National Healthcare Quality and Disparities Report
Latest available findings on quality of and access to health care
Data
- Data Infographics
- Data Visualizations
- Data Tools
- Data Innovations
- All-Payer Claims Database
- Healthcare Cost and Utilization Project (HCUP)
- Medical Expenditure Panel Survey (MEPS)
- AHRQ Quality Indicator Tools for Data Analytics
- State Snapshots
- United States Health Information Knowledgebase (USHIK)
- Data Sources Available from AHRQ
Search All Research Studies
AHRQ Research Studies Date
Topics
- Adverse Drug Events (ADE) (1)
- Antibiotics (2)
- Arthritis (2)
- Autism (2)
- Back Health and Pain (2)
- Behavioral Health (5)
- Blood Pressure (2)
- Blood Thinners (2)
- Cancer (2)
- Cancer: Breast Cancer (1)
- Cancer: Colorectal Cancer (1)
- Cancer: Ovarian Cancer (1)
- Cardiovascular Conditions (6)
- Caregiving (2)
- Case Study (1)
- Catheter-Associated Urinary Tract Infection (CAUTI) (1)
- Central Line-Associated Bloodstream Infections (CLABSI) (1)
- Children/Adolescents (9)
- Chronic Conditions (4)
- Clinical Decision Support (CDS) (1)
- Clinician-Patient Communication (3)
- Clostridium difficile Infections (1)
- Colonoscopy (1)
- Communication (4)
- Community-Based Practice (1)
- Community Partnerships (1)
- Comparative Effectiveness (25)
- Complementary and Alternative Medicine (2)
- Cultural Competence (1)
- Data (7)
- Decision Making (10)
- Dementia (1)
- Depression (3)
- Diabetes (2)
- Diagnostic Safety and Quality (3)
- Disparities (2)
- Education: Continuing Medical Education (1)
- Elderly (2)
- Emergency Department (1)
- Emergency Medical Services (EMS) (2)
- (-) Evidence-Based Practice (115)
- Falls (1)
- Family Health and History (1)
- Genetics (1)
- Guidelines (36)
- Healthcare-Associated Infections (HAIs) (2)
- Healthcare Delivery (4)
- Healthcare Utilization (1)
- Health Information Technology (HIT) (2)
- Health Insurance (1)
- Health Promotion (2)
- Health Services Research (HSR) (5)
- Health Systems (1)
- Heart Disease and Health (3)
- Home Healthcare (1)
- Hospitals (3)
- Human Immunodeficiency Virus (HIV) (2)
- Implementation (5)
- Infectious Diseases (1)
- Injuries and Wounds (2)
- Inpatient Care (1)
- Intensive Care Unit (ICU) (1)
- Kidney Disease and Health (1)
- Lifestyle Changes (2)
- Long-Term Care (1)
- Maternal Care (1)
- Medicaid (1)
- Medical Devices (1)
- Medical Errors (1)
- Medicare (1)
- Medication (16)
- Newborns/Infants (1)
- Nursing (2)
- Nursing Homes (2)
- Nutrition (5)
- Obesity (3)
- Opioids (2)
- Outcomes (7)
- Pain (2)
- Palliative Care (2)
- Patient-Centered Healthcare (2)
- Patient-Centered Outcomes Research (33)
- Patient and Family Engagement (5)
- Patient Experience (2)
- Patient Safety (8)
- Patient Self-Management (2)
- Policy (2)
- Practice Patterns (2)
- Pregnancy (2)
- Pressure Ulcers (1)
- Prevention (15)
- Primary Care (2)
- Provider (2)
- Provider: Physician (2)
- Quality Improvement (6)
- Quality of Care (6)
- Quality of Life (1)
- Racial and Ethnic Minorities (1)
- Registries (2)
- Research Methodologies (31)
- Respiratory Conditions (2)
- Risk (4)
- Rural Health (2)
- Screening (7)
- Sex Factors (1)
- Skin Conditions (1)
- Sleep Problems (3)
- Surgery (7)
- TeamSTEPPS (2)
- Telehealth (1)
- Tools & Toolkits (2)
- Training (3)
- Trauma (1)
- Treatments (2)
- U.S. Preventive Services Task Force (USPSTF) (12)
- Urinary Tract Infection (UTI) (2)
- Vitamins and Supplements (2)
- Vulnerable Populations (1)
- Women (4)
AHRQ Research Studies
Sign up: AHRQ Research Studies Email updates
Research Studies is a compilation of published research articles funded by AHRQ or authored by AHRQ researchers.
Results
1 to 25 of 115 Research Studies DisplayedCooper LB, Lippmann SJ, Greiner MA
Use of mineralocorticoid receptor antagonists in patients with heart failure and comorbid diabetes mellitus or chronic kidney disease.
Perceived risks of hyperkalemia and acute renal insufficiency may limit use of mineralocorticoid receptor antagonist (MRA) therapy in patients with heart failure, especially those with diabetes mellitus or chronic kidney disease. In their study, the investigators found that among patients with heart failure and diabetes mellitus or chronic kidney disease, MRA use was associated with lower risk of all-cause readmission despite greater risk of hyperkalemia and acute renal insufficiency.
AHRQ-funded; HS021092.
Citation: Cooper LB, Lippmann SJ, Greiner MA .
Use of mineralocorticoid receptor antagonists in patients with heart failure and comorbid diabetes mellitus or chronic kidney disease.
J Am Heart Assoc 2017 Dec 23;6(12):pii: e006540. doi: 10.1161/jaha.117.006540..
Keywords: Cardiovascular Conditions, Chronic Conditions, Diabetes, Evidence-Based Practice, Heart Disease and Health, Kidney Disease and Health, Outcomes, Patient-Centered Outcomes Research, Registries
Chou R, Korthuis PT, McCarty D
Management of suspected opioid overdose with naloxone in out-of-hospital settings: a systematic review.
This review synthesized evidence on 1) the effects of naloxone route of administration and dosing for suspected opioid overdose in out-of-hospital settings on mortality, reversal of overdose, and harms, and 2) the need for transport to a health care facility. It concluded that higher-concentration intranasal naloxone (2 mg/mL) seems to have efficacy similar to that of intramuscular naloxone for reversal of opioid overdose, with no difference in adverse events.
AHRQ-funded; 290201500009I.
Citation: Chou R, Korthuis PT, McCarty D .
Management of suspected opioid overdose with naloxone in out-of-hospital settings: a systematic review.
Ann Intern Med 2017 Dec 19;167(12):867-75. doi: 10.7326/m17-2224.
.
.
Keywords: Emergency Medical Services (EMS), Evidence-Based Practice, Medication, Opioids, Patient-Centered Outcomes Research
Gartlehner G, Patel SV, Feltner C
Hormone therapy for the primary prevention of chronic conditions in postmenopausal women: evidence report and systematic review for the US Preventive Services Task Force.
This review updated evidence for the US Preventive Services Task Force on the benefits and harms of hormone therapy in reducing risks for chronic conditions. It concluded that hormone therapy for the primary prevention of chronic conditions in menopausal women is associated with some beneficial effects but also with a substantial increase of risks for harms. The available evidence regarding benefits and harms of early initiation of hormone therapy is inconclusive.
AHRQ-funded; 290201200015I.
Citation: Gartlehner G, Patel SV, Feltner C .
Hormone therapy for the primary prevention of chronic conditions in postmenopausal women: evidence report and systematic review for the US Preventive Services Task Force.
JAMA 2017 Dec 12;318(22):2234-49. doi: 10.1001/jama.2017.16952.
.
.
Keywords: Chronic Conditions, Evidence-Based Practice, Guidelines, Prevention, U.S. Preventive Services Task Force (USPSTF), Women
Mistry KB, Forrest CB
AHRQ Author: Mistry KB
Applying evidence from clinical trials: need for pediatric learning health system research.
The authors argue that to fill the many gaps in the understanding of major depressive disorder management (and more generally, the pediatric knowledge base), a new approach for augmenting the conventional randomized controlled trial is needed. They believe that the emerging field of learning health system research addresses this need.
AHRQ-authored.
Citation: Mistry KB, Forrest CB .
Applying evidence from clinical trials: need for pediatric learning health system research.
Pediatrics 2017 Dec;140(6). doi: 10.1542/peds.2017-3098.
.
.
Keywords: Depression, Evidence-Based Practice, Health Systems, Children/Adolescents
Asher GN, Gartlehner G, Gaynes BN
Comparative benefits and harms of complementary and alternative medicine therapies for initial treatment of major depressive disorder: systematic review and meta-analysis.
The objective of this study was to report the comparative benefits and harms of exercise and complementary and alternative medicine (CAM) treatments with second-generation antidepressants (SGA) for major depressive disorder (MDD). The investigators indicated that although they found little difference in the comparative efficacy of most CAM therapies or exercise and SGAs, the overall poor quality of the available evidence base tempers any conclusions that they might draw from those trials.
AHRQ-funded; 290201200008I.
Citation: Asher GN, Gartlehner G, Gaynes BN .
Comparative benefits and harms of complementary and alternative medicine therapies for initial treatment of major depressive disorder: systematic review and meta-analysis.
Journal Altern Complement Med 2017 Dec;23(12):907-19. doi: 10.1089/acm.2016.0261..
Keywords: Comparative Effectiveness, Complementary and Alternative Medicine, Depression, Evidence-Based Practice, Behavioral Health
Kemper AR, Fan T, Grossman DC
AHRQ Author: Fan T
Gaps in evidence regarding iron deficiency anemia in pregnant women and young children: summary of US Preventive Services Task Force recommendations.
The USPSTF found insufficient evidence to recommend routine iron supplementation for pregnant women or routine screening for iron deficiency anemia in pregnant women or young children. The USPSTF identified a critical evidence gap that is related to whether changing hematologic indexes in otherwise asymptomatic pregnant women or in infants within populations who are reflective of the United States leads to an improvement in maternal or child health outcomes.
AHRQ-authored.
Citation: Kemper AR, Fan T, Grossman DC .
Gaps in evidence regarding iron deficiency anemia in pregnant women and young children: summary of US Preventive Services Task Force recommendations.
Am J Clin Nutr 2017 Dec;106(Suppl 6):1555s-58s. doi: 10.3945/ajcn.117.155788.
.
.
Keywords: Children/Adolescents, Evidence-Based Practice, Maternal Care, U.S. Preventive Services Task Force (USPSTF)
Aslakson R, Dy SM, Wilson RF
Patient and caregiver-reported assessment tools for palliative care: summary of the 2017 AHRQ Technical Brief.
This paper summarizes palliative care assessment tools completed by or with patients or caregivers, and identifies needs for future tool development and evaluation. It concluded that few to no tools address the spiritual, ethical, or cultural domains or patient-reported experience with end of life care. While some data exists on psychometric properties of tools, the responsiveness of different tools to change and/or comparisons between tools have not been evaluated.
AHRQ-funded; 290201500006I.
Citation: Aslakson R, Dy SM, Wilson RF .
Patient and caregiver-reported assessment tools for palliative care: summary of the 2017 AHRQ Technical Brief.
J Pain Symptom Manage 2017 Dec;54(6):961-72.e16. doi: 10.1016/j.jpainsymman.2017.04.022.
.
.
Keywords: Caregiving, Evidence-Based Practice, Palliative Care, Patient Experience, Patient-Centered Outcomes Research
Dykewicz MS, Wallace DV, Baroody F
Treatment of seasonal allergic rhinitis: an evidence-based focused 2017 guideline update.
This article provides an evidence-based focused 2017 guideline update for the treatment of seasonal allergic rhinitis.
AHRQ-funded; HS024599
Citation: Dykewicz MS, Wallace DV, Baroody F .
Treatment of seasonal allergic rhinitis: an evidence-based focused 2017 guideline update.
Ann Allergy Asthma Immunol 2017 Dec;119(6):489-511.e41. doi: 10.1016/j.anai.2017.08.012..
Keywords: Evidence-Based Practice, Guidelines, Patient-Centered Outcomes Research
Ji X, Machiraju R, Ritter A
Visualizing article similarities via sparsified article network and map projection for systematic reviews.
In this study, the authors visualized article similarities to extend its utilization in practical settings for SR researchers, aiming to promote human comprehension of article distributions and hidden patterns. To prompt an effective visualization in an interpretable, intuitive, and scalable way, they implemented a graph-based network visualization with three network sparsification approaches and a distance-based map projection via dimensionality reduction.
AHRQ-funded; HS025047.
Citation: Ji X, Machiraju R, Ritter A .
Visualizing article similarities via sparsified article network and map projection for systematic reviews.
Stud Health Technol Inform 2017;245:422-26.
.
.
Keywords: Data, Evidence-Based Practice, Health Services Research (HSR), Research Methodologies
Ganiats TG, Bierman AS
AHRQ Author: Ganiats TG, Bierman AS
AHRQ's tools for better practice: helping family physicians manage today's challenges.
AHRQ is engaged in the dissemination and widespread implementation of what works in primary care. The agency’s main point of contact with the primary care community is the National Center for Excellence in Primary Care Research (NCEPCR). The authors discuss the variety of tools and resources made available by the NCEPCR.
AHRQ-authored.
Citation: Ganiats TG, Bierman AS .
AHRQ's tools for better practice: helping family physicians manage today's challenges.
Am Fam Physician 2017 Nov 1;96(9):569-70.
.
.
Keywords: Communication, Evidence-Based Practice, Provider: Physician, Primary Care, Tools & Toolkits
Kim DH, Uno H, Wei J
Restricted mean survival time as a measure to interpret clinical trial results.
In this article, the investigators explain how different measures of treatment effect are interpreted for evidence-based communication, and their caveats, using the 5-year follow- up data from the Placement of Aortic Transcatheter Valves (PARTNER) A and B trials as an example.
AHRQ-funded; HS022193.
Citation: Kim DH, Uno H, Wei J .
Restricted mean survival time as a measure to interpret clinical trial results.
JAMA Cardiol 2017 Nov;2(11):1179-80. doi: 10.1001/jamacardio.2017.2922..
Keywords: Cardiovascular Conditions, Evidence-Based Practice, Research Methodologies
Probst MA, Kanzaria HK, Schoenfeld EM
Shared decisionmaking in the emergency department: a guiding framework for clinicians.
The authors developed a simple framework to illustrate how shared decisionmaking should be approached in clinical practice. They believe it should be the preferred or default approach to decisionmaking, except in clinical situations in which 3 factors interfere. These 3 factors are lack of clinical uncertainty or equipoise, patient decisionmaking ability, and time, all of which can render shared decisionmaking infeasible. The authors next discuss how to address each factor.
AHRQ-funded; HS021271; HS024311.
Citation: Probst MA, Kanzaria HK, Schoenfeld EM .
Shared decisionmaking in the emergency department: a guiding framework for clinicians.
Ann Emerg Med 2017 Nov;70(5):688-95. doi: 10.1016/j.annemergmed.2017.03.063.
.
.
Keywords: Decision Making, Emergency Department, Emergency Medical Services (EMS), Evidence-Based Practice, Guidelines
Guise JM, Chang C, Butler M
AHRQ Author: Chang C
AHRQ series on complex intervention systematic reviews-paper 1: an introduction to a series of articles that provide guidance and tools for reviews of complex interventions.
The seven articles in this series reflect and distill the discussions from the in-person meeting and follow-up workgroups on tools and approaches to systematic reviews of complex interventions. The first three articles address how systematic reviews for complex interventions are conceptualized and operationalized for the protocol. The next two articles discuss how to choose appropriate analytic methods to implement analyses of complex interventions. The final two articles describe proposed reporting elements for systematic reviews of complex interventions.
AHRQ-authored; AHRQ-funded; 290201200004C; 290201200016I; 290201500011I.
Citation: Guise JM, Chang C, Butler M .
AHRQ series on complex intervention systematic reviews-paper 1: an introduction to a series of articles that provide guidance and tools for reviews of complex interventions.
J Clin Epidemiol 2017 Oct;90:6-10. doi: 10.1016/j.jclinepi.2017.06.011.
.
.
Keywords: Data, Evidence-Based Practice, Guidelines, Research Methodologies
Kelly MP, Noyes J, Kane RL
AHRQ Author: Chang C
AHRQ series on complex intervention systematic reviews-paper 2: defining complexity, formulating scope, and questions.
This paper builds on concepts introduced in paper 1 of this series. It describes the methodological, practical, and philosophical challenges and potential approaches for formulating the questions and scope of systematic reviews of complex interventions. Furthermore, it discusses the use of theory to help organize reviews of complex interventions.
AHRQ-authored; AHRQ-funded; 290-2012-00004-C; 290-2015-00008I; 290-2015-00011I.
Citation: Kelly MP, Noyes J, Kane RL .
AHRQ series on complex intervention systematic reviews-paper 2: defining complexity, formulating scope, and questions.
J Clin Epidemiol 2017 Oct;90:11-18. doi: 10.1016/j.jclinepi.2017.06.012.
.
.
Keywords: Data, Evidence-Based Practice, Guidelines, Research Methodologies
Butler M, Epstein RA, Totten A
AHRQ series on complex intervention systematic reviews-paper 3: adapting frameworks to develop protocols.
This article identifies and describes elements of frameworks and how they can be adapted to inform the protocol and conduct of systematic reviews of complex interventions. Possible approaches to analytic frameworks for complex interventions that illustrate causal and associative linkages are outlined, including time elements, which systematic reviews of complex interventions may need to address.
AHRQ-funded; 290201200004C; 290201500008I; 290201500005I; 290201500006I; 290201500010I.
Citation: Butler M, Epstein RA, Totten A .
AHRQ series on complex intervention systematic reviews-paper 3: adapting frameworks to develop protocols.
J Clin Epidemiol 2017 Oct;90:19-27. doi: 10.1016/j.jclinepi.2017.06.013.
.
.
Keywords: Comparative Effectiveness, Evidence-Based Practice, Patient-Centered Outcomes Research, Research Methodologies
Viswanathan M, McPheeters ML, Murad MH
AHRQ series on complex intervention systematic reviews-paper 4: selecting analytic approaches.
This article addresses the uncertainty that systematic reviewers face in selecting methods for reviews of complex interventions. Specifically, it lays out parameters for systematic reviewers to consider when selecting analytic approaches that best answer the questions at hand and suggests analytic techniques that may be appropriate in different circumstances.
AHRQ-funded; 290201200004C.
Citation: Viswanathan M, McPheeters ML, Murad MH .
AHRQ series on complex intervention systematic reviews-paper 4: selecting analytic approaches.
J Clin Epidemiol 2017 Oct;90:28-36. doi: 10.1016/j.jclinepi.2017.06.014.
.
.
Keywords: Data, Evidence-Based Practice, Guidelines, Research Methodologies
Pigott T, Noyes J, Umscheid CA
AHRQ series on complex intervention systematic reviews-paper 5: advanced analytic methods.
In this paper, the authors emphasize that the specific research question posed in the review should be used as a guide for choosing the appropriate analytic method. They present advanced analytic approaches that address some common questions that guide reviews of complex interventions such as: (1) How effective is the intervention? and (2) For whom does the intervention work and in what contexts?
AHRQ-funded; 290-2012-00004C; 290-2015-00005I; 290-2015-00004I; 290-2015-00009I; 290-2015-00013I; 290-2015-00011I; 290-2015-00003I.
Citation: Pigott T, Noyes J, Umscheid CA .
AHRQ series on complex intervention systematic reviews-paper 5: advanced analytic methods.
J Clin Epidemiol 2017 Oct;90:37-42. doi: 10.1016/j.jclinepi.2017.06.015.
.
.
Keywords: Decision Making, Evidence-Based Practice, Guidelines, Research Methodologies
Guise JM, Butler ME, Chang C
AHRQ series on complex intervention systematic reviews-paper 6: PRISMA-CI extension statement and checklist.
This paper provides a stand-alone extension to the Preferred Reporting Items for Systematic Reviews and Meta-analyses (PRISMA) reporting tool for complex interventions-PRISMA-CI-to help authors, publishers, and readers understand and apply to systematic reviews of complex interventions. PRISMA-CI development followed the Enhancing the QUAlity and Transparency Of health Research Network guidance for extensions and focused on adding or modifying only essential items.
AHRQ-funded; 290201200004C; 290201200016I; 290201500011I.
Citation: Guise JM, Butler ME, Chang C .
AHRQ series on complex intervention systematic reviews-paper 6: PRISMA-CI extension statement and checklist.
J Clin Epidemiol 2017 Oct;90:43-50. doi: 10.1016/j.jclinepi.2017.06.016.
.
.
Keywords: Evidence-Based Practice, Guidelines, Patient-Centered Outcomes Research, Research Methodologies
Guise JM, Butler M, Chang C
AHRQ Author: Chang C
AHRQ series on complex intervention systematic reviews-paper 7: PRISMA-CI elaboration and explanation.
The Complex Interventions Methods Workgroup developed an extension to the Preferred Reporting Items for Systematic Reviews and Meta-Analyses for Complex Interventions (PRISMA-CI). Following the guidance for Preferred Reporting Items for Systematic Reviews and Meta-Analysis extensions, this Explanation and Elaboration (EE) document accompanies the PRISMA-CI checklist to promote consistency in reporting of systematic reviews of complex interventions.
AHRQ-authored; AHRQ-funded; 290201200004C; 290201200016I; 290201500011I.
Citation: Guise JM, Butler M, Chang C .
AHRQ series on complex intervention systematic reviews-paper 7: PRISMA-CI elaboration and explanation.
J Clin Epidemiol 2017 Oct;90:51-58. doi: 10.1016/j.jclinepi.2017.06.017.
.
.
Keywords: Data, Evidence-Based Practice, Guidelines, Research Methodologies
Roghmann MC, Andronescu LR, Stucke EM
Clostridium difficile colonization of nursing home residents.
This letter to the editor notes that Clostridum difficile is a leading cause of infectious diarrhea in nursing homes and asserts that evidence-based infection control guidelines are needed to reduce transmission of C. difficile in these settings.
AHRQ-funded; HS019979.
Citation: Roghmann MC, Andronescu LR, Stucke EM .
Clostridium difficile colonization of nursing home residents.
Infect Control Hosp Epidemiol 2017 Oct;38(10):1267-68. doi: 10.1017/ice.2017.172..
Keywords: Clostridium difficile Infections, Evidence-Based Practice, Guidelines, Nursing Homes
Braun D, Gorfine M, Parmigiani G
Propensity scores with misclassified treatment assignment: a likelihood-based adjustment.
The researchers show that misclassification of treatment assignment can impact three distinct stages of a propensity score analysis. They examine how error in the treatment assignment impacts each stage in the context of three common propensity score implementations: subclassification, matching, and inverse probability of treatment weighting (IPTW). They propose a two-step likelihood-based approach which fully adjusts for treatment misclassification bias under subclassification
AHRQ-funded; HS021991.
Citation: Braun D, Gorfine M, Parmigiani G .
Propensity scores with misclassified treatment assignment: a likelihood-based adjustment.
Biostatistics 2017 Oct 1;18(4):695-710. doi: 10.1093/biostatistics/kxx014.
.
.
Keywords: Comparative Effectiveness, Evidence-Based Practice, Patient-Centered Outcomes Research, Research Methodologies
Ban KA, Gibbons MM, Ko CY
Surgical technical evidence review for colorectal surgery conducted for the AHRQ Safety Program for Improving Surgical Care and Recovery.
The objective of this article is to provide a comprehensive review of the evidence supporting the surgical components of the Improving Surgical Care and Recovery (ISCR) colorectal (CR) pathway. This review will evaluate the evidence supporting CR pathways and develop an evidence-based CR protocol to help hospitals participating in the ISCR program implement evidence-based practices.
AHRQ-funded; 233201500020I.
Citation: Ban KA, Gibbons MM, Ko CY .
Surgical technical evidence review for colorectal surgery conducted for the AHRQ Safety Program for Improving Surgical Care and Recovery.
J Am Coll Surg 2017 Oct;225(4):548-57.e3. doi: 10.1016/j.jamcollsurg.2017.06.017.
.
.
Keywords: Evidence-Based Practice, Hospitals, Patient Safety, Quality Improvement, Surgery, Quality of Care, Guidelines
Landsittel DP, Kessler L, Schmid CH
Training in patient-centered outcomes research for specific researcher communities.
A number of publications have discussed approaches to training the scientific workforce in comparative effectiveness research (CER) and patient-centered outcomes research (PCOR). To extend these efforts into specific researcher communities, the AHRQ developed a Funding Opportunity Announcement that called for training for a specific researcher community in collaboration with associated program partners. This paper describes the strategies developed by the 5 subsequently funded programs, and the challenges associated with developing in-person and online programs.
AHRQ-funded; HS023214; HS023199; HS023299; HS023207; HS023185.
Citation: Landsittel DP, Kessler L, Schmid CH .
Training in patient-centered outcomes research for specific researcher communities.
J Clin Transl Sci 2017 Oct;1(5):278-84. doi: 10.1017/cts.2017.307.
.
.
Keywords: Comparative Effectiveness, Evidence-Based Practice, Patient-Centered Outcomes Research, Research Methodologies, Training
Bykov K, Schneeweiss S, Glynn RJ
Updating the evidence of the interaction between clopidogrel and CYP2C19-inhibiting selective serotonin reuptake inhibitors: a cohort study and meta-analysis.
The aim of this study was to assess clinical outcomes following initiation of a CYP2C19-inhibiting selective serotonin reuptake inhibitor (SSRI) versus initiation of other SSRIs among patients treated with clopidogrel and to update existing evidence on the clinical impact of clopidogrel-SSRI interaction. It concluded that the updated evidence still indicates a small decrease in clopidogrel effectiveness associated with concomitant exposure to clopidogrel and CYP2C19-inhibiting SSRIs.
AHRQ-funded; HS023122.
Citation: Bykov K, Schneeweiss S, Glynn RJ .
Updating the evidence of the interaction between clopidogrel and CYP2C19-inhibiting selective serotonin reuptake inhibitors: a cohort study and meta-analysis.
Drug Saf 2017 Oct;40(10):923-32. doi: 10.1007/s40264-017-0556-8.
.
.
Keywords: Adverse Drug Events (ADE), Medication, Evidence-Based Practice, Patient-Centered Outcomes Research
Aarons GA, Sklar M, Mustanski B
"Scaling-out" evidence-based interventions to new populations or new health care delivery systems.
This paper introduces a new concept for implementation called "scaling-out" when evidence-based interventions are adapted either to new populations or new delivery systems, or both. Using existing external validity theories and multilevel mediation modeling, the authors provide a logical framework for determining what new empirical evidence is required for an intervention to retain its evidence-based standard in this new context.
AHRQ-funded; HS024192.
Citation: Aarons GA, Sklar M, Mustanski B .
"Scaling-out" evidence-based interventions to new populations or new health care delivery systems.
Implement Sci 2017 Sep 6;12(1):111. doi: 10.1186/s13012-017-0640-6..
Keywords: Healthcare Delivery, Evidence-Based Practice, Health Services Research (HSR)