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AHRQ Research Studies
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Research Studies is a compilation of published research articles funded by AHRQ or authored by AHRQ researchers.
Results
1 to 10 of 10 Research Studies DisplayedYang G, Zhang M, Zhou S
Incompleteness of health-related quality of life assessments before left ventricular assist device implant: a novel quality metric.
Investigators hypothesized that pre-implant health-related quality of life (HRQOL) incompleteness in The Society of Thoracic Surgeons' Intermacs registry for patients undergoing left ventricular assist device (LVAD) implantation predicts 90-day outcomes. They found that HRQOL incompleteness at high-rate hospitals was more often due to administrative reasons and less likely due to patient reasons. Increases in the adjusted pre-implant incompleteness rates were significantly associated with higher risk of infection-related mortality, infection, and renal dysfunction. They concluded that hospital adjusted pre-implant HRQOL incompleteness was predictive of 90-day post-implant outcomes and may serve as a novel quality metric.
AHRQ-funded; HS026003.
Citation: Yang G, Zhang M, Zhou S .
Incompleteness of health-related quality of life assessments before left ventricular assist device implant: a novel quality metric.
J Heart Lung Transplant 2022 Oct;41(10):1520-28. doi: 10.1016/j.healun.2022.07.001..
Keywords: Quality of Life, Medical Devices, Heart Disease and Health, Cardiovascular Conditions
Ahmad FS, Jackson KL, Yount SE
The development and initial validation of the PROMIS®+HF-27 and PROMIS+HF-10 profiles.
This paper describes the continued refinement of the PROMIS®-Plus-HF (PROMIS+HF) profile measure, including universal and HF-specific items, to develop shorter PROMIS+HF profiles intended for research and clinical use. The authors developed the PROMIS+HF-27 and PROMIS+HF-10 profiles with summary scores (0-100) for overall, physical, mental, and social health. In a cross-sectional sample (n = 600), they measured internal consistency reliability (Cronbach's alpha and Spearman-Brown), test-retest reliability (intraclass coefficient; n = 100), known-groups validity via New York Heart Association (NYHA) class, and convergent validity with Kansas City Cardiomyopathy Questionnaire (KCCQ) scores. They also evaluated responsiveness of baseline/follow-up scores in a longitudinal sample of 75 by calculating mean differences and Cohen’s d and comparing with paired t-tests. PROMIS+HF-27 scores showed good to excellent internal consistency and acceptable to good for PROMIS+HF-10 scores. Good psychometric characteristics were shown for both measures with evidence of responsiveness for overall and physical health.
AHRQ-funded; HS026385.
Citation: Ahmad FS, Jackson KL, Yount SE .
The development and initial validation of the PROMIS®+HF-27 and PROMIS+HF-10 profiles.
ESC Heart Fail 2022 Jul 15;9(5):3380-92. doi: 10.1002/ehf2.14061..
Keywords: Heart Disease and Health, Cardiovascular Conditions, Quality of Life, Patient-Centered Outcomes Research
Wells R, Dionne-Odom JN, Azuero A
Examining adherence and dose effect of an early palliative care intervention for advanced heart failure patients.
The objective of this study was to examine the "dose" effect of PC intervention completion vs. noncompletion on quality of life (QoL) and healthcare use in patients with advanced heart failure (HF) over 32 weeks. The investigators concluded that higher intervention completion rates of an early PC intervention was associated with QoL improvements in patients with advanced HF.
AHRQ-funded; HS013852.
Citation: Wells R, Dionne-Odom JN, Azuero A .
Examining adherence and dose effect of an early palliative care intervention for advanced heart failure patients.
J Pain Symptom Manage 2021 Sep;62(3):471-81. doi: 10.1016/j.jpainsymman.2021.01.136..
Keywords: Palliative Care, Heart Disease and Health, Cardiovascular Conditions, Quality of Life, Telehealth, Health Information Technology (HIT)
Askew RL, Capo-Lugo CE, Sangha R
Trade-offs in quality-of-life assessment between the modified Rankin Scale and Neuro-QoL measures.
The objective of this study was to describe the physical and cognitive health of patients with differing levels of post-stroke disability as defined by modified Rankin Scale (mRS) scores. Cross-sectional correlations were also compared between the mRS and the Quality of Life in Neurological Disorders (Neuro-QoL) T-scores to longitudinal correlations of change estimates for each measure. A total of 745 patients with ischemic stroke (79%) or transient ischemic attack (21%) were enrolled in this study. There were larger differences observed in cognitive function for the severe mRS groups. Larger differences in physical function were observed in the mild-moderate mRS groups. These findings undermine the validity and utility as an outcome measure in longitudinal studies in ischemic stroke patients. But it is still efficient at capturing important differences in patient-reported quality of life, and is useful for identifying meaning cross-sectional differences among clinical subgroups.
AHRQ-funded; HS024366; HS023437; HS000078.
Citation: Askew RL, Capo-Lugo CE, Sangha R .
Trade-offs in quality-of-life assessment between the modified Rankin Scale and Neuro-QoL measures.
Value Health 2020 Oct;23(10):1366-72. doi: 10.1016/j.jval.2020.06.011..
Keywords: Quality of Life, Stroke, Outcomes, Neurological Disorders, Cardiovascular Conditions
Askew RL, Capo-Lugo CE, Naidech A
Differential effects of time to initiation of therapy on disability and quality of life in patients with mild and moderate to severe ischemic stroke.
This study’s objective was to assess the effect of time to therapy consult and treatment on health-related quality of life (HRQoL) and disability after ischemic stroke. This prospective cohort study was conducted at a comprehensive stroke center in a large metropolitan city. A modified Rankin Scale (mRS) and Barthel Index (BI) were used to assess disability status. HRQoL was assessed using the Quality of Life in Neurological Disorders measures of executive function, general cognitive concerns, upper extremity dexterity and lower extremity mobility. A longer time to therapy treatment led to increased disability and lower mobility T scores. It also had an effect on poststroke disability and HRQoL up to 1 month after ischemic stroke and TIA.
AHRQ-funded; HS024366; HS023437; HS000078.
Citation: Askew RL, Capo-Lugo CE, Naidech A .
Differential effects of time to initiation of therapy on disability and quality of life in patients with mild and moderate to severe ischemic stroke.
Arch Phys Med Rehabil 2020 Sep;101(9):1515-22.e1. doi: 10.1016/j.apmr.2020.05.005..
Keywords: Stroke, Cardiovascular Conditions, Quality of Life
Ahmad FS, Kallen MA, Schifferdecker KE
Development and initial validation of the PROMIS(R)-Plus-HF profile measure.
This paper describes the efforts to develop and validate the PROMIS®-Plus-HF (Patient-Reported Outcomes Measurement Information System®-Plus-Heart Failure) profile measure. The authors conducted 8 focus groups with 61 patients with HF and phone interviews with 10 HF clinicians. They tested the measure with a 600-patient sample. Validity was analyzed and confirmed using Pearson r and Spearman rho correlations with Kansas City Cardiomyopathy Questionnaire subscores. The measure consists of 86 items across 18 domains.
AHRQ-funded; HS026385.
Citation: Ahmad FS, Kallen MA, Schifferdecker KE .
Development and initial validation of the PROMIS(R)-Plus-HF profile measure.
Circ Heart Fail 2019 Jun;12(6):e005751. doi: 10.1161/circheartfailure.118.005751.
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Keywords: Patient-Centered Outcomes Research, Heart Disease and Health, Cardiovascular Conditions, Decision Making, Quality of Life, Health Status
Uy V, Hays RD, Xu JJ
Do the unlabeled response categories of the Minnesota Living with Heart Failure Questionnaire satisfy the monotonicity assumption of simple-summated scoring?
Half of the 21-item Minnesota Living with Heart Failure Questionnaire (MLHFQ) response categories are labeled (0 = No, 1 = Very little, 5 = Very much) and half are not (2, 3, and 4). In this study, the investigators hypothesized that the unlabeled response options would not be more likely to be chosen at some place along the scale continuum than other response options and, therefore, not satisfy the monotonicity assumption of simple-summated scoring.
AHRQ-funded; HS019311.
Citation: Uy V, Hays RD, Xu JJ .
Do the unlabeled response categories of the Minnesota Living with Heart Failure Questionnaire satisfy the monotonicity assumption of simple-summated scoring?
Qual Life Res 2020 May;29(5):1349-60. doi: 10.1007/s11136-020-02422-8..
Keywords: Heart Disease and Health, Cardiovascular Conditions, Chronic Conditions, Quality of Life
Annapureddy A, Valero-Elizondo J, Khera R
Association between financial burden, quality of life, and mental health among those with atherosclerotic cardiovascular disease in the United States.
Currently, there is little information about the relationship between the financial burden of healthcare for patients with atherosclerotic cardiovascular disease (ASCVD) and their health-related quality of life (HRQoL), well-being, and psychological health. Accordingly, the authors of this study, determined the relationship between healthcare financial burden and patient-reported HRQoL, self-perception of health, psychological distress, and risk of depression in a nationally representative US adult population with established ASCVD.
AHRQ-funded; HS023000.
Citation: Annapureddy A, Valero-Elizondo J, Khera R .
Association between financial burden, quality of life, and mental health among those with atherosclerotic cardiovascular disease in the United States.
Circ Cardiovasc Qual Outcomes 2018 Nov;11(11):e005180. doi: 10.1161/circoutcomes.118.005180..
Keywords: Cardiovascular Conditions, Healthcare Costs, Behavioral Health, Quality of Life
Bachmann JM, Goggins KM, Nwosu SK
Perceived health competence predicts health behavior and health-related quality of life in patients with cardiovascular disease.
The authors sought to evaluate the effect of perceived health competence on health behavior and health-related quality of life. They found that perceived health competence was highly associated with health behaviors and health-related quality of life, while low perceived health competence was associated with a decrease in health-related quality of life between hospitalization and 90 days after discharge. They concluded that perceived health competence predicts health behavior and health-related quality of life in patients hospitalized with cardiovascular disease as well as change in health-related quality of life after discharge.
AHRQ-funded; HS022990.
Citation: Bachmann JM, Goggins KM, Nwosu SK .
Perceived health competence predicts health behavior and health-related quality of life in patients with cardiovascular disease.
Patient Educ Couns 2016 Dec;99(12):2071-79. doi: 10.1016/j.pec.2016.07.020.
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Keywords: Cardiovascular Conditions, Heart Disease and Health, Health Literacy, Patient Adherence/Compliance, Quality of Life
Piccini JP, Simon DN, Steinberg BA
Differences in clinical and functional outcomes of atrial fibrillation in women and men: two-year results from the ORBIT-AF Registry.
The purpose of this paper was to determine whether symptoms, quality of life, treatment, and outcomes differ between women and men with atrial fibrillation (AF). The authors found that women with AF have more symptoms and worse quality of life, lower risk-adjusted all-cause and cardiovascular death compared with men, but higher stroke rates.
AHRQ-funded; HS021092.
Citation: Piccini JP, Simon DN, Steinberg BA .
Differences in clinical and functional outcomes of atrial fibrillation in women and men: two-year results from the ORBIT-AF Registry.
JAMA Cardiol 2016 Jun 1;1(3):282-91. doi: 10.1001/jamacardio.2016.0529.
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Keywords: Heart Disease and Health, Cardiovascular Conditions, Sex Factors, Patient-Centered Outcomes Research, Outcomes, Quality of Life, Registries, Evidence-Based Practice