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Research Studies is a monthly compilation of research articles funded by AHRQ or authored by AHRQ researchers and recently published in journals or newsletters.
Results1 to 3 of 3 Research Studies Displayed
Majid A, McAninch J, Morgan DJ
Predictors of early treatment discontinuation in a cohort of patients treated with boceprevir-based therapy for hepatitis C infection.
This study aimed to assess early treatment discontinuation rates and identify underlying risk factors for discontinuation in a real-world boceprevir-based treatment cohort. Nearly half of patients started on boceprevir-based hepatitis C triple therapy stopped treatment by 24 weeks, with more discontinuing because of treatment intolerance than virologic failure. Early discontinuation was significantly more common in patients with comorbidities.
Citation: Majid A, McAninch J, Morgan DJ . Predictors of early treatment discontinuation in a cohort of patients treated with boceprevir-based therapy for hepatitis C infection. J Viral Hepat 2014 Aug;21(8):585-9. doi: 10.1111/jvh.12201.
Keywords: Hepatitis, Adverse Events, Medication, Risk
Yehia BR, Herati RS, Fleishman JA
AHRQ Author: Fleishman JA
Hepatitis C virus testing in adults living with HIV: a need for improved screening efforts.
The authors sought to understand hepatitis C virus (HCV) testing practices in people living with HIV (PLWH) in order to improve compliance with guidelines and help identify areas for future intervention. They concluded that additional efforts to improve compliance with HCV testing guidelines are needed.
AHRQ-authored; AHRQ-funded; 290201100007C.
Citation: Yehia BR, Herati RS, Fleishman JA . Hepatitis C virus testing in adults living with HIV: a need for improved screening efforts. PLoS One 2014 Jul 17;9(7):e102766. doi: 10.1371/journal.pone.0102766.
Keywords: Guidelines, Healthcare Utilization, Hepatitis, Human Immunodeficiency Virus (HIV), Screening
Southern WN, Drainoni ML, Smith BD
Physician nonadherence with a hepatitis C screening program.
The researchers sought to measure adherence to an hepatitis C virus (HCV) screening protocol during a multifaceted continuous intervention. They found that overall adherence to the guideline was low, suggesting that attitudinal and external barriers remained. They concluded that when implementing complex clinical practice guidelines, planners must address attitudinal and external barriers to maximize adherence.
Citation: Southern WN, Drainoni ML, Smith BD . Physician nonadherence with a hepatitis C screening program. Qual Manag Health Care 2014 Jan-Mar;23(1):1-9. doi: 10.1097/qmh.0000000000000007..
Keywords: Hepatitis, Screening, Patient Adherence/Compliance