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AHRQ Research Studies Date
Topics
- Antimicrobial Stewardship (3)
- Children/Adolescents (2)
- Community-Acquired Infections (2)
- Community-Based Practice (1)
- Community Partnerships (1)
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- Diagnostic Safety and Quality (1)
- Elderly (1)
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- Healthcare-Associated Infections (HAIs) (4)
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- Injuries and Wounds (1)
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- (-) Methicillin-Resistant Staphylococcus aureus (MRSA) (14)
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- Nursing Homes (1)
- Patient-Centered Outcomes Research (1)
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- Risk (3)
- Screening (1)
- Skin Conditions (1)
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AHRQ Research Studies
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Research Studies is a compilation of published research articles funded by AHRQ or authored by AHRQ researchers.
Results
1 to 14 of 14 Research Studies DisplayedEricson JE, Popoola VO, Smith PB
Burden of invasive staphylococcus aureus infections in hospitalized infants.
This study compared demographics and mortality of inf ants with invasive methicillin-resistant S aureus (MRSA) and methicillin-susceptible S aureus (MSSA), to determine the annual proportion of S aureus infections that were MRSA. It found that infant mortality after invasive MRSA and MSSA infections was similar, but MSSA caused more infections and more deaths in infants than MRSA.
AHRQ-funded; HS022872.
Citation: Ericson JE, Popoola VO, Smith PB .
Burden of invasive staphylococcus aureus infections in hospitalized infants.
JAMA Pediatr 2015 Dec;169(12):1105-11. doi: 10.1001/jamapediatrics.2015.2380..
Keywords: Newborns/Infants, Methicillin-Resistant Staphylococcus aureus (MRSA), Mortality, Hospitalization, Risk
Peterson LR, Wright MO, Beaumont JL
Nonimpact of decolonization as an adjunctive measure to contact precautions for the control of methicillin-resistant Staphylococcus aureus transmission in acute care.
This was an observational study comparing methicillin-resistant Staphylococcus aureus (MRSA) transmission with no decolonization of medical patients to required decolonization of all MRSA carriers during two consecutive periods: baseline with no decolonization of medical patients and universal MRSA carrier decolonization. The study concluded that decolonization of MRSA patients does not add benefit when contact precautions are used for patients colonized with MRSA in acute (hospital) care.
AHRQ-funded; HS019968.
Citation: Peterson LR, Wright MO, Beaumont JL .
Nonimpact of decolonization as an adjunctive measure to contact precautions for the control of methicillin-resistant Staphylococcus aureus transmission in acute care.
Antimicrob Agents Chemother 2015 Oct 12;60(1):99-104. doi: 10.1128/aac.02046-15.
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Keywords: Methicillin-Resistant Staphylococcus aureus (MRSA), Critical Care, Antimicrobial Stewardship, Elderly, Patient Safety
Morelli JJ, Hogan PG, Sullivan ML
Antimicrobial susceptibility profiles of Staphylococcus aureus isolates recovered from humans, environmental surfaces, and companion animals in households of children with community-onset Methicillin-Resistant S. aureus infections.
The study objective was to determine the antibiotic susceptibility profiles of Staphylococcus aureus isolates recovered from 110 households of children with community-onset methicillin-resistant S. aureus (MRSA) infections. It found that the S. aureus isolates were heterogeneous, although more than half were methicillin resistant. The highest proportion of MRSA was found in bathrooms.
AHRQ-funded; HS021736.
Citation: Morelli JJ, Hogan PG, Sullivan ML .
Antimicrobial susceptibility profiles of Staphylococcus aureus isolates recovered from humans, environmental surfaces, and companion animals in households of children with community-onset Methicillin-Resistant S. aureus infections.
Antimicrob Agents Chemother 2015 Oct;59(10):6634-7. doi: 10.1128/aac.01492-15.
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Keywords: Antimicrobial Stewardship, Methicillin-Resistant Staphylococcus aureus (MRSA), Children/Adolescents
Teshome BF, Lee GC, Reveles KR
Application of a methicillin-resistant Staphylococcus aureus risk score for community-onset pneumonia patients and outcomes with initial treatment.
The study objective was to assess the effect of initial MRSA therapy on mortality in community–onset (CO) pneumonia patients that a new MRSA prediction score had classified into low, medium, and high-risk groups based on objective criteria available at baseline. The study demonstrated improved survival with initial MRSA therapy in the 2 percent of CO-pneumonia patients classified as high-risk.
AHRQ-funded; HS022418.
Citation: Teshome BF, Lee GC, Reveles KR .
Application of a methicillin-resistant Staphylococcus aureus risk score for community-onset pneumonia patients and outcomes with initial treatment.
BMC Infect Dis 2015 Sep 18;15:380. doi: 10.1186/s12879-015-1119-1..
Keywords: Methicillin-Resistant Staphylococcus aureus (MRSA), Risk, Patient-Centered Outcomes Research, Hospitalization
Creech CB, Al-Zubeidi DN, Fritz SA
Prevention of recurrent staphylococcal skin infections.
Staphylococcus aureus infections pose a significant health burden. As S aureus colonization is associated with subsequent infection, decolonization is recommended for patients with recurrent skin and soft tissue infections or in settings of ongoing transmission. S aureus infections often cluster within households, and asymptomatic carriers serve as reservoirs for transmission; therefore, a household approach to decolonization is more effective than measures performed by individuals alone.
AHRQ-funded; HS021736.
Citation: Creech CB, Al-Zubeidi DN, Fritz SA .
Prevention of recurrent staphylococcal skin infections.
Infect Dis Clin North Am 2015 Sep;29(3):429-64. doi: 10.1016/j.idc.2015.05.007.
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Keywords: Prevention, Methicillin-Resistant Staphylococcus aureus (MRSA), Antimicrobial Stewardship, Patient Safety
Roghmann MC, Johnson JK, Sorkin JD
Transmission of methicillin-resistant Staphylococcus aureus (MRSA) to healthcare worker gowns and gloves during care of nursing home residents.
This study estimated the frequency of methicillin-resistant Staphylococcus aureus (MRSA) transmission to gowns and gloves worn by healthcare workers (HCWs) interacting with nursing home residents to better inform infection prevention policies in this setting. It found that MRSA transmission from MRSA-positive residents to health care worker gown and gloves is substantial; high-contact activities of daily living confer the highest risk.
AHRQ-funded; HS019979.
Citation: Roghmann MC, Johnson JK, Sorkin JD .
Transmission of methicillin-resistant Staphylococcus aureus (MRSA) to healthcare worker gowns and gloves during care of nursing home residents.
Infect Control Hosp Epidemiol 2015 Sep;36(9):1050-7. doi: 10.1017/ice.2015.119..
Keywords: Methicillin-Resistant Staphylococcus aureus (MRSA), Patient Safety, Nursing Homes, Prevention
Pardos de la Gandara M, Raygoza Garay JA, Mwangi M
Molecular types of methicillin-resistant staphylococcus aureus and methicillin-sensitive S. aureus strains causing skin and soft tissue infections and nasal colonization, identified in community health centers in New York City.
In November 2011, a research and learning collaborative project with six community health centers in the New York City metropolitan area was launched to determine the nature (clonal type) of community-acquired Staphylococcus aureus strains causing skin and soft tissue infections (SSTIs). It found that of 63 patients with S. aureus infections, 16 of the colonizing isolates were MRSA, and 14 were MSSA, and the majority of the colonizing isolates belonged to the USA300 clonal group.
AHRQ-funded; HS021667.
Citation: Pardos de la Gandara M, Raygoza Garay JA, Mwangi M .
Molecular types of methicillin-resistant staphylococcus aureus and methicillin-sensitive S. aureus strains causing skin and soft tissue infections and nasal colonization, identified in community health centers in New York City.
J Clin Microbiol 2015 Aug;53(8):2648-58. doi: 10.1128/jcm.00591-15..
Keywords: Community-Acquired Infections, Community Partnerships, Community-Based Practice, Genetics, Methicillin-Resistant Staphylococcus aureus (MRSA)
Wardyn SE, Forshey BM, Farina SA
Swine farming is a risk factor for infection with and high prevalence of carriage of multidrug-resistant Staphylococcus aureus.
The researchers conducted a large-scale prospective study of 1,342 Iowans, including individuals with livestock contact and a community-based comparison group. They found that current swine workers are 6 times more likely to carry multidrug-resistant S. aureus than those without current swine exposure. Also, they observed active infections caused by livestock-associated S. aureus.
AHRQ-funded; HS019966.
Citation: Wardyn SE, Forshey BM, Farina SA .
Swine farming is a risk factor for infection with and high prevalence of carriage of multidrug-resistant Staphylococcus aureus.
Clin Infect Dis 2015 Jul 1;61(1):59-66. doi: 10.1093/cid/civ234..
Keywords: Risk, Methicillin-Resistant Staphylococcus aureus (MRSA)
Morgan DJ, Pineles L, Shardell M
Effect of chlorhexidine bathing and other infection control practices on the Benefits of Universal Glove and Gown (BUGG) trial: a subgroup analysis.
The researchers report the results of a subgroup analysis of the Benefits of Universal Glove and Gown trial. In 20 intensive care units, the reduction in acquisition of methicillin-resistant Staphylococcus aureus observed in this trial was observed in units also using chlorhexidine bathing and in those that previously performed active surveillance.
AHRQ-funded; HS018111; 290200600015.
Citation: Morgan DJ, Pineles L, Shardell M .
Effect of chlorhexidine bathing and other infection control practices on the Benefits of Universal Glove and Gown (BUGG) trial: a subgroup analysis.
Infect Control Hosp Epidemiol 2015 Jun;36(6):734-7. doi: 10.1017/ice.2015.33..
Keywords: Patient Safety, Prevention, Intensive Care Unit (ICU), Methicillin-Resistant Staphylococcus aureus (MRSA), Healthcare-Associated Infections (HAIs)
Finnell SM, Rosenman MB, Christenson JC
Decolonization of children after incision and drainage for MRSA abscess: a retrospective cohort study.
The researchers sought to determine whether decolonization following incision and drainage (I&D) for methicillin-resistant Staphylococcus aureus (MRSA) abscess decreases repeat I&D and MRSA-positive cultures in children. They found that no statistically significant association between referral to the Pediatric Infectious Disease Service for decolonization and the outcomes.
AHRQ-funded; HS020014.
Citation: Finnell SM, Rosenman MB, Christenson JC .
Decolonization of children after incision and drainage for MRSA abscess: a retrospective cohort study.
Clin Pediatr 2015 May;54(5):445-50. doi: 10.1177/0009922814556059..
Keywords: Children/Adolescents, Methicillin-Resistant Staphylococcus aureus (MRSA), Healthcare-Associated Infections (HAIs), Healthcare-Associated Infections (HAIs), Treatments
Patel PA, Robicsek A, Grayes A
Evaluation of multiple real-time PCR tests on nasal samples in a large MRSA surveillance program.
The researchers evaluated the LightCycler MRSA Advanced Test (Roche Molecular Diagnostics, Pleasanton, CA), the BD MAX MRSA assay (Becton Dickinson, Franklin Lakes, NJ), and the Xpert MRSA assay (Cepheid, Sunnyvale, CA) on nasal samples using the same population. Their results suggest that the performance of the three commercial assays is similar.
AHRQ-funded; HS019968.
Citation: Patel PA, Robicsek A, Grayes A .
Evaluation of multiple real-time PCR tests on nasal samples in a large MRSA surveillance program.
Am J Clin Pathol 2015 May;143(5):652-8. doi: 10.1309/ajcpmdy32ztdxpfc..
Keywords: Methicillin-Resistant Staphylococcus aureus (MRSA), Healthcare-Associated Infections (HAIs), Patient Safety, Diagnostic Safety and Quality, Genetics
Balachandra S, Pardos de la Gandara M, Salvato S
Recurrent furunculosis caused by a community-acquired Staphylococcus aureus strain belonging to the USA300 clone.
This study is a clinical history of a patient with recurrent skin infections caused by a strain of CA-MRSA belonging to the USA300 clone. The strain was recovered repeatedly from wounds and lower body sites but never from the nostrils. The clinical history of recurrence strongly suggests the existence of a common environmental source of the MRSA strain.
AHRQ-funded; HS021667.
Citation: Balachandra S, Pardos de la Gandara M, Salvato S .
Recurrent furunculosis caused by a community-acquired Staphylococcus aureus strain belonging to the USA300 clone.
Microb Drug Resist 2015 Apr;21(2):237-43. doi: 10.1089/mdr.2014.0283..
Keywords: Skin Conditions, Methicillin-Resistant Staphylococcus aureus (MRSA), Injuries and Wounds, Community-Acquired Infections
Banach DB, Bearman GM, Morgan DJ
Infection control precautions for visitors to healthcare facilities.
Infection transmission in healthcare facilities is a growing concern. Visitation to healthcare facilities is very common, though the potential role of visitors in the transmission of infection is unknown. Decisions regarding whether to implement transmission-based precautions among visitors should take into account the organism of concern and means of transmission as well as factors pertaining to the visitor and the healthcare setting.
AHRQ-funded; HS018111.
Citation: Banach DB, Bearman GM, Morgan DJ .
Infection control precautions for visitors to healthcare facilities.
Infection control precautions for visitors to healthcare facilities..
Keywords: Methicillin-Resistant Staphylococcus aureus (MRSA), Prevention, Patient Safety
Lee CS, Montalmont B, O'Hara JA
Screening for methicillin-resistant Staphylococcus aureus colonization using sponges.
The researchers investigated whether the additional use of a sponge to collect skin culture samples would significantly improve the sensitivity of MRSA detection. They found that the sensitivity of nasal swab culture for screening MRSA carriage is low, but it can be improved significantly by adding a second method, either sampling the skin or the pharynx.
AHRQ-funded; HS021521.
Citation: Lee CS, Montalmont B, O'Hara JA .
Screening for methicillin-resistant Staphylococcus aureus colonization using sponges.
Infect Control Hosp Epidemiol 2015 Jan;36(1):28-33. doi: 10.1017/ice.2014.4..
Keywords: Methicillin-Resistant Staphylococcus aureus (MRSA), Healthcare-Associated Infections (HAIs), Patient Safety, Quality of Care, Screening