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AHRQ Research Studies
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Research Studies is a compilation of published research articles funded by AHRQ or authored by AHRQ researchers.
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1 to 2 of 2 Research Studies DisplayedKunst NR, Alarid-Escudero F, Paltiel AD
A value of information analysis of research on the 21-gene assay for breast cancer management.
The authors aimed to quantify the value of conducting further research to reduce decision uncertainty in the use of the 21-gene assay Oncotype DX (21-GA). They found that current evidence strongly supports the use of the 21-GA in intermediate- and high-risk women and recommended that further research focus on low-risk women.
AHRQ-funded; HS023900.
Citation: Kunst NR, Alarid-Escudero F, Paltiel AD .
A value of information analysis of research on the 21-gene assay for breast cancer management.
Value Health 2019 Oct;22(10):1102-10. doi: 10.1016/j.jval.2019.05.004..
Keywords: Genetics, Cancer: Breast Cancer, Cancer, Decision Making, Research Methodologies
Rockova V
Bayesian estimation of sparse signals with a continuous spike-and-slab prior.
The authors introduced the family of Spike-and-Slab LASSO (SS-LASSO) priors, which form a continuum between the Laplace prior and the point-mass spike-and-slab prior. They established several frequentist properties of SS-LASSO priors, contrasting them with these two limiting cases. They concluded that the SS-LASSO priors, despite being continuous, possess similar optimality properties as the "theoretically ideal" point-mass mixtures.
AHRQ-funded; HS021854.
Citation: Rockova V .
Bayesian estimation of sparse signals with a continuous spike-and-slab prior.
Ann Statist 2018;46(1):401-37. doi: 10.1214/17-AOS1554.
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Keywords: Research Methodologies