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AHRQ Research Studies
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Research Studies is a compilation of published research articles funded by AHRQ or authored by AHRQ researchers.
Results
1 to 24 of 24 Research Studies DisplayedBartsch SM, Taitel MS, DePasse JV
Epidemiologic and economic impact of pharmacies as vaccination locations during an influenza epidemic.
During an influenza epidemic, where early vaccination is crucial, pharmacies may be a resource to increase vaccine distribution reach and capacity. In this paper, the investigators utilized an agent-based model of the US and a clinical and economics outcomes model to simulate the impact of different influenza epidemics and the impact of utilizing pharmacies in addition to traditional (hospitals, clinic/physician offices, and urgent care centers) locations for vaccination for the year 2017.
AHRQ-funded; HS023317.
Citation: Bartsch SM, Taitel MS, DePasse JV .
Epidemiologic and economic impact of pharmacies as vaccination locations during an influenza epidemic.
Vaccine 2018 Nov 12;36(46):7054-63. doi: 10.1016/j.vaccine.2018.09.040..
Keywords: Healthcare Costs, Influenza, Provider: Pharmacist, Public Health, Vaccination
Wedlock PT, Mitgang EA, Siegmund SS
Dual-chamber injection device for measles-rubella vaccine: the potential impact of introducing varying sizes of the devices in 3 countries.
The purpose of this study was to identify the ideal size for dual-chamber injection devices used in routine immunization programs. Vaccine supply chain models of the Republic of Benin, the Republic of Mozambique, and Bihar were generated using the HERMES modeling software to simulate the effects of replacing a 10-dose lyophilized measles-rubella vaccine with single-dose, dual-chamber injection devices of varying sizes and prices. Optimal volume-per-dose was identified as either improving or causing no change in vaccine availability, wastage, or supply-chain costs in comparison to the existing program. The study concludes that a single-dose, dual-chamber measles-rubella injection device would need to be no larger than 5.2cm(3) to not significantly impair the flow of other vaccines.
AHRQ-funded; HS023317.
Citation: Wedlock PT, Mitgang EA, Siegmund SS .
Dual-chamber injection device for measles-rubella vaccine: the potential impact of introducing varying sizes of the devices in 3 countries.
Vaccine 2018 Sep 18;36(39):5879-85. doi: 10.1016/j.vaccine.2018.08.026..
Keywords: Public Health, Vaccination
Shah PD, Trogdon JG, Golden SD
Impact of pharmacists on access to vaccine providers: a geospatial analysis.
This study analyzed the impact of pharmacists on access to vaccines. The study concluded that pharmacists are more geographically dispersed across census tracts than primary care physicians. As a result, adding pharmacists to the workforce would increase the availability of vaccine providers in areas with inadequate primary care provider coverage.
AHRQ-funded; HS000032.
Citation: Shah PD, Trogdon JG, Golden SD .
Impact of pharmacists on access to vaccine providers: a geospatial analysis.
Milbank Q 2018 Sep;96(3):568-92. doi: 10.1111/1468-0009.12342.
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Keywords: Access to Care, Provider: Pharmacist, Vaccination
Shah PD, Calo WA, Marciniak MW
Support for pharmacist-provided HPV vaccination: national surveys of U.S. physicians and parents.
Cancer Epidemiol Biomarkers Prev 2018 Aug;27(8):970-78. doi: 10.1158/1055-9965.Epi-18-0380.
State laws about pharmacists providing human papillomavirus (HPV) vaccines vary considerably, limiting many pharmacists' ability to provide this important cancer prevention service. In this study, the investigators characterized physician and parent support for pharmacist-provided HPV vaccination for adolescents who are past due for vaccination. The authors concluded that to increase support for HPV vaccination services, pharmacists should raise awareness about their immunization training and standardize vaccination protocols that ensure coordination with primary care.
State laws about pharmacists providing human papillomavirus (HPV) vaccines vary considerably, limiting many pharmacists' ability to provide this important cancer prevention service. In this study, the investigators characterized physician and parent support for pharmacist-provided HPV vaccination for adolescents who are past due for vaccination. The authors concluded that to increase support for HPV vaccination services, pharmacists should raise awareness about their immunization training and standardize vaccination protocols that ensure coordination with primary care.
AHRQ-funded; HS000032.
Citation: Shah PD, Calo WA, Marciniak MW .
Support for pharmacist-provided HPV vaccination: national surveys of U.S. physicians and parents.
Cancer Epidemiol Biomarkers Prev 2018 Aug;27(8):970-78. doi: 10.1158/1055-9965.Epi-18-0380..
Keywords: Caregiving, Children/Adolescents, Infectious Diseases, Provider, Provider: Pharmacist, Provider: Physician, Vaccination
Daley MF, Narwaney KJ, Shoup JA
Addressing parents' vaccine concerns: a randomized trial of a social media intervention.
Successful strategies are needed to address parental vaccine hesitancy, a significant public health issue. The study objective was to assess whether an Internet-based platform with vaccine information and interactive social media components improved parents' vaccine-related attitudes. The authors concluded that among vaccine-hesitant parents, an Internet-based intervention improved parents' attitudes about vaccines.
AHRQ-funded; HS021492.
Citation: Daley MF, Narwaney KJ, Shoup JA .
Addressing parents' vaccine concerns: a randomized trial of a social media intervention.
Am J Prev Med 2018 Jul;55(1):44-54. doi: 10.1016/j.amepre.2018.04.010..
Keywords: Caregiving, Patient Safety, Social Media, Vaccination, Web-Based
Shah PD, Marciniak MW, Golden SD
Pharmacies versus doctors' offices for adolescent vaccination.
This study sought to understand the relative advantage of pharmacies compared to doctors' offices for delivering HPV vaccination to adolescents. The authors concluded that to be more appealing to parents as HPV vaccine providers, pharmacy providers within community and hospital settings should build on their relative advantage with respect to accessibility and enhance their appeal of their healthcare environment.
AHRQ-funded; HS000032.
Citation: Shah PD, Marciniak MW, Golden SD .
Pharmacies versus doctors' offices for adolescent vaccination.
Vaccine 2018 Jun 7;36(24):3453-59. doi: 10.1016/j.vaccine.2018.04.088..
Keywords: Children/Adolescents, Health Services Research (HSR), Ambulatory Care and Surgery, Provider: Pharmacist, Vaccination
Shay LA, Baldwin AS, Betts AC
Parent-provider communication of HPV vaccine hesitancy.
The authors of this study developed a typology characterizing parent-provider communication around the human papillomavirus (HPV) vaccine in order to assist providers in communicating more effectively with parents around HPV vaccine hesitancy. Visits with unvaccinated adolescents at six pediatric clinics in Dallas, Texas, in which parents were undecided about HPV vaccination, were audio-recorded. The parents’ verbal expression of hesitancy and whether the providers responded with acquiescence and/or persistence were qualitatively coded, and the frequency of parent and provider communication codes and same-day vaccination described. The results indicate that providers who engage hesitant parents and address their concerns can lead to same-day HPV vaccination, and that even parents who make assertive statements are amenable to influence by providers.
AHRQ-funded; HS022418.
Citation: Shay LA, Baldwin AS, Betts AC .
Parent-provider communication of HPV vaccine hesitancy.
Pediatrics 2018 Jun;141(6). doi: 10.1542/peds.2017-2312..
Keywords: Clinician-Patient Communication, Communication, Decision Making, Infectious Diseases, Vaccination
Shoup JA, Narwaney KJ, Wagner NM
Social media vaccine websites: a comparative analysis of public and moderated websites.
This study examined vaccine social media (VSM) websites and compared expert moderated VSM websites to nonmoderated websites. Accuracy of information, vaccine stance, and tone was coded for 79 public blogs and discussion boards and 61 expert moderated VSM websites. The public VSM websites had a lot of inaccurate information and tended to have a negative stance towards vaccines. Expert moderated websites had a more civil tone, little to no inaccurate information and very little participant-to-participant interaction.
AHRQ-funded; HS021492.
Citation: Shoup JA, Narwaney KJ, Wagner NM .
Social media vaccine websites: a comparative analysis of public and moderated websites.
Health Educ Behav 2018 Jun;46(3):454-62. doi: 10.1177/1090198118818253..
Keywords: Education: Patient and Caregiver, Social Media, Vaccination
de Montigny S, Adamson BJS, Masse BR
Projected effectiveness and added value of HIV vaccination campaigns in South Africa: a modeling study.
Sci Rep 2018 Apr 17;8(1):6066. doi: 10.1038/s41598-018-24268-4.
In this paper, the authors estimated the potential epidemiological and economic impact of HIV vaccine campaigns compared to continuous vaccination, assuming that vaccine efficacy was transient and dependent on immune response. The investigators concluded that results suggested a partially effective HIV vaccine would have substantial impact on the HIV epidemic in South Africa and offer good value if priced less than $105 for a five-dose series. They suggested that vaccination campaigns every two years may offer greater value for money than continuous vaccination reaching the same coverage level.
In this paper, the authors estimated the potential epidemiological and economic impact of HIV vaccine campaigns compared to continuous vaccination, assuming that vaccine efficacy was transient and dependent on immune response. The investigators concluded that results suggested a partially effective HIV vaccine would have substantial impact on the HIV epidemic in South Africa and offer good value if priced less than $105 for a five-dose series. They suggested that vaccination campaigns every two years may offer greater value for money than continuous vaccination reaching the same coverage level.
AHRQ-funded; HS013853.
Citation: de Montigny S, Adamson BJS, Masse BR .
Projected effectiveness and added value of HIV vaccination campaigns in South Africa: a modeling study.
Sci Rep 2018 Apr 17;8(1):6066. doi: 10.1038/s41598-018-24268-4..
Keywords: Health Services Research (HSR), Healthcare Costs, Human Immunodeficiency Virus (HIV), Public Health, Vaccination
Wang SV, Abdurrob A, Spoendlin J
Methods for addressing "innocent bystanders" when evaluating safety of concomitant vaccines.
The need to develop methods for studying the safety of childhood immunization schedules has been recognized by the Institute of Medicine and Department of Health and Human Services. The recommended childhood immunization schedule includes multiple vaccines in a visit. A key concern is safety of concomitant (same day) versus separate day vaccination. This paper addressed a methodological challenge for observational studies using a self-controlled design to investigate the safety of concomitant vaccination.
AHRQ-funded; HS022193.
Citation: Wang SV, Abdurrob A, Spoendlin J .
Methods for addressing "innocent bystanders" when evaluating safety of concomitant vaccines.
Pharmacoepidemiol Drug Saf 2018 Apr;27(4):405-12. doi: 10.1002/pds.4399..
Keywords: Adverse Drug Events (ADE), Adverse Events, Children/Adolescents, Patient Safety, Vaccination
Shah PD, Calo WA, Marciniak MW
Service quality and parents' willingness to get adolescents HPV vaccine from pharmacists.
The researchers sought to examine whether pharmacy service quality was associated with parents' willingness to have immunizing pharmacists administer human papillomavirus (HPV) vaccine to their adolescent children. They found that parents who went to independent pharmacies had lower willingness to get HPV vaccine from pharmacists compared to parents who went to chain pharmacies, but there was no difference in willingness for parents who went to clinic versus chain pharmacies.
AHRQ-funded; HS000032.
Citation: Shah PD, Calo WA, Marciniak MW .
Service quality and parents' willingness to get adolescents HPV vaccine from pharmacists.
Prev Med 2018 Apr;109:106-12. doi: 10.1016/j.ypmed.2018.01.002.
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Keywords: Children/Adolescents, Decision Making, Infectious Diseases, Provider: Pharmacist, Vaccination
Shah MP, Lopman BA, Tate JE
AHRQ Author: Steiner CA
Use of Internet search data to monitor rotavirus vaccine impact in the United States, United Kingdom, and Mexico.
In this study, researchers aimed to study the correlation between internet query searches (IQS) for "rotavirus" and rotavirus disease activity in the United States, United Kingdom, and Mexico before and after introduction of rotavirus vaccine. They found positive correlation between the rotavirus IQS and laboratory reports in the United States and United Kingdom and between the rotavirus IQS and acute gastroenteritis hospitalizations in the United States and Mexico for all correlations.
AHRQ-authored.
Citation: Shah MP, Lopman BA, Tate JE .
Use of Internet search data to monitor rotavirus vaccine impact in the United States, United Kingdom, and Mexico.
J Pediatric Infect Dis Soc 2018 Feb 19;7(1):56-63. doi: 10.1093/jpids/pix004.
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Keywords: Healthcare Cost and Utilization Project (HCUP), Vaccination, Web-Based
Szilagyi PG, Schaffer S, Rand CM
School-located influenza vaccinations for adolescents: a randomized controlled trial.
In this study, the investigators aimed to evaluate the effect of school-located influenza vaccination (SLIV) on adolescents' influenza vaccination rates. In 2015-2016, they performed a cluster-randomized trial of adolescent SLIV in middle/high schools. They concluded that SLIV in this community increased influenza vaccination rates among adolescents attending suburban schools.
AHRQ-funded; HS021163.
Citation: Szilagyi PG, Schaffer S, Rand CM .
School-located influenza vaccinations for adolescents: a randomized controlled trial.
J Adolesc Health 2018 Feb;62(2):157-63. doi: 10.1016/j.jadohealth.2017.09.021..
Keywords: Children/Adolescents, Education, Influenza, Prevention, Public Health, Vaccination
Anderson LJ, Shekelle P, Keeler E
The cost of interventions to increase influenza vaccination: a systematic review.
This study sought to systematically review economic evaluations of healthcare-based quality improvement interventions for improving influenza vaccination uptake among general populations and healthcare workers. The investigators concluded that quality improvement interventions for influenza vaccination involved per-enrollee costs that were similar to the cost of the vaccine itself ($11.78-$36.08/dose). They suggested that based on limited available evidence in general populations, quality improvement interventions may be cost saving to cost effective for the health system.
AHRQ-funded; HS022644.
Citation: Anderson LJ, Shekelle P, Keeler E .
The cost of interventions to increase influenza vaccination: a systematic review.
Am J Prev Med 2018 Feb;54(2):299-315. doi: 10.1016/j.amepre.2017.11.010..
Keywords: Healthcare Costs, Influenza, Quality Improvement, Vaccination
Pringle KD, Burke RM, Steiner CA
AHRQ Author: Steiner CA
Trends in rate of seizure-associated hospitalizations among children <5 years old before and after rotavirus vaccine introduction in the United Sates, 2000-2013.
Since rotavirus vaccine introduction, hospitalizations for treatment of acute gastroenteritis have decreased. Researchers assessed whether there has been an associated decrease in seizure-associated hospitalizations. Their analysis provides evidence for a decrease in seizure hospitalizations following rotavirus vaccine introduction in the United States, with the greatest impact in age groups with a high rotavirus-associated disease burden and during rotavirus infection season.
AHRQ-authored.
Citation: Pringle KD, Burke RM, Steiner CA .
Trends in rate of seizure-associated hospitalizations among children <5 years old before and after rotavirus vaccine introduction in the United Sates, 2000-2013.
J Infect Dis 2018 Jan 30;217(4):581-88. doi: 10.1093/infdis/jix589.
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Keywords: Adverse Drug Events (ADE), Children/Adolescents, Healthcare Cost and Utilization Project (HCUP), Hospitalization, Vaccination
Greenhawt M, Turner PJ, Kelso JM
Administration of influenza vaccines to egg allergic recipients: a practice parameter update 2017.
The purpose of this practice parameter update is to review new data pertaining to the safety of influenza vaccines in egg allergic individuals and provide recommendations regarding annual influenza vaccination in egg allergic individuals. This focused practice parameter answers four questions.
AHRQ-funded; HS024599.
Citation: Greenhawt M, Turner PJ, Kelso JM .
Administration of influenza vaccines to egg allergic recipients: a practice parameter update 2017.
Ann Allergy Asthma Immunol 2018 Jan;120(1):49-52. doi: 10.1016/j.anai.2017.10.020.
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Keywords: Adverse Drug Events (ADE), Guidelines, Prevention, Vaccination
Fiscella K
Tackling disparities in influenza vaccination in primary care: it takes a team.
This article discusses a study in the same issue by Maurer. Fiscella describes reasons involving influenza vaccination disparities and points out that the emergence of accountable care organizations creates opportunities for better integration of primary care and public health.
AHRQ-funded; HS022440.
Citation: Fiscella K .
Tackling disparities in influenza vaccination in primary care: it takes a team.
J Gen Intern Med 2014 Dec;29(12):1579-81. doi: 10.1007/s11606-014-2999-2.
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Keywords: Disparities, Influenza, Primary Care, Teams, Vaccination
Geynisman DM, Chien CR, Smieliauskas F
Economic evaluation of therapeutic cancer vaccines and immunotherapy: a systematic review.
The researchers performed a comprehensive literature review of cost and cost-effectiveness research on therapeutic cancer vaccines and monoclonal antibodies, to better understand the economic impacts of these treatments. They discussed the implications surrounding the economic factors involved in cancer immunotherapies and suggested that further research on cost and cost-effectiveness of newer cancer vaccines and immunotherapies were warranted as this is a rapidly growing field with many new drugs on the horizon.
AHRQ-funded; HS018535.
Citation: Geynisman DM, Chien CR, Smieliauskas F .
Economic evaluation of therapeutic cancer vaccines and immunotherapy: a systematic review.
Hum Vaccin Immunother 2014;10(11):3415-24. doi: 10.4161/hv.29407.
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Keywords: Cancer, Healthcare Costs, Vaccination
Ahrens KA, Louik C, Kerr S
Seasonal influenza vaccination during pregnancy and the risks of preterm delivery and small for gestational age birth.
The researchers examined the associations between seasonal influenza vaccination during pregnancy and the risks of PTD and SGA among a multiyear retrospective cohort of pregnancies. With the exception of pre-term delivery (PTD) associated with the 2009–10 seasonal vaccine, they found no meaningful increases in PTD or small for gestational age risks associated with seasonal trivalent influenza vaccination during pregnancy.
AHRQ-funded; HS018463.
Citation: Ahrens KA, Louik C, Kerr S .
Seasonal influenza vaccination during pregnancy and the risks of preterm delivery and small for gestational age birth.
Paediatr Perinat Epidemiol 2014 Nov;28(6):498-509. doi: 10.1111/ppe.12152..
Keywords: Influenza, Vaccination, Pregnancy, Labor and Delivery
Campbell LJ, Li Q, Li Y
Healthcare worker influenza vaccination in Oregon nursing homes: correlates of facility characteristics.
The authors identified nursing home (NH) characteristics that may be associated with employee influenza vaccination rates (EVRs). They concluded that, as NHs generally have low EVRs, it may be necessary to target low-performing facilities to achieve substantial improvements.
AHRQ-funded; HS000044.
Citation: Campbell LJ, Li Q, Li Y .
Healthcare worker influenza vaccination in Oregon nursing homes: correlates of facility characteristics.
J Am Med Dir Assoc 2014 Oct;15(10):768-72. doi: 10.1016/j.jamda.2014.06.005.
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Keywords: Provider: Health Personnel, Influenza, Nursing Homes, Prevention, Vaccination
Perry LM, Winthrop KL, Curtis JR
Vaccinations for rheumatoid arthritis.
The goal of this paper is to highlight the most recent literature on the key vaccines and the specific considerations for the rheumatologist and their rheumatoid arthritis (RA) patients, with a particular focus on influenza, pneumococcal, and herpes zoster vaccines. It is important for rheumatologists to understand which vaccines are live and what potential contraindications exist for giving vaccines to RA patients.
AHRQ-funded; HS018517
Citation: Perry LM, Winthrop KL, Curtis JR .
Vaccinations for rheumatoid arthritis.
Curr Rheumatol Rep. 2014 Aug;16(8):431. doi: 10.1007/s11926-014-0431-x..
Keywords: Arthritis, Vaccination, Prevention
Khazeni N, Hutton DW, Collins CI
Health and economic benefits of early vaccination and nonpharmaceutical interventions for a human influenza A (H7N9) pandemic: a modeling study.
In order to determine how quickly vaccination should be completed to reduce infections, deaths, and health care costs in a severe influenza pandemic in a large metropolitan area, researchers used a dynamic transmission model. They found that vaccination in an influenza-A (H7N9) pandemic would need to be completed much faster than in the 2009 pandemic to substantially reduce morbidity, mortality, and health care costs.
AHRQ-funded; HS019816
Citation: Khazeni N, Hutton DW, Collins CI .
Health and economic benefits of early vaccination and nonpharmaceutical interventions for a human influenza A (H7N9) pandemic: a modeling study.
Ann Intern Med. 2014 May 20;160(10):684-94. doi: 10.7326/M13-2071..
Keywords: Vaccination, Influenza, Mortality, Healthcare Costs, Public Health
Humiston SG, Poehling KA, Szilagyi PG
School-located influenza vaccination: can collaborative efforts go the distance?
This commentary discusses school-located influenza vaccination during the school day and includes the survey results from Kempe et al., in the same issue. The authors conclude that increasing influenza vaccination rates will require vaccinating “outside the box,” utilizing a site in which school-aged youth already tend to congregate.
AHRQ-funded; HS021163.
Citation: Humiston SG, Poehling KA, Szilagyi PG .
School-located influenza vaccination: can collaborative efforts go the distance?
Acad Pediatr 2014 May-Jun;14(3):219-20. doi: 10.1016/j.acap.2014.03.004.
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Keywords: Children/Adolescents, Influenza, Vaccination
Panozzo CA, Becker-Dreps S, Pate V
Direct, indirect, total, and overall effectiveness of the rotavirus vaccines for the prevention of gastroenteritis hospitalizations in privately insured US children, 2007-2010.
This study demonstrated how direct, indirect, total, and overall effectiveness estimates and absolute benefits of rotavirus vaccines vary through the years following vaccine introduction. It found that direct effectiveness of 1 or more doses of rotavirus vaccine in preventing rotavirus gastroenteritis hospitalizations ranged from 87 to 92 percent each year.
AHRQ-funded; HS017950
Citation: Panozzo CA, Becker-Dreps S, Pate V .
Direct, indirect, total, and overall effectiveness of the rotavirus vaccines for the prevention of gastroenteritis hospitalizations in privately insured US children, 2007-2010.
Am J Epidemiol. 2014 Apr 1;179(7):895-909. doi: 10.1093/aje/kwu001..
Keywords: Comparative Effectiveness, Vaccination, Children/Adolescents, Hospitalization