National Healthcare Quality and Disparities Report
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Topics
- Access to Care (1)
- Adverse Drug Events (ADE) (1)
- Adverse Events (13)
- Ambulatory Care and Surgery (1)
- Asthma (1)
- Blood Thinners (2)
- Brain Injury (2)
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- COVID-19 (1)
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- Disparities (1)
- Elderly (7)
- Electronic Health Records (EHRs) (2)
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- Evidence-Based Practice (6)
- Healthcare Cost and Utilization Project (HCUP) (4)
- Health Information Technology (HIT) (3)
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- Heart Disease and Health (6)
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- Hospitalization (2)
- Hospital Readmissions (7)
- Hospitals (3)
- Imaging (1)
- Injuries and Wounds (3)
- Intensive Care Unit (ICU) (1)
- Kidney Disease and Health (3)
- Low-Income (2)
- Maternal Care (1)
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- Medication: Safety (1)
- Mortality (11)
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- Obesity: Weight Management (1)
- (-) Outcomes (58)
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- Rehabilitation (1)
- Research Methodologies (1)
- Respiratory Conditions (4)
- (-) Risk (58)
- Rural Health (1)
- Sex Factors (3)
- Sleep Problems (1)
- Social Determinants of Health (2)
- Stroke (2)
- Substance Abuse (1)
- Surgery (24)
- Tobacco Use (1)
- Tools & Toolkits (1)
- Transplantation (3)
- Trauma (3)
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AHRQ Research Studies
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Research Studies is a compilation of published research articles funded by AHRQ or authored by AHRQ researchers.
Results
26 to 50 of 58 Research Studies DisplayedDesai RJ, Wyss R, Jin Y
Extension of disease risk score-based confounding adjustments for multiple outcomes of interest: an empirical evaluation.
Use of disease risk score (DRS)-based confounding adjustment when estimating treatment effects on multiple outcomes is not well studied. In this empirical cohort study, the investigators compared dabigatran initiators and warfarin initiators with respect to risks of ischemic stroke and major bleeding in 12 sequential monitoring periods (90 days each), using data from the Truven Marketscan database (Truven Health Analytics, Ann Arbor, Michigan).
AHRQ-funded; HS022193.
Citation: Desai RJ, Wyss R, Jin Y .
Extension of disease risk score-based confounding adjustments for multiple outcomes of interest: an empirical evaluation.
Am J Epidemiol 2018 Nov;187(11):2439-48. doi: 10.1093/aje/kwy130.
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Keywords: Blood Thinners, Cardiovascular Conditions, Medication, Outcomes, Research Methodologies, Risk, Stroke
Dworsky JQ, Childers CP, Maggard-Gibbons M
High-risk colorectal surgery: what are the outcomes for geriatric patients?
This study examines the national burden and age-specific outcomes of previously defined high-risk colorectal procedures (HRCP) in geriatric patients using the 2014 National Inpatient Sample. The authors found that outcomes after HRCP are worse for older patients and for nonelective cases. They suggest that this information can inform preoperative counseling and targeted quality improvement projects.
AHRQ-funded; HS000046.
Citation: Dworsky JQ, Childers CP, Maggard-Gibbons M .
High-risk colorectal surgery: what are the outcomes for geriatric patients?
Am Surg 2018 Oct;84(10):1650-54..
Keywords: Elderly, Healthcare Cost and Utilization Project (HCUP), Outcomes, Risk, Surgery
Wahl TS, Graham LA, Morris MS
Association between preoperative proteinuria and postoperative acute kidney injury and readmission.
This retrospective cohort study investigated whether preoperative proteinuria is associated with surgical outcomes including postoperative acute kidney injury (AKI) and readmission. The cohort used were undergoing elective inpatient surgery at 119 Veterans Affairs facilities from October 2007 to September 2014. The data collected was for a 7-month period in 2016. A higher probability of 30-day unplanned readmission was associated with preoperative proteinuria and postoperative AKI.
AHRQ-funded; HS013852.
Citation: Wahl TS, Graham LA, Morris MS .
Association between preoperative proteinuria and postoperative acute kidney injury and readmission.
JAMA Surg 2018 Sep;153(9):e182009. doi: 10.1001/jamasurg.2018.2009..
Keywords: Kidney Disease and Health, Injuries and Wounds, Adverse Events, Surgery, Risk, Hospital Readmissions, Outcomes
Goto T, Shimada YJ, Faridi MK
Incidence of acute cardiovascular event after acute exacerbation of COPD.
There is a lack of comprehensive view of the association between acute exacerbation of COPD (AECOPD) and the risk of acute cardiovascular events. The purpose of this study was to determine the association of AECOPD with 30-day and 1-year incidences of acute cardiovascular event. The investigators concluded that AECOPD was associated with increased 30-day and 1-year incidences of acute cardiovascular event.
AHRQ-funded; HS023305.
Citation: Goto T, Shimada YJ, Faridi MK .
Incidence of acute cardiovascular event after acute exacerbation of COPD.
J Gen Intern Med 2018 Sep;33(9):1461-68. doi: 10.1007/s11606-018-4518-3.
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Keywords: Respiratory Conditions, Cardiovascular Conditions, Risk, Chronic Conditions, Heart Disease and Health, Outcomes
Garcia AV, Ladd MR, Crawford T
Analysis of risk factors for morbidity in children undergoing the Kasai procedure for biliary atresia.
The purpose of the study was to evaluate the perioperative risk factors for 30-day complications of the Kasai procedure in a large, cross-institutional, modern dataset. The authors concluded that major cardiac risk factors and perioperative blood transfusions increased the risk of post-operative complications in children undergoing the Kasai procedure. They assert that further research is warranted in the perioperative use of blood transfusions in this population.
AHRQ-funded; HS022932.
Citation: Garcia AV, Ladd MR, Crawford T .
Analysis of risk factors for morbidity in children undergoing the Kasai procedure for biliary atresia.
Pediatr Surg Int 2018 Aug;34(8):837-44. doi: 10.1007/s00383-018-4298-1.
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Keywords: Children/Adolescents, Outcomes, Risk, Surgery
Flory JH, Keating SJ, Siscovick D
Identifying prevalence and risk factors for metformin non-persistence: a retrospective cohort study using an electronic health record.
Non-persistence may be a significant barrier to the use of metformin. The objective of this study was to assess reasons for metformin non-persistence, and whether initial metformin dosing or use of extended release (ER) formulations affect persistence to metformin therapy. The investigators concluded that their data supported the routine prescribing of low starting doses of metformin as a tool to improve persistence.
AHRQ-funded; HS023898.
Citation: Flory JH, Keating SJ, Siscovick D .
Identifying prevalence and risk factors for metformin non-persistence: a retrospective cohort study using an electronic health record.
BMJ Open 2018 Jul 23;8(7):e021505. doi: 10.1136/bmjopen-2018-021505..
Keywords: Diabetes, Electronic Health Records (EHRs), Health Information Technology (HIT), Medication, Patient Adherence/Compliance, Outcomes, Patient-Centered Outcomes Research, Risk
Wu P, Escobar GJ, Gebretsadik T
Effectiveness of respiratory syncytial virus immunoprophylaxis in reducing bronchiolitis hospitalizations among high-risk infants.
This retrospective cohort study examined the effectiveness of respiratory syncytial virus (RSV) prophylaxis for infants born between 1996 and 2008. The infants were enrolled in the Kaiser Permanente Northern California integrated health system. Infants who ever received RSV immunoprophylaxis had a 32% decreased risk of bronchiolitis hospitalization and finants with chronic lung disease (CLD) had a 52% decreased risk. The 2014 American Academy of Pediatrics (AAP) guidelines changed recommendations for RSV immunoprophylaxis which made 48% of infants no longer eligible but nearly all infants with CLD would remain eligible.
AHRQ-funded; HS018454.
Citation: Wu P, Escobar GJ, Gebretsadik T .
Effectiveness of respiratory syncytial virus immunoprophylaxis in reducing bronchiolitis hospitalizations among high-risk infants.
Am J Epidemiol 2018 Jul;187(7):1490-500. doi: 10.1093/aje/kwy008..
Keywords: Comparative Effectiveness, Evidence-Based Practice, Hospitalization, Newborns/Infants, Outcomes, Patient-Centered Outcomes Research, Prevention, Respiratory Conditions, Risk
Westover AN, Nakonezny PA, Halm EA
Risk of amphetamine use disorder and mortality among incident users of prescribed stimulant medications in the Veterans Administration.
This study's aims were to ascertain the demographics of stimulant medication users compared with non-users, examine temporal trends of stimulant medication use and estimate risk factors for development of amphetamine use disorder (AUD) and mortality among new users of stimulant medications. The investigators concluded that in their cohort comorbid substance use disorders were common and were risk factors for development of (AUD).
AHRQ-funded; HS022418.
Citation: Westover AN, Nakonezny PA, Halm EA .
Risk of amphetamine use disorder and mortality among incident users of prescribed stimulant medications in the Veterans Administration.
Addiction 2018 May;113(5):857-67. doi: 10.1111/add.14122..
Keywords: Substance Abuse, Medication, Risk, Mortality, Patient-Centered Outcomes Research, Outcomes
Rudra S, Hui C, Rao YJ
Effect of radiation treatment volume reduction on lymphopenia in patients receiving chemoradiotherapy for glioblastoma.
The purpose of this study was to evaluate whether reduction in glioblastoma radiation treatment (RT) volume can reduce risk of acute severe lymphopenia (ASL). The investigators concluded that, among other findings, limited-field RT was associated with less lymphopenia after RT plus temozolomide and did not adversely affect progression-free survival or overall survival.
AHRQ-funded; HS022888.
Citation: Rudra S, Hui C, Rao YJ .
Effect of radiation treatment volume reduction on lymphopenia in patients receiving chemoradiotherapy for glioblastoma.
Int J Radiat Oncol Biol Phys 2018 May 1;101(1):217-25. doi: 10.1016/j.ijrobp.2018.01.069..
Keywords: Outcomes, Patient Safety, Risk
Spatz ES, Wang Y, Beckman AL
Traditional Chinese medicine for acute myocardial infarction in western medicine hospitals in China.
This study examined the use of traditional Chinese medicine (TCM) in patients admitted for acute myocardial infarction (AMI) in China during the first 24 hours of hospitalization. The data came from the China Patient-centered Evaluative Assessment of Cardiac Events Retrospective Study of Acute Myocardial Infarction. A chart review was done of randomly sampled patients in 2001, 2006 and 2011 in 162 Western medicine hospitals across China. Nearly all (99%) hospitals used some form of TCM, with Salvia miltiorrhiza being the most commonly prescribed. This TCM treatment (and others) was used intravenously and use has increased over the span of the study, despite lack of evidence of benefit or harm.
AHRQ-funded; HS023000.
Citation: Spatz ES, Wang Y, Beckman AL .
Traditional Chinese medicine for acute myocardial infarction in western medicine hospitals in China.
Circ Cardiovasc Qual Outcomes 2018 Mar;11(3):e004190. doi: 10.1161/circoutcomes.117.004190..
Keywords: Adverse Events, Cardiovascular Conditions, Complementary and Alternative Medicine, Heart Disease and Health, Hospitals, Mortality, Outcomes, Patient-Centered Outcomes Research, Patient Safety, Practice Patterns, Risk
Cardet JC, Louisias M, King TS
Income is an independent risk factor for worse asthma outcomes.
The authors investigated whether low income, low education, and high perceived stress were independent risk factors for treatment failure and asthma exacerbations in the context of a randomized controlled trial. They found that participants with lower income were more likely to experience adverse asthma outcomes independent of education, perceived stress, race, and medication adherence.
AHRQ-funded; HS022986.
Citation: Cardet JC, Louisias M, King TS .
Income is an independent risk factor for worse asthma outcomes.
J Allergy Clin Immunol 2018 Feb;141(2):754-60.e3. doi: 10.1016/j.jaci.2017.04.036..
Keywords: Asthma, Chronic Conditions, Low-Income, Outcomes, Patient-Centered Outcomes Research, Risk, Social Determinants of Health
Dimou FM, Mehta HB, Adhikari D
The role of extended criteria donors in liver transplantation for nonalcoholic steatohepatitis.
The authors' objective was to determine the use of extended criteria donors (ECD) in patients with nonalcoholic steatohepatitis undergoing liver transplantation to stimulate a liver-specific predictive model for ECD use. They found that ECDs in nonalcoholic steatohepatitis were associated with similar overall survival but increased risk of graft failure. The authors concluded that creation of an easily calculated, liver-specific model similar to the Kidney Donor Profile Index may help risk stratify patients and improve organ allocation.
AHRQ-funded; HS022134.
Citation: Dimou FM, Mehta HB, Adhikari D .
The role of extended criteria donors in liver transplantation for nonalcoholic steatohepatitis.
Surgery 2016 Dec;160(6):1533-43. doi: 10.1016/j.surg.2016.06.051.
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Keywords: Transplantation, Patient-Centered Outcomes Research, Risk, Mortality, Outcomes
Humble SS, Wilson LD, McKenna JW
Tracheostomy risk factors and outcomes after severe traumatic brain injury.
The researchers sought to determine risk factors associated with tracheostomy placement after severe traumatic brain injury (TBI) and subsequent outcomes among those who did and did not receive a tracheostomy. They concluded that age and insurance status are independently associated with tracheostomy placement, but not with mortality after severe TBI. Tracheostomy placement is associated with increased survival after severe TBI.
AHRQ-funded; HS013833.
Citation: Humble SS, Wilson LD, McKenna JW .
Tracheostomy risk factors and outcomes after severe traumatic brain injury.
Brain Inj 2016;30(13-14):1642-47. doi: 10.1080/02699052.2016.1199915.
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Keywords: Adverse Events, Brain Injury, Outcomes, Risk, Trauma
Lipman GS, Krabak BJ, Rundell SD
Incidence and prevalence of acute kidney injury during multistage ultramarathons.
The objective of this study was to determine the prevalence, incidence, and risk factors of acute kidney injury (AKI) during multistage ultramarathons. The authors found that prevalence of AKI was 63%-78% during multistage ultramarathons, and that female sex, lower pack weight, and greater weight loss were associated with renal impairment.
AHRQ-funded; HS022982.
Citation: Lipman GS, Krabak BJ, Rundell SD .
Incidence and prevalence of acute kidney injury during multistage ultramarathons.
Clin J Sport Med 2016 Jul;26(4):314-9. doi: 10.1097/jsm.0000000000000253.
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Keywords: Injuries and Wounds, Risk, Sex Factors, Outcomes
Koroukian SM, Schiltz N, Warner DF
Combinations of chronic conditions, functional limitations, and geriatric syndromes that predict health outcomes.
The researchers aimed to identify combinations of chronic conditions, functional limitations, and geriatric syndromes that predict poor health outcomes. They found that functional limitations and/or geriatric syndromes were the most prominent conditions in predicting health outcomes. They concluded that accounting for chronic conditions alone may be less informative than also accounting for the co-occurrence of functional limitations and geriatric syndromes, as the latter conditions appear to drive health outcomes in older individuals.
AHRQ-funded; HS023113.
Citation: Koroukian SM, Schiltz N, Warner DF .
Combinations of chronic conditions, functional limitations, and geriatric syndromes that predict health outcomes.
J Gen Intern Med 2016 Jun;31(6):630-7. doi: 10.1007/s11606-016-3590-9.
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Keywords: Elderly, Chronic Conditions, Risk, Outcomes, Health Status
Bangalore S, Guo Y, Samadashvili Z
Revascularization in patients with multivessel coronary artery disease and severe left ventricular systolic dysfunction: everolimus-eluting stents versus coronary artery bypass graft surgery.
This study compared outcomes for patients with multivessel disease and severe left ventricular systolic dysfunction (ejection fraction </=35%) who underwent either percutaneous coronary intervention (PCI) with everolimus-eluting stent or coronary artery bypass graft surgery (CABG). It found that PCI with everolimus-eluting stent had comparable long-term survival in comparison with CABG. PCI was associated with higher risk of myocardial infarction (in those with incomplete revascularization) and repeat revascularization.
AHRQ-funded; HS023683.
Citation: Bangalore S, Guo Y, Samadashvili Z .
Revascularization in patients with multivessel coronary artery disease and severe left ventricular systolic dysfunction: everolimus-eluting stents versus coronary artery bypass graft surgery.
Circulation 2016 May 31;133(22):2132-40. doi: 10.1161/circulationaha.115.021168.
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Keywords: Cardiovascular Conditions, Heart Disease and Health, Surgery, Outcomes, Risk
McElroy LM, Khorzad R, Nannicelli AP
Failure mode and effects analysis: a comparison of two common risk prioritisation methods.
The investigators compared a simplified scoring method with the traditional scoring method to determine the degree of congruence in identifying high-risk failures. They found that the simplified method did not result in the same degree of discrimination in the ranking of failures offered by the traditional method.
AHRQ-funded; HS000078.
Citation: McElroy LM, Khorzad R, Nannicelli AP .
Failure mode and effects analysis: a comparison of two common risk prioritisation methods.
BMJ Qual Saf 2016 May;25(5):329-36. doi: 10.1136/bmjqs-2015-004130.
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Keywords: Adverse Events, Intensive Care Unit (ICU), Outcomes, Patient Safety, Risk
Siegel CA, Horton H, Siegel LS
A validated web-based tool to display individualised Crohn's disease predicted outcomes based on clinical, serologic and genetic variables.
The researchers developed a validated, individualised, web-based tool for patients and clinicians to visualise individualised risks for developing Crohn's disease complications. Their web-based tool displays an individualised predicted outcome for adult patients with Crohn's disease based on clinical, serologic and genetic variables. This tool can be used to help providers and patients make personalised decisions about treatment options.
AHRQ-funded; HS021747.
Citation: Siegel CA, Horton H, Siegel LS .
A validated web-based tool to display individualised Crohn's disease predicted outcomes based on clinical, serologic and genetic variables.
Aliment Pharmacol Ther 2016 Jan;43(2):262-71. doi: 10.1111/apt.13460.
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Keywords: Web-Based, Tools & Toolkits, Risk, Outcomes
Fisher SR, Graham JE, Krishnan S
Predictors of 30-day readmission following inpatient rehabilitation for patients at high risk for hospital readmission.
The purpose of this study was to identify variables in the full administrative medical record, particularly in regard to physical function, that could help clinicians further discriminate between patients who are and are not likely to be readmitted to an acute care hospital within 30 days of rehabilitation discharge. It found that functional outcomes and rehabilitation length of stay were the best predictors of 30-day rehospitalization.
AHRQ-funded; HS022134.
Citation: Fisher SR, Graham JE, Krishnan S .
Predictors of 30-day readmission following inpatient rehabilitation for patients at high risk for hospital readmission.
Phys Ther 2016 Jan;96(1):62-70. doi: 10.2522/ptj.20150034..
Keywords: Hospital Readmissions, Rehabilitation, Outcomes, Risk, Elderly
Chang AL, Hurwitz E, Miyamura J
Maternal risk factors and perinatal outcomes among pacific islander groups in Hawaii: a retrospective cohort study using statewide hospital data.
This study compared perinatal outcomes between Pacific Islander and White women who delivered a singleton liveborn in any Hawaii hospital from January 2010 to December 2011. Significant differences in perinatal outcomes between Pacific Islander and White women and newborns were noted. All Pacific Islander groups had an increased risk of hypertension. Native Hawaiians had the highest risk of low birthweight infants.
AHRQ-funded; HS021903.
Citation: Chang AL, Hurwitz E, Miyamura J .
Maternal risk factors and perinatal outcomes among pacific islander groups in Hawaii: a retrospective cohort study using statewide hospital data.
BMC Pregnancy Childbirth 2015 Oct 05;15:239. doi: 10.1186/s12884-015-0671-4.
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Keywords: Maternal Care, Risk, Racial and Ethnic Minorities, Outcomes, Newborns/Infants
Tsilimingras D, Schnipper J, Duke A
Post-discharge adverse events among urban and rural patients of an urban community hospital: a prospective cohort study.
The researchers aimed to determine the rate of postdischarge adverse events (AEs), classify the types of post-discharge AEs, and identify risk factors for post-discharge AEs in urban and rural patients. They found that post-discharge AEs were common in both urban and rural patients and many were preventable or ameliorable.
AHRQ-funded; HS018694.
Citation: Tsilimingras D, Schnipper J, Duke A .
Post-discharge adverse events among urban and rural patients of an urban community hospital: a prospective cohort study.
J Gen Intern Med 2015 Aug;30(8):1164-71. doi: 10.1007/s11606-015-3260-3..
Keywords: Adverse Events, Hospital Discharge, Outcomes, Risk, Rural Health
Shah UH, Mandl LA, Mertelsmann-Voss C
Systemic lupus erythematosus is not a risk factor for poor outcomes after total hip and total knee arthroplasty.
The researchers sought to determine if systemic lupus erythematosus (SLE) remains an independent risk factor for poor arthroplasty outcomes or if other factors, such as avascular necrosis , continue to play a role. They found that SLE was not an independent risk factor for poor short-term pain or function after either hip or knee arthroplasty.
AHRQ-funded; HS016075.
Citation: Shah UH, Mandl LA, Mertelsmann-Voss C .
Systemic lupus erythematosus is not a risk factor for poor outcomes after total hip and total knee arthroplasty.
Lupus 2015 Aug;24(9):900-8. doi: 10.1177/0961203314566635.
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Keywords: Surgery, Risk, Outcomes, Adverse Events
Fink HA, Hemmy LS, MacDonald R
Intermediate- and long-term cognitive outcomes after cardiovascular procedures in older adults: a systematic review.
This study summarized evidence about cognitive outcomes in adults aged 65 years or older at least 3 months after coronary or carotid revascularization, cardiac valve procedures, or ablation for atrial fibrillation. It concluded that intermediate- and long-term cognitive impairment in older adults attributable to the studied cardiovascular procedures may be uncommon.
AHRQ-funded; 2902007100641.
Citation: Fink HA, Hemmy LS, MacDonald R .
Intermediate- and long-term cognitive outcomes after cardiovascular procedures in older adults: a systematic review.
Ann Intern Med 2015 Jul 21;163(2):107-17. doi: 10.7326/m14-2793..
Keywords: Cardiovascular Conditions, Elderly, Neurological Disorders, Outcomes, Patient-Centered Outcomes Research, Risk, Surgery
Santos CA, Brennan DC, Chapman WC
Delayed-onset cytomegalovirus disease coded during hospital readmission in a multicenter, retrospective cohort of liver transplant recipients.
The researchers sought to determine the risk factors and outcomes of delayed-onset CMV disease among a representative cohort of liver transplant recipients from multiple centers. They found that delayed-onset CMV disease coded during hospital readmission occurred more commonly than early-onset CMV disease and that prior transplant failure or rejection was a risk factor for delayed-onset CMV disease.
AHRQ-funded; HS019455.
Citation: Santos CA, Brennan DC, Chapman WC .
Delayed-onset cytomegalovirus disease coded during hospital readmission in a multicenter, retrospective cohort of liver transplant recipients.
Liver Transpl 2015 May;21(5):581-90. doi: 10.1002/lt.24089..
Keywords: Healthcare Cost and Utilization Project (HCUP), Risk, Transplantation, Outcomes
Ault MJ, Rosen BT, Scher J
Thoracentesis outcomes: a 12-year experience.
The researchers evaluated specific demographic and clinical factors that have been commonly associated with complications such as iatrogenic pneumothorax, re-expansion pulmonary edema and bleeding. They found that thoracenteses had a very low complication rate and concluded that current clinical guidelines and practice patterns may not reflect evidence-based best practices.
AHRQ-funded; HS021202.
Citation: Ault MJ, Rosen BT, Scher J .
Thoracentesis outcomes: a 12-year experience.
Thorax 2015 Feb;70(2):127-32. doi: 10.1136/thoraxjnl-2014-206114..
Keywords: Risk, Evidence-Based Practice, Respiratory Conditions, Respiratory Conditions, Outcomes