National Healthcare Quality and Disparities Report
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AHRQ Research Studies
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Research Studies is a compilation of published research articles funded by AHRQ or authored by AHRQ researchers.
Results
1 to 25 of 57 Research Studies DisplayedPotosky AL, O'Neill SC, Isaacs C
Population-based study of the effect of gene expression profiling on adjuvant chemotherapy use in breast cancer patients under the age of 65 years.
The authors evaluated the relation between gene expression profiling (GEP) testing and the use of adjuvant chemotherapy by women treated in a general oncology practice. They found that adjuvant chemotherapy use after GEP testing is generally consistent with the recommended test interpretation for women with a high or low predicted risk of recurrence. Chemotherapy use in the intermediate-risk group increased with Recurrence Score values, and evidence from ongoing randomized trials may help to clarify whether this finding reflects optimal interpretation of GEP test results.
AHRQ-funded; HS022915.
Citation: Potosky AL, O'Neill SC, Isaacs C .
Population-based study of the effect of gene expression profiling on adjuvant chemotherapy use in breast cancer patients under the age of 65 years.
Cancer 2015 Nov 15;121(22):4062-70. doi: 10.1002/cncr.29621.
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Keywords: Cancer, Cancer: Breast Cancer, Treatments, Decision Making, Genetics, Practice Patterns, Women
Dinan MA, Mi X, Reed SD
Association between use of the 21-gene recurrence score assay and receipt of chemotherapy among Medicare beneficiaries with early-stage breast cancer, 2005-2009.
The researchers examined whether adoption of the 21-Gene Recurrence Score (RS) assay in a nationally representative sample of patients with early-stage breast cancer was associated with use of chemotherapy. They found that the impact of the adoption of the RS assay on receipt of chemotherapy was strongly population dependent and was associated with relatively lower chemotherapy use in groups with high-risk disease and relatively higher chemotherapy use in patients with low-risk disease.
AHRQ-funded; HS022189.
Citation: Dinan MA, Mi X, Reed SD .
Association between use of the 21-gene recurrence score assay and receipt of chemotherapy among Medicare beneficiaries with early-stage breast cancer, 2005-2009.
JAMA Oncol 2015 Nov 1;1(8):1098-109. doi: 10.1001/jamaoncol.2015.2722..
Keywords: Cancer, Cancer: Breast Cancer, Treatments, Genetics, Medicare, Women
Crandall CJ, Hovey KM, Andrews CA
Bone mineral density as a predictor of subsequent wrist fractures: findings from the Women's Health Initiative Study.
This paper's objective was to examine associations between the Fracture Risk Assessment Tool (FRAX)-predicted risk of major osteoporotic fracture (MOF), bone mineral density (BMD), BMD change, and wrist fracture. Results showed that lumbar spine and femoral neck BMDs were associated with incident wrist fracture, but the FRAX threshold recommended to identify screening candidates did not identify the majority of women who subsequently experienced wrist fracture.
AHRQ-funded; HS023009.
Citation: Crandall CJ, Hovey KM, Andrews CA .
Bone mineral density as a predictor of subsequent wrist fractures: findings from the Women's Health Initiative Study.
J Clin Endocrinol Metab 2015 Nov;100(11):4315-24. doi: 10.1210/jc.2015-2568.
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Keywords: Injuries and Wounds, Osteoporosis, Risk, Women
Upadhya KK, Burke AE, Marcell AV
AHRQ Author: Mistry K
Contraceptive service needs of women with young children presenting for pediatric care.
The primary objective of this study was to characterize the need for contraceptive services and contraceptive method use among women with young children presenting to child health clinics. It found that most women presenting with young children for pediatric care indicated that they were not currently trying to become pregnant and reported current methods of pregnancy prevention that ranged from none to highly effective.
AHRQ-authored.
Citation: Upadhya KK, Burke AE, Marcell AV .
Contraceptive service needs of women with young children presenting for pediatric care.
Contraception 2015 Nov;92(5):508-12. doi: 10.1016/j.contraception.2015.07.004..
Keywords: Pregnancy, Women, Sexual Health
Schussler-Fiorenza Rose SM, Gangnon RE, Chewning B
Increasing discussion rates of incontinence in primary care: a randomized controlled trial.
The study’s aim was to evaluate whether the use of an electronic pelvic floor assessment questionnaire (ePAQ-PF) improves communication about incontinence in primary care. It found that use of the ePAQ-PF prior to clinic visits increases discussion of urinary and fecal incontinence, particularly clinician-initiated discussion.
AHRQ-funded; HS017028.
Citation: Schussler-Fiorenza Rose SM, Gangnon RE, Chewning B .
Increasing discussion rates of incontinence in primary care: a randomized controlled trial.
J Womens Health 2015 Nov;24(11):940-9. doi: 10.1089/jwh.2015.5230..
Keywords: Clinician-Patient Communication, Communication, Primary Care, Women
Heslin KC, Gable A, Dobalian A
AHRQ Author: Heslin KC
Special services for women in substance use disorders treatment: how does the Department of Veterans Affairs compare with other providers?
The researchers examined the prevalence of programs and key services for women in VA facilities in a survey of 14,311 substance use disorder treatment facilities. Approximately 31 percent of facilities had special programs exclusively for women. Although the VA had the lowest prevalence of programs for women, at 19.1 percent, it offered a significantly higher average number of key services for women.
AHRQ-authored.
Citation: Heslin KC, Gable A, Dobalian A .
Special services for women in substance use disorders treatment: how does the Department of Veterans Affairs compare with other providers?
Womens Health Issues 2015 Nov-Dec;25(6):666-72. doi: 10.1016/j.whi.2015.07.005.
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Keywords: Substance Abuse, Women, Healthcare Delivery
Patnode CD, Henderson JT, Thompson JH
Behavioral counseling and pharmacotherapy interventions for tobacco cessation in adults, including pregnant women: a review of reviews for the U.S. Preventive Services Task Force.
The researchers reviewed the effectiveness and safety of pharmacotherapy and behavioral interventions for tobacco cessation. They concluded that behavioral and pharmacotherapy interventions improve rates of smoking cessation among the general adult population, alone or in combination. Data on the effectiveness and safety of electronic nicotine delivery systems are limited.
AHRQ-funded; 290201200015I.
Citation: Patnode CD, Henderson JT, Thompson JH .
Behavioral counseling and pharmacotherapy interventions for tobacco cessation in adults, including pregnant women: a review of reviews for the U.S. Preventive Services Task Force.
Ann Intern Med 2015 Oct 20;163(8):608-21. doi: 10.7326/m15-0171..
Keywords: Behavioral Health, Evidence-Based Practice, Medication, Pregnancy, Prevention, Tobacco Use, U.S. Preventive Services Task Force (USPSTF), Women
Highfield L, Rajan SS, Valerio MA
A non-randomized controlled stepped wedge trial to evaluate the effectiveness of a multi-level mammography intervention in improving appointment adherence in underserved women.
This study evaluated a theoretically based, systematically designed implementation strategy to support adoption and implementation of a patient navigation-based intervention, called Peace of Mind Program (PMP), aimed at improving breast cancer screening among underserved women.. Any potential confounding or bias will be controlled in the analysis. Outcomes such as appointment adherence, patient referral to diagnostics, time to diagnostic referral, patient referral to treatment, time to treatment referral, and budget impact of the intervention will be assessed.
AHRQ-funded; HS023255.
Citation: Highfield L, Rajan SS, Valerio MA .
A non-randomized controlled stepped wedge trial to evaluate the effectiveness of a multi-level mammography intervention in improving appointment adherence in underserved women.
Implement Sci 2015 Oct 14;10:143. doi: 10.1186/s13012-015-0334-x.
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Keywords: Cancer: Breast Cancer, Cancer, Screening, Patient Adherence/Compliance, Women, Vulnerable Populations, Prevention, Imaging
Hernandez I, Zhang Y
Comparing clinical and economic outcomes of biologic and conventional medications in postmenopausal women with osteoporosis.
This study compared clinical and economic outcomes between teriparatide (monthly costs $1120) and bisphosphonates (monthly costs $14) among postmenopausal women with osteoporosis. It found that teriparatide users had higher risk of fracture and higher costs, compared with similar bisphosphonates users. The hazard ratios of fracture for teriparatide relative to bisphosphonates ranged from 1.37 to 2.12, depending on methods.
AHRQ-funded; HS018657.
Citation: Hernandez I, Zhang Y .
Comparing clinical and economic outcomes of biologic and conventional medications in postmenopausal women with osteoporosis.
J Eval Clin Pract 2015 Oct;21(5):840-7. doi: 10.1111/jep.12389.
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Keywords: Medication, Women, Osteoporosis, Healthcare Costs
Feldman DS, Bollman DL, Fridman M
Do laborists improve delivery outcomes for laboring women in California community hospitals?
The researchers sought to determine the impact of the laborists staffing model on cesarean rates and maternal morbidity in California community hospitals. They were unable to demonstrate differences in cesarean and maternal childbirth complication rates in community hospitals with and without laborists.
AHRQ-funded; HS020915.
Citation: Feldman DS, Bollman DL, Fridman M .
Do laborists improve delivery outcomes for laboring women in California community hospitals?
Am J Obstet Gynecol 2015 Oct;213(4):587.e1-87.e13. doi: 10.1016/j.ajog.2015.05.051..
Keywords: Labor and Delivery, Outcomes, Patient Safety, Women
Mortel M, Rauscher GH, Murphy AM
Racial and ethnic disparity in symptomatic breast cancer awareness despite a recent screen: the role of tumor biology and mammography facility characteristics.
In a racially and ethnically diverse sample of recently diagnosed urban patients with breast cancer, the researchers examined associations of patient, tumor biology, and mammography facility characteristics on the probability of symptomatic discovery of their breast cancer despite a recent prior screening mammogram. They concluded that facility resources and tumor aggressiveness explain much of the racial/ethnic disparity in symptomatic breast cancer among recently screened patients.
AHRQ-funded; HS018366.
Citation: Mortel M, Rauscher GH, Murphy AM .
Racial and ethnic disparity in symptomatic breast cancer awareness despite a recent screen: the role of tumor biology and mammography facility characteristics.
Cancer Epidemiol Biomarkers Prev 2015 Oct;24(10):1599-606. doi: 10.1158/1055-9965.epi-15-0305.
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Keywords: Cancer: Breast Cancer, Cancer, Disparities, Women, Racial and Ethnic Minorities, Screening, Prevention
Jones SM, Gell NM, Roth JA
The relationship of perceived risk and biases in perceived risk to fracture prevention behavior in older women.
The researchers compared perceived risk and biases in perceived risk for fracture to fracture preventive behavior. They found that higher perceived risk was related to lower quality of life and self-reported health, more medication and calcium use, increased bone density scan use, and less walking. Bias was only associated with less medication use. Neither perceived risk nor bias predicted medication adherence.
AHRQ-funded; HS022982.
Citation: Jones SM, Gell NM, Roth JA .
The relationship of perceived risk and biases in perceived risk to fracture prevention behavior in older women.
Ann Behav Med 2015 Oct;49(5):696-703. doi: 10.1007/s12160-015-9702-7.
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Keywords: Injuries and Wounds, Women, Risk, Prevention, Education: Patient and Caregiver
Cha S, Chapman DA, Wan W
Intimate partner violence and postpartum contraceptive use: the role of race/ethnicity and prenatal birth control counseling.
The objective of the study was to examine the extent to which intimate partner violence (IPV) around the time of pregnancy is associated with postpartum contraceptive use among women in the United States. Approximately 6.2 percent of women reported IPV, and 15.5 percent reported no postpartum contraceptive use. Regardless of the timing of abuse, IPV-exposed women were significantly less likely to report contraceptive use after delivery.
AHRQ-funded; HS023724.
Citation: Cha S, Chapman DA, Wan W .
Intimate partner violence and postpartum contraceptive use: the role of race/ethnicity and prenatal birth control counseling.
Contraception 2015 Sep;92(3):268-75. doi: 10.1016/j.contraception.2015.04.009..
Keywords: Domestic Violence, Sexual Health, Women, Pregnancy
Pu J, Zhao B, Wang EJ
Racial/ethnic differences in gestational diabetes prevalence and contribution of common risk factors.
This study aimed to assess racial/ethnic differences in relative contribution of risk factors of gestational diabetes mellitus (GDM) among Asian subgroups (Asian Indian, Chinese, Filipino, Japanese, Korean, and Vietnamese), Hispanics, non-Hispanic blacks, and non-Hispanic whites. It found that GDM was most prevalent among Asian Indians (19.3 percent). Relative risks were similar across all race/ethnic groups.
AHRQ-funded; HS019815.
Citation: Pu J, Zhao B, Wang EJ .
Racial/ethnic differences in gestational diabetes prevalence and contribution of common risk factors.
Paediatr Perinat Epidemiol 2015 Sep;29(5):436-43. doi: 10.1111/ppe.12209.
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Keywords: Diabetes, Obesity, Pregnancy, Racial and Ethnic Minorities, Risk, Women
Conover MM, Howell JO, Wu JM
Incidence of opioid-managed pelvic pain after hysteroscopic sterilization versus laparoscopic sterilization, US 2005-2012.
The researchers compared the incidence of opioid-managed pelvic pain within 12 months after hysteroscopic and laparoscopic sterilization. They found that among women without recent history of childbirth, there was no compelling evidence of a clinically meaningful increase in the incidence of pelvic pain requiring opioids during the year after hysteroscopic sterilization.
AHRQ-funded; HS017950.
Citation: Conover MM, Howell JO, Wu JM .
Incidence of opioid-managed pelvic pain after hysteroscopic sterilization versus laparoscopic sterilization, US 2005-2012.
Pharmacoepidemiol Drug Saf 2015 Aug;24(8):875-84. doi: 10.1002/pds.3766..
Keywords: Comparative Effectiveness, Medication, Opioids, Pain, Women
Bertrand KA, Baer HJ, Orav EJ
Body fatness during childhood and adolescence and breast density in young women: a prospective analysis.
The authors examined associations of early life body fatness with adult breast density in 182 women in the Dietary Intervention Study in Children (DISC) who were ages 25-29 at follow-up. Their results support the hypothesis that body fatness during childhood and adolescence may play an important role in premenopausal breast density, independent of current BMI, and further suggest direct or indirect influences on absolute dense breast volume.
AHRQ-funded; HS019789.
Citation: Bertrand KA, Baer HJ, Orav EJ .
Body fatness during childhood and adolescence and breast density in young women: a prospective analysis.
Breast Cancer Res 2015 Jul 16;17:95. doi: 10.1186/s13058-015-0601-4.
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Keywords: Cancer: Breast Cancer, Children/Adolescents, Obesity, Women
Thomas HN, Hess R, Thurston RC
Correlates of sexual activity and satisfaction in midlife and older women.
The authors gave updated prevalence estimates of sexual activity among women and elucidated factors associated with sexual activity and sexual satisfaction. Using the National Survey of Midlife Development in the United States, they found that a considerable proportion of midlife and older women remain sexually active if they have a partner available. Additionally, psychosocial factors matter more to sexual satisfaction than aging among midlife and older women.
AHRQ-funded; HS022989.
Citation: Thomas HN, Hess R, Thurston RC .
Correlates of sexual activity and satisfaction in midlife and older women.
Ann Fam Med 2015 Jul-Aug;13(4):336-42. doi: 10.1370/afm.1820.
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Keywords: Elderly, Women, Sexual Health, Quality of Life
Shorten A, Fagerlin A, Illuzzi J
Developing an Internet-based decision aid for women choosing between vaginal birth after cesarean and planned repeat cesarean.
This article is part of a series that address midwifery innovations in clinical practice, education, interprofessional collaboration, health policy, and global health. The authors outlined a framework and process used to create an Internet-based decision aid about birth choices after previous cesarean. They transformed a paper-based decision aid into a secure, interactive Web site to meet the diverse needs of women and providers.
AHRQ-funded; HS022114.
Citation: Shorten A, Fagerlin A, Illuzzi J .
Developing an Internet-based decision aid for women choosing between vaginal birth after cesarean and planned repeat cesarean.
J Midwifery Womens Health 2015 Jul-Aug;60(4):390-400. doi: 10.1111/jmwh.12298.
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Keywords: Decision Making, Health Information Technology (HIT), Pregnancy, Web-Based, Women
Andrews SE, Alston MJ, Allshouse AA
Does the number of forceps deliveries performed in residency predict use in practice?
The researchers aimed to determine whether a threshold number of forceps deliveries in residency predicts use of forceps in independent practice. They concluded that, although exceeding 13 forceps deliveries made it highly likely that obstetricians would use them in practice, further study is necessary to set goals for a number of resident forceps deliveries that translate into use in practice.
AHRQ-funded; HS022143.
Citation: Andrews SE, Alston MJ, Allshouse AA .
Does the number of forceps deliveries performed in residency predict use in practice?
Am J Obstet Gynecol 2015 Jul;213(1):93.e1-4. doi: 10.1016/j.ajog.2015.03.025..
Keywords: Labor and Delivery, Patient-Centered Outcomes Research, Practice Patterns, Training, Women
Scifres CM, Abebe KZ, Jones KA
Gestational diabetes diagnostic methods (GD2M) pilot randomized trial.
The researchers tested the feasibility of conducting a pragmatic randomized controlled trial (RCT) comparing the International Association of Diabetes in Pregnancy Study Groups (IADPSG) versus Carpenter-Coustan diagnostic criteria for gestational diabetes (GDM), and examined patient and provider views on GDM screening. They found that both pregnant women and providers value GDM screening, and pregnant women can be recruited to a blinded, randomized GDM screening trial with minimal attrition and missing data.
AHRQ-funded; HS019461.
Citation: Scifres CM, Abebe KZ, Jones KA .
Gestational diabetes diagnostic methods (GD2M) pilot randomized trial.
Matern Child Health J 2015 Jul;19(7):1472-80. doi: 10.1007/s10995-014-1651-4..
Keywords: Diabetes, Diagnostic Safety and Quality, Pregnancy, Screening, Women
Irvin VL, Breen N, Meissner HI
AHRQ Author: Kaplan RM
Non-normal screening mammography results, lumpectomies, and breast cancer reported by California women, 2001-2009.
This study report trends in self-reported non-normal screening mammography results, lumpectomies, and breast cancer in California women. Between 2001 and 2009, the percent of California women who reported having been diagnosed with breast cancer was relatively stable. For each of the three age groups studied, the percentage of non-normal mammography results increased and the percentages of lumpectomies decreased.
AHRQ-authored.
Citation: Irvin VL, Breen N, Meissner HI .
Non-normal screening mammography results, lumpectomies, and breast cancer reported by California women, 2001-2009.
AHRQ-authored..
Keywords: Cancer: Breast Cancer, Cancer, Screening, Imaging, Women
Tang JW, Foster KE, Pumarino J
Perspectives on prevention of type 2 diabetes after gestational diabetes: a qualitative study of Hispanic, African-American and White women.
This qualitative study explored the perspectives of Hispanic, African-American, and White women affected by gestational diabetes mellitus (GDM). The goal is for this work to inform the development of effective approaches to engage diverse populations affected by GDM in taking steps to reduce their risk for type 2 diabetes mellitus.
AHRQ-funded; HS021141.
Citation: Tang JW, Foster KE, Pumarino J .
Perspectives on prevention of type 2 diabetes after gestational diabetes: a qualitative study of Hispanic, African-American and White women.
Matern Child Health J 2015 Jul;19(7):1526-34. doi: 10.1007/s10995-014-1657-y..
Keywords: Diabetes, Lifestyle Changes, Pregnancy, Prevention, Racial and Ethnic Minorities, Risk, Women
Suskind AM, Clemens JQ, Zhang Y
Physician use of sacral neuromodulation among Medicare beneficiaries with overactive bladder and urinary retention.
This study identified physician-level factors associated with high rates of sacral neuromodulation testing. It found that, over time, physicians are testing more patients but are not implanting more devices. Additionally, there is an inverse relationship between rates of device testing and implantation, suggesting opportunities to improve efficiency and resource utilization.
AHRQ-funded; HS018726.
Citation: Suskind AM, Clemens JQ, Zhang Y .
Physician use of sacral neuromodulation among Medicare beneficiaries with overactive bladder and urinary retention.
Urology 2015 Jul;86(1):30-4. doi: 10.1016/j.urology.2015.04.003..
Keywords: Elderly, Medicare, Treatments, Women
Kim SC, Glynn RJ, Giovannucci E
Risk of high-grade cervical dysplasia and cervical cancer in women with systemic inflammatory diseases: a population-based cohort study.
This study assessed the risk of high-grade cervical dysplasia, a surrogate endpoint for cervical cancer and cervical cancer, in women with systemic inflammatory diseases (SID), including IBD, psoriasis, rheumatoid arthritis (RA) or systemic lupus erythematosus (SLE), compared with the risk in women without SID. It found that the risk of high-grade cervical dysplasia and cervical cancer was 1.5 times higher in women with RA and SLE than in those without SID.
AHRQ-funded; HS018533.
Citation: Kim SC, Glynn RJ, Giovannucci E .
Risk of high-grade cervical dysplasia and cervical cancer in women with systemic inflammatory diseases: a population-based cohort study.
Ann Rheum Dis 2015 Jul;74(7):1360-7. doi: 10.1136/annrheumdis-2013-204993..
Keywords: Arthritis, Risk, Women, Cancer: Cervical Cancer, Cancer
Atkins DN, Bradford WD
Association between increased emergency contraception availability and risky sexual practices.
The researchers use a national survey of youth to explore the relationship between increased emergency contraception (EC) availability and the probability of risky sexual practices for women over age 18. They found that FDA approval of behind the counter sales of an EC pill was associated with a reduction in the probability of sexual activity, and in the likelihood of reporting multiple partnerships; however, there was no relationship between the new policy and unprotected sexual activity.
AHRQ-funded; HS011326
Citation: Atkins DN, Bradford WD .
Association between increased emergency contraception availability and risky sexual practices.
Health Serv Res. 2015 Jun;50(3):809-29. doi: 10.1111/1475-6773.12251.
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Keywords: Women, Sexual Health, Young Adults, Policy