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Research Studies is a monthly compilation of research articles funded by AHRQ or authored by AHRQ researchers and recently published in journals or newsletters.
Results1 to 5 of 5 Research Studies Displayed
Hersh AL, Gerber JS, Hicks LA
Lessons learned in antibiotic stewardship: fluoroquinolone use in pediatrics.
For adults, fluoroquinolones are the leading class of antibiotics prescribed in ambulatory care visits, whereas, in children, they are the least frequently prescribed class. This paper highlights the impact of physicians' perception of direct patient harm in antibiotic decision making which has implications for antibiotic stewardship.
Citation: Hersh AL, Gerber JS, Hicks LA . Lessons learned in antibiotic stewardship: fluoroquinolone use in pediatrics. J Pediatric Infect Dis Soc 2015 Mar;4(1):57-9. doi: 10.1093/jpids/piu044.
Keywords: Antibiotics, Children/Adolescents, Medication, Children/Adolescents, Practice Patterns
Sore throat: avoid overcomplicating the uncomplicated.
In this editorial, the author described issues involving sore throat diagnosis and delineated various points concerning an article within the same journal issue, concluding that physicians should remember that the prevalence of group A streptococcus in adults with a sore throat is approximately 10%; and that they should use the Centor scoring criteria; selectively use rapid antigen-detection testing; limit antibiotic treatment to patients most likely to have group A streptococcus; and most of the time when prescribing antibiotics, use penicillin.
Citation: Linder JA . Sore throat: avoid overcomplicating the uncomplicated. Ann Intern Med 2015 Feb 17;162(4):311-2. doi: 10.7326/m14-2899.
Keywords: Antibiotics, Diagnostic Safety and Quality, Infectious Diseases, Medication, Pneumonia, Respiratory Conditions, Practice Patterns
Downes KJ, Rao MB, Kahill L
Daily serum creatinine monitoring promotes earlier detection of acute kidney injury in children and adolescents with cystic fibrosis.
The purpose of this study was to determine the impact of daily serum creatinine (SCr) measurement on amino-glycoside (AG)-associated acute kidney injury detection among patients with cystic fibrosis (CF). The study included 87 patients at a children’s hospital who received a total of 227 AG courses of 3 days or more.
Citation: Downes KJ, Rao MB, Kahill L . Daily serum creatinine monitoring promotes earlier detection of acute kidney injury in children and adolescents with cystic fibrosis. J Cyst Fibros. 2014 Jul;13(4):435-41. doi: 10.1016/j.jcf.2014.03.005..
Keywords: Adverse Drug Events (ADE), Antibiotics, Children/Adolescents, Medication, Respiratory Conditions
Barnett ML, Linder JA
Antibiotic prescribing for adults with acute bronchitis in the United States, 1996-2010.
To estimate the association of ongoing CDC efforts to reduce antibiotic prescribing for acute bronchitis, the researchers evaluated the change in antibiotic prescribing rates for this condition in the U.S. between 1996 and 2010. They found that the antibiotic prescribing rate for this condition was 71 percent initially and increased during the study period.
Citation: Barnett ML, Linder JA . Antibiotic prescribing for adults with acute bronchitis in the United States, 1996-2010. JAMA. 2014 May 21;311(19):2020-2. doi: 10.1001/jama.2013.286141..
Keywords: Antibiotics, Antimicrobial Stewardship, Healthcare Utilization, Medication
Barnett ML, Linder JA
Antibiotic prescribing to adults with sore throat in the United States, 1997-2010.
In only about 10 percent of cases of sore throat (those related to A Streptococcus infection) are antibiotics indicated. However, a new study, combined with an earlier study, finds that despite efforts to reduce overprescribing, antibiotic use dropped from roughly 80 to 70 percent around 1993 and then to around 60 percent by 2000 where it has remained as of 2010.
Citation: Barnett ML, Linder JA . Antibiotic prescribing to adults with sore throat in the United States, 1997-2010. JAMA Intern Med. 2014 Jan;174(1):138-40. doi: 10.1001/jamainternmed.2013.11673..
Keywords: Antibiotics, Antimicrobial Stewardship, Medication, Healthcare Utilization