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Research Studies is a monthly compilation of research articles funded by AHRQ or authored by AHRQ researchers and recently published in journals or newsletters.
Results1 to 10 of 10 Research Studies Displayed
Singh JA, Lewallen DG
Are outcomes after total knee arthroplasty worsening over time? A time-trends study of activity limitation and pain outcomes.
The authors examined whether function and pain outcomes of patients undergoing primary total knee arthroplasty (TKA) are changing over time. Using Mayo Clinic Total Joint Registry data, they found that patient-reported function and pain outcomes after primary TKA have worsened over the study period 1993-95 to 2002-05; this time-trend is independent of changes in preoperative pain/limitation and certain patient characteristics.
Citation: Singh JA, Lewallen DG . Are outcomes after total knee arthroplasty worsening over time? A time-trends study of activity limitation and pain outcomes. BMC Musculoskelet Disord 2014 Dec 17;15:440. doi: 10.1186/1471-2474-15-440.
Keywords: Centers for Education and Research on Therapeutics (CERTs), Orthopedics, Pain, Patient-Centered Outcomes Research, Surgery
Raebel MA, Newcomer SR, Bayliss EA
Chronic opioid use emerging after bariatric surgery.
The purpose of this study was to determine opioid use the year after bariatric surgery among patients who did not use opioids chronically pre-surgery and to identify pre-surgery characteristics associated with chronic opioid use after surgery. It found that patients dispensed 60 to 119 days’ supply during the pre-surgery year were 13.23 to 14.29 times more likely to use opioids chronically post-surgery than patients without opioid use pre-surgery.
Citation: Raebel MA, Newcomer SR, Bayliss EA . Chronic opioid use emerging after bariatric surgery. Pharmacoepidemiol Drug Saf 2014 Dec;23(12):1247-57. doi: 10.1002/pds.3625..
Keywords: Medication, Obesity, Opioids, Pain, Substance Abuse, Surgery
Merlin JS, Walcott M, Ritchie C
'Two pains together': patient perspectives on psychological aspects of chronic pain while living with HIV.
The researchers’ objective was to explore HIV-infected patients’ perspectives on psychological aspects of chronic pain using in-depth qualitative interviews. Key themes that emerged included the close relationship between mood and pain; mood and pain in the context of living with HIV; use of alcohol/drugs to self-medicate for pain; and the challenge of receiving prescription pain medications while dealing with substance use disorders.
Citation: Merlin JS, Walcott M, Ritchie C . 'Two pains together': patient perspectives on psychological aspects of chronic pain while living with HIV. PLoS One 2014 Nov 3;9(11):e111765. doi: 10.1371/journal.pone.0111765..
Keywords: Care Management, Chronic Conditions, Human Immunodeficiency Virus (HIV), Pain, Patient-Centered Outcomes Research, Patient Self-Management
Kilaru AS, Gadsden SM, Perrone J
How do physicians adopt and apply opioid prescription guidelines in the emergency department? A qualitative study.
This qualitative study of emergency physicians attempted to gain insight into the adoption, use, and perceived relevance of opioid-prescribing guidelines. Most of the 61 participants interviewed in a convenience sample had a positive perspective on the intent and role of such guidelines and used them most commonly as communication tools with patients.
Citation: Kilaru AS, Gadsden SM, Perrone J . How do physicians adopt and apply opioid prescription guidelines in the emergency department? A qualitative study. Ann Emerg Med 2014 Nov;64(5):482-89.e1. doi: 10.1016/j.annemergmed.2014.03.015.
Keywords: Emergency Medical Services (EMS), Opioids, Pain, Guidelines, Practice Patterns
Diaz OV, Guendelman S, Kuppermann M
Subjective social status and depression symptoms: a prospective study of women with noncancerous pelvic problems.
The investigators sought to examine the effect of community and national subjective social status (SSS) on symptoms of depression in a racially/ethnically diverse sample of adult women with noncancerous uterine conditions. They found that low perceived community social status is predictive of symptoms suggestive of major or other depressive disorder among women with noncancerous uterine conditions.
Citation: Diaz OV, Guendelman S, Kuppermann M . Subjective social status and depression symptoms: a prospective study of women with noncancerous pelvic problems. Womens Health Issues 2014 Nov-Dec;24(6):649-55. doi: 10.1016/j.whi.2014.07.003.
Keywords: Depression, Health Status, Pain, Social Determinants of Health, Women
Goode AP, Shi XA, Gracely RH
Associations between pressure-pain threshold, symptoms, and radiographic knee and hip osteoarthritis.
The researchers sought to determine the association between generalized evoked pressure pain sensitivity with distal pressure–pain threshold and the presence, severity, or number of involved knee/hip joints with radiographic osteoarthritis or related symptoms. They found that as a participant’s sensitivity for pressure pain decreased, there were several significant associations with presence, severity, and number of joints with symptoms, regardless of the knee or hip joint.
Citation: Goode AP, Shi XA, Gracely RH . Associations between pressure-pain threshold, symptoms, and radiographic knee and hip osteoarthritis. Arthritis Care Res. 2014 Oct;66(10):1513-9. doi: 10.1002/acr.22321..
Keywords: Arthritis, Pain, Comparative Effectiveness
Curtin CM, Hernandez-Boussard T
Readmissions after treatment of distal radius fractures.
The authors assessed the rates and associated diagnoses of readmissions for patients having received an intervention for treatment of distal radius fracture. Using AHRQ data sets, they found that many distal radius fracture patients return to the health care system for pain-related issues, and they recommended implementation of better pain management.
Citation: Curtin CM, Hernandez-Boussard T . Readmissions after treatment of distal radius fractures. J Hand Surg Am 2014 Oct;39(10):1926-32. doi: 10.1016/j.jhsa.2014.07.041.
Keywords: Injuries and Wounds, Quality of Care, Healthcare Cost and Utilization Project (HCUP), Pain, Hospital Readmissions
Suri P, Boyko EJ, Goldberg J
Longitudinal associations between incident lumbar spine MRI findings and chronic low back pain or radicular symptoms: retrospective analysis of data from the longitudinal assessment of imaging and disability of the back (LAIDBACK).
The researchers examined the association of incident lumbar MRI findings with two specific spine-related symptom outcomes: 1) incident chronic bothersome lower back pain, and 2) incident radicular symptoms such as pain, weakness, or sensation alterations in the lower extremity. They found that even when applying more specific definitions for spine-related symptom outcomes, few MRI findings show strong associations with symptom outcomes.
Citation: Suri P, Boyko EJ, Goldberg J . Longitudinal associations between incident lumbar spine MRI findings and chronic low back pain or radicular symptoms: retrospective analysis of data from the longitudinal assessment of imaging and disability of the back (LAIDBACK). BMC Musculoskelet Disord. 2014 May 13;15:152. doi: 10.1186/1471-2474-15-152..
Keywords: Back Health and Pain, Chronic Conditions, Diagnostic Safety and Quality, Imaging, Pain
Kim DH, Lin Y, Goytizolo EA
Adductor canal block versus femoral nerve block for total knee arthroplasty: a prospective, randomized, controlled trial.
In a study of pain relief for patients recovering from a total knee arthroplasty, researchers found that adductor canal block (ACB) results in less motor impairment for quadriceps muscles after surgery than femoral nerve block (FNB) and it provides a comparable level of pain relief. The prospective, randomized, controlled study included 46 patients receiving ACB and 47 receiving FNB.
Citation: Kim DH, Lin Y, Goytizolo EA . Adductor canal block versus femoral nerve block for total knee arthroplasty: a prospective, randomized, controlled trial. Anesthesiology. 2014 Mar;120(3):540-50. doi: 10.1097/ALN.0000000000000119..
Keywords: Medication, Opioids, Outcomes, Pain, Surgery
Martinez KA, Aslakson RA, Wilson RF
A systematic review of health care interventions for pain in patients with advanced cancer.
The authors sought to synthesize the evidence on the effectiveness of pain-focused interventions in patients with advanced cancer. In nineteen studies, they found moderate strength of evidence that pain management in advanced cancer can be improved using health care interventions, particularly nurse-led patient-centered interventions.
Citation: Martinez KA, Aslakson RA, Wilson RF . A systematic review of health care interventions for pain in patients with advanced cancer. Am J Hosp Palliat Care 2014 Feb;31(1):79-86. doi: 10.1177/1049909113476129.
Keywords: Cancer, Comparative Effectiveness, Pain, Palliative Care, Quality Improvement