National Healthcare Quality and Disparities Report
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Topics
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- (-) Vaccination (28)
AHRQ Research Studies
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Research Studies is a compilation of published research articles funded by AHRQ or authored by AHRQ researchers.
Results
1 to 25 of 28 Research Studies DisplayedFitzpatrick MC, Shah HA, Pandey A
One Health approach to cost-effective rabies control in India.
The authors developed a data-driven rabies transmission model fit to human rabies autopsy data and human rabies surveillance data from Tamil Nadu, India. They found that highly feasible strategies focused on stray dogs, vaccinating as few as 7% of dogs annually, could very cost-effectively reduce human rabies deaths by 70% within 5 years, and a modest expansion to vaccinating 13% of stray dogs could cost-effectively reduce human rabies by almost 90%. Futher, if owners are willing to bring dogs to central point campaigns at double the rate that campaign teams can capture strays, expanded annual targets become cost-effective.
AHRQ-funded; HS000055.
Citation: Fitzpatrick MC, Shah HA, Pandey A .
One Health approach to cost-effective rabies control in India.
Proc Natl Acad Sci U S A 2016 Dec 20;113(51):14574-81. doi: 10.1073/pnas.1604975113.
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Keywords: Healthcare Costs, Infectious Diseases, Prevention, Vaccination
Wiese AD, Griffin MR, Zhu Y
Changes in empyema among U.S. children in the pneumococcal conjugate vaccine era.
The authors assessed changes in the incidence of empyema hospitalizations among U.S. children after the PCV13 vaccine introduction. They found that although empyema hospitalization rates among U.S. children peaked after the PCV7 vaccine introduction, rates decreased substantially following the introduction of PCV13.
AHRQ-funded; HS022342.
Citation: Wiese AD, Griffin MR, Zhu Y .
Changes in empyema among U.S. children in the pneumococcal conjugate vaccine era.
Vaccine 2016 Dec 7;34(50):6243-49. doi: 10.1016/j.vaccine.2016.10.062.
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Keywords: Children/Adolescents, Healthcare Cost and Utilization Project (HCUP), Hospitalization, Vaccination
Bilinski AM, Fitzpatrick MC, Rupprecht CE
Optimal frequency of rabies vaccination campaigns in Sub-Saharan Africa.
The purpose of this paper was to evaluate the cost-effectiveness of rabies canine vaccination campaigns at varying coverage and frequency. The researchers, studying two districts of northwest Tanzania, found that optimal vaccination strategies were every 2 years, at 80% coverage in Ngorongoro and annually at 70% coverage in Serengeti. They further found that coordinated campaigns may provide monetary savings in addition to public health benefits. They concluded that frequency and coverage of canine vaccination campaigns should be evaluated simultaneously and tailored to local canine ecology as well as to the risk of disease reintroduction from surrounding regions.
AHRQ-funded; HS000055.
Citation: Bilinski AM, Fitzpatrick MC, Rupprecht CE .
Optimal frequency of rabies vaccination campaigns in Sub-Saharan Africa.
Proc Biol Sci 2016 Nov 16;283(1842). doi: 10.1098/rspb.2016.1211.
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Keywords: Patient Safety, Prevention, Vaccination
Denman DC, Baldwin AS, Marks EG
Modification and validation of the Treatment Self Regulation Questionnaire to assess parental motivation for HPV vaccination of adolescents.
The researchers investigated measures of motivation for HPV vaccination using confirmatory factor analysis to test a three-factor measurement model. Their findings support the use of three subscales to measure motivation in HPV vaccination and suggest possible cultural differences in motivation.
AHRQ-funded; HS022418.
Citation: Denman DC, Baldwin AS, Marks EG .
Modification and validation of the Treatment Self Regulation Questionnaire to assess parental motivation for HPV vaccination of adolescents.
Vaccine 2016 Sep 22;34(41):4985-90. doi: 10.1016/j.vaccine.2016.08.037.
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Keywords: Children/Adolescents, Education: Patient and Caregiver, Infectious Diseases, Patient and Family Engagement, Vaccination
Shay LA, Street RL, Jr., Baldwin AS
Characterizing safety-net providers' HPV vaccine recommendations to undecided parents: a pilot study.
The researchers developed a tool to describe strength and content of provider HPV vaccination recommendations. The tool showed how providers undercut their recommendations through qualifications or support them with a rationale. The authors recommended that providers would benefit from communication skills training on how to make explicit recommendations with an evidence-based rationale.
AHRQ-funded; HS022418.
Citation: Shay LA, Street RL, Jr., Baldwin AS .
Characterizing safety-net providers' HPV vaccine recommendations to undecided parents: a pilot study.
Patient Educ Couns 2016 Sep;99(9):1452-60. doi: 10.1016/j.pec.2016.06.027.
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Keywords: Practice Patterns, Vaccination, Infectious Diseases, Sexual Health, Clinician-Patient Communication, Guidelines, Evidence-Based Practice, Communication
Tate JE, Yen C, Steiner CA
AHRQ Author: Steiner CA
Intussusception rates before and after the introduction of rotavirus vaccine.
The researchers examined trends in intussusception hospitalizations before (2000-2005) and after (2007-2013) rotavirus vaccine introduction to assess whether this observed temporal risk translates into more hospitalized cases at the population level. They concluded that, given the magnitude of declines in rotavirus disease compared with this small increase in intussusception, the benefits of rotavirus vaccination outweigh the increase risk of intussusception.
AHRQ-authored.
Citation: Tate JE, Yen C, Steiner CA .
Intussusception rates before and after the introduction of rotavirus vaccine.
Pediatrics 2016 Sep;138(3). doi: 10.1542/peds.2016-1082.
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Keywords: Healthcare Cost and Utilization Project (HCUP), Vaccination, Adverse Drug Events (ADE), Hospitalization
de St Maurice A, Schaffner W, Griffin MR
Persistent sex disparities in invasive pneumococcal diseases in the conjugate vaccine era.
The authors examined sex differences in rates of invasive pneumococcal disease (IPD) and trends after the introduction of pneumococcal conjugate vaccines (PCVs). They concluded that rates of IPD were generally higher in male than in female subjects.
AHRQ-funded; HS022342.
Citation: de St Maurice A, Schaffner W, Griffin MR .
Persistent sex disparities in invasive pneumococcal diseases in the conjugate vaccine era.
J Infect Dis 2016 Sep 01;214(5):792-7. doi: 10.1093/infdis/jiw222.
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Keywords: Pneumonia, Sex Factors, Vaccination, Prevention
Yun H, Yang S, Chen L
Risk of herpes zoster in autoimmune and inflammatory diseases: implications for vaccination.
This study was undertaken to evaluate the age-stratified incidence of herpes zoster (HZ) in patients with autoimmune or inflammatory (AI) diseases as compared to older adults for whom the HZ vaccine is currently recommended by the US Centers for Disease Control and Prevention. The researchers found that systemic lupus erythematosus, inflammatory bowel disease, and rheumatoid arthritis are AI diseases associated with a higher risk of HZ compared to that in older adults for whom vaccination is currently recommended, suggesting that individuals with these conditions who are as young as age 40 years could potentially benefit from the HZ vaccine.
AHRQ-funded; HS021694; HS018517.
Citation: Yun H, Yang S, Chen L .
Risk of herpes zoster in autoimmune and inflammatory diseases: implications for vaccination.
Arthritis Rheumatol 2016 Sep;68(9):2328-37. doi: 10.1002/art.39670.
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Keywords: Infectious Diseases, Prevention, Arthritis, Risk, Sexual Health, Vaccination
Trogdon JG, Shafer PR, Shah PD
Are state laws granting pharmacists authority to vaccinate associated with HPV vaccination rates among adolescents?
Researchers explored whether state laws allowing pharmacists to administer human papillomavirus (HPV) vaccinations to adolescents are associated with a higher likelihood of HPV vaccine uptake. They concluded that, as currently implemented, state laws allowing pharmacists to administer HPV vaccine to adolescents were not associated with uptake.
AHRQ-funded; HS000032.
Citation: Trogdon JG, Shafer PR, Shah PD .
Are state laws granting pharmacists authority to vaccinate associated with HPV vaccination rates among adolescents?
Vaccine 2016 Aug 31;34(38):4514-19. doi: 10.1016/j.vaccine.2016.07.056.
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Keywords: Children/Adolescents, Infectious Diseases, Policy, Provider: Pharmacist, Vaccination
Haidari LA, Brown ST, Constenla D
The economic value of increasing geospatial access to tetanus toxoid immunization in Mozambique.
The researchers assessed how well tetanus toxoid (TT) immunization locations meet population demand in Mozambique. They found that TT immunization locations are not geographically accessible by a significant proportion of pregnant women, resulting in substantial healthcare and productivity costs that could potentially be averted by adding or reconfiguring TT immunization locations.
AHRQ-funded; HS023317.
Citation: Haidari LA, Brown ST, Constenla D .
The economic value of increasing geospatial access to tetanus toxoid immunization in Mozambique.
Vaccine 2016 Jul 29;34(35):4161-65. doi: 10.1016/j.vaccine.2016.06.065.
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Keywords: Access to Care, Healthcare Costs, Health Services Research (HSR), Pregnancy, Vaccination
Haidari LA, Brown ST, Ferguson M
The economic and operational value of using drones to transport vaccines.
Using a simulation model, the researchers performed sensitivity analyses to assess the impact of using an unmanned aerial system (UAS) for routine vaccine distribution under a range of circumstances . They found that implementing a UAS could increase vaccine availability and decrease costs in a wide range of settings and circumstances if the drones are used frequently enough to overcome the capital costs of installing and maintaining the system.
AHRQ-funded; HS023317.
Citation: Haidari LA, Brown ST, Ferguson M .
The economic and operational value of using drones to transport vaccines.
Vaccine 2016 Jul 25;34(34):4062-7. doi: 10.1016/j.vaccine.2016.06.022.
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Keywords: Health Information Technology (HIT), Healthcare Costs, Vaccination
Simons BC, Spradling PR, Bruden DJ
A longitudinal hepatitis B vaccine cohort demonstrates long-lasting hepatitis B virus (HBV) cellular immunity despite loss of antibody against HBV surface antigen.
The purpose of this paper is to determine long-lasting protection resulting from hepatitis B vaccine, despite loss of antibody against hepatitis B virus (HBV) surface antigen (anti-HBs). All participants tested positive for tumor necrosis factor α, interleukin 10, or interleukin 6 production by HBV surface antigen-specific T cells. No participant had evidence of breakthrough HBV infection. The authors concluded that protection afforded by primary immunization with plasma-derived hepatitis B vaccine during childhood and adulthood lasts at least 32 years.
AHRQ-funded; HS000046.
Citation: Simons BC, Spradling PR, Bruden DJ .
A longitudinal hepatitis B vaccine cohort demonstrates long-lasting hepatitis B virus (HBV) cellular immunity despite loss of antibody against HBV surface antigen.
J Infect Dis 2016 Jul 15;214(2):273-80. doi: 10.1093/infdis/jiw142.
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Keywords: Hepatitis, Prevention, Vaccination
Mueller LE, Haidari LA, Wateska AR
The impact of implementing a demand forecasting system into a low-income country's supply chain.
The authors evaluated the potential impact and value of applications of data from demand forecasting systems implemented in a lower-income country's vaccine supply chain with different levels of population change to urban areas. They used their HERMES software to study Niger's entire vaccine supply chain and found that demand forecasting systems have the potential to greatly improve vaccine demand fulfilment, and decrease logistics cost/dose, when implemented with storage and transportation increases.
AHRQ-funded; HS023317.
Citation: Mueller LE, Haidari LA, Wateska AR .
The impact of implementing a demand forecasting system into a low-income country's supply chain.
Vaccine 2016 Jul 12;34(32):3663-9. doi: 10.1016/j.vaccine.2016.05.027.
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Keywords: Access to Care, Health Services Research (HSR), Low-Income, Medication, Vaccination
Shah MP, Tate JE, Steiner CA
AHRQ Author: Steiner CA
Decline in emergency department visits for acute gastroenteritis among children in 10 US states after implementation of rotavirus vaccination, 2003-2013.
The researchers compared the rates of gastroenteritis- and rotavirus-coded ED visits among children <5 years of age in pre-rotavirus vaccine (2003 to 2006) with those in postvaccine (2008-2013) years; 2007 was excluded as a transition year They concluded that. ED visits for gastroenteritis in US children have declined since the introduction of rotavirus vaccine.
AHRQ-authored.
Citation: Shah MP, Tate JE, Steiner CA .
Decline in emergency department visits for acute gastroenteritis among children in 10 US states after implementation of rotavirus vaccination, 2003-2013.
Pediatr Infect Dis J 2016 Jul;35(7):782-6. doi: 10.1097/inf.0000000000001175.
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Keywords: Healthcare Cost and Utilization Project (HCUP), Children/Adolescents, Vaccination, Emergency Medical Services (EMS), Digestive Disease and Health
Wiese AD, Grijalva CG, Zhu Y
Changes in childhood pneumonia hospitalizations by race and sex associated with pneumococcal conjugate vaccines.
Introduction of pneumococcal conjugate vaccines in the childhood immunization schedule was associated with decreases in all-cause pneumonia hospitalizations among black and white children in Tennessee, USA. Although racial disparities that existed before introduction of these vaccines have been substantially reduced, rates remain higher in boys than in girls among young children.
AHRQ-funded; HS022342.
Citation: Wiese AD, Grijalva CG, Zhu Y .
Changes in childhood pneumonia hospitalizations by race and sex associated with pneumococcal conjugate vaccines.
Emerg Infect Dis 2016 Jun;22(6). doi: 10.3201/eid2206.152023.
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Keywords: Hospitalization, Vaccination, Children/Adolescents, Racial and Ethnic Minorities
Stockwell MS, Natarajan K, Ramakrishnan R
Immunization data exchange with electronic health records.
The researchers assessed the impact of exchange of immunization information between an immunization information system (IIS) and an electronic health record on up-to-date rates, overimmunization, and immunization record completeness for low-income, urban children and adolescents. Their findings demonstrated that data exchange can improve child and adolescent immunization status.
AHRQ-funded; HS022667.
Citation: Stockwell MS, Natarajan K, Ramakrishnan R .
Immunization data exchange with electronic health records.
Pediatrics 2016 Jun;137(6). doi: 10.1542/peds.2015-4335.
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Keywords: Children/Adolescents, Communication, Electronic Health Records (EHRs), Health Information Exchange (HIE), Health Information Technology (HIT), Vaccination
Hu T, Decker SL, Chou SY
AHRQ Author: Decker SL
Medicaid pay for performance programs and childhood immunization status.
This national study examined the effects of pay for performance (P4P) programs on childhood immunization rates. It found no overall effect of Medicaid P4P on the chance that children aged 19-35 months had completed the 4:3:1:3:3:1 vaccination series. However, there was a 4 percentage point increase in the chance that a child 19-23 months had completed the series.
AHRQ-authored.
Citation: Hu T, Decker SL, Chou SY .
Medicaid pay for performance programs and childhood immunization status.
Am J Prev Med 2016 May;50(5 Suppl 1):S51-7. doi: 10.1016/j.amepre.2016.01.012.
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Keywords: Newborns/Infants, Children/Adolescents, Medicaid, Vaccination, Payment, Health Insurance
Bartsch SM, Hotez PJ, Hertenstein DL
Modeling the economic and epidemiologic impact of hookworm vaccine and mass drug administration (MDA) in Brazil, a high transmission setting.
The authors evaluated the potential economic and epidemiologic impact of a preventive hookworm vaccine. A pediatric hookworm vaccine drastically decreased hookworm prevalence in children. A booster in adulthood further reduced the overall prevalence and nearly eliminated hookworm infection in children. The authors conclude that a human hookworm vaccine would provide both health benefits and cost savings.
AHRQ-funded; HS023317.
Citation: Bartsch SM, Hotez PJ, Hertenstein DL .
Modeling the economic and epidemiologic impact of hookworm vaccine and mass drug administration (MDA) in Brazil, a high transmission setting.
Vaccine 2016 Apr 27;34(19):2197-206. doi: 10.1016/j.vaccine.2016.03.018.
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Keywords: Vaccination, Healthcare Costs, Children/Adolescents, Newborns/Infants
Strom MA, Silverberg JI
Utilization of preventive health care in adults and children with eczema.
This study examined associations of eczema with vaccination, disease screening, health maintenance, and healthcare utilization. Childhood eczema was associated with higher rates of vaccination for influenza; well child checkups; and interaction with most types of healthcare providers . Adult eczema was associated with higher odds of vaccination for various diseases. It was also associated with increased measurement of blood glucose; cholesterol; blood pressure and HIV infection.
AHRQ-funded; HS023011.
Citation: Strom MA, Silverberg JI .
Utilization of preventive health care in adults and children with eczema.
Am J Prev Med 2016 Feb;50(2):e33-44. doi: 10.1016/j.amepre.2015.07.029.
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Keywords: Vaccination, Prevention, Screening, Healthcare Utilization, Patient-Centered Outcomes Research
Saville AW, Gurfinkel D, Sevick C
Provider preferences and experiences with a countywide centralized collaborative reminder/recall for childhood immunizations.
The researchers assessed among providers in Colorado where a collaborative centralized reminder/recall (CC-R/R) using the Colorado Immunization Information System (CIIS) was performed: 1) preferences about CC-R/R conducted by the public health department (PHD); and 2) experiences with including their name on CC-R/R notices. Most practices are accepting of the PHD centrally conducting R/R, but most prefer collaboration that includes their name.
AHRQ-funded; HS021138.
Citation: Saville AW, Gurfinkel D, Sevick C .
Provider preferences and experiences with a countywide centralized collaborative reminder/recall for childhood immunizations.
Acad Pediatr 2016 Jan-Feb;16(1):50-6. doi: 10.1016/j.acap.2015.09.002.
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Keywords: Public Health, Vaccination, Health Information Technology (HIT), Children/Adolescents, Practice Patterns
Fiscella K
Tackling disparities in influenza vaccination in primary care: it takes a team.
This article discusses a study in the same issue by Maurer. Fiscella describes reasons involving influenza vaccination disparities and points out that the emergence of accountable care organizations creates opportunities for better integration of primary care and public health.
AHRQ-funded; HS022440.
Citation: Fiscella K .
Tackling disparities in influenza vaccination in primary care: it takes a team.
J Gen Intern Med 2014 Dec;29(12):1579-81. doi: 10.1007/s11606-014-2999-2.
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Keywords: Disparities, Influenza, Primary Care, Teams, Vaccination
Geynisman DM, Chien CR, Smieliauskas F
Economic evaluation of therapeutic cancer vaccines and immunotherapy: a systematic review.
The researchers performed a comprehensive literature review of cost and cost-effectiveness research on therapeutic cancer vaccines and monoclonal antibodies, to better understand the economic impacts of these treatments. They discussed the implications surrounding the economic factors involved in cancer immunotherapies and suggested that further research on cost and cost-effectiveness of newer cancer vaccines and immunotherapies were warranted as this is a rapidly growing field with many new drugs on the horizon.
AHRQ-funded; HS018535.
Citation: Geynisman DM, Chien CR, Smieliauskas F .
Economic evaluation of therapeutic cancer vaccines and immunotherapy: a systematic review.
Hum Vaccin Immunother 2014;10(11):3415-24. doi: 10.4161/hv.29407.
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Keywords: Cancer, Healthcare Costs, Vaccination
Ahrens KA, Louik C, Kerr S
Seasonal influenza vaccination during pregnancy and the risks of preterm delivery and small for gestational age birth.
The researchers examined the associations between seasonal influenza vaccination during pregnancy and the risks of PTD and SGA among a multiyear retrospective cohort of pregnancies. With the exception of pre-term delivery (PTD) associated with the 2009–10 seasonal vaccine, they found no meaningful increases in PTD or small for gestational age risks associated with seasonal trivalent influenza vaccination during pregnancy.
AHRQ-funded; HS018463.
Citation: Ahrens KA, Louik C, Kerr S .
Seasonal influenza vaccination during pregnancy and the risks of preterm delivery and small for gestational age birth.
Paediatr Perinat Epidemiol 2014 Nov;28(6):498-509. doi: 10.1111/ppe.12152..
Keywords: Influenza, Vaccination, Pregnancy, Labor and Delivery
Campbell LJ, Li Q, Li Y
Healthcare worker influenza vaccination in Oregon nursing homes: correlates of facility characteristics.
The authors identified nursing home (NH) characteristics that may be associated with employee influenza vaccination rates (EVRs). They concluded that, as NHs generally have low EVRs, it may be necessary to target low-performing facilities to achieve substantial improvements.
AHRQ-funded; HS000044.
Citation: Campbell LJ, Li Q, Li Y .
Healthcare worker influenza vaccination in Oregon nursing homes: correlates of facility characteristics.
J Am Med Dir Assoc 2014 Oct;15(10):768-72. doi: 10.1016/j.jamda.2014.06.005.
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Keywords: Provider: Health Personnel, Influenza, Nursing Homes, Prevention, Vaccination
Perry LM, Winthrop KL, Curtis JR
Vaccinations for rheumatoid arthritis.
The goal of this paper is to highlight the most recent literature on the key vaccines and the specific considerations for the rheumatologist and their rheumatoid arthritis (RA) patients, with a particular focus on influenza, pneumococcal, and herpes zoster vaccines. It is important for rheumatologists to understand which vaccines are live and what potential contraindications exist for giving vaccines to RA patients.
AHRQ-funded; HS018517
Citation: Perry LM, Winthrop KL, Curtis JR .
Vaccinations for rheumatoid arthritis.
Curr Rheumatol Rep. 2014 Aug;16(8):431. doi: 10.1007/s11926-014-0431-x..
Keywords: Arthritis, Vaccination, Prevention