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Research Studies is a monthly compilation of research articles funded by AHRQ or authored by AHRQ researchers and recently published in journals or newsletters.
Results1 to 2 of 2 Research Studies Displayed
Yi J, Wood JB, Creech CB
Clinical epidemiology and outcomes of pediatric musculoskeletal infections.
The objective of this study was to understand the epidemiology of acute hematogenous osteomyelitis and septic arthritis, including clinical and demographic features, microbiology, treatment approaches, treatment-associated complications, and outcomes. Musculoskeletal infections are challenging pediatric infections. The investigators concluded that S aureus remained the most common pathogen, with methicillin-resistant S aureus accounting for 25% of all cases. Concurrent acute hematogenous osteomyelitis/septic arthritis was associated with more severe disease and worse outcomes.
Citation: Yi J, Wood JB, Creech CB . Clinical epidemiology and outcomes of pediatric musculoskeletal infections. J Pediatr 2021 Jul;234:236-44.e2. doi: 10.1016/j.jpeds.2021.03.028..
Keywords: Children/Adolescents, Arthritis
Mannion ML, Xie F, Curtis JR
Recent trends in medication usage for the treatment of juvenile idiopathic arthritis and the influence of tumor necrosis factor inhibitors.
The researchers investigated temporal trends in medication use among children diagnosed with juvenile idiopathic arthritis (JIA). They found that the use of tumor necrosis factor inhibitors (TNFi) in the treatment of JIA increased 2- to 3-fold from 2005 to 2012. New TNFi use was associated with decreased NSAID and oral glucocorticoids use. TNFi may be replacing, rather than complementing, methotrexate in the treatment of many patients.
Citation: Mannion ML, Xie F, Curtis JR . Recent trends in medication usage for the treatment of juvenile idiopathic arthritis and the influence of tumor necrosis factor inhibitors. J Rheumatol 2014 Oct;41(10):2078-84. doi: 10.3899/jrheum.140012.
Keywords: Children/Adolescents, Medication, Patient-Centered Outcomes Research, Practice Patterns, Arthritis