National Healthcare Quality and Disparities Report
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AHRQ Research Studies
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Research Studies is a compilation of published research articles funded by AHRQ or authored by AHRQ researchers.
Results
101 to 125 of 199 Research Studies DisplayedBadawy SM, Barrera L, Cai S
Association between participants' characteristics, patient-reported outcomes, and clinical outcomes in youth with sickle cell disease.
Researchers studied the effects of sickle disease (SCD) on the quality of life (QOL) on youths with the disease. Participant characteristics, chronic pain, and medication adherence were measured against clinical outcomes. Older and female participants had worse QOL than males overall.
AHRQ-funded; HS023011.
Citation: Badawy SM, Barrera L, Cai S .
Association between participants' characteristics, patient-reported outcomes, and clinical outcomes in youth with sickle cell disease.
Biomed Res Int 2018 Jul 18;2018:8296139. doi: 10.1155/2018/8296139..
Keywords: Children/Adolescents, Outcomes, Patient-Centered Outcomes Research, Quality of Life, Sickle Cell Disease
Taylor YJ, Tapp H, Shade LE
Impact of shared decision making on asthma quality of life and asthma control among children.
This study evaluated the impact of shared decision making (SDM) on quality of life and symptom control in children with asthma. The investigators found that implementation of SDM within clinical practices using a standardized toolkit was associated with improved asthma quality of life and asthma control for low-income children with asthma when compared to usual care with decision support.
AHRQ-funded; HS019946.
Citation: Taylor YJ, Tapp H, Shade LE .
Impact of shared decision making on asthma quality of life and asthma control among children.
J Asthma 2018 Jun;55(6):675-83. doi: 10.1080/02770903.2017.1362423..
Keywords: Children/Adolescents, Asthma, Respiratory Conditions, Chronic Conditions, Decision Making, Quality of Life
Hudson KE, Wolf SP, Samsa GP
The surprise question and identification of palliative care needs among hospitalized patients with advanced hematologic or solid malignancies.
Little is known about quality of life (QOL), depression, and end-of-life (EOL) outcomes among hospitalized patients with advanced cancer. The objective of this study was to assess whether a surprise question identified inpatients with advanced cancer likely to have unmet palliative care needs. The investigators indicated that hospitalized patients with advanced cancer may benefit from palliative care interventions to improve mood, QOL, and EOL care, and the surprise question is a practical method to identify those with unmet needs.
AHRQ-funded; HS023681.
Citation: Hudson KE, Wolf SP, Samsa GP .
The surprise question and identification of palliative care needs among hospitalized patients with advanced hematologic or solid malignancies.
J Palliat Med 2018 Jun;21(6):789-95. doi: 10.1089/jpm.2017.0509..
Keywords: Palliative Care, Cancer, Inpatient Care, Quality of Life, Depression, Behavioral Health
Wu S, Leff B
Frailty measurement and its contribution to clinical care and health services: a commentary.
Frailty is associated with poorer quality of life and higher healthcare utilization and spending. Despite its importance, no clear consensus exists on the definition of frailty. The recent IJHPR article by Buch et al. significantly contributes to the advancement of Israel's understanding of frailty by estimating for the first time the prevalence of frailty in the country. This commentary discusses the context of past and current advancements in measuring frailty and discusses how frailty measurement can contribute to both clinical care and the organization of health services to care for frail older adults in Israel and other developed countries.
AHRQ-funded; HS000029.
Citation: Wu S, Leff B .
Frailty measurement and its contribution to clinical care and health services: a commentary.
Isr J Health Policy Res 2018 May 23;7(1):27. doi: 10.1186/s13584-018-0225-0.
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Keywords: Elderly, Health Services Research (HSR), Quality of Life
Roy B, Riley C, Herrin J
Identifying county characteristics associated with resident well-being: a population based study.
The authors aimed to identify county attributes that are independently associated with a comprehensive, multi-dimensional assessment of individual well-being. They identified twelve county-level factors that were independently associated with individual well-being scores. Collectively, these twelve factors explained 91% of the variance in individual well-being scores, and they represent four conceptually distinct categories: demographic; social and economic; clinical care; and physical environment.
AHRQ-funded; HS023000.
Citation: Roy B, Riley C, Herrin J .
Identifying county characteristics associated with resident well-being: a population based study.
PLoS One 2018 May 23;13(5):e0196720. doi: 10.1371/journal.pone.0196720.
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Keywords: Health Status, Quality of Life, Social Determinants of Health
McCreedy EM, Weinstein BE, Chodosh J
Hearing loss: why does it matter for nursing homes?
This paper examines the impact of hearing loss on residents in nursing home settings and provides an estimate of prevalence using the Minimum Data Set (MDS v.3.0). They outline steps to mitigate hearing loss and discuss solutions that may be inexpensive and low-tech.
AHRQ-funded; HS000011.
Citation: McCreedy EM, Weinstein BE, Chodosh J .
Hearing loss: why does it matter for nursing homes?
J Am Med Dir Assoc 2018 Apr;19(4):323-27. doi: 10.1016/j.jamda.2017.12.007..
Keywords: Nursing Homes, Elderly, Quality of Life, Depression, Behavioral Health
Vakharia PP, Chopra R, Sacotte R
Severity strata for five patient-reported outcomes in adults with atopic dermatitis.
Several patient-reported outcomes have been used to assess the burden of atopic dermatitis (AD). Some are disease specific, such as the Patient-Oriented Eczema Measure (POEM), while others pertain to itch, for example the numerical rating scale (NRS)-itch, ItchyQoL and 5-D itch, or dermatological disease in general, for example the Dermatology Life Quality Index (DLQI). The purpose of this study was to confirm previously developed strata for POEM, DLQI and raw ItchyQoL, and develop strata for the NRS-itch, mean ItchyQoL and 5-D itch scale for use in adults with AD.
AHRQ-funded; HS023011.
Citation: Vakharia PP, Chopra R, Sacotte R .
Severity strata for five patient-reported outcomes in adults with atopic dermatitis.
Br J Dermatol 2018 Apr;178(4):925-30. doi: 10.1111/bjd.16078..
Keywords: Outcomes, Patient-Centered Outcomes Research, Quality of Life, Skin Conditions
Bush RA, Beaumont JL, Liotta EM
Fever burden and health-related quality of life after intracerebral hemorrhage.
In this prospective observational cohort study, the investigators tested the hypothesis that increased burden of fever is independently associated with decreased health-related quality of life (HRQoL) at follow-up. The authors found that each additional day with a fever was predictive of worse HRQoL domains of Cognitive Function and Mobility after intracerebral hemorrhage up to 1 year. They suggest that HRQoL outcomes may be a sensitive and powerful way to measure the efficacy of fever control in future research.
AHRQ-funded; HS023437.
Citation: Bush RA, Beaumont JL, Liotta EM .
Fever burden and health-related quality of life after intracerebral hemorrhage.
Neurocrit Care 2018 Mar 29;29(2):189-94. doi: 10.1007/s12028-018-0523-y..
Keywords: Brain Injury, Neurological Disorders, Outcomes, Patient-Centered Outcomes Research, Quality of Life
Khan S, Biju A, Wang S
Mobile critical care recovery program (m-CCRP) for acute respiratory failure survivors: study protocol for a randomized controlled trial.
The Mobile Critical Care Recovery Program (m-CCRP) study is a two arm, randomized clinical trial. The researchers will randomize 620 patients admitted to the ICU with acute respiratory failure requiring mechanical ventilation to one of two arms - m-CCRP intervention versus attention control. Their primary aim is to assess the efficacy of m-CCRP in improving the quality of life of acute respiratory failure survivors at 12 months
AHRQ-funded; HS024384.
Citation: Khan S, Biju A, Wang S .
Mobile critical care recovery program (m-CCRP) for acute respiratory failure survivors: study protocol for a randomized controlled trial.
Trials 2018 Feb 7;19(1):94. doi: 10.1186/s13063-018-2449-2.
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Keywords: Critical Care, Intensive Care Unit (ICU), Quality of Life, Respiratory Conditions, Respiratory Conditions
Dickerson JF, Feeny DH, Clarke GN
Evidence on the longitudinal construct validity of major generic and utility measures of health-related quality of life in teens with depression.
This study examined the longitudinal construct validity in the assessment of changes in depressive symptoms of widely used utility and generic health-related quality of life (HRQL) instruments in teens. Its findings support the longitudinal construct validity of included HRQL instruments for the assessment of change in depression outcomes in teens.
AHRQ-funded; HS017720.
Citation: Dickerson JF, Feeny DH, Clarke GN .
Evidence on the longitudinal construct validity of major generic and utility measures of health-related quality of life in teens with depression.
Qual Life Res 2018 Feb;27(2):447-54. doi: 10.1007/s11136-017-1728-9.
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Keywords: Children/Adolescents, Depression, Genetics, Quality of Life
Greenhawt M, Oppenheimer JJ
Is the better part of valor truly discretion?
The authors argue that the current model for managing peanut allergy is broken, and this fracture is hallmarked by the rapid increase in poor quality of life and poor empowerment of patients. The risk of fatality is often overblown in the face of data that suggest food allergy fatality is exceedingly low. However, the horizon is bright for future therapies and additional risk modeling, which can better arm decision making and means to inform patients about how to personalize management of their food allergy going forward.
AHRQ-funded; HS024599.
Citation: Greenhawt M, Oppenheimer JJ .
Is the better part of valor truly discretion?
Ann Allergy Asthma Immunol 2018 Feb;120(2):111-12. doi: 10.1016/j.anai.2017.11.003.
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Keywords: Decision Making, Mortality, Patient-Centered Outcomes Research, Patient Self-Management, Quality of Life
Yanez BR, Buitrago D, Buscemi J
Study design and protocol for My Guide: an e-health intervention to improve patient-centered outcomes among Hispanic breast cancer survivors.
This article describes a randomized controlled trial designed to investigate the feasibility and efficacy of a Smartphone application intended to improve health-related quality of life (HRQoL) among Hispanic breast cancer survivors. Participants are randomized to receive either the intervention application My Guide, or the health education control condition application My Health for six weeks, and also receive weekly telecoaching to enhance adherence to both applications. The study's outcomes are measured prior to intervention, immediately after, and eight weeks following initial application use.
AHRQ-funded; HS023011.
Citation: Yanez BR, Buitrago D, Buscemi J .
Study design and protocol for My Guide: an e-health intervention to improve patient-centered outcomes among Hispanic breast cancer survivors.
Contemp Clin Trials 2018 Feb;65:61-68. doi: 10.1016/j.cct.2017.11.018..
Keywords: Cancer, Cancer: Breast Cancer, Health Information Technology (HIT), Outcomes, Patient-Centered Healthcare, Patient-Centered Outcomes Research, Quality of Life, Racial and Ethnic Minorities, Women
Roydhouse JK, Gutman R, Keating NL
Proxy and patient reports of health-related quality of life in a national cancer survey.
The objective of this study was to evaluate the difference between patient and proxy reports of patient HRQOL in a large national cancer survey, and determine if this difference could be mitigated by adjusting for clinical and sociodemographic information about patients. It concluded that the proxy-reported outcome scores for both physical and mental health were clinically and significantly lower than patient-reported scores for these outcomes.
AHRQ-funded; HS000011.
Citation: Roydhouse JK, Gutman R, Keating NL .
Proxy and patient reports of health-related quality of life in a national cancer survey.
Health Qual Life Outcomes 2018 Jan 5;16(1):6. doi: 10.1186/s12955-017-0823-5.
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Keywords: Cancer, Quality of Life, Patient-Centered Healthcare, Patient-Centered Outcomes Research, Behavioral Health
Prescott HC, Costa DK
Improving long-term outcomes after sepsis.
This study discusses how to improve long term outcomes after sepsis and asserts that to improve long-term outcomes, in-hospital care should focus on early, effective treatment of sepsis; minimization of delirium, distress, and immobility; and preparing patients for hospital discharge.
AHRQ-funded; HS024552.
Citation: Prescott HC, Costa DK .
Improving long-term outcomes after sepsis.
Crit Care Clin 2018 Jan;34(1):175-88. doi: 10.1016/j.ccc.2017.08.013..
Keywords: Outcomes, Quality of Life, Sepsis
Domenick Sridharan N, Fish L, Yu L
The associations of hemodialysis access type and access satisfaction with health-related quality of life.
This study sought to understand the impact of hemodialysis (HD) access type on health-related quality of life (HRQOL). The study concluded that HD patients experience greatest satisfaction with fistula, and access satisfaction is significantly associated with better HRQOL. Controlling for access satisfaction, there is no significant independent association of access type on HRQOL.
AHRQ-funded; HS019486.
Citation: Domenick Sridharan N, Fish L, Yu L .
The associations of hemodialysis access type and access satisfaction with health-related quality of life.
J Vasc Surg 2018 Jan;67(1):229-35. doi: 10.1016/j.jvs.2017.05.131..
Keywords: Kidney Disease and Health, Kidney Disease and Health, Patient Experience, Quality of Life, Surgery, Patient-Centered Outcomes Research
Li Z, Frost HR, Tosteson TD
A semiparametric joint model for terminal trend of quality of life and survival in palliative care research.
A unique feature of palliative care clinical trials is that patients will experience decreasing quality of life (QOL) during the trial despite potentially beneficial treatment. Often longitudinal QOL and survival data are highly correlated which, in the face of censoring, makes it challenging to properly analyze and interpret terminal QOL trend. To address these issues, the authors of this study proposed a novel semiparametric statistical approach to jointly model the terminal trend of QOL and survival data.
AHRQ-funded; HS020263.
Citation: Li Z, Frost HR, Tosteson TD .
A semiparametric joint model for terminal trend of quality of life and survival in palliative care research.
Stat Med 2017 Dec 20;36(29):4692-704. doi: 10.1002/sim.7445..
Keywords: Palliative Care, Quality of Life
Vakharia PP, Chopra R, Sacotte R
Burden of skin pain in atopic dermatitis.
This study sought to characterize the patient burden of skin pain in AD. It found that twenty-four (16.8 percent) patients thought the skin pain was part of their itch, 16 (11.2 percent) from scratching, and 77 (72.0 percent) from both. Patients with skin pain were more likely to describe their itch using terms that resembled neuropathic pain.
AHRQ-funded; HS023011.
Citation: Vakharia PP, Chopra R, Sacotte R .
Burden of skin pain in atopic dermatitis.
Ann Allergy Asthma Immunol 2017 Dec;119(6):548-52.e3. doi: 10.1016/j.anai.2017.09.076.
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Keywords: Chronic Conditions, Pain, Quality of Life, Skin Conditions
Adam SS, Flahiff CM, Kamble S
Depression, quality of life, and medical resource utilization in sickle cell disease.
Researchers performed an analytic epidemiologic prospective study to determine the prevalence of depression in adult patients with sickle cell disease and its association with health-related quality of life (HRQoL) and medical resource utilization. They found that depression was associated with worse physical and mental HRQoL scores and during the 6 months following diagnosis, mean total health care costs were significantly higher in depressed patients than in nondepressed patients.
AHRQ-funded; HS017645.
Citation: Adam SS, Flahiff CM, Kamble S .
Depression, quality of life, and medical resource utilization in sickle cell disease.
Blood Adv 2017 Oct 12;1(23):1983-92. doi: 10.1182/bloodadvances.2017006940.
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Keywords: Depression, Healthcare Costs, Healthcare Utilization, Quality of Life, Sickle Cell Disease
Burgette JM, Preisser JS, Weinberger M
Early head start, pediatric dental use, and oral health-related quality of life.
The objective of the study was to examine the mediating effect of child dental use on the effectiveness of North Carolina Early Head Start (EHS) in improving oral health-related quality of life (OHRQoL). It concluded that EHS increases child dental use, which worsens family OHRQoL. However, EHS is associated with improved OHRQoL overall.
AHRQ-funded; HS000032.
Citation: Burgette JM, Preisser JS, Weinberger M .
Early head start, pediatric dental use, and oral health-related quality of life.
JDR Clin Trans Res 2017 Oct;2(4):353-62. doi: 10.1177/2380084417709758.
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Keywords: Children/Adolescents, Dental and Oral Health, Quality of Life, Children/Adolescents
Burgette JM, Preisser JS, Weinberger M
Enrollment in early head start and oral health-related quality of life.
Researchers examined the effect of enrollment in North Carolina Early Head Start (EHS) - a federally funded early education program for children under three years of age and their families - on oral health-related quality of life (OHRQoL). Their study is the first to demonstrate that families of young children enrolled in EHS report improved OHRQoL compared to their non-enrolled peers.
AHRQ-funded; HS000032.
Citation: Burgette JM, Preisser JS, Weinberger M .
Enrollment in early head start and oral health-related quality of life.
Qual Life Res 2017 Oct;26(10):2607-18. doi: 10.1007/s11136-017-1584-7.
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Keywords: Children/Adolescents, Dental and Oral Health, Quality of Life
Rhoten BA
Conceptual issues surrounding body image for oncology nurses.
This paper discusses conceptual issues surrounding cancer survivors’ body image. It targets oncology nurses so they may have a better understanding of the historic overview of body image conceptualization, as well as a more contemporary, cancer-specific approach to understanding how this population of patients may be particularly affected.
AHRQ-funded; HS022990.
Citation: Rhoten BA .
Conceptual issues surrounding body image for oncology nurses.
Oncol Nurs Forum 2017 Sep 1;44(5):534-36. doi: 10.1188/17.onf.534-536..
Keywords: Cancer, Patient-Centered Healthcare, Provider, Quality of Life
Thomas HN, Hamm M, Hess R
Patient-centered outcomes and treatment preferences regarding sexual problems: a qualitative study among midlife women.
This study sought a better understanding of the sexual function outcomes that were most important to sexually active women 45 to 60 years old and the types of treatments they would prefer from individual interviews and focus groups. It found that many midlife women in the sample expressed a preference for behavioral approaches over pharmaceutical approaches for the treatment of sexual dysfunction.
AHRQ-funded; HS022989.
Citation: Thomas HN, Hamm M, Hess R .
Patient-centered outcomes and treatment preferences regarding sexual problems: a qualitative study among midlife women.
J Sex Med 2017 Aug;14(8):1011-17. doi: 10.1016/j.jsxm.2017.05.014..
Keywords: Sexual Health, Women, Patient-Centered Outcomes Research, Quality of Life
Roydhouse JK, Wilson IB
Systematic review of caregiver responses for patient health-related quality of life in adult cancer care.
The aim of this review is to help cancer researchers select a validated health-related quality of life tool if they anticipate using proxy-reported data. It concluded that the evidence base is strongest for the EORTC (disease-specific tools), COOP/WONCA (generic tools), and MQOL (end-of-life-specific tools).
AHRQ-funded; HS000011.
Citation: Roydhouse JK, Wilson IB .
Systematic review of caregiver responses for patient health-related quality of life in adult cancer care.
Qual Life Res 2017 Aug;26(8):1925-54. doi: 10.1007/s11136-017-1540-6.
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Keywords: Cancer, Caregiving, Patient-Centered Outcomes Research, Quality of Life
Lin C, Lee J, Chatterjee N
Predicting domain-specific health-related quality of life using acute infarct volume.
This study evaluated whether acute infarct volume predicts domain-specific Neuro-Quality of Life scores at 3 months after stroke. It found that acute infarct volume is a poor predictor of health-related quality of life (HRQOL) domains after ischemic stroke, with the exception of the cognitive domain. Overall, clinical and imaging variables explained less than 50 percent of the variance in HRQOL outcomes at 3 months.
AHRQ-funded; HS023437.
Citation: Lin C, Lee J, Chatterjee N .
Predicting domain-specific health-related quality of life using acute infarct volume.
Stroke 2017 Jul;48(7):1925-31. doi: 10.1161/strokeaha.117.017094.
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Keywords: Quality of Life, Stroke, Patient-Centered Outcomes Research
Silverberg JI
Selected comorbidities of atopic dermatitis: atopy, neuropsychiatric, and musculoskeletal disorders.
Atopic dermatitis (AD) is a chronic pruritic inflammatory skin disease with substantial morbidity and quality of life impairment. This review summarizes recent developments in the atopic and neuropsychiatric comorbidities of AD. For example, it concludes that persons with AD appear to be at higher risk for multiple neuropsychiatric disorders, including depression, attention-deficit/hyperactivity disorder, speech disorders in childhood, headaches, and seizures.
AHRQ-funded; HS023011.
Citation: Silverberg JI .
Selected comorbidities of atopic dermatitis: atopy, neuropsychiatric, and musculoskeletal disorders.
Clin Dermatol 2017 Jul - Aug;35(4):360-66. doi: 10.1016/j.clindermatol.2017.03.008.
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Keywords: Skin Conditions, Chronic Conditions, Behavioral Health, Quality of Life, Children/Adolescents