: a systematic review.
This study summarized evidence about cognitive outcomes in adults aged 65 years or older at least 3 months after coronary or carotid revascularization, cardiac valve procedures, or ablation for atrial fibrillation. It concluded that intermediate- and long-term cognitive impairment in older adults attributable to the studied cardiovascular procedures may be uncommon.
AHRQ-funded; 2902007100641.
Citation: Fink HA, Hemmy LS, MacDonald R .
Intermediate- and long-term cognitive outcomes after cardiovascular procedures in older adults: a systematic review.
Ann Intern Med 2015 Jul 21;163(2):107-17. doi: 10.7326/m14-2793..
Keywords: Cardiovascular Conditions, Elderly, Neurological Disorders, Outcomes, Patient-Centered Outcomes Research, Risk, Surgery
Chen CY, Stevenson LW, Stewart GC
Real world effectiveness of primary implantable cardioverter defibrillators implanted during hospital admissions for exacerbation of heart failure or other acute co-morbidities: cohort study of older patients with heart failure.
The researchers examined the effectiveness of primary implantable cardioverter defibrillators (ICDs) in elderly patients receiving the device during a hospital admission for exacerbation of heart failure or other acute co-morbidities. They concluded that the benefits of primary ICD therapy seen in pivotal trials were not apparent in patients aged 66 or over who received ICDs during a hospital admission for exacerbation of heart failure or other acute co-morbidities.
AHRQ-funded; 290-2005-0016-I -TO3; HS017731.
Citation: Chen CY, Stevenson LW, Stewart GC .
Real world effectiveness of primary implantable cardioverter defibrillators implanted during hospital admissions for exacerbation of heart failure or other acute co-morbidities: cohort study of older patients with heart failure.
BMJ 2015 Jul 14;351:h3529. doi: 10.1136/bmj.h3529..
Keywords: Comparative Effectiveness, Elderly, Medical Devices, Heart Disease and Health, Outcomes
Moghavem N, Morrison D, Ratliff JK
Cranial neurosurgical 30-day readmissions by clinical indication.
The objects of this study were to determine population-level, 30-day, all-cause readmission rates for cranial neurosurgery and identify factors associated with readmission. It fund that the frequency of 30-day readmission rates for patients undergoing cranial neurosurgery varied by diagnosis between 14% and 24%. Important patient characteristics and comorbidities that were associated with an increased readmission risk were identified.
AHRQ-funded; HS018558.
Citation: Moghavem N, Morrison D, Ratliff JK .
Cranial neurosurgical 30-day readmissions by clinical indication.
J Neurosurg 2015 Jul;123(1):189-97. doi: 10.3171/2014.12.jns14447..
Keywords: Hospital Readmissions, Surgery, Patient Safety, Outcomes
Osterman MT, Haynes K, Delzell E
Effectiveness and safety of immunomodulators with anti-tumor necrosis factor therapy in Crohn's disease.
This study assessed the effectiveness and safety of immunomodulators with anti-tumor necrosis factor (anti-TNF) therapy in Crohn’s disease (CD). It found that continuation of immunomodulators after “stepping up” to anti-TNF therapy did not improve outcomes but was associated with an increased risk of opportunistic infection.
AHRQ-funded; HS018517.
Citation: Osterman MT, Haynes K, Delzell E .
Effectiveness and safety of immunomodulators with anti-tumor necrosis factor therapy in Crohn's disease.
Clin Gastroenterol Hepatol 2015 Jul;13(7):1293-301.e5; quiz e70, e72. doi: 10.1016/j.cgh.2015.02.017..
Keywords: Patient Safety, Comparative Effectiveness, Patient-Centered Outcomes Research, Outcomes
Reistetter TA, Kuo YF, Karmarkar AM
Geographic and facility variation in inpatient stroke rehabilitation: multilevel analysis of functional status.
This study examined geographic and facility variation in cognitive and motor functional outcomes after postacute inpatient rehabilitation in patients with stroke. Its findings suggest that variation in motor and cognitive function at discharge after postacute rehabilitation in patients with stroke is accounted for more by facility than geographic location.
AHRQ-funded; HS022134.
Citation: Reistetter TA, Kuo YF, Karmarkar AM .
Geographic and facility variation in inpatient stroke rehabilitation: multilevel analysis of functional status.
Arch Phys Med Rehabil 2015 Jul;96(7):1248-54. doi: 10.1016/j.apmr.2015.02.020..
Keywords: Stroke, Cardiovascular Conditions, Inpatient Care, Outcomes
Patel MB, Wilson LD, Bregman JA
Neurologic functional and quality of life outcomes after TBI: clinic attendees versus non-attendees.
This study describes the relationship between TBI patient demographics, quality of life outcome, and functional status outcome among clinic attendees and non-attendees. All participants were telephone surveyed using the Extended-Glasgow Outcome Scale (GOSE), the Quality of Life after Brain Injury (QOLIBRI) scale, and a post-discharge therapy questionnaire. Risk factors for GOSE and QOLIBRI outcomes included age, injury characteristics, clinic attendance, insurance status, post-discharge rehabilitation, and time from injury.
AHRQ-funded; HS013833.
Citation: Patel MB, Wilson LD, Bregman JA .
Neurologic functional and quality of life outcomes after TBI: clinic attendees versus non-attendees.
J Neurotrauma 2015 Jul 1;32(13):984-9. doi: 10.1089/neu.2014.3652..
Keywords: Brain Injury, Registries, Outcomes
Dahabreh IJ, Steele DW, Shah N
Oral mechanical bowel preparation for colorectal surgery: systematic review and meta-analysis.
The purpose of this review was to synthesize the evidence on the comparative effectiveness and safety of oral mechanical bowel preparation versus no preparation or enema. It found weak evidence suggesting that oral mechanical bowel preparation has similar effectiveness compared with no preparation with respect to all-cause mortality, anastomotic leakage, wound infection, and peritonitis for patients undergoing elective surgery for colorectal cancer.
AHRQ-funded; 290201200012I.
Citation: Dahabreh IJ, Steele DW, Shah N .
Oral mechanical bowel preparation for colorectal surgery: systematic review and meta-analysis.
Dis Colon Rectum 2015 Jul;58(7):698-707. doi: 10.1097/dcr.0000000000000375..
Keywords: Comparative Effectiveness, Surgery, Outcomes, Adverse Events
Durkin MJ, Dicks KV, Baker AW
Postoperative infection in spine surgery: does the month matter?
The authors evaluated for seasonal variation of surgical site infection (SSI) following spine surgery in a network of nonteaching community hospitals. They found that the rate of SSI following fusion or spinal laminectomy/laminoplasty was higher during the summer in this network of community hospitals, most likely due to S. aureus rather than the July effect.
AHRQ-funded; HS023866.
Citation: Durkin MJ, Dicks KV, Baker AW .
Postoperative infection in spine surgery: does the month matter?
J Neurosurg Spine 2015 Jul;23(1):128-34. doi: 10.3171/2014.10.spine14559.
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Keywords: Surgery, Healthcare-Associated Infections (HAIs), Injuries and Wounds, Adverse Events, Patient Safety, Hospitals, Outcomes, Quality of Care
Abdelsattar ZM, Hendren S, Wong SL
Variation in transfusion practices and the effect on outcomes after noncardiac surgery.
The researchers assessed the hospital-level variation in transfusion practices for packed red blood cells and the patient-level effects on outcomes after noncardiac general or vascular surgery, using population-based prospectively collected data. They found that postoperative transfusions after noncardiac surgery are associated with increased adverse postoperative outcomes, with the exception of postoperative myocardial infarction.
AHRQ-funded; HS000053.
Citation: Abdelsattar ZM, Hendren S, Wong SL .
Variation in transfusion practices and the effect on outcomes after noncardiac surgery.
Ann Surg 2015 Jul;262(1):1-6. doi: 10.1097/sla.0000000000001264..
Keywords: Patient Safety, Surgery, Outcomes, Adverse Events
Yehia BR, Stephens-Shields AJ, Fleishman JA
AHRQ Author: Fleishman JA
The HIV care continuum: changes over time in retention in care and viral suppression.
The researchers followed individual patients over a three-year period to determine how retention in care and viral suppression statuses interact and change over time. Overall, 65.8 percent of patients were retained/suppressed, 17.4 percent retained/not-suppressed, 10.0 percent not-retained/suppressed, and 6.8 percent not-retained/not-suppressed in 2010. 59.5 percent of patients maintained the same status in 2011 and 53.3 percent maintained the same status in 2012.
AHRQ-authored; AHRQ-funded; 290201100007C.
Citation: Yehia BR, Stephens-Shields AJ, Fleishman JA .
The HIV care continuum: changes over time in retention in care and viral suppression.
PLoS One 2015 Jun 18;10(6):e0129376. doi: 10.1371/journal.pone.0129376..
Keywords: Human Immunodeficiency Virus (HIV), Outcomes
Briesacher BA, Madden JM, Zhang F
Did Medicare Part D affect national trends in health outcomes or hospitalizations? A time-series analysis.
The researchers examined changes in health outcomes and medical services in the Medicare population after implementation of Medicare Part D. They found that 5 years after implementation, and contrary to previous reports, there was no evidence of Part D's effect on a range of population-level health indicators among Medicare enrollees. Further, there was no clear evidence of gains in medical care efficiencies.
AHRQ-funded; HS018577
Citation: Briesacher BA, Madden JM, Zhang F .
Did Medicare Part D affect national trends in health outcomes or hospitalizations? A time-series analysis.
Ann Intern Med. 2015 Jun 16;162(12):825-33. doi: 10.7326/m14-0726..
Keywords: Hospitalization, Outcomes, Medicare, Health Status, Elderly
Masoudi FA, Go AS, Magid DJ
Age and sex differences in long-term outcomes following implantable cardioverter-defibrillator placement in contemporary clinical practice: findings from the Cardiovascular Research Network.
The objectives of this study were to characterize the risks of adverse outcomes in women and older patients. following implantable cardioverter-defibrillator placement with a focus on death, hospitalization, and complications. It concluded that the burden of adverse outcomes is substantial and varies according to patient age and sex. These differences in outcome generally do not vary according to baseline heart failure characteristics.
AHRQ-funded; 290050033; HS019814.
Citation: Masoudi FA, Go AS, Magid DJ .
Age and sex differences in long-term outcomes following implantable cardioverter-defibrillator placement in contemporary clinical practice: findings from the Cardiovascular Research Network.
J Am Heart Assoc 2015 Jun 2;4(6):e002005. doi: 10.1161/jaha.115.002005..
Keywords: Medical Devices, Cardiovascular Conditions, Patient-Centered Outcomes Research, Elderly, Outcomes
Borden WB, Chiang YP, Kronick R
AHRQ Author: Kronick, R
Bringing patient-centered outcomes research to life.
Achieving better health outcomes requires both the generation of new patient-centered outcomes research (PCOR) knowledge and the appropriate and timely dissemination of that knowledge into practice. This article highlights the work AHRQ has done, is doing, and will do to improve the uptake of PCOR findings.
AHRQ-authored
Citation: Borden WB, Chiang YP, Kronick R .
Bringing patient-centered outcomes research to life.
Value Health. 2015 Jun;18(4):355-7. doi: 10.1016/j.jval.2015.01.010..
Keywords: Communication, Evidence-Based Practice, Outcomes, Patient-Centered Healthcare, Patient-Centered Outcomes Research, Implementation
Sjoding MW, Prescott HC, Wunsch H
Hospitals with the highest intensive care utilization provide lower quality pneumonia care to the elderly.
The researchers investigate the relationship between a hospital’s ICU admission rate for elderly patients with pneumonia and the quality of care it provided to patients with pneumonia. They found that quality of care was lower among hospitals with the highest rates of ICU admission for elderly patients with pneumonia; such hospitals were less likely to deliver pneumonia processes of care and had worse outcomes for patients with pneumonia.
AHRQ-funded; HS020672.
Citation: Sjoding MW, Prescott HC, Wunsch H .
Hospitals with the highest intensive care utilization provide lower quality pneumonia care to the elderly.
Crit Care Med 2015 Jun;43(6):1178-86. doi: 10.1097/ccm.0000000000000925..
Keywords: Intensive Care Unit (ICU), Elderly, Inpatient Care, Quality of Care, Outcomes
Frasier LL, Leverson G, Gosain A
Laparoscopic versus open Ladd's procedure for intestinal malrotation in adults.
This study was designed to investigate outcomes for adults undergoing laparoscopic surgery vs. open Ladd’s repair for malrotation. It found no significant differences in complication rates, need for re-operation, or symptom resolution. There was a statistically significant decrease in length of stay following laparoscopy compared to open surgery.
AHRQ-funded; HS022403.
Citation: Frasier LL, Leverson G, Gosain A .
Laparoscopic versus open Ladd's procedure for intestinal malrotation in adults.
Surg Endosc 2015 Jun;29(6):1598-604. doi: 10.1007/s00464-014-3849-3..
Keywords: Surgery, Outcomes, Patient-Centered Outcomes Research, Adverse Events, Comparative Effectiveness
Gibbons MB, Thompson SM, Mack RA
The relation of baseline skills to psychotherapy outcome across diverse psychotherapies.
The researchers explored the role of baseline skills deficits in compensatory skills and self-understanding across both cognitive and dynamic treatment modalities. Their results support a capitalization model for cognitive therapy but failed to support either a compensation model or a capitalization model for the short-term dynamic model.
AHRQ-funded; HS022124.
Citation: Gibbons MB, Thompson SM, Mack RA .
The relation of baseline skills to psychotherapy outcome across diverse psychotherapies.
J Clin Psychol 2015 Jun;71(6):491-9. doi: 10.1002/jclp.22165..
Keywords: Comparative Effectiveness, Depression, Behavioral Health, Outcomes, Patient-Centered Outcomes Research
Francis DO, Krishnaswami S, Mcpheeters M
Treatment of ankyloglossia and breastfeeding outcomes: a systematic review.
This systematic review of literature on surgical and nonsurgical treatments for infants with ankyloglossia, a condition restricting tongue mobility in infants, found that frenotomy may be associated with mother-reported improvements in breastfeeding, and potentially in nipple pain. Since the existing studies are small and short-term with inconsistent methodology, the strength of the evidence is low to insufficient.
AHRQ-funded; 290201200009I.
Citation: Francis DO, Krishnaswami S, Mcpheeters M .
Treatment of ankyloglossia and breastfeeding outcomes: a systematic review.
Pediatrics 2015 Jun;135(6):e1458-66. doi: 10.1542/peds.2015-0658..
Keywords: Breast Feeding, Outcomes, Comparative Effectiveness, Evidence-Based Practice, Newborns/Infants
Chinnadurai S, Francis DO, Epstein RA
Treatment of ankyloglossia for reasons other than breastfeeding: a systematic review.
The researchers systematically reviewed literature on feeding, speech, and social outcomes of treatments for infants and children with ankyloglossia. After analyzing two randomized controlled trials, 2 cohort studies, and 11 case series assessing the effects of frenotomy on feeding, speech, and social outcomes, they determined that data are currently insufficient for assessing the effects of frenotomy on nonbreastfeeding outcomes that may be associated with ankyloglossia.
AHRQ-funded; 290201200009I.
Citation: Chinnadurai S, Francis DO, Epstein RA .
Treatment of ankyloglossia for reasons other than breastfeeding: a systematic review.
Pediatrics 2015 Jun;135(6):e1467-74. doi: 10.1542/peds.2015-0660..
Keywords: Breast Feeding, Children/Adolescents, Outcomes, Comparative Effectiveness
Juckett DA, Davis FN, Gostine M
Patient-reported outcomes in a large community-based pain medicine practice: evaluation for use in phenotype modeling.
The researchers aimed to build a phenotype-to-outcome model targeting chronic pain to be used to drive clinical decision support for pain medicine in the community setting. Exploratory factor analysis of the intake Pain Health Assessment revealed 15 orthogonal factors representing pain levels; physical, social, and emotional functions; the effects of pain on these functions; vitality and health; and measures of outcomes and satisfaction.
AHRQ-funded; HS022335.
Citation: Juckett DA, Davis FN, Gostine M .
Patient-reported outcomes in a large community-based pain medicine practice: evaluation for use in phenotype modeling.
BMC Med Inform Decis Mak 2015 May 28;15:41. doi: 10.1186/s12911-015-0164-4..
Keywords: Care Management, Chronic Conditions, Community-Based Practice, Electronic Health Records (EHRs), Health Information Technology (HIT), Outcomes, Pain
Jules-Elysee KM, Goon AK, Westrich GH
Patient-controlled epidural analgesia or multimodal pain regimen with periarticular injection after total hip arthroplasty: a randomized, double-blind, placebo-controlled study.
This randomized, double-blind, placebo-controlled study compared the use of patient-controlled epidural analgesia (PCEA) with use of a multimodal pain regimen including periarticular injection (PAI). It found that PAI did not decrease the time to discharge and was associated with higher pain scores and greater opioid consumption but lower ORSDS scores compared with PCEA.
AHRQ-funded; HS021734.
Citation: Jules-Elysee KM, Goon AK, Westrich GH .
Patient-controlled epidural analgesia or multimodal pain regimen with periarticular injection after total hip arthroplasty: a randomized, double-blind, placebo-controlled study.
J Bone Joint Surg Am 2015 May 20;97(10):789-98. doi: 10.2106/jbjs.n.00698..
Keywords: Medication, Opioids, Outcomes, Pain, Surgery
Walker J, Tucker LY, Goodney P
Adherence to endovascular aortic aneurysm repair device instructions for use guidelines has no impact on outcomes.
The authors reported on their long-term endovascular aortic aneurysm repair (EVAR) experience in a large multicenter registry with regard to adherence to instructions for use (IFU) guidelines. They found that overall mortality and aneurysm-related mortality were unaffected by IFU adherence, and that rates of endoleak and reintervention after initial EVAR were similar, suggesting that lack of IFU-based anatomic suitability was not a driver of outcomes.
AHRQ-funded; HS021581.
Citation: Walker J, Tucker LY, Goodney P .
Adherence to endovascular aortic aneurysm repair device instructions for use guidelines has no impact on outcomes.
J Vasc Surg 2015 May;61(5):1151-9. doi: 10.1016/j.jvs.2014.12.053.
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Keywords: Adverse Events, Guidelines, Medical Devices, Outcomes
Camelo Castillo W, Boggess K, Sturmer T
Association of adverse pregnancy outcomes with glyburide vs insulin in women with gestational diabetes.
The purpose of this study was to estimate the risks of adverse pregnancy outcomes among women receiving glyburide compared with insulin for the treatment of gestational diabetes mellitus (GDM) in a US population-based cohort. It found an association between glyburide (compared with insulin) and elevated risk of NICU admission, neonatal hypoglycemia, respiratory distress, birth injury, and large for gestational age in women with GDM.
AHRQ-funded; HS017950.
Citation: Camelo Castillo W, Boggess K, Sturmer T .
Association of adverse pregnancy outcomes with glyburide vs insulin in women with gestational diabetes.
JAMA Pediatr 2015 May;169(5):452-8. doi: 10.1001/jamapediatrics.2015.74..
Keywords: Adverse Drug Events (ADE), Adverse Events, Comparative Effectiveness, Diabetes, Labor and Delivery, Maternal Care, Medication, Newborns/Infants, Outcomes, Pregnancy, Women
Santos CA, Brennan DC, Chapman WC
Delayed-onset cytomegalovirus disease coded during hospital readmission in a multicenter, retrospective cohort of liver transplant recipients.
The researchers sought to determine the risk factors and outcomes of delayed-onset CMV disease among a representative cohort of liver transplant recipients from multiple centers. They found that delayed-onset CMV disease coded during hospital readmission occurred more commonly than early-onset CMV disease and that prior transplant failure or rejection was a risk factor for delayed-onset CMV disease.
AHRQ-funded; HS019455.
Citation: Santos CA, Brennan DC, Chapman WC .
Delayed-onset cytomegalovirus disease coded during hospital readmission in a multicenter, retrospective cohort of liver transplant recipients.
Liver Transpl 2015 May;21(5):581-90. doi: 10.1002/lt.24089..
Keywords: Healthcare Cost and Utilization Project (HCUP), Risk, Transplantation, Outcomes
Santos CA, Brennan DC, Chapman WC
Delayed-onset cytomegalovirus disease coded during hospital readmission in a multicenter, retrospective cohort of liver transplant recipients.
The researchers sought to determine the risk factors and outcomes associated with delayed-onset cytomegalovirus (CMV) disease among liver transplant recipients. Data from a group of 7,229 adult liver transplant recipients showed that delayed onset CMV disease was twice as likely as early onset CMV disease, with transplant failure or rejection being a risk factor.
AHRQ-funded; HS019455
Citation: Santos CA, Brennan DC, Chapman WC .
Delayed-onset cytomegalovirus disease coded during hospital readmission in a multicenter, retrospective cohort of liver transplant recipients.
Liver Transpl. 2015 May;21(5):581-90. doi: 10.1002/lt.24089..
Keywords: Outcomes, Transplantation, Quality of Care, Chronic Conditions