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Research Studies is a compilation of published research articles funded by AHRQ or authored by AHRQ researchers.
Results
1 to 7 of 7 Research Studies DisplayedSico JJ, Kundu S, So-Armah K
Depression as a risk factor for incident ischemic stroke among HIV-positive veterans in the veterans aging cohort study.
Background HIV infection and depression are each associated with increased ischemic stroke risk. Whether depression is a risk factor for stroke within the HIV population is unknown. In this study the investigators examined depression as a risk factor for incident ischemic stroke among HIV-positive veterans in the veterans aging cohort study. The investigators concluded that depression is associated with an increased risk of stroke among HIV-positive people after adjusting for sociodemographic characteristics, traditional cerebrovascular risk factors, and HIV-specific factors.
AHRQ-funded; HS023464.
Citation: Sico JJ, Kundu S, So-Armah K .
Depression as a risk factor for incident ischemic stroke among HIV-positive veterans in the veterans aging cohort study.
J Am Heart Assoc 2021 Jul 6;10(13):e017637. doi: 10.1161/jaha.119.017637..
Keywords: Depression, Behavioral Health, Risk, Human Immunodeficiency Virus (HIV), Stroke, Cardiovascular Conditions
Kuperberg M, Katz D, Greenebaum SLA
Psychotic symptoms during bipolar depressive episodes and suicidal ideation.
Researchers examined the relationship between psychotic symptoms during a depressive episode and suicidal ideation in bipolar patients. Psychotic symptoms in adult, depressed outpatients with bipolar disorder (BD) in a comparative effectiveness study of quetiapine versus lithium were assessed via Bipolar Inventory of Signs and Symptoms Scale (BISS); depressive episodes were assessed via Mini-International Neuropsychiatric Interview (MINI). The researchers found that, while a small proportion of bipolar disorder outpatients had current symptoms of psychosis during their depressive episode, those who did were more likely to endorse active suicidal thoughts, including suicide methods and plans.
AHRQ-funded; HS019371.
Citation: Kuperberg M, Katz D, Greenebaum SLA .
Psychotic symptoms during bipolar depressive episodes and suicidal ideation.
J Affect Disord 2021 Mar 1;282:1241-46. doi: 10.1016/j.jad.2020.12.184..
Keywords: Depression, Behavioral Health, Risk
Yu SH, Silverberg JI
Association between atopic dermatitis and depression in US adults.
The researchers sought to determine the prevalence of depression in US adults with atopic dermatitis (AD). They concluded that approximately one in three US adults with AD reported any symptoms of depression and one in three adults with AD met diagnostic criteria for major depressive disorder.
AHRQ-funded; HS023011.
Citation: Yu SH, Silverberg JI .
Association between atopic dermatitis and depression in US adults.
J Invest Dermatol 2015 Dec;135(12):3183-6. doi: 10.1038/jid.2015.337..
Keywords: Depression, Behavioral Health, Risk, Skin Conditions
Alcantara C, Muntner P, Edmondson D
Perfect storm: concurrent stress and depressive symptoms increase risk of myocardial infarction or death.
A recently offered psychosocial perfect storm conceptual model hypothesizes amplified risk will occur in those with concurrent stress and depressive symptoms. The authors tested this hypothesis in a large sample of US adults with coronary heart disease. They found that those with low stress and high depressive symptoms or high stress and low depressive symptoms were not at increased risk, while participants with concurrent high stress and high depressive symptoms had increased risk for myocardial infarction or death relative to those with low stress and low depressive symptoms. They concluded that their results provide initial support for a psychosocial perfect storm conceptual model.
AHRQ-funded; HS023009.
Citation: Alcantara C, Muntner P, Edmondson D .
Perfect storm: concurrent stress and depressive symptoms increase risk of myocardial infarction or death.
Circ Cardiovasc Qual Outcomes 2015 Mar;8(2):146-54. doi: 10.1161/circoutcomes.114.001180.
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Keywords: Depression, Heart Disease and Health, Mortality, Risk, Stress
Gibbons RD, Coca Perraillon M, Hur K
Antidepressant treatment and suicide attempts and self-inflicted injury in children and adolescents.
This study explores the relationship between antidepressant treatment and suicide attempt and self-inflicted injury in depressed children ages 5–17. Using two large claim datasets (LifeLink and MarketScan), the researchers find that after taking into account the time-varying effect of confounders, the apparent link between antidepressant use and suicide attempts and self-inflicted injury is diminished and not statistically significant.
AHRQ-funded; HS021093; HS000084
Citation: Gibbons RD, Coca Perraillon M, Hur K .
Antidepressant treatment and suicide attempts and self-inflicted injury in children and adolescents.
Pharmacoepidemiol Drug Saf 2015 Feb;24(2):208-14. doi: 10.1002/pds.3713..
Keywords: Medication, Children/Adolescents, Depression, Risk
Olfson M, Gerhard T
Re-examining antidepressant risk of self-injury in children and adolescents.
This commentary discusses issues raised in the study by Gibbons, et al. that focused on the association between antidepressant treatment and risk of medically injurious self-inflicted harm in young people diagnosed with depression. One example is the threat of unmeasured confounding that arises from the wide range of self-injury risk factors that are not represented in claims data.
AHRQ-funded; HS021112.
Citation: Olfson M, Gerhard T .
Re-examining antidepressant risk of self-injury in children and adolescents.
Pharmacoepidemiol Drug Saf 2015 Feb;24(2):215-7. doi: 10.1002/pds.3737..
Keywords: Medication, Children/Adolescents, Depression, Risk
Ojard C, Donnelly JP, Safford MM
Psychosocial stress as a risk factor for sepsis: a population-based cohort study.
This study characterized the relationship between stress and future risk of sepsis and evaluated the role of depression in this relationship. It found that increased stress was associated with higher 1-year adjusted incidence of sepsis, even after accounting for depressive symptoms.
AHRQ-funded; HS013852.
Citation: Ojard C, Donnelly JP, Safford MM .
Psychosocial stress as a risk factor for sepsis: a population-based cohort study.
Psychosom Med 2015 Jan;77(1):93-100. doi: 10.1097/psy.0000000000000120..
Keywords: Risk, Depression, Stress