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AHRQ Research Studies
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Research Studies is a compilation of published research articles funded by AHRQ or authored by AHRQ researchers.
Results
1 to 25 of 26 Research Studies DisplayedAmick HR, Gartlehner G, Gaynes BN
Comparative benefits and harms of second generation antidepressants and cognitive behavioral therapies in initial treatment of major depressive disorder: systematic review and meta-analysis.
This systematic review sought to identify the benefits and harms of second generation antidepressants and cognitive behavioral therapies (CBTs) in the initial treatment of a current episode of major depressive disorder in adults. It concluded that the available evidence suggests no difference in treatment effects of second generation antidepressants and CBT, either alone or in combination, although small numbers may preclude detection of small but clinically meaningful differences.
AHRQ-funded; 290-2012-00008I
Citation: Amick HR, Gartlehner G, Gaynes BN .
Comparative benefits and harms of second generation antidepressants and cognitive behavioral therapies in initial treatment of major depressive disorder: systematic review and meta-analysis.
BMJ 2015 Dec 8;351:h6019. doi: 10.1136/bmj.h6019..
Keywords: Medication, Behavioral Health, Comparative Effectiveness, Depression
Yu SH, Silverberg JI
Association between atopic dermatitis and depression in US adults.
The researchers sought to determine the prevalence of depression in US adults with atopic dermatitis (AD). They concluded that approximately one in three US adults with AD reported any symptoms of depression and one in three adults with AD met diagnostic criteria for major depressive disorder.
AHRQ-funded; HS023011.
Citation: Yu SH, Silverberg JI .
Association between atopic dermatitis and depression in US adults.
J Invest Dermatol 2015 Dec;135(12):3183-6. doi: 10.1038/jid.2015.337..
Keywords: Depression, Behavioral Health, Risk, Skin Conditions
Mitchell SE, Martin JM, Krizman K
Design and rationale for a randomized controlled trial to reduce readmissions among patients with depressive symptoms.
This study aims to examine the effectiveness of RED-D, a modified brief Cognitive behavioral therapy (CBT) protocol delivered as a post-discharge extension of the Re-Engineered Discharge (RED), in reducing 30-day readmissions rates and emergency department use as well as depressive symptoms for medical patients with comorbid depressive symptoms.
AHRQ-funded; HS019700.
Citation: Mitchell SE, Martin JM, Krizman K .
Design and rationale for a randomized controlled trial to reduce readmissions among patients with depressive symptoms.
Contemp Clin Trials 2015 Nov;45(Pt B):151-6. doi: 10.1016/j.cct.2015.08.016.
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Keywords: Depression, Emergency Department, Hospital Discharge, Hospital Readmissions, Behavioral Health
Brent DA, Brunwasser SM, Hollon SD
Effect of a cognitive-behavioral prevention program on depression 6 years after implementation among at-risk adolescents: a randomized clinical trial.
The objective of this paper is to determine whether a cognitive-behavioral prevention (CBP) program reduced the incidence of depressive episodes, increased depression-free days, and improved developmental competence 6 years after implementation. Over the 75-month follow-up, youths assigned to CBP had a lower incidence of depression; the CBP program's overall significant effect was driven by a lower incidence of depressive episodes during the first 9 months after enrollment.
AHRQ-funded; HS022990.
Citation: Brent DA, Brunwasser SM, Hollon SD .
Effect of a cognitive-behavioral prevention program on depression 6 years after implementation among at-risk adolescents: a randomized clinical trial.
JAMA Psychiatry 2015 Nov;72(11):1110-8. doi: 10.1001/jamapsychiatry.2015.1559.
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Keywords: Behavioral Health, Children/Adolescents, Depression, Patient-Centered Outcomes Research
Pfoh E, Mojtabai R, Bailey J
Impact of Medicare annual wellness visits on uptake of depression screening.
This study assessed whether patients with an initial annual wellness visit (AWV) were more likely to be screened for depression than those with a primary care visit. Fifteen percent of patients with non-AWVs and 10 percent of patients with AWVs received depression screening. After accounting for clustering, there was no statistically significant difference in depression screening by visit type.
AHRQ-funded; HS000029.
Citation: Pfoh E, Mojtabai R, Bailey J .
Impact of Medicare annual wellness visits on uptake of depression screening.
Psychiatr Serv 2015 Nov;66(11):1207-12. doi: 10.1176/appi.ps.201400524.
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Keywords: Depression, Screening, Medicare, Elderly, Primary Care
Radovic A, Reynolds K, McCauley HL
Parents' role in adolescent depression care: primary care provider perspectives.
This study aimed to understand how primary care providers (PCPs) perceive barriers to adolescent depression care in order to inform strategies to increase treatment engagement. PCPs perceived that parental unwillingness to accept the depression diagnosis, family dysfunction, and trauma were common barriers. PCPs contrasted this with examples of good family support they believed would enable adolescents to attend follow-up appointments and have a “life coach” at home.
AHRQ-funded; HS022989; HS019486.
Citation: Radovic A, Reynolds K, McCauley HL .
Parents' role in adolescent depression care: primary care provider perspectives.
J Pediatr 2015 Oct;167(4):911-8. doi: 10.1016/j.jpeds.2015.05.049..
Keywords: Caregiving, Children/Adolescents, Depression, Behavioral Health, Primary Care
Abdus S, Zuvekas SH
AHRQ Author: Abdus S, Zuvekas SH
Racial/ethnic differences in the relationship between obesity and depression treatment.
This study examined the relationship between obesity and the treatment of depression across racial/ethnic subgroups, controlling for depressive symptoms, self-rated mental health, health status, and socioeconomic characteristics. It found that the association between obesity and depression-related medication was significant for white women but not for black or Hispanic women. The results for men were, in general, mixed and inconsistent.
AHRQ-authored.
Citation: Abdus S, Zuvekas SH .
Racial/ethnic differences in the relationship between obesity and depression treatment.
J Behav Health Serv Res 2015 Oct;42(4):486-503. doi: 10.1007/s11414-014-9391-1..
Keywords: Obesity, Depression, Social Determinants of Health, Racial and Ethnic Minorities, Medical Expenditure Panel Survey (MEPS)
Fernandes-Taylor S, Adesoye T, Bloom JR
Managing psychosocial issues faced by young women with breast cancer at the time of diagnosis and during active treatment.
This review examines recent literature on the psychosocial needs of and interventions for young women. It focuses on the active treatment period given the toxicity of treatment, the incidence of anxiety, and depressive symptoms in these women during treatment. It concluded that shared decision-making, balancing body image, fear of recurrence, and recommended treatment, and palliative care for metastasis are essential research priorities for the clinical setting.
AHRQ-funded; HS023395.
Citation: Fernandes-Taylor S, Adesoye T, Bloom JR .
Managing psychosocial issues faced by young women with breast cancer at the time of diagnosis and during active treatment.
Curr Opin Support Palliat Care 2015 Sep;9(3):279-84. doi: 10.1097/spc.0000000000000161..
Keywords: Anxiety, Cancer: Breast Cancer, Decision Making, Depression, Quality of Life
Chung H, Kim J, Askew RL
Assessing measurement invariance of three depression scales between neurologic samples and community samples.
The purpose of this study was to test measurement invariance of three patient-reported measures of depressive symptoms between neurologic and community samples. Its results suggest that depressive symptoms as measured by three different outcome measures have the same meaning across clinical and community samples. Thus, the use of these measures for group comparisons is supported.
AHRQ-funded; HS020700.
Citation: Chung H, Kim J, Askew RL .
Assessing measurement invariance of three depression scales between neurologic samples and community samples.
Qual Life Res 2015 Aug;24(8):1829-34. doi: 10.1007/s11136-015-0927-5..
Keywords: Depression, Outcomes, Comparative Effectiveness
Palar K, Kushel M, Frongillo EA
Food insecurity is longitudinally associated with depressive symptoms among homeless and marginally-housed individuals living with HIV.
The researchers assessed the longitudinal association of food insecurity with symptoms of depression using validated measures among participants living with HIV from the Research on Access to Care in the Homeless cohort in San Francisco. They found that over half of participants (55.0 percent) were food insecure and 35.8 percent had symptoms of depression.
AHRQ-funded; HS00046.
Citation: Palar K, Kushel M, Frongillo EA .
Food insecurity is longitudinally associated with depressive symptoms among homeless and marginally-housed individuals living with HIV.
AIDS Behav 2015 Aug;19(8):1527-34. doi: 10.1007/s10461-014-0922-9..
Keywords: Human Immunodeficiency Virus (HIV), Depression, Vulnerable Populations
Earnshaw VA, Smith LR, Cunningham CO
Intersectionality of internalized HIV stigma and internalized substance use stigma: implications for depressive symptoms.
The researchers examined whether the relationship between internalized HIV stigma and depressive symptoms is moderated by internalized substance use stigma. They found that participants who internalized HIV stigma experienced greater depressive symptoms only if they also internalized substance use stigma.
AHRQ-funded; HS022986.
Citation: Earnshaw VA, Smith LR, Cunningham CO .
Intersectionality of internalized HIV stigma and internalized substance use stigma: implications for depressive symptoms.
J Health Psychol 2015 Aug;20(8):1083-9. doi: 10.1177/1359105313507964..
Keywords: Depression, Human Immunodeficiency Virus (HIV), Behavioral Health, Social Stigma, Substance Abuse
Jolles MP, Haynes-Maslow L, Roberts MC
Mental health service use for adult patients with co-occurring depression and physical chronic health care needs, 2007-2010.
This study examines (1) whether the presence of chronic physical conditions is associated with mental health service use for individuals with depression who visit a primary care physician, and (2) whether race modifies this relationship. It found that most patient office visits (70 percent) where a depression diagnosis was recorded also had co-occurring chronic physical conditions recorded.
AHRQ-funded; HS000032.
Citation: Jolles MP, Haynes-Maslow L, Roberts MC .
Mental health service use for adult patients with co-occurring depression and physical chronic health care needs, 2007-2010.
Med Care 2015 Aug;53(8):708-12. doi: 10.1097/mlr.0000000000000389..
Keywords: Depression, Behavioral Health, Chronic Conditions, Primary Care
Connolly Gibbons MB, Kurtz JE, Thompson DL
The effectiveness of clinician feedback in the treatment of depression in the community mental health system.
This article described the development and evaluation of a clinician feedback intervention for use in community mental health settings. The Community Clinician Feedback System (CCFS) was developed in collaboration with a community partner to meet the needs of providers working in such community settings. Satisfaction ratings of the CCFS indicated that the system was widely accepted by clinicians and patients.
AHRQ-funded; HS022124.
Citation: Connolly Gibbons MB, Kurtz JE, Thompson DL .
The effectiveness of clinician feedback in the treatment of depression in the community mental health system.
J Consult Clin Psychol 2015 Aug;83(4):748-59. doi: 10.1037/a0039302..
Keywords: Community-Based Practice, Community Partnerships, Depression, Behavioral Health, Patient Experience
Sims M, Redmond N, Khodneva Y
Depressive symptoms are associated with incident coronary heart disease or revascularization among blacks but not among whites in the Reasons for Geographical and Racial Differences in Stroke study.
The authors examined the association of depressive symptoms with coronary heart disease (CHD) end points by race and income. They found that high depressive symptoms were associated with higher risk of CHD or revascularization for blacks but not whites.
AHRQ-funded; HS023009.
Citation: Sims M, Redmond N, Khodneva Y .
Depressive symptoms are associated with incident coronary heart disease or revascularization among blacks but not among whites in the Reasons for Geographical and Racial Differences in Stroke study.
Ann Epidemiol 2015 Jun;25(6):426-32. doi: 10.1016/j.annepidem.2015.03.014.
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Keywords: Depression, Disparities, Heart Disease and Health, Racial and Ethnic Minorities, Stroke
Sorkin DH, Billimek J, August KJ
AHRQ Author: Ngo-Metzger Q
Mental health symptoms and patient-reported diabetes symptom burden: implications for medication regimen changes.
The aim of this paper was to examine the relative contribution of glycaemic control (HbA1C) and depressive symptoms on diabetes-related symptom burden (hypoglycaemia and hyperglycaemia) in order to guide medication modification. The authors found that mental health symptoms are associated with higher levels of patient-reported diabetes-related symptoms, but the association between diabetes-related symptoms and subsequent regimen modifications is diminished in patients with greater depressive symptoms.
AHRQ-authored.
Citation: Sorkin DH, Billimek J, August KJ .
Mental health symptoms and patient-reported diabetes symptom burden: implications for medication regimen changes.
Fam Pract 2015 Jun;32(3):317-22. doi: 10.1093/fampra/cmv014.
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Keywords: Depression, Diabetes, Medication, Practice Patterns, Social Determinants of Health
Gibbons MB, Thompson SM, Mack RA
The relation of baseline skills to psychotherapy outcome across diverse psychotherapies.
The researchers explored the role of baseline skills deficits in compensatory skills and self-understanding across both cognitive and dynamic treatment modalities. Their results support a capitalization model for cognitive therapy but failed to support either a compensation model or a capitalization model for the short-term dynamic model.
AHRQ-funded; HS022124.
Citation: Gibbons MB, Thompson SM, Mack RA .
The relation of baseline skills to psychotherapy outcome across diverse psychotherapies.
J Clin Psychol 2015 Jun;71(6):491-9. doi: 10.1002/jclp.22165..
Keywords: Comparative Effectiveness, Depression, Behavioral Health, Outcomes, Patient-Centered Outcomes Research
Samples H, Mojtabai R
Antidepressant self-discontinuation: results from the collaborative psychiatric epidemiology surveys.
The authors examined the extent and correlates of self-discontinuation of antidepressant medications without physician advice using the Collaborative Psychiatric Epidemiology Surveys. They concluded that physicians prescribing antidepressants need to communicate clearly about the expected benefits of treatment, the minimum duration of use required to experience benefits, and the potential side effects of these medications, particularly to younger patients, those with anxiety disorders, and patients treated in general medical settings, all of whom have increased odds of self-discontinuation.
AHRQ-funded; HS000029.
Citation: Samples H, Mojtabai R .
Antidepressant self-discontinuation: results from the collaborative psychiatric epidemiology surveys.
Psychiatr Serv 2015 May;66(5):455-62. doi: 10.1176/appi.ps.201400021.
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Keywords: Medication, Depression, Medication: Safety, Behavioral Health, Patient Adherence/Compliance
Yawn BP, Bertram S, Kurland M
Repeated depression screening during the first postpartum year.
The researchers report a substudy of a large pragmatic trial of early post-partum depression screening and practice management, the Translating Research into Practice for Postpartum Depression (TRIPPD) study. They concluded that repeated PPD screening at 6 and 12 months’ postpartum increases the percentage of women identified as being at high risk of PPD.
AHRQ-funded; HS014744.
Citation: Yawn BP, Bertram S, Kurland M .
Repeated depression screening during the first postpartum year.
Ann Fam Med 2015 May-Jun;13(3):228-34. doi: 10.1370/afm.1777..
Keywords: Depression, Implementation, Screening, Prevention
Mayberry LS, Egede LE, Wagner JA
Stress, depression and medication nonadherence in diabetes: test of the exacerbating and buffering effects of family support.
The researchers tested the moderation hypotheses that the associations between stressors/depressive symptoms and nonadherence would be stronger in the context of more obstructive family behaviors (exacerbating hypothesis) and weaker in the context of more supportive family behaviors (buffering hypothesis). They found that stressors and nonadherence were only associated at higher levels of obstructive family behaviors. Similarly, depressive symptoms and nonadherence were only associated at higher levels of obstructive family behaviors.
AHRQ-funded; HS022990.
Citation: Mayberry LS, Egede LE, Wagner JA .
Stress, depression and medication nonadherence in diabetes: test of the exacerbating and buffering effects of family support.
J Behav Med 2015 Apr;38(2):363-71. doi: 10.1007/s10865-014-9611-4..
Keywords: Diabetes, Medication, Patient Adherence/Compliance, Depression, Stress
Adams AS, Soumerai SB, Zhang F
Effects of eliminating drug caps on racial differences in antidepressant use among dual enrollees with diabetes and depression.
This study aimed to evaluate the impact of removing a significant financial barrier to prescription medications (drug caps) on existing black-white disparities in antidepressant treatment rates among patients with diabetes and comorbid depression. It found that policies that remove financial barriers to medications may increase depression treatment rates among patients with diabetes overall while exacerbating treatment disparities.
AHRQ-funded; HS018577; HS018072.
Citation: Adams AS, Soumerai SB, Zhang F .
Effects of eliminating drug caps on racial differences in antidepressant use among dual enrollees with diabetes and depression.
Clin Ther 2015 Mar;37(3):597-609. doi: 10.1016/j.clinthera.2014.12.011..
Keywords: Medication, Disparities, Depression, Diabetes, Healthcare Costs
Alcantara C, Muntner P, Edmondson D
Perfect storm: concurrent stress and depressive symptoms increase risk of myocardial infarction or death.
A recently offered psychosocial perfect storm conceptual model hypothesizes amplified risk will occur in those with concurrent stress and depressive symptoms. The authors tested this hypothesis in a large sample of US adults with coronary heart disease. They found that those with low stress and high depressive symptoms or high stress and low depressive symptoms were not at increased risk, while participants with concurrent high stress and high depressive symptoms had increased risk for myocardial infarction or death relative to those with low stress and low depressive symptoms. They concluded that their results provide initial support for a psychosocial perfect storm conceptual model.
AHRQ-funded; HS023009.
Citation: Alcantara C, Muntner P, Edmondson D .
Perfect storm: concurrent stress and depressive symptoms increase risk of myocardial infarction or death.
Circ Cardiovasc Qual Outcomes 2015 Mar;8(2):146-54. doi: 10.1161/circoutcomes.114.001180.
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Keywords: Depression, Heart Disease and Health, Mortality, Risk, Stress
Gibbons RD, Coca Perraillon M, Hur K
Antidepressant treatment and suicide attempts and self-inflicted injury in children and adolescents.
This study explores the relationship between antidepressant treatment and suicide attempt and self-inflicted injury in depressed children ages 5–17. Using two large claim datasets (LifeLink and MarketScan), the researchers find that after taking into account the time-varying effect of confounders, the apparent link between antidepressant use and suicide attempts and self-inflicted injury is diminished and not statistically significant.
AHRQ-funded; HS021093; HS000084
Citation: Gibbons RD, Coca Perraillon M, Hur K .
Antidepressant treatment and suicide attempts and self-inflicted injury in children and adolescents.
Pharmacoepidemiol Drug Saf 2015 Feb;24(2):208-14. doi: 10.1002/pds.3713..
Keywords: Medication, Children/Adolescents, Depression, Risk
Madden JM, Adams AS, LeCates RF
Changes in drug coverage generosity and untreated serious mental illness: transitioning from Medicaid to Medicare Part D.
This study examined the effects of transitioning to Part D coverage among disabled dual enrollees with schizophrenia or a bipolar disorder, comparing enrollees in states with strict Medicaid cap policies with enrollees in states without caps. It found significant reductions in the number of people with a serious mental illness who were not treated owing to the transition to Part D from strictly capped Medicaid coverage.
AHRQ-funded; HS018577.
Citation: Madden JM, Adams AS, LeCates RF .
Changes in drug coverage generosity and untreated serious mental illness: transitioning from Medicaid to Medicare Part D.
JAMA Psychiatry 2015 Feb;72(2):179-88. doi: 10.1001/jamapsychiatry.2014.1259..
Keywords: Behavioral Health, Medication, Medicare, Medicaid, Depression
Olfson M, Gerhard T
Re-examining antidepressant risk of self-injury in children and adolescents.
This commentary discusses issues raised in the study by Gibbons, et al. that focused on the association between antidepressant treatment and risk of medically injurious self-inflicted harm in young people diagnosed with depression. One example is the threat of unmeasured confounding that arises from the wide range of self-injury risk factors that are not represented in claims data.
AHRQ-funded; HS021112.
Citation: Olfson M, Gerhard T .
Re-examining antidepressant risk of self-injury in children and adolescents.
Pharmacoepidemiol Drug Saf 2015 Feb;24(2):215-7. doi: 10.1002/pds.3737..
Keywords: Medication, Children/Adolescents, Depression, Risk
Ojard C, Donnelly JP, Safford MM
Psychosocial stress as a risk factor for sepsis: a population-based cohort study.
This study characterized the relationship between stress and future risk of sepsis and evaluated the role of depression in this relationship. It found that increased stress was associated with higher 1-year adjusted incidence of sepsis, even after accounting for depressive symptoms.
AHRQ-funded; HS013852.
Citation: Ojard C, Donnelly JP, Safford MM .
Psychosocial stress as a risk factor for sepsis: a population-based cohort study.
Psychosom Med 2015 Jan;77(1):93-100. doi: 10.1097/psy.0000000000000120..
Keywords: Risk, Depression, Stress