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AHRQ Research Studies Date
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AHRQ Research Studies
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Research Studies is a compilation of published research articles funded by AHRQ or authored by AHRQ researchers.
Results
1 to 14 of 14 Research Studies DisplayedGephart SM, Hanson C, Wetzel CM
NEC-zero recommendations from scoping review of evidence to prevent and foster timely recognition of necrotizing enterocolitis.
The purpose of this paper is to present a scoping review with two new meta-analyses, clinical recommendations, and implementation strategies to prevent and foster timely recognition of necrotizing enterocolitis. The researchers conducted a stakeholder-engaged scoping review to classify strength of evidence and form implementation recommendations across subgroup areas: 1) promoting human milk, 2) feeding protocols and transfusion, 3) timely recognition strategies, and 4) medication stewardship.
AHRQ-funded; HS022908.
Citation: Gephart SM, Hanson C, Wetzel CM .
NEC-zero recommendations from scoping review of evidence to prevent and foster timely recognition of necrotizing enterocolitis.
Matern Health Neonatol Perinatol 2017 Dec;3:23. doi: 10.1186/s40748-017-0062-0.
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Keywords: Adverse Events, Digestive Disease and Health, Guidelines, Newborns/Infants, Prevention
Leeds IL, Canner JK, Efron JE
The independent effect of cancer on outcomes: a potential limitation of surgical risk prediction.
This study aims to compare the use of common risk models for benign versus malignant gastrointestinal disease. It found that the National Surgical Quality Improvement Program (NSQIP) prediction models less effectively evaluate the risk of death in cancer patients as compared to patients with benign disease. A diagnosis of cancer is independently associated with an increased risk of surgical complications.
AHRQ-funded; HS024736.
Citation: Leeds IL, Canner JK, Efron JE .
The independent effect of cancer on outcomes: a potential limitation of surgical risk prediction.
J Surg Res 2017 Dec;220:402-09.e6. doi: 10.1016/j.jss.2017.08.039.
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Keywords: Adverse Events, Cancer, Digestive Disease and Health, Risk, Surgery
Balbale SN, Trivedi I, O'Dwyer LC
Strategies to identify and reduce opioid misuse among patients with gastrointestinal disorders: a systematic scoping review.
In this study, the investigators conducted a systematic scoping review to describe published scientific literature on strategies to identify and reduce opioid misuse among patients with gastrointestinal (GI) symptoms and disorders. They concluded that prescription drug monitoring and self-management interventions may be promising strategies to identify and reduce opioid misuse in GI care. They suggest that rigorous, empirical research is needed to evaluate the longer-term impact of these strategies.
AHRQ-funded; HS000084.
Citation: Balbale SN, Trivedi I, O'Dwyer LC .
Strategies to identify and reduce opioid misuse among patients with gastrointestinal disorders: a systematic scoping review.
Dig Dis Sci 2017 Oct;62(10):2668-85. doi: 10.1007/s10620-017-4705-9..
Keywords: Behavioral Health, Chronic Conditions, Digestive Disease and Health, Medication, Medication: Safety, Opioids, Patient Self-Management, Prevention, Substance Abuse
Symer MM, Abelson JS, Milsom J
A mobile health application to track patients after gastrointestinal surgery: results from a pilot study.
Many surgical readmissions are preventable. Mobile health technology can identify nascent complications and potentially prevent readmission. The researchers performed a pilot study of a new mobile health application in adults undergoing major abdominal surgery and determined the app can track patient recovery from major abdominal surgery, is easy to use, and has potential to improve outcomes.
AHRQ-funded; HS000066.
Citation: Symer MM, Abelson JS, Milsom J .
A mobile health application to track patients after gastrointestinal surgery: results from a pilot study.
J Gastrointest Surg 2017 Sep;21(9):1500-05. doi: 10.1007/s11605-017-3482-2..
Keywords: Telehealth, Health Information Technology (HIT), Hospital Readmissions, Surgery, Adverse Events, Patient Safety, Digestive Disease and Health, Prevention
Feuille E, Menon NR, Huang F
Knowledge of food protein-induced enterocolitis syndrome among general pediatricians.
In this study, investigators examined knowledge of food protein-induced enterocolitis syndrome among general pediatricians. They created a 32-question survey, collecting information regarding participants’ experience with FPIES and knowledge of FPIES diagnosis and management. Investigators found that many pediatricians had a basic but incomplete understanding of FPIES diagnosis and initial management.
AHRQ-funded; HS024599.
Citation: Feuille E, Menon NR, Huang F .
Knowledge of food protein-induced enterocolitis syndrome among general pediatricians.
Ann Allergy Asthma Immunol 2017 Sep;119(3):291-92.e3. doi: 10.1016/j.anai.2017.07.001..
Keywords: Children/Adolescents, Digestive Disease and Health, Diagnostic Safety and Quality, Nutrition, Provider, Provider: Clinician, Provider: Physician
Karkar R, Schroeder J, Epstein DA
Tummytrials: a feasibility study of using self-experimentation to detect individualized food triggers.
The researchers designed, developed, and evaluated a mobile app that applies a self experimentation framework to support patients suffering from irritable bowel syndrome (IBS) in identifying their personal food triggers. In examining the feasibility of this approach in a field study with 15 IBS patients, they found that participants could use the tool to reliably undergo a self-experiment.
AHRQ-funded; HS023654.
Citation: Karkar R, Schroeder J, Epstein DA .
Tummytrials: a feasibility study of using self-experimentation to detect individualized food triggers.
Proc SIGCHI Conf Hum Factor Comput Syst 2017 May 2:6850-63. doi: 10.1145/3025453.3025480..
Keywords: Digestive Disease and Health, Health Information Technology (HIT), Nutrition, Patient Self-Management
Bounthavong M, Li M, Watanabe JH
An evaluation of health care expenditures in Crohn's disease using the United States Medical Expenditure Panel Survey from 2003 to 2013.
The goal of this study was to update cost estimates of Crohn's disease based on a representative sample of the US population from the most recent 11 years (2003-2013) of the Medical Expenditure Panel Survey (MEPS). A secondary aim was to describe expenditure trends in respondents with and without Crohn's disease pre-post FDA approvals of new biologics and the American College of Gastroenterology Crohn's disease treatment guidelines.
AHRQ-funded; HS013853.
Citation: Bounthavong M, Li M, Watanabe JH .
An evaluation of health care expenditures in Crohn's disease using the United States Medical Expenditure Panel Survey from 2003 to 2013.
Res Social Adm Pharm 2017 May-Jun;13(3):530-38. doi: 10.1016/j.sapharm.2016.05.042..
Keywords: Healthcare Costs, Digestive Disease and Health, Medical Expenditure Panel Survey (MEPS)
Stone B, Hester G, Jackson D
Effectiveness of fundoplication or gastrojejunal feeding in children with neurologic impairment.
Gastroesophageal reflux (GER), aspiration, and secondary complications lead to morbidity and mortality in children with neurologic impairment (NI), dysphagia, and gastrostomy feeding. Fundoplication and gastrojejunal (GJ) feeding can reduce risk. A comparison of GJ to fundoplication using first-year postprocedure reflux-related hospitalization (RRH) rates found that in children with NI, GER, and dysphagia,:fundoplication and GJ feeding have similar RRH outcomes.
AHRQ-funded; HS019862.
Citation: Stone B, Hester G, Jackson D .
Effectiveness of fundoplication or gastrojejunal feeding in children with neurologic impairment.
Hosp Pediatr 2017 Mar;7(3):140-48. doi: 10.1542/hpeds.2016-0126.
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Keywords: Children/Adolescents, Digestive Disease and Health, Neurological Disorders, Nutrition, Outcomes, Treatments
Predmore Z, Nie X, Main R
Anesthesia service use during outpatient gastroenterology procedures continued to increase from 2010 to 2013 and potentially discretionary spending remained high.
Previous studies have identified an increasing number of gastroenterology (GI) procedures using anesthesia services to provide sedation, with a majority of these services delivered to low-risk patients. The aim of this study was to update these trends with the most recent years of data. It found that during 2010 to 2013, anesthesia service use in GI procedures continued to increase and the proportion of these services rendered for low-risk patients remained high.
AHRQ-funded; HS000029.
Citation: Predmore Z, Nie X, Main R .
Anesthesia service use during outpatient gastroenterology procedures continued to increase from 2010 to 2013 and potentially discretionary spending remained high.
Am J Gastroenterol 2017 Feb;112(2):297-302. doi: 10.1038/ajg.2016.266.
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Keywords: Digestive Disease and Health, Ambulatory Care and Surgery, Healthcare Costs
Banerjee T, Meyer TW, Shafi T
Free and total p-cresol sulfate levels and infectious hospitalizations in hemodialysis patients in CHOICE and HEMO.
P-cresol sulfate (PCS), a prototype protein-bound uremic retention solute, has been shown to exert toxic effects in vitro. The researchers explored the relationship between free and total PCS and indoxyl sulfate (IS) with infection-related hospitalizations (IH) and septicemia in 2 cohorts. Their results suggest an association between higher concentrations of free PCS and infection-related and sepsis-related hospitalizations in hemodialysis patients.
AHRQ-funded; HS008365.
Citation: Banerjee T, Meyer TW, Shafi T .
Free and total p-cresol sulfate levels and infectious hospitalizations in hemodialysis patients in CHOICE and HEMO.
Medicine 2017 Feb;96(6):e5799. doi: 10.1097/md.0000000000005799.
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Keywords: Hospitalization, Kidney Disease and Health, Kidney Disease and Health, Digestive Disease and Health, Sepsis
Schroeder J, Hoffswell J, Chung CF
Supporting patient-provider collaboration to identify individual triggers using food and symptom journals.
The researchers examined patient-provider collaboration to interpret patient-generated data. Irritable bowel syndrome (IBS) management often requires patient-provider collaboration using a patient's food and symptom journal to identify the patient's triggers. Drawing upon individual and collaborative interviews with patients and providers, the researchers found that collaborative review helps improve data comprehension and build mutual trust.
AHRQ-funded; HS023654.
Citation: Schroeder J, Hoffswell J, Chung CF .
Supporting patient-provider collaboration to identify individual triggers using food and symptom journals.
CSCW 2017 Feb 25;2017:1726-39. doi: 10.1145/2998181.2998276.
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Keywords: Digestive Disease and Health, Health Information Technology (HIT), Nutrition, Clinician-Patient Communication, Patient Self-Management
Zia JK, Chung CF, Schroeder J
The feasibility, usability, and clinical utility of traditional paper food and symptom journals for patients with irritable bowel syndrome.
The primary aim of this study was to evaluate the feasibility, usability, and clinical utility of paper food and gastrointestinal symptom journals as a data collection tool. Over half of the 17 participants perceived paper journaling of food and symptoms as feasible, usable, and clinically useful. Thirteen participants demonstrated a strong association with at least one symptom and meal nutrient.
AHRQ-funded; HS023654.
Citation: Zia JK, Chung CF, Schroeder J .
The feasibility, usability, and clinical utility of traditional paper food and symptom journals for patients with irritable bowel syndrome.
Neurogastroenterol Motil 2017 Feb;29(2). doi: 10.1111/nmo.12935.
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Keywords: Digestive Disease and Health, Nutrition, Patient Experience, Patient Self-Management
Lee GJ, Dotson JL, Kappelman MD
Seasonality and pediatric inflammatory bowel disease.
The researchers sought to determine whether disease activity in pediatric-onset inflammatory bowel disease (IBD) is associated with a seasonal pattern. Studying 1325 patients with Crohn disease and 587 patients with ulcerative colitis, their findings do not support any strong associations between season of the year and disease activity in pediatric IBD.
AHRQ-funded; HS020024.
Citation: Lee GJ, Dotson JL, Kappelman MD .
Seasonality and pediatric inflammatory bowel disease.
J Pediatr Gastroenterol Nutr 2014 Jul;59(1):25-8. doi: 10.1097/mpg.0000000000000362.
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Keywords: Children/Adolescents, Digestive Disease and Health, Children/Adolescents
Liu TC, Gao F, McGovern DP
Spatial and temporal stability of paneth cell phenotypes in Crohn's disease: implications for prognostic cellular biomarker development.
The researchers sought to develop Paneth cell phenotype as a prognostic biomarker in Crohn’s disease by additional characterization building on their earlier research. Specifically, they examined the effects of disease activity, phenotype duration, and the minimal crypt number that would allow for accurate Paneth cell phenotyping. They demonstrated that Paneth cell phenotypes are not affected either by disease activity or by exposure to therapeutic agents.
AHRQ-funded; HS021747.
Citation: Liu TC, Gao F, McGovern DP .
Spatial and temporal stability of paneth cell phenotypes in Crohn's disease: implications for prognostic cellular biomarker development.
Inflamm Bowel Dis 2014 Apr;20(4):646-51. doi: 10.1097/01.MIB.0000442838.21040.d7..
Keywords: Chronic Conditions, Digestive Disease and Health