National Healthcare Quality and Disparities Report
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AHRQ Research Studies Date
Topics
- Adverse Events (2)
- Antibiotics (2)
- Arthritis (1)
- Cancer: Lung Cancer (1)
- Cardiovascular Conditions (1)
- Care Management (1)
- Children/Adolescents (6)
- Chronic Conditions (2)
- Comparative Effectiveness (4)
- Data (1)
- Diagnostic Safety and Quality (3)
- Elderly (4)
- Emergency Department (2)
- Evidence-Based Practice (1)
- Guidelines (1)
- Healthcare Cost and Utilization Project (HCUP) (4)
- Healthcare Utilization (1)
- Heart Disease and Health (1)
- Home Healthcare (1)
- Hospitalization (3)
- Hospital Readmissions (1)
- Imaging (2)
- Infectious Diseases (2)
- Injuries and Wounds (1)
- Medicaid (1)
- Medicare (2)
- Medication (5)
- Newborns/Infants (3)
- Outcomes (3)
- Pain (1)
- Palliative Care (1)
- Patient-Centered Outcomes Research (5)
- Patient Safety (3)
- Pneumonia (2)
- Practice Patterns (1)
- Primary Care (1)
- Provider: Pharmacist (1)
- Public Health (1)
- Quality of Care (2)
- Quality of Life (1)
- Racial and Ethnic Minorities (1)
- Research Methodologies (1)
- (-) Respiratory Conditions (28)
- Risk (5)
- Sleep Problems (1)
- Surgery (2)
AHRQ Research Studies
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Research Studies is a compilation of published research articles funded by AHRQ or authored by AHRQ researchers.
Results
1 to 25 of 28 Research Studies DisplayedGullett J, Donnelly JP, Sinert R
Interobserver agreement in the evaluation of B-lines using bedside ultrasound.
The researchers evaluated agreement among trained emergency physicians assessing the degree of B-line presence on bedside ultrasound in patients presenting to the emergency department (ED) with acute undifferentiated dyspnea. They concluded that interrater agreement was best in the anterior/superior thoracic zones followed by the lateral/superior zones for both expert/expert and expert/novice pairs.
AHRQ-funded; HS013852.
Citation: Gullett J, Donnelly JP, Sinert R .
Interobserver agreement in the evaluation of B-lines using bedside ultrasound.
J Crit Care 2015 Dec;30(6):1395-9. doi: 10.1016/j.jcrc.2015.08.021.
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Keywords: Emergency Department, Imaging, Respiratory Conditions
Cristea AI, Ackerman VL, Swigonski NL
Physiologic findings in children previously ventilator dependent at home due to bronchopulmonary dysplasia.
Bronchopulmonary dysplasia (BPD) is the primary respiratory complication of premature birth. Little is known about spirometric indices in patients with severe BPD who were previously ventilator dependent at home. The study concluded that extreme prematurity associated with severe BPD requiring home ventilator support carries significant risks of morbidity. These patients had substantially diminished respiratory function reflecting airflow abnormalities that remained static over time.
AHRQ-funded; HS017588.
Citation: Cristea AI, Ackerman VL, Swigonski NL .
Physiologic findings in children previously ventilator dependent at home due to bronchopulmonary dysplasia.
Pediatr Pulmonol 2015 Nov;50(11):1113-8. doi: 10.1002/ppul.23129.
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Keywords: Children/Adolescents, Newborns/Infants, Newborns/Infants, Respiratory Conditions
Curtis JR, Sarsour K, Napalkov P
Incidence and complications of interstitial lung disease in users of tocilizumab, rituximab, abatacept and anti-tumor necrosis factor alpha agents, a retrospective cohort study.
Interstitial lung disease (ILD) is a common extra-articular condition in rheumatoid arthritis (RA), but few studies have systematically investigated its incidence and risk factors in patients receiving anti-tumor necrosis factor-alpha (anti-TNFα) agents or alternate mechanisms of action (MOAs). After examining 13,795 episodes of biologic exposure in 11,219 patients, researchers found no significant differences in the risk of ILD and its related complications between RA patients receiving anti-TNFα agents and those receiving alternate MOA agents.
AHRQ-funded; HS018517.
Citation: Curtis JR, Sarsour K, Napalkov P .
Incidence and complications of interstitial lung disease in users of tocilizumab, rituximab, abatacept and anti-tumor necrosis factor alpha agents, a retrospective cohort study.
Arthritis Res Ther 2015 Nov 11;17:319. doi: 10.1186/s13075-015-0835-7..
Keywords: Arthritis, Comparative Effectiveness, Medication, Respiratory Conditions, Risk
Ajmera M, Sambamoorthi U, Metzger A
Multimorbidity and COPD Medication receipt among Medicaid beneficiaries with newly diagnosed COPD.
The aim of this study was to examine the association between multimorbidity and chronic obstructive pulmonary disease ( COPD) medication receipt among Medicaid beneficiaries with newly diagnosed COPD. It found that in this group 81.9 percen had at least one co-occurring chronic condition. After controlling for subject characteristics, adults with multimorbidity were less likely to receive COPD medications compared with those without any inflammation-related multimorbidity.
AHRQ-funded; HS022444.
Citation: Ajmera M, Sambamoorthi U, Metzger A .
Multimorbidity and COPD Medication receipt among Medicaid beneficiaries with newly diagnosed COPD.
Respir Care 2015 Nov;60(11):1592-602. doi: 10.4187/respcare.03788.
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Keywords: Chronic Conditions, Respiratory Conditions, Medication, Medicaid
Bhattacharyya S, Gesteland PH, Korgenski K
Cross-immunity between strains explains the dynamical pattern of paramyxoviruses.
The researchers used long-term incidence data on Respiratory Syncytial Virus (RSV), three serotypes of Human Parainfluenza Virus (HPIV), and Human Metapneumovirus to study mathematical models of different mechanisms of pathogen interaction. Their results showed a strong signal of cross-protection from RSV in controlling the timing and magnitude of HPIV outbreaks, and a stronger interaction with more closely related serotypes.
AHRQ-funded; HS018538.
Citation: Bhattacharyya S, Gesteland PH, Korgenski K .
Cross-immunity between strains explains the dynamical pattern of paramyxoviruses.
Proc Natl Acad Sci U S A 2015 Oct 27;112(43):13396-400. doi: 10.1073/pnas.1516698112..
Keywords: Data, Public Health, Respiratory Conditions
Downes KJ, Patil NR, Rao MB
Risk factors for acute kidney injury during aminoglycoside therapy in patients with cystic fibrosis.
The aim of this study was to identify factors associated with acute kidney injury (AKI) during intravenous aminoglycoside (AG) courses in this population. It identified receipt of an AG within 90 days prior to admission, longer duration of AG therapy, low serum albumin, and receipt of trimethoprim/ sulfamethoxazole as independent risk factors for developing AKI.
AHRQ-funded; HS021114.
Citation: Downes KJ, Patil NR, Rao MB .
Risk factors for acute kidney injury during aminoglycoside therapy in patients with cystic fibrosis.
Pediatr Nephrol 2015 Oct;30(10):1879-88. doi: 10.1007/s00467-015-3097-3..
Keywords: Adverse Events, Patient-Centered Outcomes Research, Patient Safety, Respiratory Conditions
Michelson KA, Monuteaux MC, Neuman MI
Glucocorticoids and hospital length of stay for children with anaphylaxis: a retrospective study.
The objective of this study was to evaluate whether glucocorticoid administration is associated with improved outcomes in children with anaphylaxis. The investigators found that the use of glucocorticoids was inversely associated with prolonged length of stay among children hospitalized with anaphylaxis, but was not associated with 3-day emergency department revisits among discharged children, thus supporting the use of glucocorticoids in children hospitalized with anaphylaxis.
AHRQ-funded; HS000063.
Citation: Michelson KA, Monuteaux MC, Neuman MI .
Glucocorticoids and hospital length of stay for children with anaphylaxis: a retrospective study.
J Pediatr 2015 Sep;167(3):719-24.e1-3. doi: 10.1016/j.jpeds.2015.05.033.
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Keywords: Children/Adolescents, Medication, Respiratory Conditions, Respiratory Conditions, Patient-Centered Outcomes Research
Wysham NG, Cox CE, Wolf SP
Symptom burden of chronic lung disease compared with lung cancer at time of referral for palliative care consultation.
The authors compared the symptom burden of chronic lung disease with that of lung cancer at the time of initial palliative care consultation. They found that patients with chronic lung disease have symptom burdens similar to those of patients with lung cancer at the time of the first palliative care encounter. They concluded that, given the population burden of chronic lung disease and limitations in the palliative care workforce, attention should be focused on ensuring that pulmonologists are prepared to assess and manage the common palliative care needs of patients with chronic lung disease.
AHRQ-funded; HS023681.
Citation: Wysham NG, Cox CE, Wolf SP .
Symptom burden of chronic lung disease compared with lung cancer at time of referral for palliative care consultation.
Ann Am Thorac Soc 2015 Sep;12(9):1294-301. doi: 10.1513/AnnalsATS.201503-180OC.
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Keywords: Respiratory Conditions, Cancer: Lung Cancer, Pain, Palliative Care, Patient-Centered Outcomes Research
Mehta AB, Syeda SN, Bajpayee L
Trends in tracheostomy for mechanically ventilated patients in the United States, 1993-2012.
This study investigated trends in tracheostomy use, timing, and outcomes in the United States. It found that over the past two decades, tracheostomy use rose substantially in the United States until 2008, when use began to decline. In addition, there was an observed dramatic increase in discharge of tracheostomy patients to long-term care facilities.
AHRQ-funded; HS020672.
Citation: Mehta AB, Syeda SN, Bajpayee L .
Trends in tracheostomy for mechanically ventilated patients in the United States, 1993-2012.
Am J Respir Crit Care Med 2015 Aug 15;192(4):446-54. doi: 10.1164/rccm.201502-0239OC..
Keywords: Healthcare Cost and Utilization Project (HCUP), Outcomes, Healthcare Utilization, Respiratory Conditions
Abdelsattar ZM, Hendren S, Wong SL
The impact of untreated obstructive sleep apnea on cardiopulmonary complications in general and vascular surgery: a cohort study.
The purpose of this study was to determine whether preoperatively untreated obstructive sleep apnea (OSA) affects postoperative outcomes. It found that compared with treated OSA, untreated OSA was independently associated with more cardiopulmonary complications (risk-adjusted rates 6.7 percent versus 4.0 percent; particularly unplanned reintubations and myocardial infarction.
AHRQ-funded; HS000053.
Citation: Abdelsattar ZM, Hendren S, Wong SL .
The impact of untreated obstructive sleep apnea on cardiopulmonary complications in general and vascular surgery: a cohort study.
Sleep 2015 Aug;38(8):1205-10. doi: 10.5665/sleep.4892..
Keywords: Sleep Problems, Surgery, Patient Safety, Risk, Heart Disease and Health, Respiratory Conditions, Chronic Conditions
Bell ML, Son JY, Peng RD
Ambient PM2.5 and risk of hospital admissions: do risks differ for men and women?
The researchers conducted a multi-site time-series analysis of short-term fine particulate matter (PM) exposure and cardiovascular and respiratory hospital admissions among older persons to examine whether effects differ by sex. They found that women may be more susceptible to PM2.5-related hospitalizations for some respiratory and cardiovascular causes.
AHRQ-funded; HS021991.
Citation: Bell ML, Son JY, Peng RD .
Ambient PM2.5 and risk of hospital admissions: do risks differ for men and women?
Epidemiology 2015 Jul;26(4):575-9. doi: 10.1097/ede.0000000000000310..
Keywords: Elderly, Hospitalization, Respiratory Conditions, Cardiovascular Conditions
Linares-Perdomo O, East TD, Brower R
Standardizing predicted body weight equations for mechanical ventilation tidal volume settings.
Predicted body weight (PBW) equations use height, age, and sex as input variables. The researchers compared National Institutes of Health (NIH) ARDS Network (ARDSNet), actuarial table (ACTUARIAL), and Stewart (STEWART) PBW equations used in clinical trials, across physiologic ranges for age and height. They concluded that significant differences between PBW equations for both men and women could be important sources of interstudy variation. Studies should adopt a standard PBW equation.
AHRQ-funded; HS006594.
Citation: Linares-Perdomo O, East TD, Brower R .
Standardizing predicted body weight equations for mechanical ventilation tidal volume settings.
Chest 2015 Jul;148(1):73-8. doi: 10.1378/chest.14-2843..
Keywords: Research Methodologies, Respiratory Conditions, Quality of Care
Kelly MS, Smieja M, Luinstra K
Association of respiratory viruses with outcomes of severe childhood pneumonia in Botswana.
The authors examined whether detection of respiratory viruses predicts acute lower respiratory tract infection (ALRI) outcomes in low- and middle-income countries. They found that respiratory viruses were detected from most children hospitalized with ALRI in Botswana, but only respiratory syncytial virus (RSV) and human metapneumovirus were more frequent than among children without ALRI. Further, detection of RSV from children with ALRI predicted a protracted illness course but lower mortality compared with non-RSV viruses.
AHRQ-funded; HS020939.
Citation: Kelly MS, Smieja M, Luinstra K .
Association of respiratory viruses with outcomes of severe childhood pneumonia in Botswana.
PLoS One 2015 May 14;10(5):e0126593. doi: 10.1371/journal.pone.0126593.
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Keywords: Children/Adolescents, Diagnostic Safety and Quality, Pneumonia, Respiratory Conditions
Uronis HE, Ekstrom MP, Currow DC
Oxygen for relief of dyspnoea in people with chronic obstructive pulmonary disease who would not qualify for home oxygen: a systematic review and meta-analysis.
The researchers conducted a systematic review and meta-analysis to determine whether oxygen therapy provides symptomatic relief in COPD patients with breathlessness who do not qualify currently for long-term oxygen. They concluded that continuous oxygen during exertion, but not short-burst therapy, reduced dyspnoea in mildly- and non-hypoxemic people with COPD who would not otherwise qualify for home oxygen therapy.
AHRQ-funded; HS000079.
Citation: Uronis HE, Ekstrom MP, Currow DC .
Oxygen for relief of dyspnoea in people with chronic obstructive pulmonary disease who would not qualify for home oxygen: a systematic review and meta-analysis.
Thorax 2015 May;70(5):492-4. doi: 10.1136/thoraxjnl-2014-205720..
Keywords: Comparative Effectiveness, Home Healthcare, Respiratory Conditions
Shah T, Churpek MM, Coca Perraillon M
Understanding why patients with COPD get readmitted: a large national study to delineate the Medicare population for the readmissions penalty expansion.
The Hospital Readmissions Reduction Program (HRRP) penalizes hospitals for 30-day readmissions and was extended to COPD in October 2014. The authors investigated readmission risk factors and reasons for readmission in order to guide hospitals in initiating programs to reduce COPD readmissions. They found that patients discharged home without home care were more likely to be readmitted for COPD than patients discharged to post-acute care, and those readmitted were more likely to be dually enrolled in Medicare and Medicaid, have a longer median length of stay, and have more comorbidities. They concluded that the addition of COPD to the readmissions penalty may further worsen the disproportionately high penalties seen in safety net hospitals.
AHRQ-funded; HS021877.
Citation: Shah T, Churpek MM, Coca Perraillon M .
Understanding why patients with COPD get readmitted: a large national study to delineate the Medicare population for the readmissions penalty expansion.
Chest 2015 May;147(5):1219-26. doi: 10.1378/chest.14-2181.
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Keywords: Respiratory Conditions, Elderly, Medicare, Hospital Readmissions
Mehrotra A, Gidengil CA, Setodji CM
Antibiotic prescribing for respiratory infections at retail clinics, physician practices, and emergency departments.
The authors compared antibiotic prescribing among retail clinics, primary care practices, and emergency departments (EDs) for acute respiratory infections (ARIs): antibiotics-may-be-appropriate ARIs and antibiotics-never-appropriate ARIs. They found that, compared with primary care practices and EDs, there was no difference at retail clinics in overall ARI antibiotic prescribing, which was more diagnosis-appropriate.
AHRQ-funded; HS018419.
Citation: Mehrotra A, Gidengil CA, Setodji CM .
Antibiotic prescribing for respiratory infections at retail clinics, physician practices, and emergency departments.
Am J Manag Care 2015 Apr;21(4):294-302.
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Keywords: Antibiotics, Emergency Department, Provider: Pharmacist, Primary Care, Respiratory Conditions
Sharma G, Meena R, Goodwin JS
Burn injury associated with home oxygen use in patients with chronic obstructive pulmonary disease.
The researchers quantified the risk of burn injury associated with home oxygen use and examined the risk factors associated with the development of this injury. They found that the absolute risk of burn injury in patients prescribed oxygen therapy was 2.98 per 1000 patients compared with 1.69 per 1000 patients not prescribed oxygen during a 22-month period.
AHRQ-funded; HS020642; HS022134.
Citation: Sharma G, Meena R, Goodwin JS .
Burn injury associated with home oxygen use in patients with chronic obstructive pulmonary disease.
Mayo Clin Proc 2015 Apr;90(4):492-9. doi: 10.1016/j.mayocp.2014.12.024..
Keywords: Injuries and Wounds, Adverse Events, Risk, Respiratory Conditions, Elderly
Nykiel-Bailey SM, McAllister JD, Schrock CR
Difficult airway consultation service for children: steps to implement and preliminary results.
The article demonstrates how to implement a consultative service focusing on difficult airway (DAW) identification, management and education. The initial 3-month experience confirmed that a majority of pediatric DAW events are associated with congenital or acquired abnormalities. Through appropriate consultation and leadership, the Difficult Airway Service was able to physically and electronically identify pediatric patients with a DAW and provide management.
AHRQ-funded; HS022265.
Citation: Nykiel-Bailey SM, McAllister JD, Schrock CR .
Difficult airway consultation service for children: steps to implement and preliminary results.
Paediatr Anaesth 2015 Apr;25(4):363-71. doi: 10.1111/pan.12625..
Keywords: Care Management, Children/Adolescents, Respiratory Conditions, Patient Safety, Risk
Nishi SP, Zhang W, Kuo YF
Oxygen therapy use in older adults with chronic obstructive pulmonary disease.
The researchers examined national trends and factors associated with the use of oxygen therapy and sustained oxygen therapy in older adults with COPD between 2001 and 2010. They found an increase in oxygen therapy use but a decrease in sustained oxygen therapy in fee-for-service Medicare beneficiaries with COPD from 2001 to 2010.
AHRQ-funded; HS022134; HS020642.
Citation: Nishi SP, Zhang W, Kuo YF .
Oxygen therapy use in older adults with chronic obstructive pulmonary disease.
PLoS One 2015 Mar 18;10(3):e0120684. doi: 10.1371/journal.pone.0120684..
Keywords: Elderly, Medicare, Respiratory Conditions
Hajizadeh N, Goldfeld
What happens to patients with COPD with long-term oxygen treatment who receive mechanical ventilation for COPD exacerbation? A 1-year retrospective follow-up study.
This study describes outcomes for patients with chronic obstructive pulmonary disease (COPD) on long-term oxygen treatment who are admitted to an ICU for respiratory failure and receive invasive mechanical ventilation. Of the 4,791 patients, 23 percent died in the hospital, and 45 percent died in the subsequent 12 months. Also, 67 percent of patients were readmitted at least once in the subsequent 12 months.
AHRQ-funded; HS019473.
Citation: Hajizadeh N, Goldfeld .
What happens to patients with COPD with long-term oxygen treatment who receive mechanical ventilation for COPD exacerbation? A 1-year retrospective follow-up study.
Thorax 2015 Mar;70(3):294-6. doi: 10.1136/thoraxjnl-2014-205248..
Keywords: Patient-Centered Outcomes Research, Outcomes, Comparative Effectiveness, Respiratory Conditions
Linder JA
Sore throat: avoid overcomplicating the uncomplicated.
In this editorial, the author described issues involving sore throat diagnosis and delineated various points concerning an article within the same journal issue, concluding that physicians should remember that the prevalence of group A streptococcus in adults with a sore throat is approximately 10%; and that they should use the Centor scoring criteria; selectively use rapid antigen-detection testing; limit antibiotic treatment to patients most likely to have group A streptococcus; and most of the time when prescribing antibiotics, use penicillin.
AHRQ-funded; HS018419.
Citation: Linder JA .
Sore throat: avoid overcomplicating the uncomplicated.
Ann Intern Med 2015 Feb 17;162(4):311-2. doi: 10.7326/m14-2899.
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Keywords: Antibiotics, Diagnostic Safety and Quality, Infectious Diseases, Medication, Pneumonia, Respiratory Conditions, Practice Patterns
Kaplan RM, Sun Q, Ries AL
AHRQ Author: Kaplan RM
Quality of well-being outcomes in the National Emphysema Treatment Trial.
The purpose of this article is to report outcomes from the National Emphysema Treatment Trial (NETT) using an index that combines quality and quantity of life. Results showed that, compared with maximal medical therapy alone, patients undergoing maximal medical therapy plus lung volume reduction surgery experienced improved health-related quality of life and gained more quality-adjusted life years.
AHRQ-authored.
Citation: Kaplan RM, Sun Q, Ries AL .
Quality of well-being outcomes in the National Emphysema Treatment Trial.
Chest 2015 Feb;147(2):377-87. doi: 10.1378/chest.14-0528.
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Keywords: Comparative Effectiveness, Patient-Centered Outcomes Research, Quality of Life, Respiratory Conditions, Surgery
Gidengil CA, Linder JA, Hunter G
The volume-quality relationship in antibiotic prescribing: when more isn't better.
The researchers examined the impact of volume on more common medical conditions such as acute respiratory infections (ARIs). They found that higher ARI volume physicians had lower quality across a number of domains, including higher antibiotic prescribing rates, higher broad-spectrum antibiotic prescribing, and lower guideline concordance. When they prescribed an antibiotic for a diagnosis for which an antibiotic may be indicated, they were less likely to prescribe guideline-concordant antibiotics.
AHRQ-funded; HS018419.
Citation: Gidengil CA, Linder JA, Hunter G .
The volume-quality relationship in antibiotic prescribing: when more isn't better.
Inquiry 2015 Feb 10;52. doi: 10.1177/0046958015571130..
Keywords: Quality of Care, Medication, Respiratory Conditions, Guidelines
Ault MJ, Rosen BT, Scher J
Thoracentesis outcomes: a 12-year experience.
The researchers evaluated specific demographic and clinical factors that have been commonly associated with complications such as iatrogenic pneumothorax, re-expansion pulmonary edema and bleeding. They found that thoracenteses had a very low complication rate and concluded that current clinical guidelines and practice patterns may not reflect evidence-based best practices.
AHRQ-funded; HS021202.
Citation: Ault MJ, Rosen BT, Scher J .
Thoracentesis outcomes: a 12-year experience.
Thorax 2015 Feb;70(2):127-32. doi: 10.1136/thoraxjnl-2014-206114..
Keywords: Risk, Evidence-Based Practice, Respiratory Conditions, Respiratory Conditions, Outcomes
Weinberger DM, Klugman KP, Steiner CA
AHRQ Author: Steiner CA
Association between respiratory syncytial virus activity and pneumococcal disease in infants: a time series analysis of US hospitalization data.
The researchers evaluated whether variations in respiratory syncytial virus (RSV) epidemic timing and magnitude are associated with variations in pneumococcal disease epidemics and whether changes in pneumococcal disease following the introduction of a pneumococcal conjugate vaccine (PCV7) were associated with changes in the rate of RSV hospitalizations. Their findings indicate that RSV is associated with increases in the incidence of pneumococcal pneumonia.
AHRQ-authored.
Citation: Weinberger DM, Klugman KP, Steiner CA .
Association between respiratory syncytial virus activity and pneumococcal disease in infants: a time series analysis of US hospitalization data.
PLoS Med 2015 Jan 6;12(1):e1001776. doi: 10.1371/journal.pmed.1001776..
Keywords: Healthcare Cost and Utilization Project (HCUP), Newborns/Infants, Respiratory Conditions, Hospitalization