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Research Studies is a compilation of published research articles funded by AHRQ or authored by AHRQ researchers.
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1 to 3 of 3 Research Studies DisplayedPatel PB, De Guerre L, Marcaccio CL
Sex-specific criteria for repair should be utilized in patients undergoing aortic aneurysm repair.
This study’s goal was determine if identifying inherent anatomic differences between sexes, aortic size index (ASI) and aortic height index (AHI) may provide an additional method for guiding treatment for abdominal aortic aneurysm (AAA) surgery. Females are more likely to undergo repair at smaller aortic diameter compared with male patients. The authors identified all patients who underwent AAA repair between 2003 and 2019 in the Vascular Quality Initiative database. The Dubois and Dubois formula was used to calculate body surface area; aortic diameter was divided by body surface area to calculate ASI, and aortic diameter was divided by height to calculate AHI. They identified 55,647 patients, of whom 12,664 were female (20%). For both types of repairs (intact and rupture), female patients were older, less likely to undergo endovascular aneurysm repair, and more likely to have comorbid conditions. Female patients underwent repair at smaller median aortic diameter compared with male patients for intact (5.4 vs 5.5 cm) and rupture repair (6.7 vs 7.7 cm). When they analyzed the cumulative distribution of rupture repair in male patients, they found that 12% of rupture repairs were performed at an aortic diameter below 5.5 cm, but to achieve the same proportion of rupture repair in female patients, the repair diameter was only 4.9 cm. When both ASI and AHI were used, female and male patients both reached 12% of rupture repair at an ASI of 2.7 cm/m(2) and an AHI of 3.0 cm/m.
AHRQ-funded; HS027285.
Citation: Patel PB, De Guerre L, Marcaccio CL .
Sex-specific criteria for repair should be utilized in patients undergoing aortic aneurysm repair.
J Vasc Surg 2022 Feb; 75(2):515-25. doi: 10.1016/j.jvs.2021.08.060..
Keywords: Sex Factors, Cardiovascular Conditions, Surgery
Brescia AA, Wu X, Paone G
Effect of sex on nadir hematocrit and rates of acute kidney injury in coronary artery bypass.
Researchers explored whether there a sex-related difference on nadir hematocrit and rates of acute kidney injury in coronary artery bypass. A prospective, observational study was conducted of 17,363 patients not on dialysis undergoing the procedure between 2011 and 2016 across 41 institutions from the Perfusion Measure and Outcomes registry. There was no sex-related differences found for nadir hematocrit or rates of acute kidney injury.
AHRQ-funded; HS026003; HS022535.
Citation: Brescia AA, Wu X, Paone G .
Effect of sex on nadir hematocrit and rates of acute kidney injury in coronary artery bypass.
J Thorac Cardiovasc Surg 2019 Oct;158(4):1073-80.e4. doi: 10.1016/j.jtcvs.2019.03.042..
Keywords: Injuries and Wounds, Sex Factors, Kidney Disease and Health, Adverse Events, Surgery, Heart Disease and Health, Cardiovascular Conditions
Duffy RP, Adams JE, Callas PW
The influence of gender on functional outcomes of lower extremity bypass.
The researchers aimed to evaluate the effect of gender on early and late procedural and functional outcomes of lower extremity bypass (LEB). They found that women have complication rates similar to men with inferior early and late functional outcomes after LEB. The reduced patency rates in women with critical limb ischemia did not translate into differences in limb salvage.
AHRQ-funded; HS021581.
Citation: Duffy RP, Adams JE, Callas PW .
The influence of gender on functional outcomes of lower extremity bypass.
J Vasc Surg 2014 Nov;60(5):1282-90, 90.e1. doi: 10.1016/j.jvs.2014.05.008.
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Keywords: Cardiovascular Conditions, Outcomes, Sex Factors, Surgery